{"id":"https://openalex.org/W1930561966","doi":null,"title":"Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.","display_name":"Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W1930561966","mag":"1930561966","pmid":"https://pubmed.ncbi.nlm.nih.gov/10213229"},"language":"en","primary_location":{"id":"pmid:10213229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10213229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032094946","display_name":"Mary K. Danks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M K Danks","raw_affiliation_strings":["Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066877678","display_name":"Christopher L. Morton","orcid":"https://orcid.org/0000-0002-4027-7050","observed_orcids":["https://orcid.org/0000-0002-4027-7050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Morton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083486073","display_name":"E J Krull","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E J Krull","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111763983","display_name":"Pamela J. Cheshire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Cheshire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037254689","display_name":"Lois B. Richmond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L B Richmond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112571656","display_name":"Clayton W. Naeve","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Naeve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049132960","display_name":"Cynthia A. Pawlik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Pawlik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Houghton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010422151","display_name":"Philip M. Potter","orcid":"https://orcid.org/0000-0001-8922-8535","observed_orcids":["https://orcid.org/0000-0001-8922-8535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Potter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3945,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.88989558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"917","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.10930000245571136,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.10400000214576721,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9020000100135803},{"id":"https://openalex.org/keywords/carboxylesterase","display_name":"carboxylesterase","score":0.9020000100135803},{"id":"https://openalex.org/keywords/enzyme-prodrug-therapy","display_name":"enzyme prodrug therapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.8169999718666077},{"id":"https://openalex.org/keywords/xenograft-tumor-regression","display_name":"xenograft tumor regression","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8230000138282776},{"id":"https://openalex.org/keywords/enzyme-specificity","display_name":"enzyme specificity","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.8673629760742188},{"id":"https://openalex.org/C2778325069","wikidata":"https://www.wikidata.org/wiki/Q409840","display_name":"Carboxylesterase","level":3,"score":0.8067023158073425},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7337666153907776},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6495616436004639},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5796778798103333},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47891509532928467},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4296238124370575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41758131980895996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3463580012321472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3357706069946289},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2781951427459717},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043182","descriptor_name":"Carboxylesterase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10213229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10213229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"},{"id":"mag:1930561966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10213229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2766956027","display_name":"SELECTIVE THERAPY OF TUMORS THAT OVEREXPRESS C MYC","funder_award_id":"R01CA076202","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5145123177","display_name":"Studies of Childhood Solid Tumors","funder_award_id":"P01CA023099","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8030065382","display_name":"INHIBITION OF DNA TOPOISOMERASES I AND II BY DMP840","funder_award_id":"R29CA063512","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1540999517","https://openalex.org/W1547123213","https://openalex.org/W1555041877","https://openalex.org/W1557866953","https://openalex.org/W1573565266","https://openalex.org/W1575463246","https://openalex.org/W1580143110","https://openalex.org/W1791027840","https://openalex.org/W1953118383","https://openalex.org/W1976542362","https://openalex.org/W1976579475","https://openalex.org/W1983729794","https://openalex.org/W1996671757","https://openalex.org/W2002553384","https://openalex.org/W2011909208","https://openalex.org/W2013319406","https://openalex.org/W2016138321","https://openalex.org/W2016722642","https://openalex.org/W2021201662","https://openalex.org/W2035051990","https://openalex.org/W2061021155","https://openalex.org/W2093464046","https://openalex.org/W2100837269","https://openalex.org/W2111198194","https://openalex.org/W2111921447","https://openalex.org/W2112170341","https://openalex.org/W2144473674","https://openalex.org/W2153424518","https://openalex.org/W2170721415","https://openalex.org/W2171811119","https://openalex.org/W2294167144"],"related_works":["https://openalex.org/W2111198194","https://openalex.org/W1993546715","https://openalex.org/W2408873872","https://openalex.org/W2032669985","https://openalex.org/W2257313773","https://openalex.org/W2081373971","https://openalex.org/W3207645175","https://openalex.org/W2281428778","https://openalex.org/W1998879743","https://openalex.org/W2317936438"],"abstract_inverted_index":{"Several":[0],"recent":[1],"studies":[2],"have":[3],"examined":[4],"the":[5,39,52,62,80,93,101,132,155,160,167,230,242],"possibility":[6],"of":[7,38,64,159,163,178,189,198,204,212,222],"producing":[8],"tumor-specific":[9],"cytotoxicity":[10],"with":[11,24,33,171],"various":[12],"enzyme/":[13],"prodrug":[14,30,53],"combinations.":[15],"The":[16,36],"enzymes":[17,84],"are":[18,85,98],"targeted":[19],"to":[20,43,111,124,146],"tumor":[21],"cells":[22,123,130],"either":[23],"antibodies":[25],"(ADEPT,":[26],"antibody":[27],"directed":[28],"enzyme":[29,47,103],"therapy)":[31],"or":[32,152],"viruses":[34],"(VDEPT).":[35],"goal":[37],"present":[40],"study":[41],"was":[42,104,116],"identify":[44],"an":[45],"appropriate":[46],"for":[48,180,183,195],"use":[49],"in":[50,72,73,76,113,120,139,210,220,236],"activating":[51],"7-ethyl-10-[4-(1-piper-idino)-1-piperidino]carbonyloxycamptothe":[54],"cin":[55],"(CPT-11).":[56],"In":[57,126],"this":[58],"study,":[59],"we":[60],"compared":[61],"efficiency":[63],"CPT-11":[65,110,147,172],"metabolism":[66],"by":[67],"rabbit":[68,81,102,133,243,248],"and":[69,75,82,92,115,135,219],"human":[70,83,156,231],"carboxylesterases":[71],"vitro":[74,114],"situ":[77],"assays.":[78],"Although":[79],"very":[86],"similar":[87],"(81%":[88],"identical;":[89],"86%":[90],"homologous)":[91],"active":[94],"site":[95],"amino":[96],"acids":[97],"100%":[99],"identical,":[100],"100-1000-fold":[105],"more":[106,118,144],"efficient":[107,119],"at":[108,175],"converting":[109],"SN-38":[112],"12-55-fold":[117],"sensitizing":[121],"transfected":[122],"CPT-11.":[125],"vivo,":[127],"Rh30":[128,217,226],"rhabdomyosarcoma":[129],"expressing":[131,154],"carboxylesterase":[134],"grown":[136],"as":[137],"xenografts":[138,151,153,164,218,227,239],"immune-deprived":[140],"mice":[141,168,214,224,237],"were":[142,149,169,208],"also":[143],"sensitive":[145],"than":[148],"control":[150,216],"enzyme.":[157,232],"Each":[158],"three":[161,199],"types":[162],"regressed":[165],"when":[166],"treated":[170],"given":[173],"i.v.":[174],"2.5":[176],"mg":[177],"CPT-11/kg/daily":[179],"5":[181],"days/week":[182],"2":[184],"weeks":[185],"[(dx5)2]":[186],"(one":[187],"cycle":[188],"therapy),":[190],"repeated":[191],"every":[192],"21":[193],"days":[194],"a":[196,252],"total":[197],"cycles.":[200],"However,":[201],"following":[202],"cessation":[203],"treatment,":[205],"recurrent":[206],"tumors":[207,234],"detected":[209],"seven":[211,213,223],"bearing":[215,225,238],"two":[221],"that":[228,240,247],"expressed":[229,241],"No":[233],"recurred":[235],"carboxylesterase.":[244],"We":[245],"conclude":[246],"carboxylesterase/CPT-11":[249],"may":[250],"be":[251],"useful":[253],"enzyme/prodrug":[254],"combination.":[255]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
