{"id":"https://openalex.org/W1933409356","doi":null,"title":"Engineering the tryptophanyl tRNA synthetase and tRNATrp for the orthogonal expansion of the genetic code","display_name":"Engineering the tryptophanyl tRNA synthetase and tRNATrp for the orthogonal expansion of the genetic code","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W1933409356","mag":"1933409356"},"language":"en","primary_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/18239","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/18239","pdf_url":"http://hdl.handle.net/2152/18239","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2152/18239","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076550740","display_name":"Randall A. Hughes","orcid":"https://orcid.org/0000-0003-4665-0335","observed_orcids":["https://orcid.org/0000-0003-4665-0335"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Randall A. Hughes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4665-0335","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076550740"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07962623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophanyl-trna-synthetase","display_name":"tryptophanyl-tRNA synthetase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/trna-trp","display_name":"tRNATrp","score":0.9390000104904175},{"id":"https://openalex.org/keywords/orthogonal-aminoacyl-trna-synthetase","display_name":"orthogonal aminoacyl-tRNA synthetase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/genetic-code-expansion","display_name":"genetic code expansion","score":0.7110000252723694},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.5440000295639038},{"id":"https://openalex.org/keywords/unnatural-amino-acids","display_name":"unnatural amino acids","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C10853874","wikidata":"https://www.wikidata.org/wiki/Q180618","display_name":"Genetic code","level":3,"score":0.6731215715408325},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.5003261566162109},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.4437694549560547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4271728992462158},{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.42652827501296997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40751415491104126},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3382304012775421},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22504746913909912},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.13549494743347168},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.13224956393241882},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositories.lib.utexas.edu:2152/18239","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/18239","pdf_url":"http://hdl.handle.net/2152/18239","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:1933409356","doi":null,"is_oa":false,"landing_page_url":"https://repositories.lib.utexas.edu/bitstream/2152/18239/2/hughesr73534.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/18239","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/18239","pdf_url":"http://hdl.handle.net/2152/18239","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1933409356.pdf","grobid_xml":"https://content.openalex.org/works/W1933409356.grobid-xml"},"referenced_works_count":254,"referenced_works":["https://openalex.org/W39064496","https://openalex.org/W135558106","https://openalex.org/W333518702","https://openalex.org/W641843773","https://openalex.org/W651022058","https://openalex.org/W1502060396","https://openalex.org/W1505293602","https://openalex.org/W1506811553","https://openalex.org/W1508225465","https://openalex.org/W1509807670","https://openalex.org/W1509956720","https://openalex.org/W1515935760","https://openalex.org/W1546157935","https://openalex.org/W1550727253","https://openalex.org/W1559808711","https://openalex.org/W1587481053","https://openalex.org/W1760388574","https://openalex.org/W1789840735","https://openalex.org/W1878070912","https://openalex.org/W1881495824","https://openalex.org/W1898646959","https://openalex.org/W1912091390","https://openalex.org/W1951639553","https://openalex.org/W1963707717","https://openalex.org/W1963724731","https://openalex.org/W1963986378","https://openalex.org/W1965205049","https://openalex.org/W1965524864","https://openalex.org/W1965843395","https://openalex.org/W1967058998","https://openalex.org/W1967304044","https://openalex.org/W1967779980","https://openalex.org/W1968321828","https://openalex.org/W1968879131","https://openalex.org/W1969737313","https://openalex.org/W1970212713","https://openalex.org/W1970470254","https://openalex.org/W1970505356","https://openalex.org/W1970743827","https://openalex.org/W1971586578","https://openalex.org/W1971884501","https://openalex.org/W1972784441","https://openalex.org/W1973295691","https://openalex.org/W1974357725","https://openalex.org/W1974487113","https://openalex.org/W1975171282","https://openalex.org/W1975924299","https://openalex.org/W1975952514","https://openalex.org/W1976159102","https://openalex.org/W1976230851","https://openalex.org/W1978075857","https://openalex.org/W1978880815","https://openalex.org/W1979755475","https://openalex.org/W1979806605","https://openalex.org/W1979867063","https://openalex.org/W1980461282","https://openalex.org/W1981529363","https://openalex.org/W1984537439","https://openalex.org/W1990559983","https://openalex.org/W1992170964","https://openalex.org/W1993111592","https://openalex.org/W1993855691","https://openalex.org/W1993926495","https://openalex.org/W1994233811","https://openalex.org/W1995143868","https://openalex.org/W1995679029","https://openalex.org/W1996142946","https://openalex.org/W1996765253","https://openalex.org/W1997255287","https://openalex.org/W1997727857","https://openalex.org/W1999265155","https://openalex.org/W1999816995","https://openalex.org/W2000577570","https://openalex.org/W2000769807","https://openalex.org/W2001650466","https://openalex.org/W2001861748","https://openalex.org/W2002209113","https://openalex.org/W2004411392","https://openalex.org/W2004676978","https://openalex.org/W2005826774","https://openalex.org/W2006440010","https://openalex.org/W2007639714","https://openalex.org/W2007893737","https://openalex.org/W2010804339","https://openalex.org/W2011165659","https