{"id":"https://openalex.org/W1931319403","doi":"https://doi.org/10.1002/ana.24388","title":"Hippocampal sclerosis and TDP \u201043 pathology in aging and A lzheimer disease","display_name":"Hippocampal sclerosis and TDP \u201043 pathology in aging and A lzheimer disease","publication_year":2015,"publication_date":"2015-02-23","ids":{"openalex":"https://openalex.org/W1931319403","doi":"https://doi.org/10.1002/ana.24388","mag":"1931319403","pmid":"https://pubmed.ncbi.nlm.nih.gov/25707479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447563"},"language":"en","primary_location":{"id":"doi:10.1002/ana.24388","doi":"https://doi.org/10.1002/ana.24388","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.24388","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447563","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015535104","display_name":"Sukriti Nag","orcid":"https://orcid.org/0000-0002-5193-1177","observed_orcids":["https://orcid.org/0000-0002-5193-1177"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sukriti Nag","raw_affiliation_strings":["Departments of Pathology (Neuropathology)","Rush Alzheimer's Disease Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology (Neuropathology)","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101937767","display_name":"Lei Yu","orcid":"https://orcid.org/0000-0002-0237-8758","observed_orcids":["https://orcid.org/0000-0002-0237-8758","https://orcid.org/0000-0002-7176-1152","https://orcid.org/0000-0002-4044-0778"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Yu","raw_affiliation_strings":["Departments of Neurological Sciences","Rush Alzheimer's Disease Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Sciences","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014401788","display_name":"Ana Werneck Capuano","orcid":"https://orcid.org/0000-0002-3505-344X","observed_orcids":["https://orcid.org/0000-0002-3505-344X","https://orcid.org/0000-0002-8233-8616"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana W. Capuano","raw_affiliation_strings":["Departments of Neurological Sciences","Rush Alzheimer's Disease Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Sciences","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert S. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Wilson","raw_affiliation_strings":["Behavioral Sciences, Rush University Medical Center, Chicago, IL","Departments of Neurological Sciences","Rush Alzheimer's Disease Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Sciences, Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Departments of Neurological Sciences","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070294274","display_name":"Sue E. Leurgans","orcid":"https://orcid.org/0000-0003-2536-1665","observed_orcids":["https://orcid.org/0000-0003-2536-1665"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue E. Leurgans","raw_affiliation_strings":["Departments of Neurological Sciences","Rush Alzheimer's Disease Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Sciences","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Bennett","raw_affiliation_strings":["Departments of Neurological Sciences","Rush Alzheimer's Disease Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Sciences","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752","observed_orcids":["https://orcid.org/0000-0002-9482-1752"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Schneider","raw_affiliation_strings":["Departments of Neurological Sciences","Departments of Pathology (Neuropathology)","Rush Alzheimer's Disease Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Sciences","institution_ids":[]},{"raw_affiliation_string":"Departments of Pathology (Neuropathology)","institution_ids":[]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015535104"],"corresponding_institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":18.0534,"has_fulltext":false,"cited_by_count":310,"citation_normalized_percentile":{"value":0.99681731,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"77","issue":"6","first_page":"942","last_page":"952"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06750000268220901,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-sclerosis","display_name":"hippocampal sclerosis","score":1.0},{"id":"https://openalex.org/keywords/tdp-43-pathology","display_name":"TDP-43 pathology","score":0.9769999980926514},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lewy-body-pathology","display_name":"Lewy body pathology","score":0.7480000257492065},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5170000195503235},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6430000066757202},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.5460000038146973},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.4129999876022339},{"id":"https://openalex.org/keywords/rush-memory-and-aging-project","display_name":"Rush Memory and Aging Project","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2777597344","wikidata":"https://www.wikidata.org/wiki/Q4421929","display_name":"Hippocampal sclerosis","level":4,"score":0.7206454277038574},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6898331046104431},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6883503794670105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5465067625045776},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5175777673721313},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4894939661026001},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.48941436409950256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48525571823120117},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4499928057193756},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.4296305775642395},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4275321066379547},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.42437005043029785},{"id":"https://openalex.org/C2994092119","wikidata":"https://www.wikidata.org/wiki/Q1881849","display_name":"Cellular