{"id":"https://openalex.org/W1935953203","doi":"https://doi.org/10.1111/cmi.12480","title":"The innate immune response in human tuberculosis","display_name":"The innate immune response in human tuberculosis","publication_year":2015,"publication_date":"2015-07-02","ids":{"openalex":"https://openalex.org/W1935953203","doi":"https://doi.org/10.1111/cmi.12480","mag":"1935953203","pmid":"https://pubmed.ncbi.nlm.nih.gov/26135005","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4832344"},"language":"en","primary_location":{"id":"doi:10.1111/cmi.12480","doi":"https://doi.org/10.1111/cmi.12480","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cmi.12480","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cmi.12480","source":{"id":"https://openalex.org/S113048938","display_name":"Cellular Microbiology","issn_l":"1462-5814","issn":["1462-5814","1462-5822"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cmi.12480","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006279136","display_name":"Thomas R. Lerner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas R. Lerner","raw_affiliation_strings":["Mill Hill Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mill Hill Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057893862","display_name":"Sophie Borel","orcid":"https://orcid.org/0000-0001-8643-224X","observed_orcids":["https://orcid.org/0000-0001-8643-224X"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sophie Borel","raw_affiliation_strings":["Mill Hill Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mill Hill Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068817299","display_name":"Maximiliano Gabriel Gutierrez","orcid":"https://orcid.org/0000-0003-3199-0337","observed_orcids":["https://orcid.org/0000-0003-3199-0337"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Maximiliano G. Gutierrez","raw_affiliation_strings":["Mill Hill Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mill Hill Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I4405285715"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068817299"],"corresponding_institution_ids":["https://openalex.org/I4405285715"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2350,"currency":"USD","value_usd":2350},"fwci":1.5137,"has_fulltext":true,"cited_by_count":159,"citation_normalized_percentile":{"value":0.82154171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"17","issue":"9","first_page":"1277","last_page":"1285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cell-autonomous-immunity","display_name":"cell-autonomous immunity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/human-genetics","display_name":"human genetics","score":0.6520000100135803},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8764731884002686},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8647421598434448},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7619391679763794},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5741273164749146},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.556267261505127},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5270973443984985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5187797546386719},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.5083665251731873},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3680068254470825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.060878217220306396},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1111/cmi.12480","doi":"https://doi.org/10.1111/cmi.12480","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cmi.12480","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cmi.12480","source":{"id":"https://openalex.org/S113048938","display_name":"Cellular Microbiology","issn_l":"1462-5814","issn":["1462-5814","1462-5822"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Microbiology","raw_type":"journal-article"},{"id":"pmid:26135005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26135005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4832344","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4832344/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Microbiol","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/15295275","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_innate_immune_response_in_human_tuberculosis/15295275","pdf_url":"https://figshare.com/articles/journal_contribution/The_innate_immune_response_in_human_tuberculosis/15295275","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.25418/crick.15295275","doi":"https://doi.org/10.25418/crick.15295275","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.15295275","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25418/crick.15295275.v1","doi":"https://doi.org/10.25418/crick.15295275.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.15295275.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"mag:2742105494","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Maximiliano_Gutierrez2/publication/279730205_The_innate_immune_response_in_human_tuberculosis/links/55b87b7b08aed621de05d2ec.