{"id":"https://openalex.org/W1934780964","doi":"https://doi.org/10.1002/jsfa.6222","title":"Using lytic bacteriophages to eliminate or significantly reduce contamination of food by foodborne bacterial pathogens","display_name":"Using lytic bacteriophages to eliminate or significantly reduce contamination of food by foodborne bacterial pathogens","publication_year":2013,"publication_date":"2013-05-13","ids":{"openalex":"https://openalex.org/W1934780964","doi":"https://doi.org/10.1002/jsfa.6222","mag":"1934780964","pmid":"https://pubmed.ncbi.nlm.nih.gov/23670852"},"language":"en","primary_location":{"id":"doi:10.1002/jsfa.6222","doi":"https://doi.org/10.1002/jsfa.6222","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.6222","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079277344","display_name":"Alexander Sulakvelidze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145290","display_name":"Intralytix (United States)","ror":"https://ror.org/04ye4vy15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145290"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander Sulakvelidze","raw_affiliation_strings":["Intralytix, Inc., The Columbus Center, Baltimore, MD, 21202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intralytix, Inc., The Columbus Center, Baltimore, MD, 21202, USA","institution_ids":["https://openalex.org/I4210145290"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079277344"],"corresponding_institution_ids":["https://openalex.org/I4210145290"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":1.2224,"has_fulltext":false,"cited_by_count":173,"citation_normalized_percentile":{"value":0.75159236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"93","issue":"13","first_page":"3137","last_page":"3146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10900","display_name":"Listeria monocytogenes in Food Safety","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lytic-phages","display_name":"lytic phages","score":0.9700000286102295},{"id":"https://openalex.org/keywords/phage-biocontrol","display_name":"phage biocontrol","score":0.9660000205039978},{"id":"https://openalex.org/keywords/foodborne-bacterial-pathogens","display_name":"foodborne bacterial pathogens","score":0.7799999713897705},{"id":"https://openalex.org/keywords/postharvest-treatment","display_name":"postharvest treatment","score":0.7620000243186951},{"id":"https://openalex.org/keywords/food-safety","display_name":"food safety","score":0.781000018119812},{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/surface-decontamination","display_name":"surface decontamination","score":0.7070000171661377},{"id":"https://openalex.org/keywords/regulatory-approval","display_name":"regulatory approval","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.7301852703094482},{"id":"https://openalex.org/C516717267","wikidata":"https://www.wikidata.org/wiki/Q909821","display_name":"Food safety","level":2,"score":0.5860905051231384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5767266154289246},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.5287030935287476},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.4758817255496979},{"id":"https://openalex.org/C2910978944","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacterial virus","level":5,"score":0.4652346968650818},{"id":"https://openalex.org/C513059894","wikidata":"https://www.wikidata.org/wiki/Q540912","display_name":"Food industry","level":2,"score":0.4455071687698364},{"id":"https://openalex.org/C88199923","wikidata":"https://www.wikidata.org/wiki/Q627371","display_name":"Food processing","level":2,"score":0.43858909606933594},{"id":"https://openalex.org/C58684123","wikidata":"https://www.wikidata.org/wiki/Q1810993","display_name":"Food microbiology","level":3,"score":0.4306367039680481},{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.4101232886314392},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3876921534538269},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3369923532009125},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3332751393318176},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11868330836296082},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1114574670791626},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.10454082489013672},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001433","descriptor_name":"Bacteriolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003666","descriptor_name":"Decontamination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005503","descriptor_name":"Food Additives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005506","descriptor_name":"Food Contamination","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005511","descriptor_name":"Food Handling","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D005516","descriptor_name":"Food Microbiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005517","descriptor_name":"Foodborne Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005517","descriptor_name":"Foodborne Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007881","descriptor_name":"Legislation, Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018556","descriptor_name":"Crops, Agricultural","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D058751","descriptor_name":"Livestock","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D059022","descriptor_name":"Food Safety","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jsfa.6222","doi":"https://doi.org/10.1002/jsfa.6222","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.6222","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},{"id":"pmid:23670852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23670852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the science of food and