{"id":"https://openalex.org/W1936199746","doi":"https://doi.org/10.4049/jimmunol.151.10.5716","title":"Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP.","display_name":"Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP.","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W1936199746","doi":"https://doi.org/10.4049/jimmunol.151.10.5716","mag":"1936199746","pmid":"https://pubmed.ncbi.nlm.nih.gov/8228257"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.151.10.5716","doi":"https://doi.org/10.4049/jimmunol.151.10.5716","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.151.10.5716","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030502605","display_name":"Murray B. Resnick","orcid":"https://orcid.org/0000-0002-9392-3415","observed_orcids":["https://orcid.org/0000-0002-9392-3415"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M B Resnick","raw_affiliation_strings":["Department of Medicine, Beth Israel Hospital and Harvard Medical School , Boston, MA 02115","Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Hospital and Harvard Medical School , Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110080253","display_name":"Sean P. Colgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S P Colgan","raw_affiliation_strings":["Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037603859","display_name":"Thomas W. Patapoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T W Patapoff","raw_affiliation_strings":["Genentech Inc. , South San Francisco, CA, 94080","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc. , South San Francisco, CA, 94080","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002768937","display_name":"Randall J. Mrsny","orcid":"https://orcid.org/0000-0001-8505-8516","observed_orcids":["https://orcid.org/0000-0001-8505-8516"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Mrsny","raw_affiliation_strings":["Genentech Inc. , South San Francisco, CA, 94080","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc. , South San Francisco, CA, 94080","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111576971","display_name":"C.S. Awtrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C S Awtrey","raw_affiliation_strings":["Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024654477","display_name":"C Delp-Archer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Delp-Archer","raw_affiliation_strings":["Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022885245","display_name":"Peter F. Weller","orcid":"https://orcid.org/0000-0001-9580-560X","observed_orcids":["https://orcid.org/0000-0001-9580-560X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P F Weller","raw_affiliation_strings":["Department of Medicine, Beth Israel Hospital and Harvard Medical School , Boston, MA 02115","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Hospital and Harvard Medical School , Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109841136","display_name":"James Madara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Madara","raw_affiliation_strings":["Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","Department of Pathology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women\u2019s Hospital, and Harvard Medical School, and the Harvard Digestive Diseases Center , Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.1921,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.78488768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"151","issue":"10","first_page":"5716","last_page":"5723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.34200000762939453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypereosinophilic-syndrome","display_name":"hypereosinophilic syndrome","score":0.875},{"id":"https://openalex.org/keywords/intestinal-chloride-secretion","display_name":"intestinal chloride secretion","score":0.765999972820282},{"id":"https://openalex.org/keywords/5-amp","display_name":"5'-AMP","score":0.9070000052452087},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/adenosine-receptors","display_name":"adenosine receptors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/ecto-5-nucleotidase","display_name":"ecto-5'-nucleotidase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.5889999866485596},{"id":"https://openalex.org/keywords/t84-cells","display_name":"T84 cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/short-circuit-current","display_name":"short-circuit current","score":0.6669999957084656},{"id":"https://openalex.org/keywords/electrogenic-chloride-secretion","display_name":"electrogenic chloride secretion","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.6893247961997986},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5380833148956299},{"id":"https://openalex.org/C2778081958","wikidata":"https://www.wikidata.org/wiki/Q14906786","display_name":"Eosinophil