{"id":"https://openalex.org/W192821765","doi":null,"title":"Hormonal and neural blockade prevents the postoperative increase in amino acid clearance and urea synthesis.","display_name":"Hormonal and neural blockade prevents the postoperative increase in amino acid clearance and urea synthesis.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W192821765","mag":"192821765","pmid":"https://pubmed.ncbi.nlm.nih.gov/1350868"},"language":"en","primary_location":{"id":"pmid:1350868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1350868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004891155","display_name":"Hans Heindorff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H Heindorff","raw_affiliation_strings":["Department of Surgery C, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery C, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Schulze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Schulze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113868211","display_name":"T. Mogensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Mogensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065526075","display_name":"Thomas Almdal","orcid":"https://orcid.org/0000-0002-7296-4656","observed_orcids":["https://orcid.org/0000-0002-7296-4656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Almdal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025881972","display_name":"Henrik Kehlet","orcid":"https://orcid.org/0000-0002-2209-1711","observed_orcids":["https://orcid.org/0000-0002-2209-1711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kehlet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056562539","display_name":"Hendrik Vilstrup","orcid":"https://orcid.org/0000-0002-9903-407X","observed_orcids":["https://orcid.org/0000-0002-9903-407X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Vilstrup","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7217,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.94653659,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"111","issue":"5","first_page":"543","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.19699999690055847,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amino-acid-clearance","display_name":"amino acid clearance","score":0.8209999799728394},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/etomidate","display_name":"etomidate","score":0.996999979019165},{"id":"https://openalex.org/keywords/thoracic-epidural-analgesia","display_name":"thoracic epidural analgesia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cholecystectomy","display_name":"cholecystectomy","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7993418574333191},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.7658144235610962},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.666085422039032},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5789929628372192},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5609322786331177},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5224387049674988},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4046882688999176},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002763","descriptor_name":"Cholecystectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005045","descriptor_name":"Etomidate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020155","descriptor_name":"3-Hydroxybutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1350868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1350868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Clinical Trial"},{"id":"mag:192821765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1350868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100632460","https://openalex.org/W1966321958","https://openalex.org/W2410919070","https://openalex.org/W2412263547","https://openalex.org/W4231102985","https://openalex.org/W2116638006","https://openalex.org/W2022616292","https://openalex.org/W4238331150","https://openalex.org/W2064791283","https://openalex.org/W6995565288"],"abstract_inverted_index":{"The":[0,155],"combined":[1,117],"effect":[2],"of":[3,6,21,54,127,167],"continuous":[4],"blockade":[5,145],"glucagon":[7],"and":[8,12,14,38,119,143,161],"cortisol":[9],"by":[10,81,93],"somatostatin":[11],"etomidate":[13],"thoracic":[15],"epidural":[16],"analgesia":[17],"on":[18,33],"hepatic":[19,86,96,152,169],"conversion":[20,91],"amino":[22,89,128],"nitrogen":[23,57,90,97,129,153],"was":[24,39,76],"studied":[25],"in":[26,150],"eight":[27],"patients":[28,43],"who":[29,44],"underwent":[30,45],"elective":[31],"cholecystectomy":[32],"day":[34],"1":[35],"after":[36,173],"operation":[37,46],"compared":[40],"with":[41],"16":[42,105],"without":[47],"blockade.":[48],"Surgery":[49],"increased":[50,79,99],"the":[51,82,85,94,116,124,144,147,168],"plasma":[52,125],"clearance":[53,98,126],"total":[55],"alpha-amino":[56],"from":[58,100,130],"5.2":[59],"+/-":[60,64,68,102,106,132,136],"0.3":[61,65,133,137],"to":[62,78,104,134,171],"6.6":[63],"ml/sec":[66,108,138],"(mean":[67],"sem;":[69],"p":[70],"less":[71,110,140],"than":[72,111,141],"0.05).":[73,112],"This":[74],"increase":[75,149],"due":[77],"elimination":[80],"liver,":[83],"because":[84],"effectiveness":[87],"for":[88],"measured":[92],"functional":[95,151],"9":[101],"2":[103],"4":[107],"(p":[109,139],"In":[113],"contrast,":[114],"during":[115],"neural":[118,163],"hormonal":[120],"blockade,":[121],"surgery":[122],"decreased":[123],"5.3":[131],"3.9":[135],"0.05),":[142],"prevented":[146],"postoperative":[148],"clearance.":[154],"results":[156],"suggest":[157],"that":[158],"glucagon,":[159],"cortisol,":[160],"afferent":[162],"reflexes":[164],"are":[165],"mediators":[166],"contribution":[170],"catabolism":[172],"operation.":[174]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