://openalex.org/W2012537676","https://openalex.org/W2012637413","https://openalex.org/W2012786788","https://openalex.org/W2012817491","https://openalex.org/W2013726100","https://openalex.org/W2014297120","https://openalex.org/W2014611104","https://openalex.org/W2015128457","https://openalex.org/W2015176117","https://openalex.org/W2015362305","https://openalex.org/W2015745958","https://openalex.org/W2016172184","https://openalex.org/W2017320993","https://openalex.org/W2017602203","https://openalex.org/W2020026065","https://openalex.org/W2021438104","https://openalex.org/W2022230559","https://openalex.org/W2022235814","https://openalex.org/W2022581012","https://openalex.org/W2023521131","https://openalex.org/W2024156903","https://openalex.org/W2025678105","https://openalex.org/W2026089250","https://openalex.org/W2026440304","https://openalex.org/W2026464022","https://openalex.org/W2027217660","https://openalex.org/W2027298209","https://openalex.org/W2029120593","https://openalex.org/W2031291845","https://openalex.org/W2032505726","https://openalex.org/W2035116306","https://openalex.org/W2036130241","https://openalex.org/W2036502774","https://openalex.org/W2036871186","https://openalex.org/W2037326729","https://openalex.org/W2037720445","https://openalex.org/W2039549031","https://openalex.org/W2040542353","https://openalex.org/W2041548460","https://openalex.org/W2042637938","https://openalex.org/W2043502580","https://openalex.org/W2044385639","https://openalex.org/W2045443147","https://openalex.org/W2046023739","https://openalex.org/W2049575563","https://openalex.org/W2051659829","https://openalex.org/W2051900539","https://openalex.org/W2052063930","https://openalex.org/W2052537416","https://openalex.org/W2052858356","https://openalex.org/W2052944687","https://openalex.org/W2054143361","https://openalex.org/W2054914863","https://openalex.org/W2055370673","https://openalex.org/W2056986521","https://openalex.org/W2057481603","https://openalex.org/W2057892106","https://openalex.org/W2058406864","https://openalex.org/W2059217450","https://openalex.org/W2060391020","https://openalex.org/W2060576378","https://openalex.org/W2060967348","https://openalex.org/W2063761644","https://openalex.org/W2064179619","https://openalex.org/W2064635236","https://openalex.org/W2064716344","https://openalex.org/W2065196325","https://openalex.org/W2065600580","https://openalex.org/W2067013502","https://openalex.org/W2068760466","https://openalex.org/W2069575698","https://openalex.org/W2069647141","https://openalex.org/W2069689608","https://openalex.org/W2069833774","https://openalex.org/W2071190573","https://openalex.org/W2071804506","https://openalex.org/W2072163663","https://openalex.org/W2072969046","https://openalex.org/W2073435845","https://openalex.org/W2073727593","https://openalex.org/W2074244626","https://openalex.org/W2075731957","https://openalex.org/W2076900876","https://openalex.org/W2076992251","https://openalex.org/W2077116582","https://openalex.org/W2077177643","https://openalex.org/W2077270147","https://openalex.org/W2077785805","https://openalex.org/W2078699438","https://openalex.org/W2079209641","https://openalex.org/W2081446858","https://openalex.org/W2081496564","https://openalex.org/W2082260955","https://openalex.org/W2082589966","https://openalex.org/W2083541735","https://openalex.org/W2085791091","https://openalex.org/W2087688292","https://openalex.org/W2088175720","https://openalex.org/W2089633089","https://openalex.org/W2089686299","https://openalex.org/W2089710023","https://openalex.org/W2091098426","https://openalex.org/W2097054029","https://openalex.org/W2098015235","https://openalex.org/W2098146850","https://openalex.org/W2099331149","https://openalex.org/W2100631905","https://openalex.org/W2100870536","https://openalex.org/W2103731920","https://openalex.org/W2103908512","https://openalex.org/W2105127489","https://openalex.org/W2105161156","https://openalex.org/W2105367672","https://openalex.org/W2105837504","https://openalex.org/W2106460302","https://openalex.org/W2106622357","https://openalex.org/W2106804637","https://openalex.org/W2108834675","https://openalex.org/W2110107663","https://openalex.org/W2110235365","https://openalex.org/W2111964513","https://openalex.org/W2112821215","https://openalex.org/W2113783192","https://openalex.org/W2117197918","https://openalex.org/W2120924356","https://openalex.org/W2121634897","https://openalex.org/W2124268486","https://openalex.org/W2125148255","https://openalex.org/W2125514960","https://openalex.org/W2125534391","https://openalex.org/W2125759893","https://openalex.org/W2127188617","https://openalex.org/W2127749120","https://openalex.org/W2128315172","https://openalex.org/W2129682645","https://openalex.org/W2130479394","https://openalex.org/W2132429713","https://openalex.org/W2134759124","https://openalex.org/W2134811034","https://openalex.org/W2136364313","https://openalex.org/W2136639243","https://openalex.org/W2137478991","https://openalex.org/W2138901597","https://openalex.org/W2139305314","https://openalex.org/W2141461868","https://openalex.org/W2142271028","https://openalex.org/W2142924838","https://openalex.org/W2144175569","https://openalex.org/W2144794655","https://openalex.org/W2145852946","https://openalex.org/W2148912121","https://openalex.org/W2150417688","https://openalex.org/W2151341878","https://openalex.org/W2155441992","https://openalex.org/W2156377423","https://openalex.org/W2157253253","https://openalex.org/W2158412952","https://openalex.org/W2159215586","https://openalex.org/W2160084442","https://openalex.org/W2160539059","https://openalex.org/W2161273461","https://openalex.org/W2165596976","https://openalex.org/W2165980400","https://openalex.org/W2170374832","https://openalex.org/W2170771823","https://openalex.org/W2173055149","https://openalex.org/W2200999990","https://openalex.org/W2338266679","https://openalex.org/W3140762575"],"related_works":["https://openalex.org/W7024874282","https://openalex.org/W6887949301","https://openalex.org/W2792039619","https://openalex.org/W111033017","https://openalex.org/W2025445740","https://openalex.org/W2160663329","https://openalex.org/W7212649806","https://openalex.org/W1985045851","https://openalex.org/W6944392553","https://openalex.org/W2335531314"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