agriculture","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"},{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W70026810","https://openalex.org/W73054411","https://openalex.org/W1156309320","https://openalex.org/W1159871134","https://openalex.org/W1533289716","https://openalex.org/W1561318260","https://openalex.org/W1564428089","https://openalex.org/W1638402242","https://openalex.org/W1969819776","https://openalex.org/W1973519735","https://openalex.org/W1976895428","https://openalex.org/W1978933046","https://openalex.org/W1980274944","https://openalex.org/W1985143991","https://openalex.org/W1988550413","https://openalex.org/W2002173785","https://openalex.org/W2006496518","https://openalex.org/W2007402746","https://openalex.org/W2013201213","https://openalex.org/W2021427972","https://openalex.org/W2024142244","https://openalex.org/W2027117705","https://openalex.org/W2038976560","https://openalex.org/W2040192496","https://openalex.org/W2040695627","https://openalex.org/W2049768040","https://openalex.org/W2057881284","https://openalex.org/W2058418421","https://openalex.org/W2065689212","https://openalex.org/W2071882484","https://openalex.org/W2078656935","https://openalex.org/W2078709216","https://openalex.org/W2078728696","https://openalex.org/W2080490082","https://openalex.org/W2081719503","https://openalex.org/W2089237704","https://openalex.org/W2093393891","https://openalex.org/W2095655760","https://openalex.org/W2097044860","https://openalex.org/W2097229149","https://openalex.org/W2101997581","https://openalex.org/W2104089552","https://openalex.org/W2104798682","https://openalex.org/W2111217273","https://openalex.org/W2112077920","https://openalex.org/W2113625817","https://openalex.org/W2118108405","https://openalex.org/W2118149696","https://openalex.org/W2118578623","https://openalex.org/W2123514247","https://openalex.org/W2125447122","https://openalex.org/W2125705288","https://openalex.org/W2128210528","https://openalex.org/W2136072391","https://openalex.org/W2137079217","https://openalex.org/W2147082482","https://openalex.org/W2148551763","https://openalex.org/W2152005348","https://openalex.org/W2154783995","https://openalex.org/W2156081659","https://openalex.org/W2162246107","https://openalex.org/W2163273115","https://openalex.org/W2165813819","https://openalex.org/W2296186783","https://openalex.org/W2314425208","https://openalex.org/W2317691308","https://openalex.org/W2402293444","https://openalex.org/W2491905025","https://openalex.org/W4206428018","https://openalex.org/W4231940808","https://openalex.org/W4255578408"],"related_works":["https://openalex.org/W2545813315","https://openalex.org/W1561790642","https://openalex.org/W4237908089","https://openalex.org/W2912451730","https://openalex.org/W4390940615","https://openalex.org/W4251842100","https://openalex.org/W2263861055","https://openalex.org/W2800035215","https://openalex.org/W1872748248","https://openalex.org/W6939951883"],"abstract_inverted_index":{"Bacteriophages":[0],"(also":[1],"called":[2,91],"'phages')":[3],"are":[4,10,53,142],"viruses":[5],"that":[6,136,211],"kill":[7],"bacteria.":[8],"They":[9],"arguably":[11],"the":[12,56,78,146,159,167,176,181,209,265],"oldest":[13],"(3":[14],"billion":[15],"years":[16],"old,":[17],"by":[18,261],"some":[19,234],"estimates)":[20],"and":[21,51,116,131,149,191,219,237],"most":[22,79,177],"ubiquitous":[23],"(total":[24],"number":[25],"estimated":[26],"to":[27,85,104,110,242],"be":[28,243],"10(30)":[29],"-10(32)":[30],")":[31],"known":[32],"organisms":[33],"on":[34,82,139,166],"Earth.":[35],"Phages":[36],"play":[37],"a":[38,216],"key":[39],"role":[40],"in":[41,45,65,108,128,264],"maintaining":[42],"microbial":[43],"balance":[44],"every":[46],"ecosystem":[47],"where":[48],"bacteria":[49],"exist,":[50],"they":[52],"part":[54,253],"of":[55,59,69,99,156,170,183,196,226,254],"normal":[57],"microflora":[58],"all":[60],"fresh,":[61],"unprocessed":[62],"foods.":[63,161],"Interest":[64],"various":[66,197,227],"practical":[67],"applications":[68,155],"bacteriophages":[70],"has":[71,173],"been":[72,174],"gaining":[73,175],"momentum":[74,178],"recently,":[75],"with":[76,145,187,229],"perhaps":[77],"attention":[80],"focused":[81],"using":[83,102],"them":[84],"improve":[86],"food":[87,133,189,204,256,262],"safety.":[88],"That":[89],"approach,":[90],"'phage":[92],"biocontrol',":[93],"typically":[94],"includes":[95],"three":[96],"main":[97],"types":[98],"applications:":[100],"(i)":[101],"phages":[103,157,213],"treat":[105],"domesticated":[106],"livestock":[107],"order":[109],"reduce":[111],"their":[112],"intestinal":[113],"colonization":[114],"with,":[115],"shedding":[117],"of,":[118],"specific":[119],"bacterial":[120,231],"pathogens;":[121,148],"(ii)":[122],"treatments":[123,152],"for":[124,202,222],"decontaminating":[125],"inanimate":[126],"surfaces":[127,141],"food-processing":[129],"facilities":[130],"other":[132],"establishments,":[134],"so":[135],"foods":[137,228],"processed":[138],"those":[140],"not":[143],"cross-contaminated":[144],"targeted":[147],"(iii)":[150],"post-harvest":[151,203],"involving":[153],"direct":[154],"onto":[158],"harvested":[160],"This":[162],"mini-review":[163],"primarily":[164],"focuses":[165],"last":[168],"type":[169],"intervention,":[171],"which":[172],"recently.":[179],"Indeed,":[180],"results":[182],"recent":[184,193],"studies":[185],"dealing":[186],"improving":[188],"safety,":[190],"several":[192],"regulatory":[194],"approvals":[195],"commercial":[198],"phage":[199,246],"preparations":[200],"developed":[201],"safety":[205,257],"applications,":[206],"strongly":[207],"support":[208],"idea":[210],"lytic":[212],"may":[214,240],"provide":[215],"safe,":[217],"environmentally-friendly,":[218],"effective":[220],"approach":[221],"significantly":[223],"reducing":[224],"contamination":[225],"foodborne":[230],"pathogens.":[232],"However,":[233],"important":[235],"technical":[236],"nontechnical":[238],"problems":[239],"need":[241],"addressed":[244],"before":[245],"biocontrol":[247],"protocols":[248],"can":[249],"become":[250],"an":[251],"integral":[252],"routine":[255],"intervention":[258],"strategies":[259],"implemented":[260],"industries":[263],"USA.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}