{"id":"https://openalex.org/W1936593340","doi":"https://doi.org/10.1242/jcs.113.18.3127","title":"Plakoglobin and \u03b2-catenin: Protein interactions, regulation and biological roles","display_name":"Plakoglobin and \u03b2-catenin: Protein interactions, regulation and biological roles","publication_year":2000,"publication_date":"2000-09-15","ids":{"openalex":"https://openalex.org/W1936593340","doi":"https://doi.org/10.1242/jcs.113.18.3127","mag":"1936593340","pmid":"https://pubmed.ncbi.nlm.nih.gov/10954412"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.113.18.3127","doi":"https://doi.org/10.1242/jcs.113.18.3127","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.113.18.3127","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070947203","display_name":"Jacob Zhurinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jacob Zhurinsky","raw_affiliation_strings":["Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016479290","display_name":"Michael S. Shtutman","orcid":"https://orcid.org/0000-0002-2458-3226","observed_orcids":["https://orcid.org/0000-0002-2458-3226"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michael Shtutman","raw_affiliation_strings":["Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083247133","display_name":"Avri Ben\u2010Ze'ev","orcid":"https://orcid.org/0000-0001-6113-3921","observed_orcids":["https://orcid.org/0000-0001-6113-3921"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avri Ben-Ze\u2032ev","raw_affiliation_strings":["Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":null,"apc_paid":null,"fwci":1.4557,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.81401515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"113","issue":"18","first_page":"3127","last_page":"3139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plakoglobin","display_name":"plakoglobin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/catenins","display_name":"catenins","score":0.8460000157356262},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.8790000081062317},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8379999995231628},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.722000002861023},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.960942268371582},{"id":"https://openalex.org/C48220470","wikidata":"https://www.wikidata.org/wiki/Q21139990","display_name":"Plakoglobin","level":5,"score":0.6911373138427734},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5538364052772522},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4150530695915222},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3670646548271179},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35123586654663086},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2174929678440094},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.18702462315559387}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051180","descriptor_name":"Desmoplakins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051185","descriptor_name":"gamma Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/jcs.113.18.3127","doi":"https://doi.org/10.1242/jcs.113.18.3127","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.113.18.3127","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:10954412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10954412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":170,"referenced_works":["https://openalex.org/W153332747","https://openalex.org/W1511545125","https://openalex.org/W1517997367","https://openalex.org/W1532353086","https://openalex.org/W1544046482","https://openalex.org/W1554815317","https://openalex.org/W1563440444","https://openalex.org/W1580962701","https://openalex.org/W1591952754","https://openalex.org/W1668735973","https://openalex.org/W1780096456","https://openalex.org/W1868158025","https://openalex.org/W1877472591","https://openalex.org/W1886443720","https://openalex.org/W1902879109","https://openalex.org/W1903413187","https://openalex.org/W1905797098","https://openalex.org/W1910399711","https://openalex.org/W1920794749","https://openalex.org/W1958512987","https://openalex.org/W1965160158","https://openalex.org/W1967113071","https://openalex.org/W1967137553","https://openalex.org/W1967243795","https://openalex.org/W1967273196","https://openalex.org/W1969808979","https://openalex.org/W1970193090","https://openalex.org/W1970661585","https://openalex.org/W1971175769","https://openalex.org/W1974160989","https://openalex.org/W1974712344","https://openalex.org/W1977552066","https://openalex.org/W1979201752","https://openalex.org/W1980295525","https://openalex.org/W1980955976","https://openalex.org/W1989215255","https://openalex.org/W1990588284","https://openalex.org/W1990768206","https://openalex.org/W1993496373","https://openalex.org/W1998616511","https://openalex.org/W2001141799","https://openalex.org/W2001355136","https://openalex.org/W2002404925","https://openalex.org/W2003637983","https://openalex.org/W2003958144","https://openalex.org/W2005088732","https://openalex.org/W2006671195","https://openalex.org/W2007711526","https://openalex.org/W2010537141","https://openalex.org/W2010867414","https://openalex.org/W2012039807","https://openalex.org/W2013116063","https://openalex.org/W2013127041","https://openalex.org/W2013460988","https://openalex.org/W2013514411","https://openalex.org/W2014748872","https://openalex.org/W2015201781","https://openalex.org/W2018884883","https://openalex.org/W2020885683","https://openalex.org/W2023002592","https://openalex.org/W2023099007","https://openalex.org/W2026533505","https://openalex.org/W2027521629","https://openalex.org/W2030491643","https://openalex.org/W2031880491","https://openalex.org/W2036935886","https://openalex.org/W2036999913","https://openalex.org/W2041123249","https://openalex.org/W2042610107","https://openalex.org/W2043377295","https://openalex.org/W2044186775","https://openalex.org/W2044259020","https://openalex.org/W2044562838","https://openalex.org/W2044631746","https://openalex.org/W2046068665","https://openalex.org/W2047392037","https://openalex.org/W2047425230","https://openalex.org/W2047427411","https://openalex.org/W2050414776","https://openalex.org/W2051032088","https://openalex.org/W2052459095","https://openalex.org/W2052484848","https://openalex.org/W2052690509","https://openalex.org/W2053791137","https://openalex.org/W2054286277","https://openalex.org/W2056833504","https://openalex.org/W2057847115","https://openalex.org/W2059759744","https://openalex.org/W2062911730","https://openalex.org/W2064367394","https://openalex.org/W2067606503","https://openalex.org/W2069704514","https://openalex.org/W2070253951","https://openalex.org/W2071377606","https://openalex.org/W2071448535","https://openalex.org/W2074018262","https://openalex.org/W2075319861","https://openalex.org/W2079959342","https://openalex.org/W2080372560","https://openalex.org/W2081057019","https://openalex.org/W2081253307","https://openalex.org/W2081758458","https://openalex.org/W2081985759","https://openalex.org/W2082135441","https://openalex.org/W2082387343","https://openalex.org/W2083573833","https://openalex.org/W2084258581","https://openalex.org/W2084555620","https://openalex.org/W2085813622","https://openalex.org/W2087762539","https://openalex.org/W2088574304","https://openalex.org/W2088681495","https://openalex.org/W2090636859","https://openalex.org/W2091605975","https://openalex.org/W2092125592","https://openalex.org/W2092261702","https://openalex.org/W2092977027","https://openalex.org/W2100070586","https://openalex.org/W2100373679","https://openalex.org/W2105015609","https://openalex.org/W2108452740","https://openalex.org/W2108639779","https://openalex.org/W2109069210","https://openalex.org/W2111021104","https://openalex.org/W2114474037","https://openalex.org/W2114753926","https://openalex.org/W2117988622","https://openalex.org/W2118252933","https://openalex.org/W2118344768","https://openalex.org/W2119077641","https://openalex.org/W2119593627","https://openalex.org/W2120492537","https://openalex.org/W2122829982","https://openalex.org/W2124713665","https://openalex.org/W2127295970","https://openalex.org/W2129946268","https://openalex.org/W2130837149","https://openalex.org/W2132475598","https://openalex.org/W2132887866","https://openalex.org/W2133578310","https://openalex.org/W2138835758","https://openalex.org/W2141175150","https://openalex.org/W2142522741","https://openalex.org/W2143578762","https://openalex.org/W2144828604","https://openalex.org/W2144917440","https://openalex.org/W2146167376","https://openalex.org/W2147430492","https://openalex.org/W2148074532","https://openalex.org/W2150153869","https://openalex.org/W2152025735","https://openalex.org/W2152678597","https://openalex.org/W2154196079","https://openalex.org/W2156172510","https://openalex.org/W2157321275","https://openalex.org/W2157452165","https://openalex.org/W2158569397","https://openalex.org/W2163183887","https://openalex.org/W2164343437","https://openalex.org/W2164692746","https://openalex.org/W2165061154","https://openalex.org/W2166851101","https://openalex.org/W2167827934","https://openalex.org/W2170899721","https://openalex.org/W2171140538","https://openalex.org/W2172160601","https://openalex.org/W2185298364","https://openalex.org/W2345057386","https://openalex.org/W4254397715","https://openalex.org/W4313371687"],"related_works":["https://openalex.org/W2084555620","https://openalex.org/W2064367394","https://openalex.org/W2115204718","https://openalex.org/W1977807736","https://openalex.org/W2006810952","https://openalex.org/W2166674733","https://openalex.org/W7096666045","https://openalex.org/W2003958144","https://openalex.org/W2079905224","https://openalex.org/W2589139101"],"abstract_inverted_index":{"Beta-catenin":[0],"can":[1,42],"play":[2],"different":[3,68,123],"roles":[4],"in":[5,91,101,118,135,139],"the":[6,46,76],"cell,":[7],"including":[8],"one":[9],"as":[10,20],"a":[11,21,30,115],"structural":[12],"protein":[13,39,55],"at":[14],"cell-cell":[15],"adherens":[16],"junctions":[17],"and":[18,41,61,83,94,142],"another":[19],"transcriptional":[22],"activator":[23],"mediating":[24],"Wnt":[25,84,102,119],"signal":[26],"transduction.":[27],"Plakoglobin":[28],"(gamma)-catenin),":[29],"close":[31],"homolog":[32],"of":[33,45,51,107,126],"beta-catenin,":[34,108],"shares":[35],"with":[36,53],"beta-catenin":[37,90],"common":[38],"partners":[40,56,70],"fulfill":[43],"some":[44],"same":[47],"functions.":[48],"The":[49,65,128],"complexing":[50],"catenins":[52,74,132],"various":[54],"is":[57,95,122,133],"regulated":[58],"by":[59,62],"phosphorylation":[60],"intramolecular":[63],"interactions.":[64],"competition":[66],"between":[67,78,131],"catenin":[69],"for":[71,99],"binding":[72],"to":[73,97],"mediates":[75],"cross-talk":[77],"cadherin-based":[79],"adhesion,":[80],"catenin-dependent":[81],"transcription":[82],"signaling.":[85],"Although":[86],"plakoglobin":[87,113],"differs":[88],"from":[89,105,124],"its":[92],"functions":[93],"unable":[96],"compensate":[98],"defects":[100],"signaling":[103,120],"resulting":[104],"lack":[106],"recent":[109],"evidence":[110],"suggests":[111],"that":[112,121,125],"plays":[114],"unique":[116],"role":[117],"beta-catenin.":[127],"functional":[129],"difference":[130],"reflected":[134],"their":[136],"differential":[137],"involvement":[138],"embryonic":[140],"development":[141],"cancer":[143],"progression.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
