{"id":"https://openalex.org/W1925996198","doi":null,"title":"SOME METABOLIC EFFECTS EXERTED BY AZASERINE AND PURINE ANALOGS IN VIVO.","display_name":"SOME METABOLIC EFFECTS EXERTED BY AZASERINE AND PURINE ANALOGS IN VIVO.","publication_year":1964,"publication_date":"1964-08-01","ids":{"openalex":"https://openalex.org/W1925996198","mag":"1925996198","pmid":"https://pubmed.ncbi.nlm.nih.gov/14216152"},"language":"en","primary_location":{"id":"pmid:14216152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14216152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111640111","display_name":"Alan C. Sartorelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C SARTORELLI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046784322","display_name":"Herbert F. Upchurch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H F UPCHURCH","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000639853","display_name":"Allan L. Bieber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L BIEBER","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110082015","display_name":"Barbara A. Booth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A BOOTH","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4811,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.57374768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":"1202","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azaserine","display_name":"azaserine","score":0.996999979019165},{"id":"https://openalex.org/keywords/purine-analogs","display_name":"purine analogues","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sarcoma-180","display_name":"sarcoma 180","score":0.9729999899864197},{"id":"https://openalex.org/keywords/6-thioguanine","display_name":"6-thioguanine","score":0.8880000114440918},{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":0.9049999713897705},{"id":"https://openalex.org/keywords/6-chloropurine","display_name":"6-chloropurine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/purine-nucleotide-biosynthesis","display_name":"purine nucleotide biosynthesis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/thioguanine-nucleotides","display_name":"thioguanine nucleotides","score":0.7440000176429749},{"id":"https://openalex.org/keywords/glycine-incorporation","display_name":"glycine incorporation","score":0.5860000252723694},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.6430000066757202},{"id":"https://openalex.org/keywords/guanine","display_name":"guanine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/adenine","display_name":"adenine","score":0.6690000295639038},{"id":"https://openalex.org/keywords/nucleotide-metabolism","display_name":"nucleotide metabolism","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2776309477","wikidata":"https://www.wikidata.org/wiki/Q4832281","display_name":"Azaserine","level":4,"score":0.9833571910858154},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.8233810663223267},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.8094143271446228},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7450903654098511},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7168936133384705},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.670041561126709},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6690189838409424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5869691371917725},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5378116369247437},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.4789179563522339},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.12819033861160278},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.12395748496055603},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06799492239952087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001377","descriptor_name":"Azaserine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001377","descriptor_name":"Azaserine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001377","descriptor_name":"Azaserine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:14216152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14216152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1964-1891","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1964/892","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1964","raw_type":"text"},{"id":"mag:1925996198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14216152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1510948506","https://openalex.org/W1539359549","https://openalex.org/W1592375687","https://openalex.org/W1594442120","https://openalex.org/W1595380517","https://openalex.org/W1794710904","https://openalex.org/W1940567743","https://openalex.org/W1995717317","https://openalex.org/W2005701657","https://openalex.org/W2118712450","https://openalex.org/W2134831609","https://openalex.org/W2224953692","https://openalex.org/W2320351732","https://openalex.org/W2896597390"],"related_works":["https://openalex.org/W1995717317","https://openalex.org/W2037114409","https://openalex.org/W2012478700","https://openalex.org/W1985453586","https://openalex.org/W2414138159","https://openalex.org/W1518941827","https://openalex.org/W1847011500","https://openalex.org/W1964024063","https://openalex.org/W2120913556","https://openalex.org/W1493402532"],"abstract_inverted_index":{"Summary":[0],"The":[2],"biochemical":[3],"mechanisms":[4],"involved":[5],"in":[6,21,37,66,132,155,175,180,211,223,233],"the":[7,53,68,71,83,89,94,100,111,123,140,176,181,212,224,230],"synergistic":[8],"anti-neoplastic":[9],"activity":[10],"of":[11,13,24,55,63,73,79,96,102,113,125,142,194,202,214,226],"combinations":[12,43],"azaserine":[14,207],"and":[15,49,107,136,147],"certain":[16],"purine":[17,32,84,126],"analogs":[18,33,90],"was":[19,29,161,173],"studied":[20],"a":[22,38,191],"subline":[23],"Sarcoma":[25,64,195],"180":[26,196],"that":[27],"neither":[28],"inhibited":[30,52,110],"by":[31,165],"alone":[34],"nor":[35],"responded":[36],"synergic":[39],"manner":[40],"to":[41,151,187,190,197],"their":[42,50],"with":[44,206,229],"azaserine.":[45],"6-Chloropurine,":[46],"6-thioguanine,":[47],"6-mercaptopurine,":[48],"ribonucleosides":[51],"incorporation":[54,72],"glycine-2-C":[56],"14":[57,145,149],"into":[59,75],"nucleic":[60,76,152,231],"acid":[61,77,153],"guanine":[62,103],"180;":[65],"addition,":[67],"purinethiols":[69],"decreased":[70,139],"glycine":[74,98],"adenine":[78,114],"this":[80],"neoplasm.":[81],"In":[82],"analog-resistant":[85],"neoplasm":[86],"(Sarcoma":[87],"180/TG),":[88],"did":[91],"not":[92],"decrease":[93],"utilization":[95],"isotopic":[97],"for":[99],"biosynthesis":[101],"nucleotides;":[104],"however,":[105,168],"6-thioguanine":[106,227],"6-thioguanosine":[108],"both":[109,133,143,156,166,234],"formation":[112],"nucleotides":[115,127],"de":[117,129],"novo":[118,130],".":[119],"Azaserine":[120],"markedly":[121],"depressed":[122],"synthesis":[124],"tumors.":[134],"6-Thioguanine":[135],"its":[137],"ribonucleoside":[138],"conversion":[141],"hypoxanthine-8-C":[144],"guanine-8-C":[148],"purines":[154],"cell":[157],"lines.":[158],"Thioguanine":[159],"mononucleotide":[160],"formed":[162],"from":[163],"thioguanine":[164,171,216],"tumors;":[167],"considerably":[169],"more":[170],"nucleotide":[172],"present":[174],"sensitive":[177],"cells":[178],"than":[179],"resistant":[182],"ones.":[183],"This":[184],"difference":[185],"appeared":[186],"be":[188],"attributable":[189],"greater":[192],"capacity":[193],"maintain":[198],"an":[199,209,221],"intracellular":[200],"concentration":[201],"analog":[203],"nucleotide.":[204],"Pretreatment":[205],"caused":[208],"increase":[210,222],"quantity":[213],"acid-soluble":[215],"nucleotide,":[217],"as":[218,220],"well":[219],"amount":[225],"associated":[228],"acids":[232],"neoplasms.":[235]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
