{"id":"https://openalex.org/W1936353033","doi":"https://doi.org/10.1186/s12943-015-0400-7","title":"Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)","display_name":"Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)","publication_year":2015,"publication_date":"2015-07-15","ids":{"openalex":"https://openalex.org/W1936353033","doi":"https://doi.org/10.1186/s12943-015-0400-7","mag":"1936353033","pmid":"https://pubmed.ncbi.nlm.nih.gov/26178901","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4504101"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-015-0400-7","doi":"https://doi.org/10.1186/s12943-015-0400-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0400-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12943-015-0400-7.pdf","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12943-015-0400-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043275768","display_name":"Bethany N. Hannafon","orcid":"https://orcid.org/0000-0003-0596-9171","observed_orcids":["https://orcid.org/0000-0003-0596-9171"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethany N. Hannafon","raw_affiliation_strings":["Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. bethany-hannafon@ouhsc.edu","Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. bethany-hannafon@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010635408","display_name":"Karla J. Carpenter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karla J. Carpenter","raw_affiliation_strings":["Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. 5karlajo5@gmail.com","Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. 5karlajo5@gmail.com","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039880533","display_name":"William L. Berry","orcid":"https://orcid.org/0000-0002-1661-5443","observed_orcids":["https://orcid.org/0000-0002-1661-5443"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Berry","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. william-berry@ouhsc.edu","Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. william-berry@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046942450","display_name":"Ralf Janknecht","orcid":"https://orcid.org/0000-0003-1741-1562","observed_orcids":["https://orcid.org/0000-0003-1741-1562"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralf Janknecht","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. ralf-janknecht@ouhsc.edu","Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA. ralf-janknecht@ouhsc.edu","Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. ralf-janknecht@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA. ralf-janknecht@ouhsc.edu","institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073604253","display_name":"William Chesnut Dooley","orcid":"https://orcid.org/0000-0002-0223-5677","observed_orcids":["https://orcid.org/0000-0002-0223-5677"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Dooley","raw_affiliation_strings":["Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. william-dooley@ouhsc.edu","Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA. william-dooley@ouhsc.edu","Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. william-dooley@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA. william-dooley@ouhsc.edu","institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043152157","display_name":"Wei\u2010Qun Ding","orcid":"https://orcid.org/0000-0001-7358-3700","observed_orcids":["https://orcid.org/0000-0001-7358-3700"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei-Qun Ding","raw_affiliation_strings":["Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. weiqun-ding@ouhsc.edu","Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA. weiqun-ding@ouhsc.edu","Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. weiqun-ding@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA. weiqun-ding@ouhsc.edu","institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I49332381"]},{"raw_affiliation_string":"Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK, 73104, USA","institution_ids":["https://openalex.org/I4390039380"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043152157"],"corresponding_institution_ids":["https://openalex.org/I4390039380","https://openalex.org/I49332381"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":7.9607,"has_fulltext":true,"cited_by_count":223,"citation_normalized_percentile":{"value":0.9847895,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"133","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.875},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/let-7a","display_name":"let-7a","score":0.6340000033378601},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/rab27a","display_name":"Rab27a","score":0.8899999856948853},{"id":"https://openalex.org/keywords/exosome-release","display_name":"exosome secretion","score":0.8709999918937683},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7440000176429749},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9143136739730835},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8241749405860901},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.7505730986595154},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6293678283691406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.62126624584198},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4962223172187805},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.4715680480003357},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4369882643222809},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.415226012468338},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3748430013656616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14795821905136108},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.10028284788131714},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075745","descriptor_name":"rab27 GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12943-015-0400-7","doi":"https://doi.org/10.1186/s12943-015-0400-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0400-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12943-015-0400-7.pdf","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4504101","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4504101","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:26178901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26178901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12943-015-0400-7","doi":"https://doi.org/10.1186/s12943-015-0400-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0400-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12943-015-0400-7.pdf","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1112083259","display_name":"Oklahoma IDeA Network of Biomedical Research