{"id":"https://openalex.org/W1932754573","doi":"https://doi.org/10.1200/jco.1997.15.1.165","title":"Randomized trial of cisplatin versus cisplatin plus mitolactol versus cisplatin plus ifosfamide in advanced squamous carcinoma of the cervix: a Gynecologic Oncology Group study.","display_name":"Randomized trial of cisplatin versus cisplatin plus mitolactol versus cisplatin plus ifosfamide in advanced squamous carcinoma of the cervix: a Gynecologic Oncology Group study.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1932754573","doi":"https://doi.org/10.1200/jco.1997.15.1.165","mag":"1932754573","pmid":"https://pubmed.ncbi.nlm.nih.gov/8996138"},"language":"en","primary_location":{"id":"doi:10.1200/jco.1997.15.1.165","doi":"https://doi.org/10.1200/jco.1997.15.1.165","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1997.15.1.165","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109537934","display_name":"G Omura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G A Omura","raw_affiliation_strings":["University of Alabama at Birmingham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111536542","display_name":"John A. Blessing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Blessing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002713489","display_name":"Luis Vaccarello","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Vaccarello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108478323","display_name":"M L Berman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Berman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108455151","display_name":"Daniel L. Clarke\u2010Pearson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D L Clarke-Pearson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076087889","display_name":"David Gardner Mutch","orcid":"https://orcid.org/0000-0002-6921-1581","observed_orcids":["https://orcid.org/0000-0002-6921-1581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D G Mutch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"B Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.9057,"has_fulltext":false,"cited_by_count":266,"citation_normalized_percentile":{"value":0.99110046,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"165","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ifosfamide","display_name":"ifosfamide","score":0.9490000009536743},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.5419999957084656},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.7720000147819519},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/central-nervous-system-toxicity","display_name":"central nervous system toxicity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.6880000233650208},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.898396909236908},{"id":"https://openalex.org/C2780435969","wikidata":"https://www.wikidata.org/wiki/Q5625186","display_name":"Gynecologic oncology","level":2,"score":0.8668062686920166},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8664671182632446},{"id":"https://openalex.org/C2777506904","wikidata":"https://www.wikidata.org/wiki/Q418560","display_name":"Ifosfamide","level":4,"score":0.7026894688606262},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.64662104845047},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6460555791854858},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5645261406898499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5118357539176941},{"id":"https://openalex.org/C2994491419","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous carcinoma","level":3,"score":0.4650344252586365},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.410910964012146},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3920103907585144},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3395848274230957},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15924972295761108}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008936","descriptor_name":"Mitolactol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008936","descriptor_name":"Mitolactol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017677","descriptor_name":"Age Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.1997.15.1.165","doi":"https://doi.org/10.1200/jco.1997.15.1.165","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1997.15.1.165","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:8996138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8996138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G4064044179","display_name":"GYNECOLOGIC ONCOLOGY GROUP STATISTICAL AND DATA CENTER","funder_award_id":"U10CA037517","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G537293791","display_name":"Gynecologic Oncology Group","funder_award_id":"U10CA027469","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079730922","https://openalex.org/W2255368071","https://openalex.org/W2106516999","https://openalex.org/W2465332485","https://openalex.org/W1968068601","https://openalex.org/W2026023655","https://openalex.org/W2070120895","https://openalex.org/W2001966180","https://openalex.org/W2000194562","https://openalex.org/W2273450130"],"abstract_inverted_index":{"PURPOSE:":[0],"Cisplatin,":[1],"mitolactol":[2,36,61],"(dibromodulcitol),":[3],"and":[4,33,90,113,117,132,154,187,206,216,233,251],"ifosfamide":[5,32,76,96],"have":[6],"been":[7],"the":[8,17,23,55,95,209,230,246],"most":[9],"active":[10],"single":[11],"agents":[12],"in":[13,165,201,236,255],"squamous":[14],"carcinoma":[15],"of":[16,29,58,208,248],"cervix":[18,238],"identified":[19],"so":[20],"far":[21],"by":[22],"Gynecologic":[24],"Oncology":[25],"Group":[26],"(GOG).":[27],"Combinations":[28],"cisplatin":[30,34,41,51,59,74,143,170,205,242],"plus":[31,35,60,75,85],"are":[37],"prospectively":[38],"compared":[39,141,168,240],"with":[40,142,169,175,188,222,241,252],"alone.":[42,144,171],"PATIENTS":[43],"AND":[44],"METHODS:":[45],"Patients":[46],"were":[47,111,152,219],"randomized":[48],"to":[49,71,103,148],"receive":[50],"50":[52],"mg/m2":[53,66],"or":[54,73,150],"same":[56],"dose":[57],"(C":[62],"+":[63,159],"M)":[64],"180":[65],"orally":[67],"on":[68],"days":[69],"2":[70],"6,":[72],"(CIFX)":[77],"5":[78],"g/m2":[79,88],"given":[80],"as":[81],"a":[82,122],"24-hour":[83],"infusion":[84],"mesna":[86],"6":[87],"during":[89],"for":[91,101,115],"12":[92],"hours":[93],"after":[94],"infusion,":[97],"every":[98],"3":[99],"weeks":[100],"up":[102],"six":[104],"courses.":[105],"Of":[106],"454":[107],"patients":[108],"entered,":[109],"438":[110],"eligible":[112],"analyzed":[114],"response":[116,124,231],"survival.":[118,256],"RESULTS:":[119],"CIFX":[120,223,228],"had":[121],"higher":[123],"rate":[125,232],"(31.1%":[126],"v":[127],"17.8%,":[128],"p":[129],"=":[130,139,194],".004)":[131],"longer":[133],"progression-free":[134],"survival":[135,203],"(PFS)":[136],"time":[137],"(P":[138,224],".003)":[140],"The":[145],"median":[146],"times":[147],"progression":[149],"death":[151],"4.6":[153],"3.2":[155],"months,":[156],"respectively.":[157],"C":[158],"M":[160],"showed":[161],"no":[162,198,253],"significant":[163,199],"improvement":[164,254],"these":[166],"parameters":[167],"Survival":[172],"was":[173,181,191,197],"associated":[174],"initial":[176],"performance":[177],"score":[178],"(PS;":[179],"0":[180],"more":[182,220],"favorable;":[183],"P":[184,193],"<":[185,225],".001)":[186],"age":[189],"(younger":[190],"unfavorable,":[192],".025).":[195],"There":[196],"difference":[200],"overall":[202],"between":[204],"either":[207],"combinations.":[210],"Leukopenia,":[211],"renal":[212],"toxicity,":[213],"peripheral":[214],"neurotoxicity,":[215],"CNS":[217],"toxicity":[218,250],"frequent":[221],".05).":[226],"CONCLUSION:":[227],"improved":[229],"PFS":[234],"duration":[235],"advanced":[237],"cancer":[239],"alone,":[243],"but":[244],"at":[245],"cost":[247],"greater":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}