{"id":"https://openalex.org/W1930626900","doi":null,"title":"Capsule biogenesis in Cryptococcus neoformans","display_name":"Capsule biogenesis in Cryptococcus neoformans","publication_year":2008,"publication_date":"2008-12-04","ids":{"openalex":"https://openalex.org/W1930626900","mag":"1930626900"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/31692","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31692","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/31692","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051145884","display_name":"Jan Grijpstra","orcid":"https://orcid.org/0009-0006-4712-5267","observed_orcids":["https://orcid.org/0009-0006-4712-5267"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jan Grijpstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051145884"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcus-neoformans","display_name":"Cryptococcus neoformans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cryptococcosis","display_name":"cryptococcosis","score":0.875},{"id":"https://openalex.org/keywords/opportunistic-fungal-infection","display_name":"opportunistic fungal infection","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cap-gene","display_name":"cap gene","score":0.6589999794960022},{"id":"https://openalex.org/keywords/acapsular-mutant","display_name":"acapsular mutant","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/fungal-pathogenesis","display_name":"fungal pathogenesis","score":0.734000027179718},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/serotype-a","display_name":"serotype A","score":0.4269999861717224},{"id":"https://openalex.org/keywords/serotype-d","display_name":"serotype D","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.9610418081283569},{"id":"https://openalex.org/C2779413141","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcosis","level":2,"score":0.8098863959312439},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6540683507919312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6163330078125},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4853893518447876},{"id":"https://openalex.org/C2778952914","wikidata":"https://www.wikidata.org/wiki/Q309498","display_name":"Cryptococcus","level":2,"score":0.465457946062088},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4586098790168762},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.4539908170700073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31078118085861206}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/31692","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31692","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/31692","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31692","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:1930626900","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31692","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/31692","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31692","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W10365697","https://openalex.org/W265042462","https://openalex.org/W378873212","https://openalex.org/W1501317944","https://openalex.org/W1508716583","https://openalex.org/W1539606662","https://openalex.org/W1547610936","https://openalex.org/W1733554212","https://openalex.org/W1739181051","https://openalex.org/W1874128528","https://openalex.org/W1874253136","https://openalex.org/W1897980476","https://openalex.org/W1912870130","https://openalex.org/W1944361623","https://openalex.org/W1948823961","https://openalex.org/W1952385550","https://openalex.org/W1963311521","https://openalex.org/W1964576347","https://openalex.org/W1965580171","https://openalex.org/W1966404042","https://openalex.org/W1966891811","https://openalex.org/W1968589300","https://openalex.org/W1977471370","https://openalex.org/W1977950017","https://openalex.org/W1979964567","https://openalex.org/W1980662022","https://openalex.org/W1982645731","https://openalex.org/W1983332448","https://openalex.org/W1988966516","https://openalex.org/W1989491358","https://openalex.org/W1992282361","https://openalex.org/W2000146338","https://openalex.org/W2004065743","https://openalex.org/W2007482560","https://openalex.org/W2010221252","https://openalex.org/W2010370860","https://openalex.org/W2014154150","https://openalex.org/W2017758723","https://openalex.org/W2018552263","https://openalex.org/W2030590794","https://openalex.org/W2039639303","https://openalex.org/W2045415344","https://openalex.org/W2049658102","https://openalex.org/W2049852572","https://openalex.org/W2055043387","https://openalex.org/W2055509787","https://openalex.org/W2056524318","https://openalex.org/W2063513729","https://openalex.org/W2068790641","https://openalex.org/W2070541423","https://openalex.org/W2070566916","https://openalex.org/W2070916151","https://openalex.org/W2071501438","https://openalex.org/W2076560869","https://openalex.org/W2078907613","https://openalex.org/W2083968901","https://openalex.org/W2087748543","https://openalex.org/W2094283515","https://openalex.org/W2095699986","https://openalex.org/W2096520432","https://openalex.org/W2096910197","https://openalex.org/W2098472248","https://openalex.org/W2098585091","https://openalex.org/W2099723019","https://openalex.org/W2101141539","https://openalex.org/W2102122585","https://openalex.org/W2103302087","https://openalex.org/W2103654565","https://openalex.org/W2103669668","https://openalex.org/W2104663609","https://openalex.org/W2105706954","https://openalex.org/W2110351331","https://openalex.org/W2111091007","https://openalex.org/W2111189608","https://openalex.org/W2111831468","https://openalex.org/W2112458089