{"id":"https://openalex.org/W1937541205","doi":"https://doi.org/10.3109/10428199709042502","title":"Apoptosis in Chronic Myelogenous Leukemia: Studies of Stage-Specific Differences","display_name":"Apoptosis in Chronic Myelogenous Leukemia: Studies of Stage-Specific Differences","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1937541205","doi":"https://doi.org/10.3109/10428199709042502","mag":"1937541205","pmid":"https://pubmed.ncbi.nlm.nih.gov/9130620"},"language":"en","primary_location":{"id":"doi:10.3109/10428199709042502","doi":"https://doi.org/10.3109/10428199709042502","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10428199709042502","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia &amp; Lymphoma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049331182","display_name":"Heinz Gisslinger","orcid":"https://orcid.org/0000-0002-0295-7629","observed_orcids":["https://orcid.org/0000-0002-0295-7629"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heinz Gisslinger","raw_affiliation_strings":["Department of Clinical Investigation, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039028985","display_name":"Meir Wetzler","orcid":"https://orcid.org/0000-0003-1397-5942","observed_orcids":["https://orcid.org/0000-0003-1397-5942"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meir Wetzler","raw_affiliation_strings":["Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109125245","display_name":"Susan L. Tucker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Tucker","raw_affiliation_strings":["Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop Kantarjian","raw_affiliation_strings":["Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027543393","display_name":"Bud Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Budd Robertson","raw_affiliation_strings":["Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, Department of Hematology, and Department of Biomathematics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011529063","display_name":"Moshe Talpaz","orcid":"https://orcid.org/0000-0003-3361-3981","observed_orcids":["https://orcid.org/0000-0003-3361-3981"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moshe Talpaz","raw_affiliation_strings":["Department of Bioimmunotherapy/ Box 302., University of Texas M.D. Anderson, Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioimmunotherapy/ Box 302., University of Texas M.D. Anderson, Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":1.1534,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76733928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"25","issue":"1-2","first_page":"121","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9829999804496765},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.8989999890327454},{"id":"https://openalex.org/keywords/blast-crisis","display_name":"blast crisis","score":0.4959999918937683},{"id":"https://openalex.org/keywords/accelerated-phase","display_name":"accelerated phase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chronic-phase","display_name":"chronic phase","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neutrophil-survival","display_name":"neutrophil survival","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cell-metabolic-activity","display_name":"cell metabolic activity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.8560000061988831},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9120000004768372},{"id":"https://openalex.org/keywords/autologous-serum","display_name":"autologous serum","score":0.7940000295639038},{"id":"https://openalex.org/keywords/bone-marrow-neutrophils","display_name":"bone marrow neutrophils","score":0.8209999799728394},{"id":"https://openalex.org/keywords/peripheral-blood-neutrophils","display_name":"peripheral blood neutrophils","score":0.8489999771118164},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6903976202011108},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6622941493988037},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.6492557525634766},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5519866943359375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5462824702262878},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5192468166351318},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.48707225918769836},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.47642406821250916},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4549815058708191},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.387312114238739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3255802392959595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26403170824050903},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2373015582561493},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21112632751464844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001752","descriptor_name":"Blast