pathology","level":2,"score":0.41500142216682434},{"id":"https://openalex.org/C2778499278","wikidata":"https://www.wikidata.org/wiki/Q1499420","display_name":"Subiculum","level":4,"score":0.41097697615623474},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34201526641845703},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33877599239349365},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16576436161994934},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.06730350852012634},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.06491458415985107},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012598","descriptor_name":"Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/ana.24388","doi":"https://doi.org/10.1002/ana.24388","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.24388","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:25707479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25707479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4447563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ann Neurol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4447563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ann Neurol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1129744104","display_name":"Epidemiologic Study of Neural Reserve and Neurobiology of Aging","funder_award_id":"R01AG017917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2576871581","display_name":"Epidemiologic Study of TDP-43 Pathology in Aging and Dementia","funder_award_id":"R01AG042210","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4174335382","display_name":null,"funder_award_id":"R01AG17917, P30AG10161, R01AG15819, R01AG42210","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4875156105","display_name":"Risk Factors, Pathology, and Clinical Expressions of AD","funder_award_id":"R01AG015819","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8497221155","display_name":"Risk Factors, Pathology, and Clinical Expressions of AD","funder_award_id":"RF1AG015819","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W35263452","https://openalex.org/W142931913","https://openalex.org/W1927378289","https://openalex.org/W1955707577","https://openalex.org/W1985903687","https://openalex.org/W1991081381","https://openalex.org/W1998088268","https://openalex.org/W2014670147","https://openalex.org/W2015759096","https://openalex.org/W2018337921","https://openalex.org/W2047972506","https://openalex.org/W2050205779","https://openalex.org/W2050784521","https://openalex.org/W2055013864","https://openalex.org/W2059980851","https://openalex.org/W2075464796","https://openalex.org/W2076631319","https://openalex.org/W2091701490","https://openalex.org/W2092646825","https://openalex.org/W2095011236","https://openalex.org/W2102113515","https://openalex.org/W2102622341","https://openalex.org/W2118117906","https://openalex.org/W2119519240","https://openalex.org/W2134408741","https://openalex.org/W2134836371","https://openalex.org/W2135374418","https://openalex.org/W2135771073","https://openalex.org/W2137620339","https://openalex.org/W2154463941","https://openalex.org/W2154520196","https://openalex.org/W2156220037","https://openalex.org/W2158969809","https://openalex.org/W2161360709","https://openalex.org/W2169119607","https://openalex.org/W4256394959"],"related_works":["https://openalex.org/W2610434432","https://openalex.org/W2487446530","https://openalex.org/W2885787808","https://openalex.org/W6993001516","https://openalex.org/W2133757567","https://openalex.org/W2980817257","https://openalex.org/W2574862016","https://openalex.org/W2118117906","https://openalex.org/W2901456743","https://openalex.org/W1991081381"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,50,55,80,149],"association":[4],"of":[5,13,39,89,151,182,252],"hippocampal":[6,81],"sclerosis":[7],"(HS)":[8],"with":[9,120,139,216,221],"TAR-DNA":[10],"binding":[11],"protein":[12],"43kDa":[14],"(TDP-43)":[15],"and":[16,30,43,54,58,66,77,87,93,141,172,192,212,254,264],"other":[17,94,173],"common":[18,104,174],"age-related":[19,95,175],"pathologies,":[20,176],"dementia,":[21,40],"probable":[22,41,193,265],"Alzheimer":[23],"disease":[24],"(AD),":[25],"mild":[26],"cognitive":[27,31,67,226,262],"impairment":[28,263],"(MCI),":[29],"domains":[32],"in":[33,45,79,105,131,224,267],"community-dwelling":[34],"older":[35,268],"subjects.":[36,269],"METHODS:":[37],"Diagnoses":[38],"AD,":[42],"MCI":[44],"636":[46],"autopsied":[47],"subjects":[48,114],"from":[49],"Religious":[51],"Order":[52],"Study":[53],"Rush":[56],"Memory":[57],"Aging":[59],"Project":[60],"were":[61,91,97],"based":[62],"on":[63],"clinical":[64],"evaluation":[65],"performance":[68],"tests.":[69],"HS":[70,101,116,132,135,152,177,211,215,229,240,253],"was":[71,102,125,219,241],"defined":[72],"as":[73],"severe":[74,127],"neuronal":[75],"loss":[76],"gliosis":[78],"CA1":[82],"and/or":[83],"subiculum.":[84],"The":[85,249],"severity":[86],"distribution":[88],"TDP-43":[90,121,146,213,218,231,238,255],"assessed,":[92],"pathologies":[96],"also":[98,136],"documented.":[99],"RESULTS:":[100],"more":[103,126],"those":[106],"aged":[107],">90":[108],"years":[109],"(18.0%)":[110],"compared":[111],"to":[112,244],"younger":[113],"(9.2%).":[115],"cases":[117,178],"commonly":[118,137],"coexisted":[119,138],"pathology":[122,147,256],"(86%),":[123],"which":[124],"(p":[128],"<":[129],"0.001)":[130],"cases.":[133],"Although":[134],"AD":[140,194,266],"Lewy":[142],"body":[143],"pathology;":[144],"only":[145],"increased":[148],"odds":[150,181],"(odds":[153],"ratio":[154],"[OR]":[155],"=":[156,162,185,189,196,200],"2.63,":[157],"95%":[158,187,198],"confidence":[159],"interval":[160],"[CI]":[161],"2.07-3.34).":[163],"In":[164,202],"logistic":[165],"regression":[166,204],"models":[167],"accounting":[168],"for":[169,210],"age,":[170],"TDP-43,":[171],"had":[179],"higher":[180],"dementia":[183],"(OR":[184,195],"3.71,":[186],"CI":[188,199],"1.93-7.16),":[190],"MCI,":[191],"3.75,":[197],"2.01-7.02).":[201],"linear":[203],"models,":[205],"including":[206],"an":[207],"interaction":[208],"term":[209],"pathology,":[214],"coexisting":[217],"associated":[220],"lower":[222,245],"function":[223],"multiple":[225],"domains,":[227],"whereas":[228],"without":[230,239],"did":[232],"not":[233],"have":[234],"statistically":[235],"significant":[236,258],"associations.":[237],"separately":[242],"related":[243],"episodic":[246],"memory.":[247],"INTERPRETATION:":[248],"combined":[250],"roles":[251],"are":[257],"factors":[259],"underlying":[260],"global":[261]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":33},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}