{"id":"https://openalex.org/W1937763560","doi":null,"title":"Cardiovascular and renal alterations on the nitric oxide pathway in spontaneous hypertension and ageing.","display_name":"Cardiovascular and renal alterations on the nitric oxide pathway in spontaneous hypertension and ageing.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1937763560","mag":"1937763560","pmid":"https://pubmed.ncbi.nlm.nih.gov/17641405"},"language":"en","primary_location":{"id":"pmid:17641405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17641405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040399381","display_name":"S\u00edlvia Llorens","orcid":"https://orcid.org/0000-0002-2104-5414","observed_orcids":["https://orcid.org/0000-0002-2104-5414"]},"institutions":[{"id":"https://openalex.org/I79189158","display_name":"University of Castilla-La Mancha","ror":"https://ror.org/05r78ng12","country_code":"ES","type":"education","lineage":["https://openalex.org/I79189158"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Llorens","raw_affiliation_strings":["Department of Medical Sciences, University of Castilla-La Mancha and Centro Regional de Investigaciones Biom\u00e9dicas, Albacete, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, University of Castilla-La Mancha and Centro Regional de Investigaciones Biom\u00e9dicas, Albacete, Spain","institution_ids":["https://openalex.org/I79189158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061878808","display_name":"Ana Patricia Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-3843-4715","observed_orcids":["https://orcid.org/0000-0002-3843-4715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Patricia Fern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024634587","display_name":"Eduardo Nava","orcid":"https://orcid.org/0000-0003-3259-0511","observed_orcids":["https://orcid.org/0000-0003-3259-0511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo Nava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.161,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75425216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"1-2","first_page":"149","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-pathway","display_name":"nitric oxide pathway","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9309999942779541},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9259999990463257},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cardiovascular-function","display_name":"cardiovascular function","score":0.8389999866485596},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.7160000205039978},{"id":"https://openalex.org/keywords/plasma-nitrate","display_name":"plasma nitrate","score":0.7260000109672546},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.875},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/left-ventricle","display_name":"left ventricle","score":0.7570000290870667},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.6589999794960022},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.7400000095367432},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.734977662563324},{"id":"https://openalex.org/C2780512574","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal medulla","level":3,"score":0.7036904692649841},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6962711811065674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6841088533401489},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6263679265975952},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5909147262573242},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5592888593673706},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.5573938488960266},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5431813597679138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5419058203697205},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5383558869361877},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4663746953010559},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3221743702888489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10600355267524719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:17641405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17641405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W274441265","https://openalex.org/W1506814648","https://openalex.org/W1971555177","https://openalex.org/W1978969417","https://openalex.org/W1979453694","https://openalex.org/W1984628764","https://openalex.org/W1988096468","https://openalex.org/W1996728375","https://openalex.org/W2044485644","https://openalex.org/W2044918962","https://openalex.org/W2058520514","https://openalex.org/W2065495110","https://openalex.org/W2082188810","https://openalex.org/W2085332804","https://openalex.org/W2089536654","https://openalex.org/W2092776120","https://openalex.org/W2099111270","https://openalex.org/W2111718849","https://openalex.org/W2114257173","https://openalex.org/W2115461812","https://openalex.org/W2118395999","https://openalex.org/W2135658051","https://openalex.org/W2140704005","https://openalex.org/W2165521770","https://openalex.org/W2177967727","https://openalex.org/W2184796864","https://openalex.org/W2217598352","https://openalex.org/W2259128162","https://openalex.org/W2317093296","https://openalex.org/W2319588775","https://openalex.org/W2322718002","https://openalex.org/W2409601557","https://openalex.org/W2434741374"],"related_works":["https://openalex.org/W2082188810","https://openalex.org/W2052700145","https://openalex.org/W2168038844","https://openalex.org/W3137956257","https://openalex.org/W2120670639","https://openalex.org/W2217598352","https://openalex.org/W1992425296","https://openalex.org/W2369377083","https://openalex.org/W2322718002","https://openalex.org/W2184991989"],"abstract_inverted_index":{"We":[0],"have":[1,87],"assessed":[2,27],"the":[3,7,31,40,46,55,62,75,95,108,121,125,129,133,151,158],"NO":[4,24,43,63,76,92,103,152],"system":[5],"in":[6,35,45,80,94,110,120,141,154,157],"cardiovascular":[8],"and":[9,15,19,49,51,101,135,143,148,165],"renal":[10,126],"systems":[11],"of":[12,33,42,61,91,97,115,124,128,160],"young,":[13],"adult":[14,98],"old":[16],"normotensive":[17],"(WKY)":[18],"hypertensive":[20],"rats":[21],"(SHR).":[22],"The":[23],"pathway":[25,77,153],"was":[26,118,139],"analytically,":[28],"by":[29,53],"measuring":[30,54],"concentration":[32],"nitrate":[34],"plasma":[36],"as":[37,39],"well":[38],"activity":[41],"synthases":[44,93,104],"left":[47],"ventricle":[48],"kidney;":[50],"functionally,":[52],"isometric":[56],"forces":[57],"generated":[58],"upon":[59],"addition":[60],"blocker,":[64],"L-NAME,":[65],"to":[66],"aortic":[67],"segments.":[68],"All":[69],"these":[70],"procedures":[71],"consistently":[72],"revealed":[73],"that":[74],"is":[78],"upregulated":[79],"hypertension":[81,147],"or":[82],"senescence.":[83],"In":[84,145],"addition,":[85],"we":[86],"performed":[88],"immunohistochemical":[89],"studies":[90],"kidney":[96,109],"animals":[99],"(WKY":[100],"SHR).":[102],"are":[105],"expressed":[106],"throughout":[107],"both":[111],"rat":[112],"strains.":[113],"Immunoreactivity":[114],"neuronal":[116],"NOS":[117,137],"higher":[119],"tubular":[122],"cells":[123],"medulla":[127],"SHR.":[130],"Staining":[131],"with":[132],"inducible":[134],"endothelial":[136],"antibodies":[138],"similar":[140],"normo-":[142],"hypertension.":[144],"summary,":[146],"ageing":[149],"upregulate":[150],"structures":[155],"involved":[156],"regulation":[159],"blood":[161],"pressure":[162],"(heart,":[163],"vessels":[164],"kidney).":[166]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
