{"id":"https://openalex.org/W1926051934","doi":null,"title":"Integrative network modeling of large multidimensional cancer datasets","display_name":"Integrative network modeling of large multidimensional cancer datasets","publication_year":2015,"publication_date":"2015-10-07","ids":{"openalex":"https://openalex.org/W1926051934","mag":"1926051934"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/39547","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/39547","pdf_url":"http://hdl.handle.net/2077/39547","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/39547","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017072634","display_name":"Teresia Kling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Teresia Kling","raw_affiliation_strings":["University of Gothenburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gothenburg","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017072634"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.11110000312328339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0568000003695488,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.781000018119812},{"id":"https://openalex.org/keywords/gene-copy-number","display_name":"gene copy number","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.9509999752044678},{"id":"https://openalex.org/keywords/causal-networks","display_name":"causal networks","score":0.7990000247955322},{"id":"https://openalex.org/keywords/excess-post-exercise-oxygen-consumption","display_name":"excess post-exercise oxygen consumption","score":0.6940000057220459},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/annexin-a2","display_name":"annexin A2","score":0.921999990940094},{"id":"https://openalex.org/keywords/mesenchymal-subtype","display_name":"mesenchymal subtype","score":0.9160000085830688},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6549999713897705},{"id":"https://openalex.org/keywords/drug-target-prediction","display_name":"drug target prediction","score":0.6179999709129333},{"id":"https://openalex.org/keywords/tumor-molecular-subtypes","display_name":"tumor molecular subtypes","score":0.5490000247955322},{"id":"https://openalex.org/keywords/the-cancer-genome-atlas","display_name":"TCGA","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6553004384040833},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.641769289970398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5866391658782959},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5258027911186218},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.49115416407585144},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.43805402517318726},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4111669957637787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37277162075042725},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3331613838672638},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3300444483757019},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3289210796356201},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25198566913604736}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/39547","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/39547","pdf_url":"http://hdl.handle.net/2077/39547","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:1926051934","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/39547/1/gupea_2077_39547_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/39547","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/39547","pdf_url":"http://hdl.handle.net/2077/39547","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1926051934.pdf","grobid_xml":"https://content.openalex.org/works/W1926051934.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W214964446","https://openalex.org/W299812171","https://openalex.org/W338754679","https://openalex.org/W1549171236","https://openalex.org/W1588116591","https://openalex.org/W1886989480","https://openalex.org/W1915855266","https://openalex.org/W1966327575","https://openalex.org/W1967220865","https://openalex.org/W1970156673","https://openalex.org/W1975428912","https://openalex.org/W1976457549","https://openalex.org/W1981509058","https://openalex.org/W1990153910","https://openalex.org/W1996729627","https://openalex.org/W2003176492","https://openalex.org/W2005895632","https://openalex.org/W2010824638","https://openalex.org/W2013973825","https://openalex.org/W2015538881","https://openalex.org/W2016661249","https://openalex.org/W2020812892","https://openalex.org/W2022495797","https://openalex.org/W2030337484","https://openalex.org/W2034269086","https://openalex.org/W2037062671","https://openalex.org/W2040191060","https://openalex.org/W2043696829","https://openalex.org/W2043834237","https://openalex.org/W2044291297","https://openalex.org/W2044433401","https://openalex.org/W2045079045","https://openalex.org/W2045260557","https://openalex.org/W2047028564","https://openalex.org/W2047287811","https://openalex.org/W2056040742","https://openalex.org/W2057159445","https://openalex.org/W2061971803","https://openalex.org/W2062375641","https://openalex.org/W2062723225","https://openalex.org/W2070571588","https://openalex.org/W2077858999","https://openalex.org/W2089031587","https://openalex.org/W2096460732","https://openalex.org/W2098341282","https://openalex.org/W2102140136","