{"id":"https://openalex.org/W193401540","doi":null,"title":"Ruolo degli adipociti nell\u2019emopoiesi umana","display_name":"Ruolo degli adipociti nell\u2019emopoiesi umana","publication_year":2014,"publication_date":"2014-04-10","ids":{"openalex":"https://openalex.org/W193401540","mag":"193401540"},"language":"it","primary_location":{"id":"pmh:oai:iris.univpm.it:11566/242863","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/242863","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108739411","display_name":"Stefania Mancini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stefania Mancini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108739411"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.15520000457763672,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-adipocytes","display_name":"bone marrow adipocytes","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hematopoietic-microenvironment","display_name":"hematopoietic microenvironment","score":0.8859999775886536},{"id":"https://openalex.org/keywords/adipocyte-phenotype","display_name":"adipocyte phenotype","score":0.414000004529953},{"id":"https://openalex.org/keywords/white-adipocytes","display_name":"white adipocytes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/brown-adipocytes","display_name":"brown adipocytes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.6430000066757202},{"id":"https://openalex.org/keywords/embryonic-stem-cell-genes","display_name":"embryonic stem cell genes","score":0.6489999890327454},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.6470000147819519},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.7770000100135803},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.6840000152587891},{"id":"https://openalex.org/keywords/gata4","display_name":"GATA4","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tbx1","display_name":"Tbx1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sox17","display_name":"SOX17","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dio2","display_name":"DIO2","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cidea","display_name":"CIDEA","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prdm16","display_name":"PRDM16","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/adipocyte-isolation","display_name":"adipocyte isolation","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.28506559133529663}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:iris.univpm.it:11566/242863","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/242863","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:193401540","doi":null,"is_oa":false,"landing_page_url":"http://openarchive.univpm.it/jspui/bitstream/123456789/1025/1/Tesi_Mancini.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1969099489","https://openalex.org/W1970291858","https://openalex.org/W1990614859","https://openalex.org/W2016818042","https://openalex.org/W2039770886","https://openalex.org/W2039992465","https://openalex.org/W2085959104","https://openalex.org/W2111511588","https://openalex.org/W2138287192","https://openalex.org/W2158048826"],"related_works":["https://openalex.org/W2110543315","https://openalex.org/W7052434116","https://openalex.org/W4417116966","https://openalex.org/W6987640521","https://openalex.org/W2521077735","https://openalex.org/W3006548616","https://openalex.org/W4283314530","https://openalex.org/W7213969477","https://openalex.org/W2963102805","https://openalex.org/W4317545829"],"abstract_inverted_index":{"Gli":[0],"adipociti":[1,18,47,100,229],"rappresentano":[2],"una":[3,22,109],"popolazione":[4],"cellulare":[5,135],"mesenchimale":[6],"naturalmente":[7],"presente":[8],"nel":[9,60,91,119],"\\nmidollo":[10],"osseo":[11,52],"umano.":[12],"In":[13],"questo":[14],"specifico":[15],"microambiente":[16,61],"gli":[17,46,99,153,175,208,235],"possono":[19],"interagire":[20],"con":[21,71,98,166,244],"\\nvarieta\u0300":[23],"di":[24,41,112,121,158,217],"cellule":[25,162,181],"differenti,":[26],"il":[27,57,83,186,238],"loro":[28,58,77,80,88],"ruolo":[29,59,247],"pero\u0300":[30],"e\u0300":[31],"in":[32,149],"larga":[33],"parte":[34],"sconosciuto.":[35],"\\nQuesto":[36],"lavoro":[37],"ha":[38],"lo":[39],"scopo":[40],"caratterizzare":[42],"molecolarmente":[43],"e":[44,73,86,188,197,205,214,224],"funzionalmente":[45],"maturi":[48],"\\nisolati":[49],"dal":[50],"midollo":[51],"umano":[53],"(BM-A)":[54],"per":[55,185,222],"studiare":[56],"emopoietico.":[62],"\\nGli":[63,106],"BM-A":[64,107,176],"normali":[65],"sono":[66,94],"stati":[67,95],"isolati":[68],"dopo":[69],"digestione":[70],"collagenasi":[72],"filtrazione,":[74],"studiata":[75],"la":[76,79,87,189],"\\nmorfologia,":[78],"espressione":[81],"genica,":[82],"profilo":[84],"immunofenotipico":[85],"capacita\u0300":[89],"funzionale":[90],"\\nmicroambiente":[92],"emopoietico,":[93],"poi":[96],"confrontati":[97],"derivati":[101],"da":[102,128,210],"tessuto":[103],"adiposo":[104],"\\n(AT-A).":[105],"hanno":[108,172],"forma":[110],"sferica":[111],"dimensioni":[113],"assai":[114],"variabili,":[115],"caratterizzata":[116],"dalla":[117],"presenza":[118],"\\ncitoplasma":[120],"un":[122,137,245],"unico":[123],"vacuolo":[124],"lipidico":[125],"che":[126,145,174,234],"occupa,":[127],"solo,":[129],"piu\u0300":[130],"del":[131,133,241],"90%":[132],"volume":[134],"ed":[136],"\\npiccolo":[138],"nucleo":[139],"appiattito,":[140],"caratteristiche":[141],"simili":[142],"agli":[143],"AT-A":[144],"non":[146,200],"vengono":[147],"perse":[148],"coltura,":[150],"inoltre,":[151],"\\ncome":[152],"AT-A,":[154],"esprimono":[155,177,201,212],"alcuni":[156,178],"antigeni":[157],"superficie":[159],"tipici":[160],"delle":[161,180],"staminali.":[163],"\\nIn":[164],"linea":[165],"queste":[167],"osservazioni,":[168],"i":[169,202],"dati":[170],"molecolari":[171,227],"mostrato":[173],"\\ngeni":[179],"staminali":[182],"embrionali":[183],"necessari":[184],"self-renewal":[187],"pluripotenza,":[190],"come":[191],"Oct4,":[192],"\\nKlf4,":[193],"c-myc,":[194],"GATA4,":[195],"Tbx1":[196],"Sox17,":[198],"ma":[199],"marcatori":[203],"Sox2":[204],"Nanog.":[206],"Inoltre":[207],"\\nadipociti":[209],"BM":[211],"Dio2":[213],"CIDEA,":[215],"regolatori":[216],"termogenesi,":[218],"mentre":[219],"risultano":[220],"negativi":[221],"\\nPrdm16":[223],"UCP1,":[225],"marker":[226],"degli":[228],"bruni.":[230],"Questi":[231],"risultati,":[232],"suggeriscono":[233],"BMA":[236],"\\nesprimono":[237],"fenotipo":[239],"molecolare":[240],"grasso":[242],"bianco":[243],"importante":[246],"nell\u2019attivita\u0300":[248],"\\nmetabolica.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}