{"id":"https://openalex.org/W1936630866","doi":"https://doi.org/10.4049/jimmunol.170.4.1925","title":"Associations of MHC Ancestral Haplotypes with Resistance/Susceptibility to AIDS Disease Development","display_name":"Associations of MHC Ancestral Haplotypes with Resistance/Susceptibility to AIDS Disease Development","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W1936630866","doi":"https://doi.org/10.4049/jimmunol.170.4.1925","mag":"1936630866","pmid":"https://pubmed.ncbi.nlm.nih.gov/12574360"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.170.4.1925","doi":"https://doi.org/10.4049/jimmunol.170.4.1925","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.4.1925","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024976962","display_name":"Pedro O. Flores-Villanueva","orcid":"https://orcid.org/0000-0002-6184-4616","observed_orcids":["https://orcid.org/0000-0002-6184-4616"]},"institutions":[{"id":"https://openalex.org/I192513696","display_name":"National University of San Marcos","ror":"https://ror.org/006vs7897","country_code":"PE","type":"education","lineage":["https://openalex.org/I192513696"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["PE","US"],"is_corresponding":false,"raw_author_name":"Pedro O Flores-Villanueva","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02115","Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando , Lima ,","\u00b6Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando, Lima, Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02115","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando , Lima ,","institution_ids":["https://openalex.org/I192513696"]},{"raw_affiliation_string":"\u00b6Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando, Lima, Peru","institution_ids":["https://openalex.org/I192513696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057607966","display_name":"Houria Hendel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Houria Hendel","raw_affiliation_strings":["Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","\u2020Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"\u2020Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France;","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004581254","display_name":"Sophie Caillat\u2010Zucman","orcid":"https://orcid.org/0000-0002-4535-3550","observed_orcids":["https://orcid.org/0000-0002-4535-3550"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Caillat-Zucman","raw_affiliation_strings":["Laboratoire d\u2019Immunologie, Ho\u0302pital Necker , Paris ,","\u2021Laboratoire d\u2019Immunologie, Ho\u0302pital Necker, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Immunologie, Ho\u0302pital Necker , Paris ,","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"\u2021Laboratoire d\u2019Immunologie, Ho\u0302pital Necker, Paris, France;","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024314884","display_name":"Jay Rappaport","orcid":"https://orcid.org/0000-0001-7916-3571","observed_orcids":["https://orcid.org/0000-0001-7916-3571"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Rappaport","raw_affiliation_strings":["Center for Neurovirology and Cancer, Temple University , Philadelphia, PA 19122","\u00a7Center for Neurovirology and Cancer, Temple University, Philadelphia, PA 19122; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurovirology and Cancer, Temple University , Philadelphia, PA 19122","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"\u00a7Center for Neurovirology and Cancer, Temple University, Philadelphia, PA 19122; and","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079150165","display_name":"Alberto Burgos-Tiburcio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto Burgos-Tiburcio","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109077468","display_name":"S\u00e9bastien Bertin-Maghit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastien Bertin-Maghit","raw_affiliation_strings":["Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","\u2020Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"\u2020Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France;","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109211595","display_name":"Jorge A Ruiz-Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge A Ruiz-Morales","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004726405","display_name":"Maria E. Teran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192513696","display_name":"National University of San Marcos","ror":"https://ror.org/006vs7897","country_code":"PE","type":"education","lineage":["https://openalex.org/I192513696"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Maria E Teran","raw_affiliation_strings":["Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando , Lima ,","\u00b6Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando, Lima, Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando , Lima ,","institution_ids":["https://openalex.org/I192513696"]},{"raw_affiliation_string":"\u00b6Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando, Lima, Peru","institution_ids":["https://openalex.org/I192513696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119962785","display_name":"Juan Rodr\u00edguez-Tafur-D\u00e1vila","orcid":"https://orcid.org/0000-0002-1301-9427","observed_orcids":["https://orcid.org/0000-0002-1301-9427","https://orcid.org/0000-0003-1372-5599"]},"institutions":[{"id":"https://openalex.org/I192513696","display_name":"National University of San Marcos","ror":"https://ror.org/006vs7897","country_code":"PE","type":"education","lineage":["https://openalex.org/I192513696"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Juan Rodriguez-Tafur","raw_affiliation_strings":["Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando , Lima ,","\u00b6Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando, Lima, Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando , Lima ,","institution_ids":["https://openalex.org/I192513696"]},{"raw_affiliation_string":"\u00b6Universidad Nacional Mayor de San Marcos, Escuela de Medicina de San Fernando, Lima, Peru","institution_ids":["https://openalex.org/I192513696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110526676","display_name":"Jean\u2010Fran\u00e7ois Zagury","orcid":"https://orcid.org/0000-0003-4309-9277","observed_orcids":["https://orcid.org/0000-0003-4309-9277"]},"institutions":[{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jean-Franc\u0327ois Zagury","raw_affiliation_strings":["Center for Neurovirology and Cancer, Temple University , Philadelphia, PA 19122","Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","\u00a7Center for Neurovirology and Cancer, Temple University, Philadelphia, PA 19122; and","\u2020Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurovirology and Cancer, Temple University , Philadelphia, PA 19122","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"\u00a7Center for Neurovirology and Cancer, Temple University, Philadelphia, PA 19122; and","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"\u2020Centre de Recherche