{"id":"https://openalex.org/W1929475465","doi":null,"title":"Adeno-associated virus serotype-9 efficiently transduces the retinal outer plexiform layer.","display_name":"Adeno-associated virus serotype-9 efficiently transduces the retinal outer plexiform layer.","publication_year":2009,"publication_date":"2009-07-17","ids":{"openalex":"https://openalex.org/W1929475465","mag":"1929475465","pmid":"https://pubmed.ncbi.nlm.nih.gov/19626133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713732"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2713732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713732","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713732","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064648564","display_name":"Bo Lei","orcid":"https://orcid.org/0000-0002-5497-0905","observed_orcids":["https://orcid.org/0000-0002-5497-0905"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Lei","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Yu Zhong District, Chongqing, China. bolei99@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Yu Zhong District, Chongqing, China. bolei99@126.com","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013077153","display_name":"Keqing Zhang","orcid":"https://orcid.org/0000-0003-2255-8454","observed_orcids":["https://orcid.org/0000-0003-2255-8454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keqing Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087280557","display_name":"Yongping Yue","orcid":"https://orcid.org/0000-0002-1640-2106","observed_orcids":["https://orcid.org/0000-0002-1640-2106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongping Yue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604743","display_name":"Arkasubhra Ghosh","orcid":"https://orcid.org/0000-0002-6570-5891","observed_orcids":["https://orcid.org/0000-0002-6570-5891"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arkasubhra Ghosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071836454","display_name":"Dongsheng Duan","orcid":"https://orcid.org/0000-0003-4109-1132","observed_orcids":["https://orcid.org/0000-0003-4109-1132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongsheng Duan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9293,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.85448997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":null,"first_page":"1374","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.28029999136924744,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aav9","display_name":"AAV9","score":0.9480000138282776},{"id":"https://openalex.org/keywords/retinal-gene-delivery","display_name":"retinal gene delivery","score":0.6830000281333923},{"id":"https://openalex.org/keywords/outer-plexiform-layer","display_name":"outer plexiform layer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/subretinal-injection","display_name":"subretinal injection","score":0.8980000019073486},{"id":"https://openalex.org/keywords/microdystrophin","display_name":"microdystrophin","score":0.7720000147819519},{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mdx-mice","display_name":"mdx mice","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytomegalovirus-promoter","display_name":"cytomegalovirus promoter","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ctbp2","display_name":"CtBP2","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dystrophin","display_name":"dystrophin","score":0.5920000076293945},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.5899999737739563},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.624688446521759},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6190732717514038},{"id":"https://openalex.org/C2777585161","wikidata":"https://www.wikidata.org/wiki/Q2357246","display_name":"Outer plexiform layer","level":3,"score":0.5852504372596741},{"id":"https://openalex.org/C2781099447","wikidata":"https://www.wikidata.org/wiki/Q4113797","display_name":"Inner plexiform layer","level":3,"score":0.5577601194381714},{"id":"https://openalex.org/C2778231335","wikidata":"https://www.wikidata.org/wiki/Q4113701","display_name":"Outer nuclear layer","level":3,"score":0.518515944480896},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4787851572036743},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.43888524174690247},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.43686461448669434},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.42707186937332153},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.41220778226852417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29774385690689087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19753485918045044},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14880383014678955},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.0973583459854126},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016189","descriptor_name":"Dystrophin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2713732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713732","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:19626133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19626133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:1929475465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19626133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2713732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713732","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G777159584","display_name":"Dual AAV Vectors for Duchenne