{"id":"https://openalex.org/W1927222016","doi":"https://doi.org/10.1111/trf.13000","title":"In vitro variables of buffy coat\u2013derived platelet concentrates with residual plasma of down to 10% are stably maintained in new\u2010generation platelet additive solutions","display_name":"In vitro variables of buffy coat\u2013derived platelet concentrates with residual plasma of down to 10% are stably maintained in new\u2010generation platelet additive solutions","publication_year":2015,"publication_date":"2015-02-10","ids":{"openalex":"https://openalex.org/W1927222016","doi":"https://doi.org/10.1111/trf.13000","mag":"1927222016","pmid":"https://pubmed.ncbi.nlm.nih.gov/25677807"},"language":"en","primary_location":{"id":"doi:10.1111/trf.13000","doi":"https://doi.org/10.1111/trf.13000","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.13000","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025163389","display_name":"Ute Gravemann","orcid":"https://orcid.org/0000-0001-9050-1295","observed_orcids":["https://orcid.org/0000-0001-9050-1295"]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ute Gravemann","raw_affiliation_strings":["German Red Cross Blood Service NSTOB, Institute Springe Springe Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Red Cross Blood Service NSTOB, Institute Springe Springe Germany","institution_ids":["https://openalex.org/I2801931480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049389466","display_name":"Thorsten Volgmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten Volgmann","raw_affiliation_strings":["German Red Cross Blood Service NSTOB, Institute Springe Springe Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Red Cross Blood Service NSTOB, Institute Springe Springe Germany","institution_ids":["https://openalex.org/I2801931480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113641352","display_name":"Kyungyoon Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157039","display_name":"Fresenius Kabi (United States)","ror":"https://ror.org/04rzhfa50","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108778","https://openalex.org/I4210157039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyungyoon Min","raw_affiliation_strings":["Fresenius Kabi USA  Lake Zurich Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Kabi USA  Lake Zurich Illinois","institution_ids":["https://openalex.org/I4210157039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006925861","display_name":"Roman Philipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roman Philipp","raw_affiliation_strings":["Fresenius Kabi Germany Bad Homburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Kabi Germany Bad Homburg Germany","institution_ids":["https://openalex.org/I4210108778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037334896","display_name":"Bernd Lambrecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Lambrecht","raw_affiliation_strings":["German Red Cross Blood Service NSTOB, Institute Springe Springe Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Red Cross Blood Service NSTOB, Institute Springe Springe Germany","institution_ids":["https://openalex.org/I2801931480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061594804","display_name":"Thomas H. M\u00fcller","orcid":"https://orcid.org/0000-0002-5417-6787","observed_orcids":["https://orcid.org/0000-0002-5417-6787"]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas H. M\u00fcller","raw_affiliation_strings":["German Red Cross Blood Service NSTOB, Institute Springe Springe Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Red Cross Blood Service NSTOB, Institute Springe Springe Germany","institution_ids":["https://openalex.org/I2801931480"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047765258","display_name":"Axel W. Seltsam","orcid":"https://orcid.org/0000-0001-5858-5097","observed_orcids":["https://orcid.org/0000-0001-5858-5097"]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Axel Seltsam","raw_affiliation_strings":["German Red Cross Blood Service NSTOB, Institute Springe Springe Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Red Cross Blood Service NSTOB, Institute Springe Springe Germany","institution_ids":["https://openalex.org/I2801931480"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047765258"],"corresponding_institution_ids":["https://openalex.org/I2801931480"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":1.5448,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82913018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"55","issue":"7","first_page":"1700","last_page":"1709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-concentrates","display_name":"platelet concentrates","score":0.9829999804496765},{"id":"https://openalex.org/keywords/platelet-additive-solution","display_name":"platelet additive solution","score":0.9599999785423279},{"id":"https://openalex.org/keywords/residual-plasma","display_name":"residual plasma","score":0.6320000290870667},{"id":"https://openalex.org/keywords/ssp","display_name":"SSP","score":0.6949999928474426},{"id":"https://openalex.org/keywords/platelet-storage","display_name":"platelet storage","score":0.6359999775886536},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/apheresis","display_name":"apheresis","score":0.6299999952316284},{"id":"https://openalex.org/keywords/platelet-quality","display_name":"platelet quality","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2778285947","wikidata":"https://www.wikidata.org/wiki/Q548079","display_name":"Buffy coat","level":2,"score":0.8852013349533081},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7060362696647644},{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.6830452680587769},{"id":"https://openalex.org/C2779867487","wikidata":"https://www.wikidata.org/wiki/Q952508","display_name":"Plateletpheresis","level":4,"score":0.6105167269706726},{"id":"https://openalex.org/C2778914503","wikidata":"https://www.wikidata.org/wiki/Q7202244","display_name":"Platelet-poor