{"id":"https://openalex.org/W19329907","doi":null,"title":"Alzheimer-type neuropathology and clinical symptoms of dementia in mentally retarded people without Down syndrome.","display_name":"Alzheimer-type neuropathology and clinical symptoms of dementia in mentally retarded people without Down syndrome.","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W19329907","mag":"19329907","pmid":"https://pubmed.ncbi.nlm.nih.gov/2706124"},"language":"en","primary_location":{"id":"pmid:2706124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2706124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of mental retardation : AJMR","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067111738","display_name":"Maria Barcikowska","orcid":"https://orcid.org/0000-0001-5657-9670","observed_orcids":["https://orcid.org/0000-0001-5657-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Barcikowska","raw_affiliation_strings":["New York State Institute for Basic Research in Developmental Disabilities, NY 10314"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Institute for Basic Research in Developmental Disabilities, NY 10314","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015463507","display_name":"Wayne P. Silverman","orcid":"https://orcid.org/0000-0002-7842-8600","observed_orcids":["https://orcid.org/0000-0002-7842-8600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Silverman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004673670","display_name":"Warren B. Zigman","orcid":"https://orcid.org/0000-0003-3907-0033","observed_orcids":["https://orcid.org/0000-0003-3907-0033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Zigman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019532010","display_name":"Piotr B. Kozlowski","orcid":"https://orcid.org/0000-0002-0283-4418","observed_orcids":["https://orcid.org/0000-0002-0283-4418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P B Kozlowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111744302","display_name":"Marek Kujawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kujawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108380424","display_name":"Raoul D. Rudelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rudelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110104011","display_name":"Henryk M. Wisniewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M Wisniewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6258,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.81853013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"93","issue":"5","first_page":"551","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.1216999962925911,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.6930000185966492},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.5460000038146973},{"id":"https://openalex.org/keywords/behavioral-problems","display_name":"behavioral problems","score":0.8650000095367432},{"id":"https://openalex.org/keywords/iq-decline","display_name":"IQ decline","score":0.9079999923706055},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.5289999842643738},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.9690307378768921},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7076414823532104},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6706832647323608},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.576636016368866},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4787975251674652},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4563570022583008},{"id":"https://openalex.org/C3019965780","wikidata":"https://www.wikidata.org/wiki/Q183560","display_name":"Mentally retarded","level":2,"score":0.4504767060279846},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4339020550251007},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3386918306350708},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2709313631057739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22778069972991943},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14061239361763},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012494","descriptor_name":"Sampling Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2706124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2706124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of mental retardation : AJMR","raw_type":"Journal Article"},{"id":"mag:19329907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2706124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3069893563","display_name":"MOROPHOMETRY OF THE CELL JUNCTIONS IN THE NERVOUS SYSTEM","funder_award_id":"F05TW003849","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G657601641","display_name":"CHANGES IN FUNCTIONING AMONG MENTALLY RETARDED ADULTS","funder_award_id":"P01HD022634","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052714539","https://openalex.org/W135170103","https://openalex.org/W2013906093","https://openalex.org/W1976863698","https://openalex.org/W578338351","https://openalex.org/W2147029696","https://openalex.org/W2016406742","https://openalex.org/W1809346617","https://openalex.org/W2043270657","https://openalex.org/W1452847604"],"abstract_inverted_index":{"Postmortem":[0],"morphometric":[1],"analyses":[2],"of":[3,9,38,68,72,86,91,113,118],"Bielschowsky":[4],"stained":[5],"sections":[6],"from":[7,46],"brains":[8],"70":[10],"mentally":[11],"retarded":[12,119],"people":[13,96],"without":[14],"Down":[15],"syndrome,":[16],"age":[17],"65":[18],"and":[19,31,75,97,103],"over":[20],"when":[21],"they":[22],"died,":[23],"indicated":[24],"Alzheimer-type":[25,40,92],"neuropathology":[26,93],"in":[27,79],"22":[28],"cases":[29],"(31%)":[30],"a":[32,76],"majority":[33],"with":[34],"at":[35],"least":[36],"presence":[37],"some":[39],"lesions.":[41],"Based":[42],"upon":[43],"information":[44],"abstracted":[45],"clinical":[47],"histories,":[48],"however,":[49],"old-age-associated":[50],"dementia":[51],"proved":[52],"to":[53,56,82,108],"be":[54,83,106],"difficult":[55],"judge":[57],"reliably.":[58],"Nevertheless,":[59],"for":[60],"otherwise":[61],"healthy":[62],"individuals":[63],"(n":[64],"=":[65],"25),":[66],"loss":[67],"motor":[69],"skills,":[70],"development":[71],"problem":[73],"behaviors,":[74],"10-point":[77],"drop":[78],"IQ":[80],"appeared":[81],"likely":[84],"indicators":[85],"Alzheimer's":[87],"disease.":[88],"Prevalence":[89],"estimates":[90],"among":[94],"nonretarded":[95],"the":[98,110],"present":[99],"sample":[100],"appear":[101],"comparable,":[102],"projections":[104],"must":[105],"made":[107],"address":[109],"special":[111],"needs":[112],"this":[114],"rapidly":[115],"growing":[116],"population":[117],"people.":[120]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
