{"id":"https://openalex.org/W1935993249","doi":null,"title":"[Drugs used for cognitive impairment. Analysis of 1.5 million prescriptions in Argentina].","display_name":"[Drugs used for cognitive impairment. Analysis of 1.5 million prescriptions in Argentina].","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1935993249","mag":"1935993249","pmid":"https://pubmed.ncbi.nlm.nih.gov/23732196"},"language":"es","primary_location":{"id":"pmid:23732196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23732196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080524982","display_name":"Galeno Jes\u00fas Rojas","orcid":"https://orcid.org/0000-0002-3912-9421","observed_orcids":["https://orcid.org/0000-0002-3912-9421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galeno Rojas","raw_affiliation_strings":["Unidad de Neurociencias Cognitivas, Instituto de Neurociencias Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Neurociencias Cognitivas, Instituto de Neurociencias Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045956136","display_name":"Ignacio Demey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ignacio Demey","raw_affiliation_strings":["Instituto de Neurociencias Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Neurociencias Buenos Aires","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026996893","display_name":"Ra\u00fal L. Arizaga","orcid":"https://orcid.org/0000-0001-6697-9803","observed_orcids":["https://orcid.org/0000-0001-6697-9803"]},"institutions":[{"id":"https://openalex.org/I4405269704","display_name":"World Federation of Neurology","ror":"https://ror.org/04za0jd83","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4405269704"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ra\u00fal L Arizaga","raw_affiliation_strings":["Federaci\u00f3n Mundial de Neurolog\u00eda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federaci\u00f3n Mundial de Neurolog\u00eda","institution_ids":["https://openalex.org/I4405269704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1982,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55363222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"73","issue":"3","first_page":"213","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.13850000500679016,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.8199999928474426},{"id":"https://openalex.org/keywords/prescribing-patterns","display_name":"prescribing patterns","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.8650000095367432},{"id":"https://openalex.org/keywords/rivastigmine","display_name":"rivastigmine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/idebenone","display_name":"idebenone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nootropics","display_name":"nootropic drugs","score":0.890999972820282},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.8529999852180481},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7229999899864197},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.8460000157356262},{"id":"https://openalex.org/keywords/regional-variation-in-prescribing","display_name":"regional variation in prescribing","score":0.7789999842643738},{"id":"https://openalex.org/keywords/argentina","display_name":"Argentina","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2776332859","wikidata":"https://www.wikidata.org/wiki/Q411887","display_name":"Rivastigmine","level":5,"score":0.923150897026062},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.8770204782485962},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.8644378185272217},{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.8090892434120178},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.8088867664337158},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6241928339004517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6020447015762329},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.48770245909690857},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.37251371145248413},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23658496141433716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19884923100471497},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12117961049079895}],"mesh":[{"descriptor_ui":"D000068836","descriptor_name":"Rivastigmine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001118","descriptor_name":"Argentina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005702","descriptor_name":"Galantamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008559","descriptor_name":"Memantine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D048448","descriptor_name":"Phenylcarbamates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:23732196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23732196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:30ac7f3417d74e97a31cdc5831441607","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/30ac7f3417d74e97a31cdc5831441607","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina (Buenos Aires), Vol 73, Iss 3, Pp 213-223 (2013)","raw_type":"article"},{"id":"mag:1935993249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23732196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1016293651","https://openalex.org/W1895538680","https://openalex.org/W1904458203","https://openalex.org/W1972682547","https://openalex.org/W1985090009","https://openalex.org/W1988630049","https://openalex.org/W2006716327","https://openalex.org/W2081016196","https://openalex.org/W2091425360","https://openalex.org/W2119283759","https://openalex.org/W2131645385","https://openalex.org/W2132806643","https://openalex.org/W2148240953","https://openalex.org/W2153631628","https://openalex.org/W2155859069","https://openalex.org/W2163404466","https://openalex.org/W2188679450","https://openalex.org/W2224965828","https://openalex.org/W2275656553","https://openalex.org/W2415218457","https://openalex.org/W2527609605"],"related_works":["https://openalex.org/W7067751637","https://openalex.org/W2981011778","https://openalex.org/W2991529178","https://openalex.org/W2415218457","https://openalex.org/W2320256195","https://openalex.org/W4313433220","https://openalex.org/W7116900911","https://openalex.org/W3206940666","https://openalex.org/W4414444280","https://openalex.org/W4390200335"],"abstract_inverted_index":{"Cognitive":[0],"impairment":[1],"and":[2,14,29,38,53,68,91,102,105,118,126,132,158,173,183,185,209],"dementia":[3,69],"treatment":[4,20,64],"costs":[5],"are":[6,23,40],"significant":[7],"for":[8,19,62,89],"health":[9],"systems.":[10],"According":[11],"to":[12,51,83,207],"national":[13],"international":[15],"guidelines,":[16],"recommended":[17,192],"drugs":[18,61,193],"of":[21,47,58,65,73,79,86,100,108,128,161,167,177,203],"dementias":[22],"cholinesterase":[24],"inhibitors":[25],"(donepezil,":[26],"galantamine,":[27],"rivastigmine)":[28],"memantine.":[30],"Despite":[31],"these":[32,147],"guidelines":[33],"recommendations,":[34],"other":[35],"nootropics,":[36],"vasodilators":[37],"antioxidants":[39],"often":[41],"used":[42,60],"in":[43,70,113,146,153,170,179,187,197],"Argentina.":[44,74],"The":[45],"purpose":[46],"this":[48],"study":[49,78],"was":[50,110,141,163],"describe":[52],"compare":[54],"the":[55,63,95,97,103,115,137,142,154,171,180,188,199],"prescription":[56,162],"pattern":[57],"commonly":[59],"cognitive":[66],"disorders":[67],"different":[71,120],"regions":[72],"An":[75,151],"observational,":[76],"retrospective":[77],"1814108":[80],"recipes":[81],"prescribed":[82,144,196],"National":[84],"Institute":[85],"Social":[87],"Services":[88],"Retired":[90],"Pensioners":[92],"outpatients":[93],"during":[94,96],"second":[98,106],"half":[99,107],"2008":[101],"first":[104],"2009":[109],"performed,":[111],"taking":[112],"count":[114],"whole":[116],"country":[117],"also":[119],"Argentina's":[121],"regions.":[122,201],"Demographic":[123],"variables,":[124],"quantity":[125],"rate":[127,166],"prescriptions,":[129],"dosage":[130],"forms":[131],"strengths":[133],"were":[134,194,205],"analyzed.":[135],"Considering":[136],"entire":[138],"country,":[139],"memantine":[140,168],"most":[143],"drug":[145],"periods":[148],"(570893":[149],"packages).":[150],"increase":[152],"memantine,":[155],"donepezil,":[156],"rivastigmine":[157],"idebenone":[159,178],"rates":[160],"observed.":[164],"Prescription":[165],"increased":[169],"North-West":[172],"North-East":[174,181,189],"regions,":[175],"that":[176],"region":[182],"Patagonia":[184],"donepezil":[186],"region.":[190],"Non":[191],"highly":[195],"all":[198],"analyzed":[200],"Some":[202],"them":[204],"indicated":[206],"young":[208],"middle-aged":[210],"patients.":[211]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}