{"id":"https://openalex.org/W1935686271","doi":null,"title":"Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study.","display_name":"Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study.","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W1935686271","mag":"1935686271","pmid":"https://pubmed.ncbi.nlm.nih.gov/16078335"},"language":"en","primary_location":{"id":"pmid:16078335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16078335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110557117","display_name":"Bernard Mazi\u00e8res","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Mazi\u00e8res","raw_affiliation_strings":["Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr","institution_ids":["https://openalex.org/I4210123497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041419953","display_name":"St\u00e9phanie Rouanet","orcid":"https://orcid.org/0009-0003-5812-3599","observed_orcids":["https://orcid.org/0009-0003-5812-3599"]},"institutions":[{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Rouanet","raw_affiliation_strings":["Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr","institution_ids":["https://openalex.org/I4210123497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090066439","display_name":"Yannick Guillon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yannick Guillon","raw_affiliation_strings":["Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr","institution_ids":["https://openalex.org/I4210123497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058969258","display_name":"Claudia Scarsi","orcid":"https://orcid.org/0009-0000-8517-2343","observed_orcids":["https://orcid.org/0009-0000-8517-2343"]},"institutions":[{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claudia Scarsi","raw_affiliation_strings":["Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr","institution_ids":["https://openalex.org/I4210123497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000031879","display_name":"Valentina Reiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentina Reiner","raw_affiliation_strings":["Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Rangueil University Hospital, Toulouse, France. mazieres@cict.fr","institution_ids":["https://openalex.org/I4210123497"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210123497"],"apc_list":null,"apc_paid":null,"fwci":3.8813,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.91899971,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"32","issue":"8","first_page":"1563","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketoprofen","display_name":"ketoprofen","score":0.9390000104904175},{"id":"https://openalex.org/keywords/topical-patch","display_name":"topical patch","score":0.843999981880188},{"id":"https://openalex.org/keywords/tendinitis","display_name":"tendinitis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/local-skin-reactions","display_name":"local skin reactions","score":0.6129999756813049},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7390000224113464},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9483146071434021},{"id":"https://openalex.org/C2780744026","wikidata":"https://www.wikidata.org/wiki/Q409192","display_name":"Ketoprofen","level":2,"score":0.8470214605331421},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7748230695724487},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.748100996017456},{"id":"https://openalex.org/C2776497992","wikidata":"https://www.wikidata.org/wiki/Q1682583","display_name":"Tendinitis","level":3,"score":0.6059452295303345},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5773694515228271},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5506253242492676},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.5233672857284546},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48069578409194946},{"id":"https://openalex.org/C202061045","wikidata":"https://www.wikidata.org/wiki/Q7200267","display_name":"Placebo-controlled study","level":5,"score":0.4750273823738098},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42771533131599426},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40668225288391113},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.2623128294944763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19728100299835205},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.12051481008529663},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052256","descriptor_name":"Tendinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16078335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16078335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.898.5874","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.898.5874","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jrheum.org/content/32/8/1563.full.pdf","raw_type":"text"},{"id":"mag:1935686271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16078335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2158963206","https://openalex.org/W2115431666","https://openalex.org/W2027921884","https://openalex.org/W2114064076","https://openalex.org/W2270615796","https://openalex.org/W2410317174","https://openalex.org/W84189284","https://openalex.org/W1542599288","https://openalex.org/W170108155","https://openalex.org/W2403058484"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,11,58,83,101,104,108,130,163,175,179,182,216,255,261],"efficacy":[4,60],"and":[5,76,90,156,165,218,228],"tolerability":[6],"of":[7,13,26,36,86,124,134,146,174,234,245,257],"ketoprofen":[8,29,164,217,248],"patch":[9,32,249],"in":[10,33,107,122,141,162,195,215,252],"treatment":[12,147,214,246,258],"tendinitis.":[14],"METHODS:":[15],"A":[16],"multicenter,":[17],"14":[18],"day,":[19],"randomized,":[20],"double":[21],"blind":[22],"placebo":[23,166,219],"controlled":[24],"trial":[25,180,238],"a":[27,51,241],"once-a-day":[28],"100":[30,52],"mg":[31],"symptomatic":[34],"tendinitis":[35],"recent":[37],"onset,":[38],"not":[39],"requiring":[40],"orthopedic":[41],"or":[42,138,210],"surgical":[43],"treatment.":[44,235],"Pain":[45],"on":[46,50,70,100,260],"daily":[47,81],"activities":[48],"scored":[49],"mm":[53,154,160],"visual":[54],"analog":[55],"scale":[56],"was":[57,98,120,150,192],"primary":[59],"criterion.":[61],"Other":[62],"criteria":[63,177],"were":[64,116,185,208],"spontaneous":[65],"pain":[66,69,74,77,88,93,142],"at":[67],"rest,":[68],"full":[71],"passive":[72],"motion,":[73],"relief,":[75],"intensity":[78,94],"assessed":[79],"twice":[80],"by":[82,247],"patient":[84],"(calculation":[85],"total":[87],"relief":[89],"summed":[91],"time-weighted":[92],"difference).":[95],"Statistical":[96],"analysis":[97],"performed":[99],"differences":[102,173],"between":[103,181],"2":[105,183],"groups":[106,184],"intention-to-treat":[109],"population.":[110],"RESULTS:":[111],"One":[112],"hundred":[113],"seventy-two":[114],"patients":[115,127],"included.":[117],"Good":[118],"compliance":[119],"obtained":[121],"98%":[123],"patients.":[125],"Twenty-six":[126],"(15%)":[128],"discontinued":[129],"study":[131],"mainly":[132],"because":[133],"adverse":[135,199,270],"events,":[136],"inefficacy,":[137],"cure.":[139],"Decrease":[140],"after":[143],"one":[144],"week":[145],"(primary":[148],"criterion)":[149],"-38.4":[151],"+/-":[152,158],"25.6":[153],"(56%)":[155],"-25.8":[157],"24.5":[159],"(37%)":[161],"groups,":[167,197,220],"respectively":[168],"(p":[169],"=":[170],"0.0013).":[171],"The":[172,264],"secondary":[176],"during":[178],"significant":[186],"more":[187],"often":[188],"than":[189],"not.":[190],"Tolerance":[191],"considered":[193],"satisfactory":[194],"both":[196],"most":[198],"events":[200],"reported":[201],"being":[202],"local":[203,223],"reactions:":[204],"47":[205],"versus":[206],"44":[207],"possibly":[209],"probably":[211],"related":[212],"to":[213,231],"respectively.":[221],"These":[222],"skin":[224],"reactions":[225],"resolved":[226],"spontaneously":[227],"rarely":[229],"led":[230],"premature":[232],"termination":[233],"CONCLUSION:":[236],"This":[237],"suggested":[239],"that":[240],"3-14":[242],"day":[243],"course":[244],"is":[250],"useful":[251],"nonarticular":[253],"rheumatisms,":[254],"duration":[256],"depending":[259],"results":[262],"obtained.":[263],"safety":[265],"profile":[266],"revealed":[267],"no":[268],"unexpected":[269],"events.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":9},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}