{"id":"https://openalex.org/W1931257488","doi":"https://doi.org/10.1083/jcb.150.1.265","title":"Creb-Binding Protein (Cbp/P300) and RNA Polymerase II Colocalize in Transcriptionally Active Domains in the Nucleus","display_name":"Creb-Binding Protein (Cbp/P300) and RNA Polymerase II Colocalize in Transcriptionally Active Domains in the Nucleus","publication_year":2000,"publication_date":"2000-07-10","ids":{"openalex":"https://openalex.org/W1931257488","doi":"https://doi.org/10.1083/jcb.150.1.265","mag":"1931257488","pmid":"https://pubmed.ncbi.nlm.nih.gov/10893273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2185550"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.150.1.265","doi":"https://doi.org/10.1083/jcb.150.1.265","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.150.1.265","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2185550","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091421447","display_name":"Anna H. von Mikecz","orcid":"https://orcid.org/0000-0002-2276-2140","observed_orcids":["https://orcid.org/0000-0002-2276-2140"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Anna von Mikecz","raw_affiliation_strings":["aJunior Research Group of Molecular Cell Biology, Medizinisches Institut f\u00fcr Umwelthygiene, Heinrich-Heine-Univers\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany","eDepartment of Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aJunior Research Group of Molecular Cell Biology, Medizinisches Institut f\u00fcr Umwelthygiene, Heinrich-Heine-Univers\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"eDepartment of Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055793122","display_name":"Suisheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suisheng Zhang","raw_affiliation_strings":["bDepartment of Biochemistry, Institut f\u00fcr Molekulare Biotechnologie, 07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Biochemistry, Institut f\u00fcr Molekulare Biotechnologie, 07745 Jena, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072518932","display_name":"Marc Montminy","orcid":"https://orcid.org/0000-0001-8118-6174","observed_orcids":["https://orcid.org/0000-0001-8118-6174"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Montminy","raw_affiliation_strings":["dThe Salk Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dThe Salk Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065446697","display_name":"Eng M. Tan","orcid":"https://orcid.org/0000-0002-8711-3248","observed_orcids":["https://orcid.org/0000-0002-8711-3248"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eng M. Tan","raw_affiliation_strings":["eDepartment of Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eDepartment of Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023087565","display_name":"Peter H. Hemmerich","orcid":"https://orcid.org/0000-0003-0719-6985","observed_orcids":["https://orcid.org/0000-0003-0719-6985"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Hemmerich","raw_affiliation_strings":["cDepartment of Molecular Biology, Institut f\u00fcr Molekulare Biotechnologie, 07745 Jena, Germany","eDepartment of Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cDepartment of Molecular Biology, Institut f\u00fcr Molekulare Biotechnologie, 07745 Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"eDepartment of Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1854,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.92663209,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"150","issue":"1","first_page":"265","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creb-binding-protein","display_name":"CREB-binding protein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.9639999866485596},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nuclear-speckles","display_name":"nuclear speckles","score":0.6690000295639038},{"id":"https://openalex.org/keywords/pml-bodies","display_name":"PML bodies","score":0.9330000281333923},{"id":"https://openalex.org/keywords/promyelocytic-leukemia-protein","display_name":"promyelocytic leukemia protein","score":0.7670000195503235},{"id":"https://openalex.org/keywords/rna-polymerase-ii-phosphorylation","display_name":"RNA polymerase II phosphorylation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.5230000019073486},{"id":"https://openalex.org/keywords/transcriptional-inhibition","display_name":"transcriptional inhibition","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7985537052154541},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.7263708114624023},{"id":"https://openalex.org/C2776603820","wikidata":"https://www.wikidata.org/wiki/Q906517","display_name":"CREB-binding protein","level":5,"score":0.6015640497207642},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6014180183410645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5775207281112671},{"id":"https://openalex.org/C144825837","wikidata":"https://www.wikidata.org/wiki/Q2316030","display_name":"General transcription factor","level":5,"score":0.5268712639808655},{"id":"https://openalex.org/C172768829","wikidata":"https://www.wikidata.org/wiki/Q14817959","display_name":"Transcription factor II D","level":5,"score":0.5150861144065857},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5066598057746887},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4765779972076416},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.42645710706710815},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.4245270788669586},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42136162519454956},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.3865395486354828},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27398812770843506},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.19091781973838806},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.1586330533027649},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1556590497493744},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1369510293006897},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000099224","descriptor_name":"p300-CBP-Associated Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1083/jcb.150.1.265","doi":"https://doi.org/10.1083/jcb.150.1.265","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.150.1.265","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:917410","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2185550","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2185550","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2185550","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:10893273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10893273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.285.4311","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.285.4311","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e3/7c/J_Cell_Biol_2000_Jul_10_150(1)_265-274.