{"id":"https://openalex.org/W193790045","doi":null,"title":"Expression of phosphorylated mTOR and its regulatory protein is related to biological behaviors of ameloblastoma.","display_name":"Expression of phosphorylated mTOR and its regulatory protein is related to biological behaviors of ameloblastoma.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W193790045","mag":"193790045","pmid":"https://pubmed.ncbi.nlm.nih.gov/22977662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438767"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2444243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438767","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100369090","display_name":"Ning Li","orcid":"https://orcid.org/0000-0002-3945-2536","observed_orcids":["https://orcid.org/0000-0002-3945-2536","https://orcid.org/0000-0003-3420-0206"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Li","raw_affiliation_strings":["Department of Pathology, School of Stomatology, China Medical University, Shengyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Stomatology, China Medical University, Shengyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101399490","display_name":"Ming Zhong","orcid":"https://orcid.org/0000-0002-1869-3648","observed_orcids":["https://orcid.org/0000-0002-1869-3648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Ming Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9034,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.82090032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"7","first_page":"660","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ameloblastoma","display_name":"ameloblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mtor-phosphorylation","display_name":"mTOR phosphorylation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/4e-bp1-phosphorylation","display_name":"4E-BP1 phosphorylation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p70s6k-phosphorylation","display_name":"p70S6K phosphorylation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nuclear-protein-localization","display_name":"nuclear protein localization","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9449999928474426},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.847000002861023},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8245189189910889},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.698755145072937},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.668606698513031},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6110050678253174},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.6020042300224304},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4412401020526886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4326283931732178},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4170665144920349},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3989407420158386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39362582564353943},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37324583530426025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3416483700275421},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29169636964797974},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2768682837486267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10465866327285767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07199788093566895}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000564","descriptor_name":"Ameloblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000564","descriptor_name":"Ameloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000564","descriptor_name":"Ameloblastoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007573","descriptor_name":"Jaw Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007573","descriptor_name":"Jaw Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007573","descriptor_name":"Jaw Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038762","descriptor_name":"Ribosomal Protein S6 Kinases, 70-kDa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2444243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22977662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22977662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3438767","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3438767/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:193790045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22977662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2444243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1513238370","https://openalex.org/W1995027830","https://openalex.org/W1999985162","https://openalex.org/W2004965467","https://openalex.org/W2006436316","https://openalex.org/W2008205044","https://openalex.org/W2038186927","https://openalex.org/W2041766504","https://openalex.org/W2050458369","https://openalex.org/W2054227402","https://openalex.org/W2056891806","https://openalex.org/W2059614347","https://openalex.org/W2060157525","https://openalex.org/W2065825082","https://openalex.org/W2066159971","https://openalex.org/W2071697398","https://openalex.org/W2072591861","https://openalex.org/W2079021353","https://openalex.org/W2090802890","https://openalex.org/W2099234003","https://openalex.org/W2114906163","https://openalex.org/W2119018696","https://openalex.org/W2125649123","https://openalex.org/W2126718734","https://openalex.org/W2129318139","https://openalex.org/W2141983633","https://openalex.org/W2142786915","https://openalex.org/W2155256293","https://openalex.org/W2157158866","https://openalex.org/W2169260922","https://openalex.org/W2375952787"],"related_works":["https://openalex.org/W2406007546","https://openalex.org/W1995027830","https://openalex.org/W2059029779","https://openalex.org/W2171807179","https://openalex.org/W3027265163","https://openalex.org/W2347635532","https://openalex.org/W7145092225","https://openalex.org/W3003473207","https://openalex.org/W1487010680","https://openalex.org/W2362311389"],"abstract_inverted_index":{"The":[0,82,110,166,203,226],"present":[1],"study":[2],"investigated":[3],"the":[4,7,15,24,33,43,49,72,80,99,108,128,137,143,149,174,179,191],"relationship":[5],"between":[6],"expression":[8,34,58,70,78,84,97,106,112,126,135,144,167,193,213,228],"of":[9,19,26,35,45,59,85,113,145,151,168,181,205,229,240,248],"p-mTOR,":[10,36,169,230],"p-4EBP1":[11,37],"and":[12,17,23,38,42,51,74,101,131,171,232,242],"p-p70S6K":[13,39,114,125,134,172,233],"in":[14,40,48,61,71,79,98,107,127,136,148,161,173,208,220],"cytoplasm":[16,52,138],"nucleus":[18,50,73,100,129,150,175],"ameloblastoma":[20],"(AB)":[21],"cells":[22],"invasiveness":[25,180],"ABs.":[27,62,182],"Immunohistochemistry":[28],"was":[29,53,56,87,115,156,176,214,234,244],"performed":[30],"to":[31,178],"detect":[32],"ABs":[41],"level":[44],"these":[46,119],"proteins":[47,147],"scored.":[54],"There":[55],"ectopic":[57,83,111],"p-mTOR":[60,69,77,192,212,224,243],"27":[63],"AB":[64,197,206],"patients":[65,91,152,209],"were":[66,93,122],"positive":[67,94,123],"for":[68,76,95,104,124,133],"47":[75],"cytoplasm.":[81,109],"p-4EBP-1":[86,96,105],"also":[88,116],"noted.":[89,117],"23":[90],"(27%)":[92],"55":[102],"(64.7%)":[103],"Of":[118],"patients,":[120],"33":[121],"(38.8%)":[130],"45":[132],"(52.9%).":[139],"Statistical":[140],"analysis":[141,184],"showed":[142,190],"three":[146],"with":[153,163,185,210,222,236],"recurrent":[154],"cancer":[155],"markedly":[157],"higher":[158,217],"than":[159,218],"that":[160,219],"those":[162,221],"primary":[164],"cancer.":[165],"p-4E-BP1":[170,231],"related":[177],"Multivariable":[183],"Cox":[186],"proportional":[187],"hazards":[188],"model":[189],"had":[194],"influence":[195],"on":[196],"recurrence":[198,207],"(OR:":[199],"6.417,":[200],"95%CI:":[201],"1.428-28.824).":[202],"possibility":[204],"nuclear":[211,227],"6.417":[215],"folds":[216],"cytoplasmic":[223],"expression.":[225],"associated":[235],"biological":[237],"behaviors":[238],"(invasiveness)":[239],"ABs,":[241],"an":[245],"independent":[246],"predictor":[247],"AB.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