https://openalex.org/W2105528101","https://openalex.org/W2110265246","https://openalex.org/W2117413570","https://openalex.org/W2117692326","https://openalex.org/W2119908855","https://openalex.org/W2120370024","https://openalex.org/W2122825543","https://openalex.org/W2123106337","https://openalex.org/W2130410032","https://openalex.org/W2132555912","https://openalex.org/W2135046866","https://openalex.org/W2139236349","https://openalex.org/W2141942950","https://openalex.org/W2148977460","https://openalex.org/W2154361640","https://openalex.org/W2154910041","https://openalex.org/W2155208906","https://openalex.org/W2155473273","https://openalex.org/W2155573334","https://openalex.org/W2156138784","https://openalex.org/W2158485828","https://openalex.org/W2161289668","https://openalex.org/W2161821474","https://openalex.org/W2163188200","https://openalex.org/W2164012646","https://openalex.org/W2164278908","https://openalex.org/W2165009258","https://openalex.org/W2165238621","https://openalex.org/W2165556326","https://openalex.org/W2168303063","https://openalex.org/W2266981417","https://openalex.org/W2329659234","https://openalex.org/W2397866408","https://openalex.org/W3099289621"],"related_works":["https://openalex.org/W2306989703","https://openalex.org/W7099565013","https://openalex.org/W2115113062","https://openalex.org/W2141452279","https://openalex.org/W86933272","https://openalex.org/W2775986295","https://openalex.org/W2973636381","https://openalex.org/W2886879322","https://openalex.org/W2578626788","https://openalex.org/W2161503024"],"abstract_inverted_index":{"Our":[0,189],"ability":[1],"to":[2,54,97,125,142,156,177,239,260,288],"conduct":[3],"detailed":[4],"molecular":[5,187,295],"investigations":[6],"on":[7],"tissue":[8],"samples":[9],"have,":[10],"during":[11],"the":[12,16,29,32,100,106,119,162,178,183,231,234,252,317],"past":[13],"decade,":[14],"enabled":[15],"formation":[17],"of":[18,24,31,48,70,105,129,151,160,182,195,205,218,233,286,294,316],"databases":[19],"containing":[20],"measurements":[21,69],"from":[22,99,241],"thousands":[23],"cancer":[25,49,227,287,303,318,327],"tumors.":[26],"To":[27,229],"harness":[28],"potential":[30,232],"amassing":[33],"data":[34,98,138,223,240,323],"sets,":[35],"we":[36,75,136,236,282],"introduce":[37],"new":[38],"modeling":[39,78,141,217,285],"techniques":[40],"and":[41,63,91,94,116,148,172,214,221,250,269,297,300,325],"generalise":[42],"existing":[43],"methods":[44,52],"for":[45,81,216,258,308],"large-scale":[46],"integration":[47],"data.":[50],"These":[51],"aim":[53],"construct":[55],"network":[56,120,140,276,284,309],"models":[57],"that":[58,118,166],"link":[59],"genetic,":[60,145,219],"epigenetic,":[61,220],"transcriptional":[62,149,222],"phenotypic":[64],"events,":[65],"by":[66,193],"combining":[67],"genome-wide":[68],"multiple":[71],"kinds.\\nIn":[72],"paper":[73,134],"I":[74],"constructed":[76],"a":[77],"framework,":[79],"EPoC,":[80],"creating":[82],"causal":[83],"networks":[84],"be-":[85],"tween":[86],"gene":[87],"copy":[88],"number":[89],"levels":[90],"mRNA":[92,173],"expression,":[93],"applied":[95,237],"it":[96,238],"brain":[101],"tumor":[102],"glioblastoma.":[103],"Some":[104],"predicted":[107,165],"regulators":[108,128,150,159],"were":[109,175,191],"tested":[110],"in":[111,132,197,245,313],"four":[112],"glioblastoma-derived":[113,198],"cell":[114,130,199],"lines":[115],"confirmed":[117],"model":[121,163,253,265],"could":[122],"be":[123],"used":[124,137],"find":[126],"unknown":[127],"growth":[131],"glioblastoma.\\nIn":[133],"II":[135],"integrative":[139],"identify":[143,289],"novel":[144],"epige-":[146],"netic":[147],"glioblastoma":[152],"subtypes.":[153],"In":[154],"addition":[155],"confirming":[157],"known":[158,267],"gliomagenesis,":[161],"also":[164],"Annexin":[167],"A2":[168],"(ANXA2)":[169],"promoter":[170],"methylation":[171],"expression":[174],"linked":[176],"signature":[179],"target":[180],"genes":[181],"clinically":[184],"aggressive":[185],"mesenchymal":[186],"subtype.":[188],"findings":[190],"validated":[192],"knockdown":[194],"ANXA2":[196],"cultures.\\nPaper":[200],"III":[201],"presents":[202],"an":[203],"extension":[204],"sparse":[206],"inverse":[207],"covariance":[208],"selection":[209],"(SICS),":[210],"which":[211],"is":[212],"adapted":[213],"optimized":[215],"across":[224],"mul-":[225],"tiple":[226],"types.":[228,304],"evaluate":[230],"method,":[235],"eight":[242],"cancers":[243],"available":[244],"The":[246,262,305],"Cancer":[247],"Genome":[248],"Atlas":[249],"published":[251],"online":[254],"at":[255],"cancerland-":[256],"scapes.org":[257],"anyone":[259],"explore.":[261],"derived":[263],"multi-cancer":[264],"detected":[266],"interactions":[268],"contained":[270],"interesting":[271],"predictions,":[272],"including":[273,321],"functionally":[274],"coupled":[275],"structures":[277],"shared":[278],"between":[279,302],"cancers.\\nIn":[280],"summary,":[281],"use":[283],"possible":[290],"drug":[291],"targets,":[292],"drivers":[293],"subclasses,":[296],"reveal":[298],"similarities":[299],"differences":[301],"developed":[306],"tools":[307],"construction":[310],"can":[311],"assist":[312],"further":[314],"investigation":[315],"genome,":[319],"potentially":[320],"other":[322],"sources":[324],"additional":[326],"diagnoses.":[328]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}