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.320","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.320","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcb.rupress.org/content/150/1/265.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:917410","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2185550","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1529048149","https://openalex.org/W1530927489","https://openalex.org/W1532893184","https://openalex.org/W1581840018","https://openalex.org/W1941419571","https://openalex.org/W1964337986","https://openalex.org/W1966063731","https://openalex.org/W1967020705","https://openalex.org/W1967946050","https://openalex.org/W1970633757","https://openalex.org/W1978224022","https://openalex.org/W1978461534","https://openalex.org/W1978943108","https://openalex.org/W1979761504","https://openalex.org/W1981176424","https://openalex.org/W1982284863","https://openalex.org/W1985063313","https://openalex.org/W1990565764","https://openalex.org/W1998475589","https://openalex.org/W2004408181","https://openalex.org/W2004988279","https://openalex.org/W2005496330","https://openalex.org/W2007274073","https://openalex.org/W2007558412","https://openalex.org/W2008432026","https://openalex.org/W2012100191","https://openalex.org/W2019309185","https://openalex.org/W2021719977","https://openalex.org/W2027361460","https://openalex.org/W2027874507","https://openalex.org/W2033529039","https://openalex.org/W2044713924","https://openalex.org/W2044827050","https://openalex.org/W2046764234","https://openalex.org/W2047119203","https://openalex.org/W2051147182","https://openalex.org/W2066016774","https://openalex.org/W2066917897","https://openalex.org/W2068500972","https://openalex.org/W2070648411","https://openalex.org/W2071801228","https://openalex.org/W2080568795","https://openalex.org/W2085077896","https://openalex.org/W2087880580","https://openalex.org/W2088534912","https://openalex.org/W2091250415","https://openalex.org/W2091955128","https://openalex.org/W2092400927","https://openalex.org/W2093814954","https://openalex.org/W2094733358","https://openalex.org/W2095217266","https://openalex.org/W2098409847","https://openalex.org/W2101956311","https://openalex.org/W2105495356","https://openalex.org/W2107395792","https://openalex.org/W2113611418","https://openalex.org/W2129842408","https://openalex.org/W2134461114","https://openalex.org/W2140791473","https://openalex.org/W2146404878","https://openalex.org/W2152464785","https://openalex.org/W2155512899","https://openalex.org/W2157111350","https://openalex.org/W2160396364","https://openalex.org/W2335929343","https://openalex.org/W4254040732"],"related_works":["https://openalex.org/W7095240078","https://openalex.org/W7095715115","https://openalex.org/W2047119203","https://openalex.org/W2152348733","https://openalex.org/W2070840393","https://openalex.org/W2059044416","https://openalex.org/W2155512899","https://openalex.org/W7095211176","https://openalex.org/W3132760156","https://openalex.org/W2013671870"],"abstract_inverted_index":{"The":[0,157],"spatial":[1],"organization":[2],"of":[3,12,22,45,54,71,97,113,122,138,154,159],"transcription-":[4],"associated":[5],"proteins":[6],"is":[7,49],"an":[8],"important":[9],"control":[10],"mechanism":[11],"eukaryotic":[13],"gene":[14],"expression.":[15],"Here":[16],"we":[17],"analyzed":[18],"the":[19,23,75,78,111,141,151,155,167],"nuclear":[20,147,164],"distribution":[21],"transcriptional":[24,152],"coactivators":[25,79,137],"CREB-binding":[26],"protein":[27],"(CBP)/p300":[28],"in":[29,37,68,82,119,145,162],"situ":[30],"by":[31,41],"confocal":[32],"laser":[33],"scanning":[34],"microscopy,":[35],"and":[36,47,56,61,99,106,116,140],"vivo":[38],"complex":[39],"formation":[40],"coimmunoprecipitation.":[42],"A":[43],"subpopulation":[44],"CBP":[46],"p300":[48],"targeted":[50],"to":[51],"active":[52],"sites":[53],"transcription":[55,139,143,170],"partially":[57],"colocalizes":[58],"with":[59,85],"hyper-":[60],"hypophosphorylated":[62],"RNA":[63],"polymerase":[64],"II":[65,101,118,161],"(pol":[66],"II)":[67],"discrete":[69,146],"regions":[70],"variable":[72],"size":[73],"throughout":[74],"nucleus.":[76],"However,":[77],"were":[80],"found":[81],"tight":[83],"association":[84],"hypophosphorylated,":[86],"but":[87],"not":[88],"hyperphosphorylated":[89],"pol":[90,100,117,160],"II.":[91],"Transcriptional":[92],"inhibition":[93],"induced":[94],"a":[95,120,132],"relocation":[96],"CBP/p300":[98],"into":[102],"speckles.":[103],"Moreover,":[104],"double":[105],"triple":[107],"immunofluorescence":[108],"analyses":[109],"revealed":[110],"presence":[112],"CBP,":[114],"p300,":[115],"subset":[121],"promyelocytic":[123],"leukemia":[124],"(PML)":[125],"bodies.":[126,175],"Our":[127],"results":[128],"provide":[129],"evidence":[130],"for":[131],"dynamic":[133],"spacial":[134],"link":[135],"between":[136],"basal":[142],"machinery":[144],"domains":[148],"dependent":[149],"upon":[150],"activity":[153],"cell.":[156],"identification":[158],"CBP/PML-containing":[163],"bodies":[165],"supports":[166],"idea":[168],"that":[169],"takes":[171],"place":[172],"at":[173],"PML":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}