{"id":"https://openalex.org/W1925891725","doi":"https://doi.org/10.1371/journal.pone.0139960","title":"Leptin Is Required for Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice","display_name":"Leptin Is Required for Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice","publication_year":2015,"publication_date":"2015-10-07","ids":{"openalex":"https://openalex.org/W1925891725","doi":"https://doi.org/10.1371/journal.pone.0139960","mag":"1925891725","pmid":"https://pubmed.ncbi.nlm.nih.gov/26445459"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0139960","doi":"https://doi.org/10.1371/journal.pone.0139960","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0139960","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139960&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139960&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044690345","display_name":"Mohamad Mokadem","orcid":"https://orcid.org/0000-0003-1402-580X","observed_orcids":["https://orcid.org/0000-0003-1402-580X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohamad Mokadem","raw_affiliation_strings":["Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America","Division of Gastroenterology and Hepatology, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America","Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076259550","display_name":"Juliet F. Zechner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliet F. Zechner","raw_affiliation_strings":["Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109136232","display_name":"Aki Uchida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aki Uchida","raw_affiliation_strings":["Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073280291","display_name":"Vincent Aguirre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Aguirre","raw_affiliation_strings":["Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, 75390, United States of America","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044690345"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.8156,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84052657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"10","first_page":"e0139960","last_page":"e0139960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/roux-en-y-gastric-bypass","display_name":"Roux-en-Y gastric bypass","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.8690000176429749},{"id":"https://openalex.org/keywords/leptin-deficiency","display_name":"leptin deficiency","score":0.8270000219345093},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.7919999957084656},{"id":"https://openalex.org/keywords/weight-maintenance","display_name":"weight maintenance","score":0.6380000114440918},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7319999933242798},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.777999997138977},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.8119999766349792},{"id":"https://openalex.org/keywords/diabetes-remission","display_name":"diabetes remission","score":0.6150000095367432},{"id":"https://openalex.org/keywords/weight-regain","display_name":"weight regain","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9085018634796143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8484383225440979},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8272212147712708},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.7745079398155212},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6407976150512695},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.6126810908317566},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5858640074729919},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.5763102769851685},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5727481842041016},{"id":"https://openalex.org/C2778707264","wikidata":"https://www.wikidata.org/wiki/Q1332886","display_name":"Calorie restriction","level":2,"score":0.49808621406555176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4583354592323303},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4117478132247925},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.32039153575897217},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.28838980197906494}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015390","descriptor_name":"Gastric Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015390","descriptor_name":"Gastric Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015390","descriptor_name":"Gastric Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0139960","doi":"https://doi.org/10.1371/journal.pone.0139960","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0139960","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139960&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:26445459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26445459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3583724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4596552","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4596552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4596552","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:48692c7f6fd44cb7981054df9c5ef366","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/48692c7f6fd44cb7981054df9c5ef366","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 10, p e0139960 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0139960","doi":"https://doi.org/10.1371/journal.pone.0139960","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0139960","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139960&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2995499364","display_name":null,"funder_award_id":"DK0073077","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3549828030","display_name":null,"funder_award_id":"NIH T32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3749087253","display_name":null,"funder_award_id":"T32DK007745","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4438913023","display_name":null,"funder_award_id":"DK100085","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4867230415","display_name":"Mechanisms for the Ghrelin Response to Caloric Restriction and Gastric Bypass","funder_award_id":"F32DK100085","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7610528146","display_name":null,"funder_award_id":"DK007745","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7639747849","display_name":null,"funder_award_id":"DK091511","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G793788843","display_name":null,"funder_award_id":"K08 DK091511","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1925891725.pdf","grobid_xml":"https://content.openalex.org/works/W1925891725.