{"id":"https://openalex.org/W1925841406","doi":null,"title":"Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.","display_name":"Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W1925841406","mag":"1925841406","pmid":"https://pubmed.ncbi.nlm.nih.gov/12576426"},"language":"en","primary_location":{"id":"pmid:12576426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12576426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011112601","display_name":"Michael S. Kinch","orcid":"https://orcid.org/0000-0003-3939-3756","observed_orcids":["https://orcid.org/0000-0003-3939-3756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S Kinch","raw_affiliation_strings":["MedImmune, Inc., Gaithersburg, Maryland 20878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune, Inc., Gaithersburg, Maryland 20878, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018648604","display_name":"Mary-Beth H Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary-Beth Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001948668","display_name":"David H. Harpole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David H Harpole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7833,"has_fulltext":false,"cited_by_count":237,"citation_normalized_percentile":{"value":0.95431169,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"2","first_page":"613","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.949999988079071},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recurrent-lung-cancer","display_name":"recurrent lung cancer","score":0.7799999713897705},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.6370000243186951},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8019999861717224},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7229999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7702179551124573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6765745878219604},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.6121991872787476},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5824794173240662},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5751280784606934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5318460464477539},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5125779509544373},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47252920269966125},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4705919027328491},{"id":"https://openalex.org/C150582083","wikidata":"https://www.wikidata.org/wiki/Q18250395","display_name":"EPH receptor A2","level":4,"score":0.4685830771923065},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4171745777130127},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4047626852989197},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3770045042037964},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32440364360809326}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12576426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12576426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:1925841406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12576426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W28936388","https://openalex.org/W160544907","https://openalex.org/W1524233852","https://openalex.org/W1575231005","https://openalex.org/W1594899067","https://openalex.org/W1966558170","https://openalex.org/W1967720639","https://openalex.org/W1986066043","https://openalex.org/W2010105978","https://openalex.org/W2010444010","https://openalex.org/W2014858105","https://openalex.org/W2032428928","https://openalex.org/W2034538527","https://openalex.org/W2069019173","https://openalex.org/W2081709843","https://openalex.org/W2085761836","https://openalex.org/W2088346679","https://openalex.org/W2088852482","https://openalex.org/W2093776977","https://openalex.org/W2094161067","https://openalex.org/W2102249975","https://openalex.org/W2120202512","https://openalex.org/W2127878747","https://openalex.org/W2138178697","https://openalex.org/W2145365512","https://openalex.org/W2164763530","https://openalex.org/W2179038141","https://openalex.org/W2338362211","https://openalex.org/W2421486816"],"related_works":["https://openalex.org/W2129927968","https://openalex.org/W1578841624","https://openalex.org/W2356888484","https://openalex.org/W2104662981","https://openalex.org/W2113822839","https://openalex.org/W3010843251","https://openalex.org/W2109850440","https://openalex.org/W2023308244","https://openalex.org/W2390985188","https://openalex.org/W1984599905"],"abstract_inverted_index":{"PURPOSE:":[0],"Underestimation":[1],"of":[2,14,38,50,63,67,90,99,104,116,151],"disease":[3,51],"severity":[4],"is":[5,43,79],"a":[6,44,64,134],"major":[7],"problem":[8],"confronting":[9],"the":[10,34,39,75,107,148],"successful":[11],"clinical":[12],"management":[13],"non-small":[15],"cell":[16],"lung":[17,124,154],"cancer.":[18],"Recent":[19],"advances":[20],"in":[21,82,106,153],"molecular":[22,135],"biological":[23],"substaging":[24],"may":[25,132,156],"provide":[26,133,157],"an":[27,158],"opportunity":[28,159],"to":[29,72,119,137],"identify":[30,138],"those":[31],"patients":[32,141],"with":[33,87],"most":[35],"aggressive":[36],"forms":[37],"disease,":[40],"but":[41],"there":[42],"continuing":[45],"need":[46],"for":[47,160],"accurate":[48],"markers":[49],"relapse":[52],"and":[53,97,139],"survival.":[54],"EXPERIMENTAL":[55],"DESIGN:":[56],"In":[57],"our":[58],"present":[59],"study,":[60],"immunohistochemical":[61],"analyses":[62],"retrospective":[65],"database":[66],"pathologic":[68],"specimens":[69],"were":[70],"used":[71],"demonstrate":[73],"that":[74,130],"EphA2":[76,91,105,117,131,152],"receptor":[77],"kinase":[78],"frequently":[80],"overexpressed":[81],"NSCLC.":[83],"RESULTS:":[84],"Initial":[85],"presentation":[86],"high":[88,102,149],"levels":[89,103,115,150],"predicts":[92],"subsequent":[93],"survival,":[94],"overall":[95],"relapse,":[96],"site":[98],"relapse.":[100],"Specifically,":[101],"primary":[108],"tumor":[109],"predict":[110,140],"brain":[111,145],"metastases,":[112],"whereas":[113],"low":[114],"relate":[118],"disease-free":[120],"survival":[121],"or":[122],"contralateral":[123],"metastasis.":[125],"CONCLUSIONS:":[126],"These":[127],"data":[128],"suggest":[129],"marker":[136],"who":[142],"have":[143],"isolated":[144],"metastases.":[146],"Moreover,":[147],"cancer":[155],"therapeutic":[161],"targeting.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