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1111/cmi.12480","doi":"https://doi.org/10.1111/cmi.12480","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cmi.12480","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cmi.12480","source":{"id":"https://openalex.org/S113048938","display_name":"Cellular Microbiology","issn_l":"1462-5814","issn":["1462-5814","1462-5822"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5956853804","display_name":null,"funder_award_id":"MC_UP_1202/11","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6653160136","display_name":null,"funder_award_id":"10092","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1935953203.pdf","grobid_xml":"https://content.openalex.org/works/W1935953203.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W78502128","https://openalex.org/W1498860801","https://openalex.org/W1513558205","https://openalex.org/W1538029215","https://openalex.org/W1544053969","https://openalex.org/W1548106543","https://openalex.org/W1552410459","https://openalex.org/W1595106840","https://openalex.org/W1595757339","https://openalex.org/W1661719389","https://openalex.org/W1794218861","https://openalex.org/W1909986873","https://openalex.org/W1951621033","https://openalex.org/W1958512527","https://openalex.org/W1966326022","https://openalex.org/W1967808562","https://openalex.org/W1971761379","https://openalex.org/W1973241546","https://openalex.org/W1985496339","https://openalex.org/W2000988467","https://openalex.org/W2001924364","https://openalex.org/W2005427598","https://openalex.org/W2005441038","https://openalex.org/W2007857314","https://openalex.org/W2008511309","https://openalex.org/W2008617601","https://openalex.org/W2012451546","https://openalex.org/W2022603305","https://openalex.org/W2023635033","https://openalex.org/W2028085337","https://openalex.org/W2028139986","https://openalex.org/W2036420717","https://openalex.org/W2036635548","https://openalex.org/W2045713451","https://openalex.org/W2048597976","https://openalex.org/W2050091105","https://openalex.org/W2051792510","https://openalex.org/W2052675140","https://openalex.org/W2053968913","https://openalex.org/W2060629409","https://openalex.org/W2062054838","https://openalex.org/W2065627587","https://openalex.org/W2070737118","https://openalex.org/W2076887890","https://openalex.org/W2078877874","https://openalex.org/W2079894465","https://openalex.org/W2081325862","https://openalex.org/W2088179560","https://openalex.org/W2091918640","https://openalex.org/W2093631337","https://openalex.org/W2094389347","https://openalex.org/W2096504220","https://openalex.org/W2101358576","https://openalex.org/W2102603631","https://openalex.org/W2103024679","https://openalex.org/W2111236188","https://openalex.org/W2111746777","https://openalex.org/W2114020987","https://openalex.org/W2119724532","https://openalex.org/W2121449107","https://openalex.org/W2121632392","https://openalex.org/W2123888778","https://openalex.org/W2124001620","https://openalex.org/W2126736305","https://openalex.org/W2127491513","https://openalex.org/W2128702173","https://openalex.org/W2132079649","https://openalex.org/W2138363231","https://openalex.org/W2140712182","https://openalex.org/W2141922592","https://openalex.org/W2142657972","https://openalex.org/W2143303543","https://openalex.org/W2144551884","https://openalex.org/W2146193668","https://openalex.org/W2148952991","https://openalex.org/W2155760262","https://openalex.org/W2161592441","https://openalex.org/W2161794466","https://openalex.org/W2163407348","https://openalex.org/W2165494441","https://openalex.org/W2325075151","https://openalex.org/W2405978957","https://openalex.org/W4313379121","https://openalex.org/W6652444459"],"related_works":["https://openalex.org/W2742105494","https://openalex.org/W1929816754","https://openalex.org/W7218032001","https://openalex.org/W2102888433","https://openalex.org/W7099618775","https://openalex.org/W2752890220","https://openalex.org/W3046013864","https://openalex.org/W7115723753","https://openalex.org/W2151456962","https://openalex.org/W4387968714"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1],"(Mtb)":[2],"infection":[3],"can":[4],"be":[5],"cleared":[6],"by":[7,68],"the":[8,13],"innate":[9,21],"immune":[10,18,35],"system":[11],"before":[12],"initiation":[14],"of":[15,26,46],"an":[16],"adaptive":[17],"response.":[19],"This":[20],"protection":[22],"requires":[23],"a":[24,58],"variety":[25],"robust":[27],"cell":[28,36],"autonomous":[29],"responses":[30],"from":[31],"many":[32],"different":[33],"host":[34],"types.":[37],"However,":[38],"Mtb":[39],"has":[40],"evolved":[41],"strategies":[42],"to":[43],"circumvent":[44],"some":[45],"these":[47,54],"defences.":[48],"In":[49],"this":[50],"mini-review,":[51],"we":[52],"discuss":[53],"host-pathogen":[55],"interactions":[56],"with":[57],"focus":[59],"on":[60],"studies":[61,71],"performed":[62],"in":[63],"human":[64,69],"cells":[65],"and/or":[66],"supported":[67],"genetics":[70],"(such":[72],"as":[73],"genome-wide":[74],"association":[75],"studies).":[76]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}