{"id":"https://openalex.org/W1926094917","doi":"https://doi.org/10.1128/jvi.62.10.3779-3788.1988","title":"Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity","display_name":"Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W1926094917","doi":"https://doi.org/10.1128/jvi.62.10.3779-3788.1988","mag":"1926094917","pmid":"https://pubmed.ncbi.nlm.nih.gov/3047430","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/253522"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.62.10.3779-3788.1988","doi":"https://doi.org/10.1128/jvi.62.10.3779-3788.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.62.10.3779-3788.1988","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC253522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032220933","display_name":"Bruce W. Chesebro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Chesebro","raw_affiliation_strings":["Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840","institution_ids":["https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034447009","display_name":"K Wehrly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Wehrly","raw_affiliation_strings":["Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840","institution_ids":["https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7378,"has_fulltext":false,"cited_by_count":303,"citation_normalized_percentile":{"value":0.94500458,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"10","first_page":"3779","last_page":"3788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hiv-neutralization","display_name":"HIV neutralization","score":0.9509999752044678},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.3889999985694885},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8238265514373779},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7895739078521729},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7250906229019165},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.701792299747467},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.5441310405731201},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.5283965468406677},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.4703747630119324},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.4595670998096466},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4338882267475128},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4174897074699402},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4061760902404785},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20429196953773499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.62.10.3779-3788.1988","doi":"https://doi.org/10.1128/jvi.62.10.3779-3788.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.62.10.3779-3788.1988","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:237973","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC253522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:253522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/253522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:3047430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3047430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:237973","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC253522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1439850982","https://openalex.org/W1522102057","https://openalex.org/W1527352542","https://openalex.org/W1535355218","https://openalex.org/W1659719610","https://openalex.org/W1829978287","https://openalex.org/W1830489709","https://openalex.org/W1963954954","https://openalex.org/W1965528983","https://openalex.org/W1967856579","https://openalex.org/W1968873679","https://openalex.org/W1971057735","https://openalex.org/W1974478130","https://openalex.org/W1977282539","https://openalex.org/W1984193383","https://openalex.org/W1984836566","https://openalex.org/W1985881197","https://openalex.org/W1989538848","https://openalex.org/W1991670386","https://openalex.org/W2001578549","https://openalex.org/W2010340688","https://openalex.org/W2015326137","https://openalex.org/W2021785678","https://openalex.org/W2042695720","https://openalex.org/W2049435145","https://openalex.org/W2056723350","https://openalex.org/W2061286251","https://openalex.org/W2064216963","https://openalex.org/W2077195343","https://openalex.org/W2080611913","https://openalex.org/W2089276240","https://openalex.org/W2090170585","https://openalex.org/W2091565871","https://openalex.org/W2094768993","https://openalex.org/W2113282092","https://openalex.org/W2136808636","https://openalex.org/W2141743444","https://openalex.org/W2142638152","https://openalex.org/W2152257738"],"related_works":["https://openalex.org/W2402295042","https://openalex.org/W2474625587","https://openalex.org/W2320951985","https://openalex.org/W1778074134","https://openalex.org/W1985881197","https://openalex.org/W2087451026","https://openalex.org/W1984836566","https://openalex.org/W2006002976","https://openalex.org/W2412728358","https://openalex.org/W1965304304"],"abstract_inverted_index":{"Accurate":[0],"and":[1,87,107,115,136],"sensitive":[2],"quantitation":[3],"of":[4,38,90,152,177],"infectious":[5],"human":[6,28,52,73,117,181],"immunodeficiency":[7],"virus":[8],"(HIV)":[9],"has":[10],"been":[11],"difficult":[12],"to":[13,33,110,146,173,193],"achieve.":[14],"In":[15],"this":[16],"report,":[17],"a":[18,43],"quantitative":[19],"focal":[20],"immunoassay":[21],"(FIA)":[22],"for":[23,60,70],"HIV":[24,34,61,85,125,127,142,178],"was":[25,88,100],"developed":[26],"using":[27,51,112,133],"HeLa":[29,189],"cells":[30,47,78,190],"rendered":[31],"susceptible":[32],"infection":[35,179],"by":[36,50,132],"introduction":[37],"the":[39,120,134,149,175],"CD4":[40],"gene":[41],"via":[42],"retrovirus":[44],"vector.":[45],"Infected":[46],"were":[48,144,171],"identified":[49,77],"anti-HIV":[53],"antibodies":[54,58,139,160],"or":[55,66,72,83],"mouse":[56,71],"monoclonal":[57,138,155],"specific":[59,69],"together":[62],"with":[63,80,141,166],"secondary":[64],"fluorescein-":[65],"peroxidase-conjugated":[67],"antibody":[68],"immunoglobulins.":[74],"The":[75,98],"assay":[76],"infected":[79],"either":[81],"wild-type":[82,124],"culture-adapted":[84],"isolates":[86],"capable":[89],"detecting":[91,104],"1":[92],"positive":[93],"cell":[94],"in":[95,108,161,180,187],"10(6)":[96],"cells.":[97],"FIA":[99,121],"also":[101],"effective":[102],"at":[103],"cell-free":[105],"HIV,":[106],"contrast":[109],"assays":[111],"A3.01,":[113],"CEM,":[114],"other":[116],"leukemia":[118],"cells,":[119],"detected":[122],"most":[123],"isolates.":[126],"neutralization":[128],"could":[129],"be":[130],"determined":[131],"FIA,":[135],"two":[137],"reactive":[140],"gp120":[143],"found":[145],"neutralize":[147],"only":[148],"LAV-IIIB":[150],"strain":[151],"HIV.":[153],"These":[154],"antibodies,":[156],"as":[157,159],"well":[158],"serum":[162],"samples":[163],"from":[164],"patients":[165],"acquired":[167],"immune":[168],"deficiency":[169],"syndrome,":[170],"able":[172],"inhibit":[174],"spread":[176],"lymphocyte":[182],"suspension":[183],"cultures":[184],"but":[185],"not":[186],"CD4-positive":[188],"growing":[191],"attached":[192],"plastic":[194],"dishes.":[195]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