des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France;","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.681,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.93898978,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"170","issue":"4","first_page":"1925","last_page":"1929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids-progression","display_name":"AIDS progression","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.5370000004768372},{"id":"https://openalex.org/keywords/hla-b35","display_name":"HLA-B35","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hla-a29","display_name":"HLA-A29","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hla-b-57","display_name":"HLA-B*57","score":1.0},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8169999718666077},{"id":"https://openalex.org/keywords/recombinant-haplotypes","display_name":"recombinant haplotypes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hla-class-i-association","display_name":"HLA class I association","score":0.6169999837875366},{"id":"https://openalex.org/keywords/immunodeficiency-virus","display_name":"immunodeficiency virus","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.9271969795227051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7089451551437378},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6979968547821045},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6465027332305908},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6190710067749023},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6079264283180237},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5735521912574768},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5684878826141357},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39175447821617126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2371569573879242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12194490432739258},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.11113831400871277},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015236","descriptor_name":"HLA-C Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.170.4.1925","doi":"https://doi.org/10.4049/jimmunol.170.4.1925","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.4.1925","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12574360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12574360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"},{"id":"pmh:oai:ateneo.unmsm.edu.pe:123456789/286","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/123456789/286","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1269294009","display_name":null,"funder_award_id":"R21 HL 72177-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3894866760","display_name":null,"funder_award_id":"K30 HL 04095-04","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4244284161","display_name":"SCHOLARS IN CLINICAL SCIENCE PROGRAM","funder_award_id":"5k30hl004095-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5281407222","display_name":"IMPROVED BLOOD SERVICE CARE FOR CYTOPENIC PATIENTS","funder_award_id":"P01HL029583","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5847402785","display_name":null,"funder_award_id":"HL 29583","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8423547221","display_name":"MCP-1 and susceptibility to active tuberculosis","funder_award_id":"R21HL072177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1928100000","https://openalex.org/W1963813930","https://openalex.org/W1967333360","https://openalex.org/W1971328622","https://openalex.org/W1980183286","https://openalex.org/W1995453338","https://openalex.org/W2005062591","https://openalex.org/W2014208459","https://openalex.org/W2032510252","https://openalex.org/W2035153413","https://openalex.org/W2035555649","https://openalex.org/W2058321555","https://openalex.org/W2060941543","https://openalex.org/W2061542205","https://openalex.org/W2063485002","https://openalex.org/W2073281249","https://openalex.org/W2075180578","https://openalex.org/W2079030854","https://openalex.org/W2093576556","https://openalex.org/W2100108036","https://openalex.org/W2104829364","https://openalex.org/W2115242638","https://openalex.org/W2116171543","https://openalex.org/W2139014493","https://openalex.org/W2142405752","https://openalex.org/W2145378546","https://openalex.org/W2156465884","https://openalex.org/W2157824753","https://openalex.org/W2162322548","https://openalex.org/W2170069789","https://openalex.org/W2319747052"],"related_works":["https://openalex.org/W631149730","https://openalex.org/W2162322548","https://openalex.org/W2066494078","https://openalex.org/W2171789044","https://openalex.org/W1963813930","https://openalex.org/W183511895","https://openalex.org/W1973163076","https://openalex.org/W2011033037","https://openalex.org/W2010594700","https://openalex.org/W2462940794"],"abstract_inverted_index":{"We":[0],"tested":[1],"the":[2,20,43,88,121,130,132,157,164,167,171,184,188,216,240],"association":[3],"of":[4,23,45,123,156,160,166,187,219],"MHC":[5,168,185,241],"ancestral":[6,38,80,111,125],"haplotypes":[7,39,81,112,162,176,192],"with":[8,29,51,84,115,146,178,194,207,225,235],"rapid":[9,85,179,222],"or":[10],"slow":[11,116,195],"progression":[12,117,180,196],"to":[13,25,47,118,181,197,232],"AIDS":[14,182],"by":[15],"comparing":[16],"their":[17],"frequencies":[18],"in":[19,32,42,129,170,221],"French":[21,35],"genetics":[22,44],"resistance/susceptibility":[24,46],"immunodeficiency":[26,48],"virus":[27,49],"cohort":[28,50],"that":[30],"reported":[31],"a":[33,52],"control":[34],"population.":[36],"Seven":[37],"were":[40,82,113,134],"identified":[41,202],"frequency":[53,122],">1%.":[54],"The":[55,154],"8.1":[56],"(odds":[57],"ratio":[58],"(OR)":[59],"=":[60,63,67,70,75,78,91,94,98,106],"3,":[61],"p":[62,69,77,93,100,108,148],"0.006),":[64],"35.1":[65],"(OR":[66,74,90,97,105],"5.7,":[68],"0.001),":[71,95],"and":[72,103,174,183,190,227],"44.2":[73,175],"3.4,":[76],"0.007)":[79],"associated":[83,114,177,193,206],"progression,":[86],"whereas":[87],"35.2":[89],"3.6,":[92],"44.1":[96,189],"5.4,":[99],"<":[101,109],"10(-4)),":[102],"57.1":[104,191],"5.8,":[107],"10(-4))":[110],"AIDS.":[119,198],"Although":[120],"each":[124],"haplotype":[126],"is":[127],"low":[128,151],"population,":[131],"OR":[133],"quite":[135],"higher":[136],"than":[137],"those":[138],"previously":[139],"obtained":[140],"for":[141],"single":[142,203],"HLA":[143,204],"allele":[144],"associations,":[145],"some":[147],"values":[149],"as":[150,152],"10(-4).":[153],"analysis":[155],"recombinant":[158,213],"fragments":[159,214],"these":[161],"allowed":[163],"identification":[165],"regions":[169,186],"35.1,":[172],"35.2,":[173],"Previous":[199],"studies":[200],"have":[201],"alleles":[205],"disease":[208],"progression.":[209,223],"Our":[210],"results":[211],"on":[212],"confirm":[215],"direct":[217],"role":[218],"HLA-B35":[220],"Associations":[224],"HLA-A29":[226],"-B57":[228],"might":[229],"be":[230],"due":[231],"linkage":[233],"disequilibrium":[234],"other":[236],"causative":[237],"genes":[238],"within":[239],"region.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}