peroxidase","level":4,"score":0.4980504512786865},{"id":"https://openalex.org/C2776202631","wikidata":"https://www.wikidata.org/wiki/Q471763","display_name":"Aminophylline","level":2,"score":0.47419625520706177},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4482819139957428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43145880103111267},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4135391414165497},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38488054275512695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.378639280796051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34987127780914307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34573039412498474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21952927112579346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18646815419197083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.151.10.5716","doi":"https://doi.org/10.4049/jimmunol.151.10.5716","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.151.10.5716","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:8228257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8228257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2564378311","display_name":"SCOR--OCCUPATIONAL AND IMMUNOLOGICAL LUNG DISEASES","funder_award_id":"P50HL046563","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G377780757","display_name":null,"funder_award_id":"AI 20241","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8580692565","display_name":"MAST CELL AND EOSINOPHIL CYTOKINES IN ALLERGIC DISORDERS","funder_award_id":"R01AI031982","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2102450646","https://openalex.org/W2035600812","https://openalex.org/W2108739659","https://openalex.org/W2037778877","https://openalex.org/W1667676744","https://openalex.org/W2013398750","https://openalex.org/W2010797369","https://openalex.org/W2133817647","https://openalex.org/W2035650572","https://openalex.org/W1984017495"],"abstract_inverted_index":{"Eosinophils":[0,58],"may":[1],"be":[2],"prominent":[3],"in":[4,29,100,104,142,148],"intestinal":[5,43,205],"diseases":[6],"including":[7],"allergic":[8],"gastroenteritis,":[9],"inflammatory":[10],"bowel":[11],"disease,":[12],"enteritis":[13],"associated":[14],"with":[15,71,117,182],"hypereosinophilic":[16],"syndromes":[17],"(HES),":[18],"and":[19,31,51,103,123,147,161,207],"parasitic":[20],"diseases.":[21],"Unlike":[22],"normal":[23],"blood":[24,49],"eosinophils,":[25],"those":[26,32],"that":[27,33,166,175,198,208],"circulate":[28],"HES":[30,81],"infiltrate":[34],"inflamed":[35],"tissue":[36],"exhibit":[37],"an":[38,156],"\"activated\"":[39],"phenotype.":[40],"To":[41],"model":[42],"epithelial-eosinophil":[44],"interactions,":[45],"we":[46],"used":[47],"peripheral":[48],"eosinophils":[50,79,146,200,212],"human":[52],"crypt-like":[53],"T84":[54,92,135],"epithelial":[55,186,206,221],"cell-line":[56],"monolayers.":[57,93],"from":[59,80,133,204],"normal,":[60],"mildly":[61],"atopic":[62],"donors,":[63],"only":[64],"if":[65],"activated":[66,145,199],"by":[67,115,124,151,211,214],"PMA":[68],"or":[69,120],"primed":[70],"granulocyte-macrophage-CSF":[72],"for":[73,130,226],"48":[74],"h,":[75],"as":[76,78,113],"well":[77],"patients":[82],"elicited":[83],"a":[84],"short":[85],"circuit":[86],"current":[87],"when":[88],"applied":[89],"apically":[90],"to":[91,178,193,217],"This":[94,137],"eosinophil-derived":[95],"bioactivity,":[96],"which":[97],"was":[98,140,176],"transferable":[99],"cell-free":[101],"supernatants":[102],"<":[105],"1000":[106],"m.w.":[107],"ultrafiltrates,":[108],"stimulated":[109],"electrogenic":[110],"Cl-":[111,202],"secretion,":[112],"indicated":[114],"inhibition":[116],"basolateral":[118],"bumetanide":[119],"gluconate":[121],"substitution":[122],"enhancement":[125],"of":[126,155,173,185],"the":[127,191,220,224],"rate":[128],"constant":[129],"125I":[131],"efflux":[132],"preloaded":[134],"cells.":[136],"secretagogue":[138],"activity":[139],"blocked":[141],"both":[143],"intact":[144],"eosinophil-conditioned":[149],"supernatants,":[150],"8-phenyl-theophylline,":[152],"indicating":[153],"involvement":[154],"adenosine":[157,179,218],"receptor.":[158],"Ion":[159],"exchange":[160],"reversed-phase":[162],"HPLC":[163],"analyses":[164],"demonstrated":[165],"eosinophil":[167],"supernatant":[168],"ultrafiltrates":[169],"contained":[170],"elevated":[171],"levels":[172],"5'-AMP":[174,209],"converted":[177],"after":[180],"incubation":[181],"epithelium.":[183],"Inhibition":[184],"apical":[187],"membrane":[188],"ecto-5'-nucleotidase":[189],"ablated":[190],"conversion":[192,216],"adenosine.":[194],"These":[195],"studies":[196],"establish":[197],"elicit":[201],"secretion":[203],"released":[210],"followed":[213],"its":[215],"at":[219],"surface":[222],"is":[223],"basis":[225],"this":[227],"response.":[228]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