","https://openalex.org/W2112619233","https://openalex.org/W2114056484","https://openalex.org/W2115314782","https://openalex.org/W2117319600","https://openalex.org/W2122322467","https://openalex.org/W2125636530","https://openalex.org/W2128169528","https://openalex.org/W2128641071","https://openalex.org/W2129369635","https://openalex.org/W2134016528","https://openalex.org/W2134936774","https://openalex.org/W2137379242","https://openalex.org/W2138084574","https://openalex.org/W2139052360","https://openalex.org/W2139205960","https://openalex.org/W2140913584","https://openalex.org/W2143142237","https://openalex.org/W2145078747","https://openalex.org/W2145742146","https://openalex.org/W2147346851","https://openalex.org/W2147443360","https://openalex.org/W2148108398","https://openalex.org/W2150004345","https://openalex.org/W2150775658","https://openalex.org/W2150860035","https://openalex.org/W2152311269","https://openalex.org/W2152995920","https://openalex.org/W2153619807","https://openalex.org/W2153951260","https://openalex.org/W2155212464","https://openalex.org/W2155570111","https://openalex.org/W2156187403","https://openalex.org/W2157311363","https://openalex.org/W2158262979","https://openalex.org/W2159046810","https://openalex.org/W2159161460","https://openalex.org/W2160712181","https://openalex.org/W2161957054","https://openalex.org/W2162294247","https://openalex.org/W2163570329","https://openalex.org/W2163791401","https://openalex.org/W2163811015","https://openalex.org/W2167996350","https://openalex.org/W2170132701","https://openalex.org/W2313508921","https://openalex.org/W2332602043","https://openalex.org/W2336331516","https://openalex.org/W2405517540","https://openalex.org/W2740005289"],"related_works":["https://openalex.org/W4391350172","https://openalex.org/W2149604935","https://openalex.org/W4415914113","https://openalex.org/W1963311521","https://openalex.org/W2134016528","https://openalex.org/W1539606662","https://openalex.org/W2115040899","https://openalex.org/W7099224318","https://openalex.org/W7098849237","https://openalex.org/W2002979144"],"abstract_inverted_index":{"Cryptococcus":[0],"neoformans":[1,78,135,227],"is":[2,42,93,110,147,175,236,261,316],"a":[3,32,142,196,237,321],"human":[4,312],"pathogen":[5],"that":[6,182,213,244,331],"mainly":[7,148],"causes":[8,31,98],"disease":[9],"in":[10,73,88,101,113,247,274,297,308,340],"immuno-compromised":[11],"individuals.":[12],"The":[13,106,130,173,242],"yeast":[14,136],"cells":[15],"or":[16],"basidiospores":[17],"spread":[18,67],"through":[19],"dissemination":[20],"from":[21,104,320],"environmental":[22],"sources,":[23],"for":[24,177,198],"example":[25],"pigeon":[26],"droppings":[27],"and":[28,30,53,124,154,163,171,179,187,233,271,285,300],"dust,":[29],"systemic":[33],"infection,":[34],"cryptococcosis.":[35],"A":[36,223],"severe":[37],"clinical":[38],"manifestation":[39],"of":[40,47,62,68,82,95,99,108,121,127,132,150,158,191,220,225,257,268,288,305,324,338],"cryptococcosis":[41,109,339],"meningo-encephalitis,":[43],"but":[44,253],"also":[45,111,328],"infection":[46],"other":[48],"organs":[49],"like":[50],"the":[51,59,66,69,83,96,114,133,151,159,188,192,199,206,221,254,258,269,283,286,289,294,303,341],"lungs,":[52],"skin":[54],"have":[55,183,210,214,250],"been":[56,211,251],"reported.":[57],"Since":[58],"increased":[60],"incidence":[61,107],"AIDS":[63],"due":[64,118],"to":[65,119,202,335],"HIV":[70],"virus,":[71],"especially":[72,117],"third":[74],"world":[75,116],"countries,":[76],"C.":[77,134,226],"has":[79],"become":[80],"one":[81,94],"most":[84],"emerging":[85],"opportunistic":[86],"pathogens":[87],"hospitals.":[89],"In":[90,264],"fact,":[91],"it":[92,195,326],"leading":[97],"death":[100],"patients":[102],"suffering":[103],"AIDS.":[105],"increasing":[112,125],"Western":[115],"use":[120],"immunosuppressive":[122],"drugs":[123],"numbers":[126],"organ":[128],"transplantations.":[129],"surface":[131],"cell":[137,207],"can":[138,332],"be":[139,333],"surrounded":[140],"by":[141,281,291,301],"thick":[143],"capsule.":[144],"This":[145,186,278,315],"capsule":[146,174,193,270,298,309],"composed":[149],"polysaccharides":[152],"GXM":[153,167],"GalXM.":[155],"GalXM":[156],"consists":[157],"monosaccharides":[160],"mannose,":[161],"xylose":[162],"glucuronic":[164],"acid,":[165],"whereas":[166],"contains":[168],"galactose,":[169],"mannose":[170],"xylose.":[172],"critical":[176],"pathogenesis":[178,275],"harbors":[180],"components":[181],"immuno-modulatory":[184],"properties.":[185],"physical":[189],"properties":[190],"makes":[194],"barrier":[197],"immune":[200],"system":[201],"reach":[203],"receptors":[204],"on":[205,311],"wall.":[208],"Mutants":[209],"isolated":[212],"an":[215],"acapsular":[216],"phenotype.":[217],"These":[218],"mutants":[219,306],"serotype":[222,238],"strain":[224],"are":[228,245],"called":[229],"CAP10,":[230],"CAP59,":[231],"CAP60":[232],"CAP64.":[234],"CAP67":[235],"D":[239],"mutant":[240],"strain.":[241],"genes":[243,260,295],"affected":[246,307],"these":[248],"strains":[249],"identified,":[252],"exact":[255],"role":[256,273],"CAP":[259],"not":[262,317],"clear.":[263],"this":[265],"Thesis":[266],"biosynthesis":[267],"its":[272],"was":[276,279],"studied.":[277],"done":[280],"investigating":[282,302],"content":[284],"structure":[287],"capsule,":[290],"looking":[292],"at":[293],"involved":[296],"biogenesis":[299,310],"effect":[304],"dendritic":[313],"cells.":[314],"only":[318],"interesting":[319],"fundamental":[322],"point":[323],"view,":[325],"may":[327],"identify":[329],"targets":[330],"used":[334],"improve":[336],"treatment":[337],"future.":[342]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
