{"id":"https://openalex.org/W193484161","doi":null,"title":"A data base of minimally frustrated alpha helical segments extracted from proteins according to an entropy criterion.","display_name":"A data base of minimally frustrated alpha helical segments extracted from proteins according to an entropy criterion.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W193484161","mag":"193484161","pmid":"https://pubmed.ncbi.nlm.nih.gov/10786288"},"language":"en","primary_location":{"id":"pmid:10786288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. International Conference on Intelligent Systems for Molecular Biology","raw_type":"Journal Article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053410790","display_name":"Rita Casadio","orcid":"https://orcid.org/0000-0002-7462-7039","observed_orcids":["https://orcid.org/0000-0002-7462-7039"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Casadio","raw_affiliation_strings":["CIRB, Biocomputing Unit, University of Bologna, Italy. casadio@kaiser.alma.unibo.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIRB, Biocomputing Unit, University of Bologna, Italy. casadio@kaiser.alma.unibo.it","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036962599","display_name":"Mario Compiani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Compiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060232841","display_name":"Piero Fariselli","orcid":"https://orcid.org/0000-0003-1811-4762","observed_orcids":["https://orcid.org/0000-0003-1811-4762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Fariselli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044479288","display_name":"Pier Luigi Martelli","orcid":"https://orcid.org/0000-0002-0274-5669","observed_orcids":["https://orcid.org/0000-0002-0274-5669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Martelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1914,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.84283143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"68","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.8320000171661377},{"id":"https://openalex.org/keywords/helix-stability","display_name":"helix stability","score":0.718999981880188},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.5490000247955322},{"id":"https://openalex.org/keywords/helix-prediction","display_name":"helix prediction","score":0.6240000128746033},{"id":"https://openalex.org/keywords/neural-network-predictor","display_name":"neural network predictor","score":0.7929999828338623},{"id":"https://openalex.org/keywords/entropy-criterion","display_name":"entropy criterion","score":0.9760000109672546},{"id":"https://openalex.org/keywords/protein-fragments","display_name":"protein fragments","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.6041658520698547},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5727337598800659},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.504613995552063},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5012044906616211},{"id":"https://openalex.org/C184538305","wikidata":"https://www.wikidata.org/wiki/Q283399","display_name":"Alpha helix","level":3,"score":0.44997674226760864},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.44793474674224854},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.36822310090065},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3509136438369751},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2913361191749573},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26721781492233276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24833369255065918},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.11825037002563477},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.10358679294586182},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08583474159240723},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C171606756","wikidata":"https://www.wikidata.org/wiki/Q506132","display_name":"Psychometrics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:10786288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. International Conference on Intelligent Systems for Molecular Biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.29.4472","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.29.4472","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://lipid.biocomp.unibo.it/piero/ismb99/RCasadio99.ps","raw_type":"text"},{"id":"mag:193484161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1481303389","https://openalex.org/W1498436455","https://openalex.org/W1965229818","https://openalex.org/W1975495422","https://openalex.org/W1979038840","https://openalex.org/W1983514815","https://openalex.org/W1989300794","https://openalex.org/W1989937542","https://openalex.org/W2005865331","https://openalex.org/W2008708467","https://openalex.org/W2013136212","https://openalex.org/W2014095962","https://openalex.org/W2016019576","https://openalex.org/W2029882922","https://openalex.org/W2043087411","https://openalex.org/W2052426592","https://openalex.org/W2056770911","https://openalex.org/W2056887931","https://openalex.org/W2059417417","https://openalex.org/W2059907401","https://openalex.org/W2062954424","https://openalex.org/W2067305692","https://openalex.org/W2067323731","https://openalex.org/W2077004663","https://openalex.org/W2079673685","https://openalex.org/W2081633976","https://openalex.org/W2083939457","https://openalex.org/W2089390551","https://openalex.org/W2091348405","https://openalex.org/W2104972430","https://openalex.org/W2125685632","https://openalex.org/W2130904570","https://openalex.org/W2144729032","https://openalex.org/W2148894908","https://openalex.org/W2171755502","https://openalex.org/W2177343774"],"related_works":["https://openalex.org/W2059417417","https://openalex.org/W6912278351","https://openalex.org/W2004522613","https://openalex.org/W2920821662","https://openalex.org/W2083939457","https://openalex.org/W2021144797","https://openalex.org/W1979040187","https://openalex.org/W2038974973","https://openalex.org/W1976679417","https://openalex.org/W2042388534"],"abstract_inverted_index":{"A":[0,48],"data":[1,27,62,90],"base":[2,28,63,91],"of":[3,60,68,88,93,103,112],"minimally":[4],"frustrated":[5],"alpha":[6,23,36,82,104],"helical":[7,24,110],"segments":[8],"is":[9,30],"defined":[10],"by":[11],"filtering":[12],"a":[13,33,58],"set":[14],"comprising":[15],"822":[16],"non":[17],"redundant":[18],"proteins,":[19],"which":[20,77,99],"contain":[21],"4783":[22],"structures.":[25],"The":[26],"definition":[29],"performed":[31],"using":[32],"neural":[34],"network-based":[35],"helix":[37],"predictor,":[38],"whose":[39],"outputs":[40],"are":[41],"rated":[42],"according":[43],"to":[44,96],"an":[45],"entropy":[46],"criterion.":[47],"comparison":[49],"with":[50],"the":[51,61,65,86,89,94,101,109],"presently":[52],"available":[53],"experimental":[54],"results":[55],"indicates":[56],"that":[57],"subset":[59],"contains":[64],"initiation":[66],"sites":[67],"protein":[69,75,114],"folding":[70],"experimentally":[71],"detected":[72],"and":[73,108],"also":[74],"fragments":[76],"fold":[78],"into":[79],"stable":[80],"isolated":[81,113],"helices.":[83],"This":[84],"suggests":[85],"usage":[87],"(and/or":[92],"predictor)":[95],"highlight":[97],"patterns":[98],"govern":[100],"stability":[102],"helices":[105],"in":[106],"proteins":[107],"behavior":[111],"fragments.":[115]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}