plasma","level":4,"score":0.5959459543228149},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5653378963470459},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5625302195549011},{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.5266059637069702},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.5006515979766846},{"id":"https://openalex.org/C2991747820","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Plasma volume","level":2,"score":0.4573099613189697},{"id":"https://openalex.org/C2777396833","wikidata":"https://www.wikidata.org/wiki/Q886722","display_name":"Blood product","level":2,"score":0.4133303165435791},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.39244621992111206},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3293418288230896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25482177734375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1791127324104309},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17382264137268066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.173764169216156},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13000959157943726},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007552","descriptor_name":"Isotonic Solutions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007552","descriptor_name":"Isotonic Solutions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058621","descriptor_name":"Blood Buffy Coat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/trf.13000","doi":"https://doi.org/10.1111/trf.13000","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.13000","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:25677807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25677807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W195866280","https://openalex.org/W1503303409","https://openalex.org/W1544004233","https://openalex.org/W1546636436","https://openalex.org/W1744085312","https://openalex.org/W1943244661","https://openalex.org/W1962801510","https://openalex.org/W1963731467","https://openalex.org/W1964356000","https://openalex.org/W1979120941","https://openalex.org/W1979377825","https://openalex.org/W1979730180","https://openalex.org/W1984282445","https://openalex.org/W1986619620","https://openalex.org/W1990666250","https://openalex.org/W1994451219","https://openalex.org/W2006870201","https://openalex.org/W2021933085","https://openalex.org/W2024923604","https://openalex.org/W2025215551","https://openalex.org/W2034512341","https://openalex.org/W2039015601","https://openalex.org/W2041774647","https://openalex.org/W2055980320","https://openalex.org/W2058376399","https://openalex.org/W2061027528","https://openalex.org/W2067465736","https://openalex.org/W2070950706","https://openalex.org/W2073282680","https://openalex.org/W2075346991","https://openalex.org/W2076199424","https://openalex.org/W2080128670","https://openalex.org/W2084391772","https://openalex.org/W2100222319","https://openalex.org/W2102717876","https://openalex.org/W2104799923","https://openalex.org/W2111983327","https://openalex.org/W2144521135","https://openalex.org/W2145560668","https://openalex.org/W2162215666","https://openalex.org/W2167943184","https://openalex.org/W2171710894","https://openalex.org/W2181184445","https://openalex.org/W2399621988"],"related_works":["https://openalex.org/W1979377825","https://openalex.org/W2055980320","https://openalex.org/W1967772045","https://openalex.org/W2047192693","https://openalex.org/W2557562932","https://openalex.org/W2394767669","https://openalex.org/W2254726001","https://openalex.org/W2029528720","https://openalex.org/W1976935407","https://openalex.org/W1503303409"],"abstract_inverted_index":{"BACKGROUND:":[0],"Platelet":[1],"additive":[2],"solutions":[3],"(PASs)":[4],"facilitate":[5],"plasma":[6,32,43,71,123,129,136,142,177,187,211,224],"recovery":[7],"and":[8,72,134,139,156,159],"may":[9],"reduce":[10],"the":[11,56,75,97,236],"risk":[12],"of":[13,58,77,101,169,182,204,219,240],"plasma-associated":[14],"adverse":[15],"transfusion":[16],"reactions.":[17],"Whereas":[18],"current":[19],"apheresis":[20],"techniques":[21],"are":[22],"able":[23],"to":[24,39,54,73,79,95,120,180],"produce":[25],"platelet":[26],"concentrates":[27],"(PCs)":[28],"with":[29,42,65,118,197,200,209,222],"reduced":[30],"residual":[31,70,122,176],"volumes,":[33],"it":[34],"is":[35,230],"still":[36],"technically":[37],"challenging":[38],"prepare":[40],"PCs":[41,105,205,221,242],"levels":[44],"less":[45,175],"than":[46,199],"20%":[47,173],"from":[48],"whole":[49],"blood.":[50],"This":[51],"study":[52],"aimed":[53],"evaluate":[55,96],"feasibility":[57],"producing":[59],"buffy":[60],"coat":[61],"(BC)-derived":[62],"platelets":[63],"(PLTs)":[64],"as":[66,68,226,228],"little":[67],"10%":[69,119,141,210,229],"test":[74],"ability":[76],"PASs":[78,233],"preserve":[80,235],"PLT":[81,154,157,192],"quality":[82,100,167,203,239],"under":[83],"these":[84],"conditions.":[85],"STUDY":[86],"DESIGN":[87],"AND":[88],"METHODS:":[89],"A":[90],"pool-and-split":[91],"design":[92],"was":[93,194,212],"used":[94],"in":[98,110,124,152,165,172,185,207,237],"vitro":[99,166,238],"semiautomatically":[102],"prepared":[103],"BC-derived":[104,220],"stored":[106,184],"for":[107,188],"7":[108],"days":[109],"either":[111],"SSP+":[112,198],"(PAS-IIIM)":[113],"or":[114,174],"Intersol-G":[115,208],"(glucose-containing":[116],"PAS)":[117],"30%":[121,128,186],"three":[125],"phases:":[126],"1)":[127],"(SSP+,":[130,137],"Intersol-G),":[131,138],"2)":[132],"20":[133],"15%":[135],"3)":[140],"(Intersol-G).":[143],"RESULTS:":[144],"The":[145,164,202],"different":[146],"plasma-reduced":[147],"PAS-PC":[148],"types":[149],"were":[150,178],"comparable":[151,179],"volume,":[153],"concentration,":[155],"yield":[158],"met":[160],"all":[161],"regulatory":[162],"requirements.":[163],"variables":[168],"PLTs":[170,183],"suspended":[171,206],"those":[181],"both":[189],"PAS":[190],"types.":[191],"activation":[193],"slightly":[195],"higher":[196],"Intersol-G.":[201],"well":[213],"maintained":[214],"during":[215,243],"storage.":[216,244],"CONCLUSIONS:":[217],"Preparation":[218],"minimal":[223],"concentrations":[225],"low":[227],"feasible.":[231],"Late-generation":[232],"satisfactorily":[234],"such":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}