Crisis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10428199709042502","doi":"https://doi.org/10.3109/10428199709042502","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10428199709042502","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia &amp; Lymphoma","raw_type":"journal-article"},{"id":"pmid:9130620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9130620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia & lymphoma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W49853543","https://openalex.org/W85529956","https://openalex.org/W140465258","https://openalex.org/W146301169","https://openalex.org/W341725904","https://openalex.org/W1501358984","https://openalex.org/W1906197854","https://openalex.org/W1964445294","https://openalex.org/W1968022845","https://openalex.org/W2036631709","https://openalex.org/W2040914101","https://openalex.org/W2041440798","https://openalex.org/W2052853635","https://openalex.org/W2060092781","https://openalex.org/W2066326340","https://openalex.org/W2071808385","https://openalex.org/W2095234347","https://openalex.org/W2332067872","https://openalex.org/W2402402931","https://openalex.org/W2403381121","https://openalex.org/W2405348726","https://openalex.org/W2413037117","https://openalex.org/W2469683579","https://openalex.org/W3043498566","https://openalex.org/W3113125785"],"related_works":["https://openalex.org/W1965018196","https://openalex.org/W2052828111","https://openalex.org/W2135838280","https://openalex.org/W2017860492","https://openalex.org/W2023075617","https://openalex.org/W2056119504","https://openalex.org/W1998432874","https://openalex.org/W1634319202","https://openalex.org/W2045974849","https://openalex.org/W1591211096"],"abstract_inverted_index":{"In":[0],"this":[1],"study":[2],"we":[3],"compared":[4,113,209],"rates":[5,62,91,195],"of":[6,32,37,48,63,92,167,196,223,253,267],"apoptosis,":[7],"survival":[8,161],"and":[9,20,28,36,42,56,69,96,104,141,171,201,214,233],"metabolic":[10,204],"activity":[11],"from":[12,24,127,155,187],"CML":[13,68,99,133,174,190,228],"peripheral":[14,18,71,116,149,169],"blood":[15,19,72,117,150,170],"neutrophils":[16,23,73,100,109,118,126,151,153,186,229],"with":[17],"bone":[21,107,157],"marrow":[22,108,158],"healthy":[25],"volunteer":[26],"donors":[27],"studied":[29],"the":[30,33,75,177,221,250,265],"influence":[31],"disease":[34],"stage":[35],"cytokines":[38],"including":[39],"G-CSF,":[40],"GM-CSF":[41,215],"IL-1beta":[43,239],"on":[44],"these":[45],"parameters.":[46],"Quantification":[47],"apoptosis":[49,64,93,197,224],"by":[50,57],"morphology,":[51],"diphenylamine":[52],"DNA":[53],"fragmentation":[54],"assay":[55],"gel":[58],"electrophoresis":[59],"showed":[60,192],"similar":[61],"in":[65,79,84,94,105,120,181,225,259],"chronic":[66,128,172,188,226],"phase":[67,98,129,132,173,189,227],"normal":[70,106,115,148,156,168,211],"when":[74],"cells":[76,178],"were":[77,89,179,216],"incubated":[78,180],"RPMI":[80,121,182],"+":[81,122,183],"FCS":[82],"or":[83,130],"serum-free":[85],"medium.":[86],"However,":[87],"there":[88],"lower":[90,194],"accelerated":[95],"blast":[97],"(p":[101,110,138,198,206,230],"<":[102,111,139,143,199,207,231],".001)":[103,112],"to":[114,210,218],"(incubated":[119],"FCS).":[123],"Survival":[124],"among":[125,147],"accelerated/blast":[131],"patients":[134,191],"was":[135],"significantly":[136],"longer":[137],"0.002":[140],"p":[142,234],"0.001,":[144],"respectively)":[145,237],"than":[146],"but":[152],"purified":[154],"had":[159],"a":[160],"rate":[162,222],"which":[163],"fell":[164],"between":[165],"that":[166,249],"patients.":[175],"When":[176],"autologous":[184],"sera,":[185],"markedly":[193],"0.001)":[200],"maintained":[202],"higher":[203],"activities":[205],"0.002)":[208],"neutrophils.":[212],"G-CSF":[213],"found":[217],"considerably":[219],"decrease":[220],"0.001":[232],"=":[235],"0.008":[236],"while":[238],"did":[240],"not":[241],"show":[242],"any":[243],"antiapoptotic":[244],"effect.":[245],"It":[246],"is":[247],"suggested":[248],"endogenous":[251],"production":[252],"growth":[254],"factors":[255],"may":[256],"therefore":[257],"participate":[258],"delaying":[260],"apoptotic":[261],"cell":[262],"death,":[263],"during":[264],"progression":[266],"CML.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}