Excellence","funder_award_id":"P20RR016478","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1855854352","display_name":"Targeting exosome-mediated intercommunication in breast cancer progression","funder_award_id":"HR14-147","funder_id":"https://openalex.org/F4320310627","funder_display_name":"Oklahoma Center for the Advancement of Science and Technology"},{"id":"https://openalex.org/G8021214027","display_name":null,"funder_award_id":"CNE-117557","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G9000883401","display_name":"Oklahoma Shared Clinical and Translational Resources","funder_award_id":"U54GM104938","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320310179","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83"},{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"},{"id":"https://openalex.org/F4320310851","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332607","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98"},{"id":"https://openalex.org/F4320333795","display_name":"Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1936353033.pdf","grobid_xml":"https://content.openalex.org/works/W1936353033.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1573681132","https://openalex.org/W1582382552","https://openalex.org/W1877686344","https://openalex.org/W1965691046","https://openalex.org/W1968904691","https://openalex.org/W1975561204","https://openalex.org/W1979751563","https://openalex.org/W1991087195","https://openalex.org/W1992722664","https://openalex.org/W1994343272","https://openalex.org/W1998802762","https://openalex.org/W2005729354","https://openalex.org/W2008775304","https://openalex.org/W2012471060","https://openalex.org/W2012538473","https://openalex.org/W2015717700","https://openalex.org/W2017426710","https://openalex.org/W2026686857","https://openalex.org/W2027461947","https://openalex.org/W2032945008","https://openalex.org/W2033230987","https://openalex.org/W2033859595","https://openalex.org/W2035844407","https://openalex.org/W2037131199","https://openalex.org/W2039687540","https://openalex.org/W2058767592","https://openalex.org/W2060264900","https://openalex.org/W2063508984","https://openalex.org/W2064360454","https://openalex.org/W2064946335","https://openalex.org/W2065019417","https://openalex.org/W2067326892","https://openalex.org/W2068893166","https://openalex.org/W2076918724","https://openalex.org/W2084287954","https://openalex.org/W2098637032","https://openalex.org/W2104678766","https://openalex.org/W2109794064","https://openalex.org/W2115093090","https://openalex.org/W2117394321","https://openalex.org/W2118258530","https://openalex.org/W2119043140","https://openalex.org/W2119764013","https://openalex.org/W2146389661","https://openalex.org/W2147056998","https://openalex.org/W2150395782","https://openalex.org/W2168031418","https://openalex.org/W2401355890","https://openalex.org/W2515330454","https://openalex.org/W2916083703"],"related_works":["https://openalex.org/W2561672803","https://openalex.org/W3041200847","https://openalex.org/W3096578069","https://openalex.org/W4391716807","https://openalex.org/W3200775708","https://openalex.org/W3175221044","https://openalex.org/W4386162050","https://openalex.org/W2737829281","https://openalex.org/W3201543339","https://openalex.org/W4400871538"],"abstract_inverted_index":{"BACKGROUND:":[0],"Docosahexaenoic":[1],"acid":[2],"(DHA)":[3],"is":[4,14,41,52,78],"a":[5,20,70],"natural":[6],"compound":[7],"with":[8,111,197],"anticancer":[9,36,96,320],"and":[10,23,49,68,104,120,152,180,226,242,244,289,314],"anti-angiogenesis":[11],"activity":[12],"that":[13,43,61,253,282,302],"currently":[15],"under":[16],"investigation":[17],"as":[18],"both":[19],"preventative":[21],"agent":[22],"an":[24,115,210],"adjuvant":[25],"to":[26,54,87,156,204,294,310],"breast":[27,84,106,175,188,285,303],"cancer":[28,47,85,107,176,286,304,327],"therapy.":[29,328],"However,":[30,75],"the":[31,44,81,125,134,171,213,219,232,254,271,295],"precise":[32],"mechanisms":[33],"of":[34,65,83,130,215,224,234,270,297],"DHA's":[35,95,260,319],"activities":[37],"are":[38,58,62,154],"unclear.":[39],"It":[40],"understood":[42],"intercommunication":[45],"between":[46],"cells":[48,108,189,194,230],"their":[50,199,235],"microenvironment":[51],"essential":[53],"tumor":[55,88,312],"angiogenesis.":[56,74,298],"Exosomes":[57,99],"extracellular":[59],"vesicles":[60],"important":[63],"mediators":[64],"intercellular":[66],"communication":[67],"play":[69],"role":[71],"in":[72,117,133,170,184,212,218,228,326],"promoting":[73],"very":[76],"little":[77],"known":[79,155],"about":[80],"contribution":[82],"exosomes":[86,92,136,172,185,200,258],"angiogenesis":[89,313],"or":[90,198],"whether":[91],"can":[93,307],"mediate":[94,259],"action.":[97,262],"RESULTS:":[98],"were":[100,164,195,201],"collected":[101],"from":[102,124,173,186],"MCF7":[103,135,193],"MDA-MB-231":[105],"after":[109],"treatment":[110,169],"DHA.":[112],"We":[113,280],"observed":[114,209],"increase":[116,211],"exosome":[118,121,145,277,287,305],"secretion":[119,288],"microRNA":[122,290],"contents":[123],"DHA-treated":[126,192],"cells.":[127,221],"The":[128,142],"expression":[129,214,233],"83":[131],"microRNAs":[132,146,163,217,255],"was":[137],"altered":[138],"by":[139,167,249,257,268],"DHA":[140,168,283],"(>2-fold).":[141],"most":[143],"abundant":[144],"(let-7a,":[147],"miR-23b,":[148],"miR-27a/b,":[149],"miR-21,":[150],"let-7,":[151],"miR-320b)":[153],"have":[157],"anti-cancer":[158],"and/or":[159],"anti-angiogenic":[160,261],"activity.":[161],"These":[162,263],"also":[165],"increased":[166],"other":[174],"lines":[177],"(MDA-MB-231,":[178],"ZR751":[179],"BT20),":[181],"but":[182],"not":[183],"normal":[187],"(MCF10A).":[190],"When":[191],"co-cultured":[196],"directly":[202],"applied":[203],"endothelial":[205,220,229,250],"cell":[206],"cultures,":[207],"we":[208],"these":[216],"Furthermore,":[222],"overexpression":[223],"miR-23b":[225],"miR-320b":[227],"decreased":[231],"pro-angiogenic":[236],"target":[237],"genes":[238],"(PLAU,":[239],"AMOTL1,":[240],"NRP1":[241],"ETS2)":[243],"significantly":[245],"inhibited":[246],"tube":[247],"formation":[248],"cells,":[251],"suggesting":[252],"transferred":[256],"effects":[264],"could":[265],"be":[266,308],"reversed":[267],"knockdown":[269],"Rab":[272],"GTPase,":[273],"Rab27A,":[274],"which":[275,292],"controls":[276],"release.":[278],"CONCLUSIONS:":[279],"conclude":[281],"alters":[284],"contents,":[291],"leads":[293],"inhibition":[296],"Our":[299],"data":[300],"demonstrate":[301],"signaling":[306],"targeted":[309],"inhibit":[311],"provide":[315],"new":[316],"insight":[317],"into":[318],"action,":[321],"further":[322],"supporting":[323],"its":[324],"use":[325]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}