{"id":"https://openalex.org/W1937136185","doi":"https://doi.org/10.1128/jb.104.1.351-359.1970","title":"Metabolic Influences on Tyrosine Excretion in Bacillus subtilis","display_name":"Metabolic Influences on Tyrosine Excretion in Bacillus subtilis","publication_year":1970,"publication_date":"1970-10-01","ids":{"openalex":"https://openalex.org/W1937136185","doi":"https://doi.org/10.1128/jb.104.1.351-359.1970","mag":"1937136185","pmid":"https://pubmed.ncbi.nlm.nih.gov/4990762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/248221"},"language":"en","primary_location":{"id":"doi:10.1128/jb.104.1.351-359.1970","doi":"https://doi.org/10.1128/jb.104.1.351-359.1970","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.104.1.351-359.1970","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC248221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056024477","display_name":"W. Scott Champney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Scott Champney","raw_affiliation_strings":["Department of Biology, State University of New York at Buffalo, Buffalo, New York 14214","Department of Microbiology, Baylor College of Medicine, Houston, Texas 77025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, State University of New York at Buffalo, Buffalo, New York 14214","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Microbiology, Baylor College of Medicine, Houston, Texas 77025","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024030506","display_name":"Roy A. Jensen","orcid":"https://orcid.org/0000-0003-4430-2281","observed_orcids":["https://orcid.org/0000-0003-4430-2281"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy A. Jensen","raw_affiliation_strings":["Department of Biology, State University of New York at Buffalo, Buffalo, New York 14214","Department of Microbiology, Baylor College of Medicine, Houston, Texas 77025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, State University of New York at Buffalo, Buffalo, New York 14214","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Microbiology, Baylor College of Medicine, Houston, Texas 77025","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2715,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.87491789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"104","issue":"1","first_page":"351","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tyrosine-biosynthesis","display_name":"tyrosine biosynthesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/prephenate-dehydrogenase","display_name":"prephenate dehydrogenase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gene-repression","display_name":"gene repression","score":0.527999997138977},{"id":"https://openalex.org/keywords/regulatory-mutants","display_name":"regulatory mutants","score":0.7630000114440918},{"id":"https://openalex.org/keywords/carbon-source-effects","display_name":"carbon source effects","score":0.7599999904632568},{"id":"https://openalex.org/keywords/temperature-effects","display_name":"temperature effects","score":0.8270000219345093},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.8224518895149231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7400815486907959},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.652066171169281},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.6046528816223145},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5813339352607727},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5458373427391052},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.473939448595047},{"id":"https://openalex.org/C2776491826","wikidata":"https://www.wikidata.org/wiki/Q7861685","display_name":"Tyrosine aminotransferase","level":4,"score":0.4190383851528168},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4119490087032318},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.09600800275802612},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07020005583763123},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06821027398109436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.054767489433288574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004794","descriptor_name":"Enzyme Repression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005827","descriptor_name":"Genetics, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.104.1.351-359.1970","doi":"https://doi.org/10.1128/jb.104.1.351-359.1970","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.104.1.351-359.1970","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:451321","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC248221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:248221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/248221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:4990762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4990762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:451321","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC248221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W73669533","https://openalex.org/W236035234","https://openalex.org/W1552756841","https://openalex.org/W1595063322","https://openalex.org/W1678808945","https://openalex.org/W1759315463","https://openalex.org/W1775749144","https://openalex.org/W1791179347","https://openalex.org/W1792853142","https://openalex.org/W1795064408","https://openalex.org/W1807458127","https://openalex.org/W1842954570","https://openalex.org/W2048854153","https://openalex.org/W2050162176","https://openalex.org/W2069381382","https://openalex.org/W2075100243","https://openalex.org/W2100723883","https://openalex.org/W2113656412","https://openalex.org/W2147945476","https://openalex.org/W2234261857","https://openalex.org/W2268498875","https://openalex.org/W2290557620"],"related_works":["https://openalex.org/W7073681132","https://openalex.org/W1792853142","https://openalex.org/W7097030162","https://openalex.org/W1572280937","https://openalex.org/W2062099094","https://openalex.org/W2077193431","https://openalex.org/W1942554446","https://openalex.org/W7073640865","https://openalex.org/W1595063322","https://openalex.org/W1542927743"],"abstract_inverted_index":{"The":[0,62,102,120,133,175],"biosynthetic":[1],"pathway":[2],"for":[3,34,124],"tyrosine":[4,30,60,65,110,131,150,155,167,187],"synthesis":[5,13,183],"is":[6,32,41],"regulated":[7],"both":[8],"by":[9,15,66,142,206],"repression":[10],"of":[11,18,39,47,53,59,64,73,91,130,136,154,177,186,204],"enzyme":[12,19],"and":[14,37,49,94,151,172,184,209],"feedback":[16,207],"inhibition":[17,208],"activity":[20,90,135],"in":[21,88,98,158,169],"Bacillus":[22],"subtilis.":[23],"Nevertheless,":[24],"wild-type":[25,67,173],"cells":[26,68],"produce":[27],"significantly":[28,126],"more":[29],"than":[31],"required":[33],"protein":[35],"synthesis,":[36],"part":[38],"this":[40],"excreted":[42,105],"into":[43],"the":[44,57,87,99,112,128,143,166,170,182,190],"medium.":[45],"Alteration":[46],"nutritional":[48],"other":[50],"environmental":[51,179],"conditions":[52,180],"cultivation":[54],"strongly":[55],"influenced":[56,127],"amount":[58],"excretion.":[61,132],"excretion":[63,83,185],"was":[69,139],"compared":[70],"with":[71,86,96,148],"that":[72,192],"a":[74,78],"regulatory":[75,103],"mutant":[76,104,171],"having":[77],"feedback-insensitive":[79],"prephenate":[80,92,137],"dehydrogenase.":[81],"Tyrosine":[82],"varied":[84],"directly":[85],"vitro":[89],"dehydrogenase":[93,138],"inversely":[95],"temperature":[97],"two":[100],"strains.":[101,174],"five":[106],"times":[107],"as":[108,111],"much":[109],"wild":[113],"type":[114],"at":[115],"all":[116],"growth":[117,125],"temperatures":[118],"examined.":[119],"carbon":[121,144],"source":[122],"used":[123,162],"level":[129],"specific":[134],"also":[140],"affected":[141],"source.":[145],"Incorporation":[146],"studies":[147],"isotopic":[149],"fluorometric":[152],"determinations":[153],"concentrations":[156],"extractable":[157],"hot":[159],"water":[160],"were":[161],"to":[163,189],"measure":[164],"operationally":[165],"pools":[168],"effects":[176],"various":[178],"on":[181],"led":[188],"conclusion":[191],"metabolic":[193],"controls":[194],"governing":[195],"end":[196],"product":[197],"contrations":[198],"exist":[199],"which":[200],"are":[201],"completely":[202],"independent":[203],"regulation":[205],"repression.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}