{"id":"https://openalex.org/W193238672","doi":null,"title":"Effect of Obestatin on Gonadal Functions in High Fat-fed Albino Rats","display_name":"Effect of Obestatin on Gonadal Functions in High Fat-fed Albino Rats","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W193238672","mag":"193238672"},"language":"en","primary_location":{"id":"mag:193238672","doi":null,"is_oa":false,"landing_page_url":"http://article.sapub.org/10.5923.j.medicine.20140303.02.html","pdf_url":null,"source":{"id":"https://openalex.org/S4210193668","display_name":"Basic Sciences of Medicine","issn_l":"2167-7344","issn":["2167-7344","2167-7352"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Basic Sciences of Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006872437","display_name":"Mohmmad H. M. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohmmad H. M. Ibrahim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032844796","display_name":"Soad Abdallah Selim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soad Abdallah Selim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004833757","display_name":"Dalia I. Abd Al-Aleem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dalia I. Abd-Alaleem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109459164","display_name":"Radwa M. Al-sayed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radwa Al-Sayed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"3","first_page":"43","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.1281999945640564,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obestatin","display_name":"obestatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.746999979019165},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gonadal-function","display_name":"gonadal function","score":0.9670000076293945},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6919999718666077},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.7689999938011169},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7089999914169312},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.984000027179718},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.6909999847412109},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.6800000071525574},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.6890000104904175},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.6000000238418579},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.6169999837875366},{"id":"https://openalex.org/keywords/gnrh-receptor","display_name":"GnRH receptor","score":0.6970000267028809},{"id":"https://openalex.org/keywords/gnrh-antagonist","display_name":"GnRH antagonist","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2781146222","wikidata":"https://www.wikidata.org/wiki/Q905680","display_name":"Obestatin","level":4,"score":0.9752182960510254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8170222043991089},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8161821365356445},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6309134364128113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48504990339279175},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.44257768988609314},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.41787683963775635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3268123269081116},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2763993740081787}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:193238672","doi":null,"is_oa":false,"landing_page_url":"http://article.sapub.org/10.5923.j.medicine.20140303.02.html","pdf_url":null,"source":{"id":"https://openalex.org/S4210193668","display_name":"Basic Sciences of Medicine","issn_l":"2167-7344","issn":["2167-7344","2167-7352"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Basic Sciences of Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W12972008","https://openalex.org/W1578728271","https://openalex.org/W1926980376","https://openalex.org/W1946263363","https://openalex.org/W1969288863","https://openalex.org/W1970126457","https://openalex.org/W1971452427","https://openalex.org/W1972234380","https://openalex.org/W1972679559","https://openalex.org/W1973227135","https://openalex.org/W1973425576","https://openalex.org/W1976453807","https://openalex.org/W1977027676","https://openalex.org/W1981052653","https://openalex.org/W1981109505","https://openalex.org/W1981468192","https://openalex.org/W1983870320","https://openalex.org/W1983928849","https://openalex.org/W1984621921","https://openalex.org/W1987484802","https://openalex.org/W1990103834","https://openalex.org/W1992076730","https://openalex.org/W1995508866","https://openalex.org/W1996266187","https://openalex.org/W2000847162","https://openalex.org/W2002005654","https://openalex.org/W2004730294","https://openalex.org/W2005699234","https://openalex.org/W2006050476","https://openalex.org/W2009486441","https://openalex.org/W2011338138","https://openalex.org/W2013163420","https://openalex.org/W2013749721","https://openalex.org/W2014269154","https://openalex.org/W2018492121","https://openalex.org/W2020753725","https://openalex.org/W2024599506","https://openalex.org/W2025413292","https://openalex.org/W2027066554","https://openalex.org/W2031484244","https://openalex.org/W2035643732","https://openalex.org/W2037226098","https://openalex.org/W2037328290","https://openalex.org/W2038919867","https://openalex.org/W2040263937","https://openalex.org/W2042927678","https://openalex.org/W2043246453","https://openalex.org/W2044437167","https://openalex.org/W2050920812","https://openalex.org/W2054174374","https://openalex.org/W2055043147","https://openalex.org/W2055308161","https://openalex.org/W2057313063","https://openalex.org/W2060982742","https://openalex.org/W2061310823","https://openalex.org/W2061510535","https://openalex.org/W2062048887","https://openalex.org/W2065504235","https://openalex.org/W2067127457","https://openalex.org/W2068061620","https://openalex.org/W2070809472","https://openalex.org/W2073104160","https://openalex.org/W2074706971","https://openalex.org/W2075971386","https://openalex.org/W2076310317","https://openalex.org/W2077815106","https://openalex.org/W2078649805","https://openalex.org/W2080680563","https://openalex.org/W2090486591","https://openalex.org/W2094476084","https://openalex.org/W2095896589","https://openalex.org/W2096299662","https://openalex.org/W2096743396","https://openalex.org/W2096830042","https://openalex.org/W2100398881","https://openalex.org/W2106111056","https://openalex.org/W2107033356","https://openalex.org/W2108576543","https://openalex.org/W2109060290","https://openalex.org/W2109287668","https://openalex.org/W2113945706","https://openalex.org/W2116167439","https://openalex.org/W2116404316","https://openalex.org/W2118713503","https://openalex.org/W2124388193","https://openalex.org/W2125419487","https://openalex.org/W2126267143","https://openalex.org/W2126695143","https://openalex.org/W2127978038","https://openalex.org/W2128081603","https://openalex.org/W2131957846","https://openalex.org/W2133833346","https://openalex.org/W2143158186","https://openalex.org/W2143565379","https://openalex.org/W2144161229","https://openalex.org/W2144999863","https://openalex.org/W2145062788","https://openalex.org/W2145977399","https://openalex.org/W2155904358","https://openalex.org/W2157787514","https://openalex.org/W2158103150","https://openalex.org/W2158108030","https://openalex.org/W2160234571","https://openalex.org/W2162557413","https://openalex.org/W2162900287","https://openalex.org/W2171034553","https://openalex.org/W2183093445","https://openalex.org/W2187535109","https://openalex.org/W2267267445","https://openalex.org/W2334777598","https://openalex.org/W2409979942","https://openalex.org/W2411219135","https://openalex.org/W2411863428","https://openalex.org/W2522030375","https://openalex.org/W2558699597","https://openalex.org/W2616973505","https://openalex.org/W2913100282","https://openalex.org/W3012226672","https://openalex.org/W3045922761","https://openalex.org/W3092986903","https://openalex.org/W4211220106"],"related_works":["https://openalex.org/W2980260221","https://openalex.org/W3179241494","https://openalex.org/W2340138722","https://openalex.org/W2981721531","https://openalex.org/W2187535109","https://openalex.org/W2763825532","https://openalex.org/W2156119780","https://openalex.org/W3031408685","https://openalex.org/W2981517989","https://openalex.org/W1983870320"],"abstract_inverted_index":{"Background:":[0],"Obestatin":[1],"is":[2],"a":[3,18,53,98,221,289,328],"peptide":[4,41],"potentially":[5],"produced":[6],"in":[7,26,42,172,225,237,248,255,265,272,283,292,309,316,343],"the":[8,36,44,59,149,192,204,226,256,260,302,305,317,363],"stomach,":[9],"pancreas":[10],"and":[11,21,64,74,81,123,155,179,195,211,234,259,280,299],"testis.":[12],"Recently,":[13],"obestatin":[14,105,139,152,246,326],"was":[15,32,106,220,288],"reported":[16],"as":[17],"novel":[19],"adipocytokine":[20],"its":[22,341],"levels":[23],"were":[24,77,96,127,158,184,197,201,213],"decreased":[25],"obese":[27],"subjects.":[28],"Objective:":[29],"This":[30],"study":[31],"designed":[33],"to":[34,55,174,340],"explore":[35],"probable":[37],"effects":[38,46],"of":[39,47,58,151,165,206,232,301,304,345,353],"obestain":[40],"modulating":[43],"adverse":[45],"obesity":[48],"on":[49,362],"gonadal":[50,235,318,334,354],"functions":[51,236],"with":[52,138,230,313],"trial":[54],"clarify":[56],"some":[57],"possible":[60],"underlying":[61],"mechanisms.":[62],"Animals":[63],"methods:":[65],"64":[66],"wistar":[67],"albino":[68],"rats":[69],"21-day":[70],"old":[71],"(32":[72],"males":[73],"32":[75],"females)":[76],"divided":[78],"equally":[79],"(8males":[80],"8females)":[82],"into":[83],"4":[84],"groups,":[85],"group":[86,93,115,122,124,241],"(Ia):":[87],"Saline-vehicle":[88,117],"treated":[89,118],"normal":[90,99],"fed":[91,97,121,128,240],"group,":[92],"(Ib):":[94],"Rats":[95,126],"chow":[100],"for":[101,112,132,143,203,215],"10":[102,113,133,144],"weeks":[103,134],"then":[104,135],"i.p":[107,137],"injected":[108,136],"(1":[109,140],"nmol)":[110,141],"daily":[111,142],"days,":[114],"(IIa):":[116],"high":[119,129,238],"fat":[120,130,239,261],"(IIb):":[125],"diet":[131],"days.":[145],"5":[146],"days":[147],"after":[148],"end":[150],"administration":[153,247],"BMI":[154],"AC/TC":[156],"ratio":[157],"calculated,":[159],"serum":[160,273,293],"glucose&":[161],"insulin":[162,266,348],"(with":[163],"calculation":[164],"HOMA-IR),":[166],"lipid":[167],"profile,":[168],"FSH,":[169],"LH,":[170],"estradiol,":[171],"addition":[173],"testosterone":[175],"(in":[176,181],"male":[177,284],"rats),":[178,183],"progesterone":[180,297],"female":[182,310],"estimated,":[185],"mesenteric":[186],"fat,":[187,189,191],"epididymal":[188],"periovarian":[190],"right":[193],"testes":[194,210],"ovaries,":[196],"weighed.":[198],"The":[199,209],"epididymes":[200],"used":[202],"evaluation":[205],"sperm":[207,277],"parameters.":[208],"ovaries":[212],"processed":[214],"histopathological":[216],"studies.":[217],"Results:":[218],"There":[219],"significant":[222,263,270,290],"(p<0.001)":[223,282],"increase":[224,271,291],"anthropometric":[227,257],"parameters":[228,258],"together":[229],"deterioration":[231],"metabolic":[233],"(group":[242,249],"IIa),":[243],"while":[244],"exogenous":[245],"IIb)":[250],"resulted":[251],"in:":[252],"Significant":[253],"decrease":[254,264],"weight,":[262],"resistance":[267],"(HOMA-IR)":[268],"(p<0.001),":[269],"LH":[274,294],"(p<0.001)&testosterone":[275],"(p<0.01),":[276],"count":[278],"(p<0.01)":[279],"motility":[281],"rats.":[285,311],"Moreover,":[286],"there":[287],"(p<0.05)":[295,298],"&":[296,347],"restoration":[300],"regularity":[303],"estrus":[306],"cycle":[307],"(p<0.0001)":[308],"Together":[312],"marked":[314],"improvement":[315],"histoarchitecture.":[319],"Conclusions:":[320],"It":[321],"could":[322],"be":[323,338],"suggested":[324],"that":[325],"has":[327],"potential":[329],"positive":[330],"role":[331,342],"against":[332],"obesity-induced":[333],"dysfunction,":[335],"which":[336],"may":[337],"due":[339],"maintenance":[344,352],"glucose":[346],"homeostasis,":[349],"and/":[350],"or":[351],"hormonal":[355],"function":[356],"via":[357],"indirect":[358],"and/or":[359],"direct":[360],"effect":[361],"gonad.":[364]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}