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W61954220","https://openalex.org/W1492605893","https://openalex.org/W1561443084","https://openalex.org/W1574365001","https://openalex.org/W1580569338","https://openalex.org/W1936184904","https://openalex.org/W1964489271","https://openalex.org/W1970727326","https://openalex.org/W1983864802","https://openalex.org/W1987000712","https://openalex.org/W1987476260","https://openalex.org/W1989671113","https://openalex.org/W1990514678","https://openalex.org/W1996800212","https://openalex.org/W1997942129","https://openalex.org/W2001716823","https://openalex.org/W2008768221","https://openalex.org/W2009604850","https://openalex.org/W2012180351","https://openalex.org/W2014093920","https://openalex.org/W2024151430","https://openalex.org/W2027141887","https://openalex.org/W2035840838","https://openalex.org/W2038406912","https://openalex.org/W2038872854","https://openalex.org/W2044156680","https://openalex.org/W2044453075","https://openalex.org/W2044939881","https://openalex.org/W2045948521","https://openalex.org/W2056402935","https://openalex.org/W2060682066","https://openalex.org/W2061855616","https://openalex.org/W2066283353","https://openalex.org/W2067242542","https://openalex.org/W2068698835","https://openalex.org/W2068769790","https://openalex.org/W2070074337","https://openalex.org/W2071859133","https://openalex.org/W2071976477","https://openalex.org/W2081136203","https://openalex.org/W2084310603","https://openalex.org/W2091087465","https://openalex.org/W2093139970","https://openalex.org/W2093587125","https://openalex.org/W2109164644","https://openalex.org/W2109742508","https://openalex.org/W2114675403","https://openalex.org/W2120454582","https://openalex.org/W2127314379","https://openalex.org/W2133635537","https://openalex.org/W2134520365","https://openalex.org/W2134934076","https://openalex.org/W2140855423","https://openalex.org/W2144631980","https://openalex.org/W2147872784","https://openalex.org/W2152315684","https://openalex.org/W2154935464","https://openalex.org/W2158151423","https://openalex.org/W2159048625","https://openalex.org/W2162582403","https://openalex.org/W2164494648","https://openalex.org/W2164714249","https://openalex.org/W2168871248","https://openalex.org/W2169216660","https://openalex.org/W2316534927","https://openalex.org/W2407470778","https://openalex.org/W4231603102","https://openalex.org/W6667799946"],"related_works":["https://openalex.org/W2122323193","https://openalex.org/W2047971516","https://openalex.org/W2015872450","https://openalex.org/W2166890779","https://openalex.org/W2319604579","https://openalex.org/W2023381149","https://openalex.org/W2027444063","https://openalex.org/W1988098212","https://openalex.org/W2103581424","https://openalex.org/W2547872027"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"Leptin,":[3],"the":[4,8,81,89,195,213,227],"protein":[5],"product":[6],"of":[7,84,95,229],"ob":[9],"gene,":[10],"increases":[11],"energy":[12],"expenditure":[13],"and":[14,27,47,72,112,163,166,187,206],"reduces":[15],"food":[16],"intake,":[17],"thereby":[18],"promoting":[19],"weight":[20,42,110,146,208,237,254],"reduction.":[21],"Leptin":[22],"also":[23,244],"regulates":[24],"glucose":[25,114,180,232],"homeostasis":[26,115,233],"hepatic":[28],"insulin":[29,185],"sensitivity":[30],"via":[31],"hypothalamic":[32],"proopiomelanocortin":[33],"neurons":[34],"in":[35,86,144,169,172,197,203,217,240,252],"mice.":[36,174,219,241],"Roux-en-Y":[37],"gastric":[38],"bypass":[39],"(RYGB)":[40],"induces":[41],"loss":[43],"that":[44,80,104,222,246],"is":[45,106,142,224],"substantial":[46],"sustained":[48,109],"despite":[49],"reducing":[50],"plasma":[51,183,189],"leptin":[52,96,105,141,223,247],"levels.":[53],"In":[54],"addition,":[55],"patients":[56],"who":[57,70],"fail":[58],"to":[59,68,73,178,212],"undergo":[60],"diabetes":[61],"remission":[62],"after":[63,117,201],"RYGB":[64,85,126,157,202,230],"are":[65],"hypoletinemic":[66],"compared":[67],"those":[69],"do":[71],"lean":[74,164],"controls.":[75],"We":[76,220],"have":[77],"previously":[78],"demonstrated":[79],"beneficial":[82],"effects":[83,228],"mice":[87,133,151,205],"require":[88],"melanocortin-4":[90],"receptor,":[91],"a":[92,250],"downstream":[93],"effector":[94],"action.":[97],"Based":[98],"on":[99,130,135,231],"these":[100],"observations,":[101],"we":[102,124,148],"hypothesized":[103],"required":[107,225],"for":[108,226],"reduction":[111,168,196],"improved":[113],"observed":[116,200],"RYGB.":[118],"METHODS:":[119],"To":[120,138],"investigate":[121,139],"this":[122],"hypothesis,":[123],"performed":[125],"or":[127,238],"sham":[128],"operations":[129],"leptin-deficient":[131],"ob/ob":[132,173,204],"maintained":[134],"regular":[136],"chow.":[137],"whether":[140],"involved":[143],"post-RYGB":[145,253],"maintenance,":[147],"challenged":[149],"post-surgical":[150],"with":[152],"high":[153],"fat":[154,162,192],"diet.":[155],"RESULTS:":[156],"reduced":[158],"total":[159],"body":[160,236],"weight,":[161],"mass":[165],"caused":[167],"calorie":[170,198],"intake":[171,199],"However,":[175],"it":[176],"failed":[177],"improve":[179],"tolerance,":[181,186],"glucose-stimulated":[182],"insulin,":[184],"fasting":[188],"insulin.":[190],"High":[191],"diet":[193],"eliminated":[194],"promoted":[207],"regain,":[209],"although":[210],"not":[211,235],"same":[214],"extent":[215],"as":[216],"sham-operated":[218],"conclude":[221],"but":[234],"composition":[239],"Our":[242],"data":[243],"suggest":[245],"may":[248],"play":[249],"role":[251],"maintenance.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
