{"id":"https://openalex.org/W1937354581","doi":null,"title":"Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET.","display_name":"Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET.","publication_year":2003,"publication_date":"2003-09-15","ids":{"openalex":"https://openalex.org/W1937354581","mag":"1937354581","pmid":"https://pubmed.ncbi.nlm.nih.gov/14519655"},"language":"en","primary_location":{"id":"pmid:14519655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14519655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105286128","display_name":"Wen G. Jiang","orcid":"https://orcid.org/0000-0002-3283-1111","observed_orcids":["https://orcid.org/0000-0002-3283-1111"]},"institutions":[{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wen G Jiang","raw_affiliation_strings":["Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK. jiangw@cf.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK. jiangw@cf.ac.uk","institution_ids":["https://openalex.org/I97429440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057395695","display_name":"David Grimshaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Grimshaw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105309586","display_name":"Tracey Amanda Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tracey A Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109408436","display_name":"Gaynor Davies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaynor Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103039485","display_name":"Christian Parr","orcid":"https://orcid.org/0000-0002-1176-8168","observed_orcids":["https://orcid.org/0000-0002-1176-8168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Parr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gareth Watkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gareth Watkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021802346","display_name":"Jane Lane","orcid":"https://orcid.org/0000-0002-1926-4909","observed_orcids":["https://orcid.org/0000-0002-1926-4909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane Lane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044442671","display_name":"Roger Abounader","orcid":"https://orcid.org/0000-0003-4075-9460","observed_orcids":["https://orcid.org/0000-0003-4075-9460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger Abounader","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068043303","display_name":"John Laterra","orcid":"https://orcid.org/0000-0002-2983-5365","observed_orcids":["https://orcid.org/0000-0002-2983-5365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Laterra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058372074","display_name":"Robert E. Mansel","orcid":"https://orcid.org/0000-0002-8051-0726","observed_orcids":["https://orcid.org/0000-0002-8051-0726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E Mansel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8178,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.90264219,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"11","first_page":"4274","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.8389999866485596},{"id":"https://openalex.org/keywords/stromal-fibroblasts","display_name":"stromal fibroblasts","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mammary-tumor-growth","display_name":"mammary tumor growth","score":0.8339999914169312},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mrc-5-fibroblasts","display_name":"MRC-5 fibroblasts","score":0.9190000295639038},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.9087594747543335},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5747315883636475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5423903465270996},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5088277459144592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5047160387039185},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5040880441665649},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.488233357667923},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4343821108341217},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4186328649520874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3301161527633667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3105669617652893},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.06422719359397888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