Muscular Dystrophy Therapy","funder_award_id":"R01AR049419","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W117970033","https://openalex.org/W350490402","https://openalex.org/W1588415812","https://openalex.org/W1963623233","https://openalex.org/W1967746676","https://openalex.org/W1970138286","https://openalex.org/W1974994635","https://openalex.org/W1982690958","https://openalex.org/W1995284319","https://openalex.org/W1995457345","https://openalex.org/W2014983986","https://openalex.org/W2022040013","https://openalex.org/W2032097547","https://openalex.org/W2045031393","https://openalex.org/W2046113375","https://openalex.org/W2057548071","https://openalex.org/W2059776549","https://openalex.org/W2065380345","https://openalex.org/W2072999519","https://openalex.org/W2073324143","https://openalex.org/W2074127387","https://openalex.org/W2079373508","https://openalex.org/W2093269958","https://openalex.org/W2105732944","https://openalex.org/W2105914045","https://openalex.org/W2111483225","https://openalex.org/W2120420989","https://openalex.org/W2125160350","https://openalex.org/W2137222303","https://openalex.org/W2141354154","https://openalex.org/W2141575938","https://openalex.org/W2151809142","https://openalex.org/W2155190242","https://openalex.org/W2168233533","https://openalex.org/W2169446693"],"related_works":["https://openalex.org/W2199562191","https://openalex.org/W935649651","https://openalex.org/W4247528418","https://openalex.org/W4414063280","https://openalex.org/W2123640323","https://openalex.org/W2018423388","https://openalex.org/W3091772022","https://openalex.org/W2155190242","https://openalex.org/W1991157268","https://openalex.org/W2015282830"],"abstract_inverted_index":{"PURPOSE:":[0],"Adeno-associated":[1],"virus":[2],"serotype-9":[3],"(AAV-9)":[4],"is":[5,236,246,292],"a":[6,73,117,136,200,228,293],"promising":[7],"gene":[8,76,84,298],"delivery":[9,277],"vector.":[10],"In":[11,36,311],"this":[12,324],"study,":[13],"we":[14,120,133,261],"evaluated":[15],"AAV-9":[16,82,114,291,302],"transduction":[17,115,175,315],"in":[18,29,116,179,187,196,239,248,258,266],"the":[19,47,60,65,177,188,203,214,231,240,267],"mouse":[20],"retina.":[21],"METHODS:":[22],"Three":[23],"different":[24,40,57],"AAV":[25],"vectors":[26,85],"were":[27,52,99,162,285],"used":[28,53,134],"our":[30,256],"study:":[31],"AAV-9.RSV.AP,":[32,279],"AAV-9.CMV.eGFP,":[33],"and":[34,46,72,107,156,195,251],"AAV-9.CMV.R4-23/C.":[35],"these":[37],"vectors,":[38],"two":[39],"promoters":[41],"(the":[42,77],"cytomegalovirus":[43],"promoter-CMV":[44],"promoter":[45],"Rous":[48],"sarcoma":[49],"virus-RSV":[50],"promoter)":[51],"to":[54,102,129],"express":[55],"three":[56,155],"transgenes":[58],"including":[59],"alkaline":[61],"phosphatase":[62],"(AP)":[63],"gene,":[64,71],"enhanced":[66],"green":[67],"fluorescent":[68],"protein":[69,225],"(eGFP)":[70],"therapeutic":[74],"microdystrophin":[75,264],"R4-23/C).":[78],"Specifically,":[79],"1":[80],"microl":[81],"reporter":[83],"(1x10(9)":[86],"viral":[87,94,124],"genome":[88,95,125],"particles":[89,96,126],"of":[90,97,127,213,278],"AAV-9.RSV.AP":[91,168],"or":[92,282],"1x10(10)":[93],"AAV-9.CMV.eGFP)":[98],"administered":[100],"subretinally":[101,122],"young":[103],"(2-3-week-old),":[104],"adult":[105],"(3-month-old),":[106],"old":[108],"(12-month-old)":[109],"C57BL/6J":[110],"mice.":[111,253],"To":[112],"evaluate":[113],"diseased":[118],"retina,":[119],"injected":[121],"1x10(9)":[123],"AAV-9.CMV.R4-23/C":[128,270],"mdx(3cv)":[130,252],"mice,":[131,260],"which":[132],"as":[135,149,151],"model":[137],"for":[138,222,230,296,318],"Duchenne":[139],"muscular":[140],"dystrophy":[141],"(DMD).":[142],"Transgene":[143],"expression":[144,184,245,265],"was":[145,185,217],"examined":[146],"by":[147,220],"histochemical":[148],"well":[150],"immunofluorescence":[152],"staining":[153],"at":[154],"five":[157,164,273],"weeks":[158,165,274],"after":[159,166,269,275],"injection.":[160,169],"Electroretinograms":[161],"recorded":[163],"subretinal":[167,276,301],"RESULTS:":[170],"Subretinal":[171],"injection":[172],"yielded":[173],"widespread":[174],"throughout":[176],"retina":[178],"all":[180],"age":[181],"groups.":[182],"Robust":[183],"seen":[186],"retinal":[189,297,309],"pigment":[190],"epithelium,":[191],"outer":[192,204],"nuclear":[193],"layer,":[194,202],"M\u00fcller":[197],"cells.":[198],"Interestingly":[199],"synaptic":[201,215,233],"plexiform":[205],"layer":[206,216],"(OPL),":[207],"also":[208],"showed":[209],"intensive":[210],"expression.":[211],"Transduction":[212],"further":[218],"confirmed":[219],"immunostaining":[221],"C-terminal":[223],"binding":[224],"2":[226],"(CtBP2),":[227],"marker":[229],"photoreceptor":[232,242],"ribbon.":[234],"Dystrophin":[235],"normally":[237],"expressed":[238],"OPL":[241,268,314],"terminals.":[243],"This":[244],"lost":[247],"DMD":[249],"patients":[250],"Consistent":[254],"with":[255],"findings":[257],"normal":[259],"observed":[262],"efficient":[263],"infection.":[271],"At":[272],"no":[280],"morphology":[281],"ERG":[283],"abnormalities":[284],"observed.":[286],"CONCLUSIONS:":[287],"We":[288],"demonstrated":[289],"that":[290,321],"potent":[294],"vector":[295],"delivery.":[299],"Furthermore,":[300],"administration":[303],"did":[304],"not":[305],"cause":[306],"appreciable":[307],"acute":[308],"damages.":[310],"summary,":[312],"AAV-9-mediated":[313],"holds":[316],"promise":[317],"treating":[319],"diseases":[320],"primarily":[322],"affect":[323],"layer.":[325]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