14519655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14519655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:1937354581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14519655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1551629532","https://openalex.org/W1679677827","https://openalex.org/W1755134370","https://openalex.org/W1938617858","https://openalex.org/W1987471320","https://openalex.org/W1991628433","https://openalex.org/W1999090780","https://openalex.org/W2000788184","https://openalex.org/W2001046604","https://openalex.org/W2002926055","https://openalex.org/W2005782838","https://openalex.org/W2006474992","https://openalex.org/W2018672261","https://openalex.org/W2035174231","https://openalex.org/W2102304220","https://openalex.org/W2104075773","https://openalex.org/W2106780193","https://openalex.org/W2111279109","https://openalex.org/W2119738345","https://openalex.org/W2126890008","https://openalex.org/W2147213688","https://openalex.org/W2154070518","https://openalex.org/W2166927748","https://openalex.org/W2170846037","https://openalex.org/W2796575992"],"related_works":["https://openalex.org/W1820115685","https://openalex.org/W2737852749","https://openalex.org/W2166927748","https://openalex.org/W2078963072","https://openalex.org/W2076355088","https://openalex.org/W2105213327","https://openalex.org/W2092064654","https://openalex.org/W2025023355","https://openalex.org/W2126890008","https://openalex.org/W2408908877"],"abstract_inverted_index":{"PURPOSE:":[0],"Hepatocyte":[1],"growth":[2,42,179,210,247],"factor/scatter":[3],"factor":[4],"(HGF/SF)":[5],"is":[6],"known":[7],"to":[8,51,134],"increase":[9],"the":[10,41,165,170,193,220,246],"invasiveness":[11,137],"and":[12,19,34,112,127,169,192,251],"migration":[13],"of":[14,27,43,161,180,204,208,215,222,248],"cancer":[15,32,70,242,250],"cells":[16,33,71,96,111,171,200,243],"in":[17,99,109,114,147,224,234,240],"vitro":[18],"induce":[20],"angiogenesis.":[21],"This":[22],"study":[23],"examined":[24],"if":[25],"inhibition":[26],"HGF/SF":[28,35,55,59,148,233],"receptor":[29,56,108,238],"expression":[30,36],"by":[31,37,124,213,219,254],"stromal":[38],"fibroblasts":[39,235],"affects":[40],"mammary":[44,69,241,249],"cancer.":[45],"EXPERIMENTAL":[46],"DESIGN:":[47],"Transgenes":[48],"encoding":[49],"ribozymes":[50,121],"specifically":[52],"target":[53],"human":[54,81],"(pLXSN-MET)":[57],"or":[58,236],"(pLXSN-HGF)":[60],"were":[61,97,116,201],"constructed":[62],"using":[63],"a":[64,100,144,158],"pLXSN":[65],"retroviral":[66],"vector.":[67],"Human":[68],"MDA":[72],"MB":[73],"231":[74],"was":[75,90,132,183,196,211],"transduced":[76,91,172],"with":[77,92,119,140,164,173,188],"pLXSN-MET":[78],"(MDA(+/+)).":[79],"A":[80],"fibroblast":[82],"cell":[83,258],"line":[84],"MRC5,":[85],"which":[86],"produces":[87],"bioactive":[88],"HGF/SF,":[89],"pLXSN-HGF":[93],"(MRC5(+/+)).":[94],"These":[95],"used":[98],"nude":[101,154],"mice":[102],"breast":[103],"tumor":[104,182,209,226],"model.":[105],"RESULTS:":[106],"HGF":[107,113],"MDA(+/+)":[110,131,156],"MRC5(+/+)cells":[115],"successfully":[117],"removed":[118],"respective":[120],"as":[122,217],"shown":[123],"reverse":[125],"transcription-PCR":[126],"Western":[128],"blotting,":[129],"respectively.":[130],"found":[133],"have":[135],"reduced":[136,197],"when":[138,186,198],"stimulated":[139],"HGF/SF.":[141],"MRC5(+/+)":[142,199],"exhibited":[143,157],"significant":[145],"reduction":[146,207,214],"production.":[149],"When":[150],"injected":[151],"into":[152],"athymic":[153],"mice,":[155],"slower":[159],"rate":[160],"growth,":[162],"compared":[163],"wild":[166],"type":[167],"(MDA(-/-)),":[168],"control":[174],"viral":[175],"vector":[176],"(MDA(+/-)).":[177],"The":[178,206],"MDA(-/-)":[181],"significantly":[184],"enhanced":[185],"coimplanted":[187,202],"wild-type":[189],"MRC5":[190],"(MRC5(-/-)),":[191],"stimulatory":[194],"effect":[195],"instead":[203],"MRC5(-/-).":[205],"accompanied":[212],"angiogenesis,":[216],"demonstrated":[218],"staining":[221],"VE-cadherin":[223],"primary":[225],"tissues.":[227],"CONCLUSIONS:":[228],"Retroviral":[229],"ribozyme":[230],"transgenes":[231],"targeting":[232],"its":[237],"cMET":[239],"can":[244],"reduce":[245],"associated":[252],"angiogenesis":[253],"inhibiting":[255],"paracrine":[256],"stromal-tumor":[257],"interactions.":[259]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
