{"id":"https://openalex.org/W1925763316","doi":"https://doi.org/10.1128/mcb.18.11.6777","title":"Involvement of CREB Binding Protein in Expression of Major Histocompatibility Complex Class II Genes via Interaction with the Class II Transactivator","display_name":"Involvement of CREB Binding Protein in Expression of Major Histocompatibility Complex Class II Genes via Interaction with the Class II Transactivator","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W1925763316","doi":"https://doi.org/10.1128/mcb.18.11.6777","mag":"1925763316","pmid":"https://pubmed.ncbi.nlm.nih.gov/9774691","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/109261"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.18.11.6777","doi":"https://doi.org/10.1128/mcb.18.11.6777","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.18.11.6777","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC109261/pdf/mb006777.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066550504","display_name":"Androniki Kretsovali","orcid":"https://orcid.org/0000-0003-2949-1619","observed_orcids":["https://orcid.org/0000-0003-2949-1619"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Androniki Kretsovali","raw_affiliation_strings":["2Department of Biology, University of Crete, Heraklion, Crete, Greece","Department of Biology, University of Crete, 2 Heraklion, Crete, Greece, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biology, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]},{"raw_affiliation_string":"Department of Biology, University of Crete, 2 Heraklion, Crete, Greece, and","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082627060","display_name":"Theodora Agalioti","orcid":"https://orcid.org/0000-0002-5898-2751","observed_orcids":["https://orcid.org/0000-0002-5898-2751"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theodora Agalioti","raw_affiliation_strings":["1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","2Department of Biology, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","institution_ids":[]},{"raw_affiliation_string":"2Department of Biology, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069903735","display_name":"Charalampos G. Spilianakis","orcid":"https://orcid.org/0000-0003-0921-1923","observed_orcids":["https://orcid.org/0000-0003-0921-1923"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Charalambos Spilianakis","raw_affiliation_strings":["1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","2Department of Biology, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","institution_ids":[]},{"raw_affiliation_string":"2Department of Biology, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050221124","display_name":"Eleni Tzortzakaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Tzortzakaki","raw_affiliation_strings":["1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","2Department of Biology, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","institution_ids":[]},{"raw_affiliation_string":"2Department of Biology, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052672620","display_name":"Menie Merika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Menie Merika","raw_affiliation_strings":["3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032","Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032#N#3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032#N#3","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009255475","display_name":"Joseph D. Papamatheakis","orcid":"https://orcid.org/0000-0003-4553-2601","observed_orcids":["https://orcid.org/0000-0003-4553-2601"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Joseph Papamatheakis","raw_affiliation_strings":["1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","2Department of Biology, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology","institution_ids":[]},{"raw_affiliation_string":"2Department of Biology, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6507,"has_fulltext":true,"cited_by_count":165,"citation_normalized_percentile":{"value":0.96081264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"11","first_page":"6777","last_page":"6783"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creb-binding-protein","display_name":"CREB-binding protein","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ciita","display_name":"CIITA","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mhc-class-ii-gene-expression","display_name":"MHC class II gene expression","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adenovirus-e1a","display_name":"adenovirus E1A","score":0.8029999732971191},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.6790000200271606},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.656000018119812},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/promoter-activation","display_name":"promoter activation","score":0.703000009059906},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2775890610","wikidata":"https://www.wikidata.org/wiki/Q14914108","display_name":"CIITA","level":5,"score":0.9881891012191772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8403754234313965},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.7235369086265564},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.6203190684318542},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5952745079994202},{"id":"https://openalex.org/C119997001","wikidata":"https://www.wikidata.org/wiki/Q21113110","display_name":"CD74","level":5,"score":0.5869388580322266},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.5835936665534973},{"id":"https://openalex.org/C2776603820","wikidata":"https://www.wikidata.org/wiki/Q906517","display_name":"CREB-binding protein","level":5,"score":0.5581052303314209},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4558587670326233},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4201474189758301},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4164779484272003},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.37998417019844055},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37803858518600464},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3767021894454956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37378832697868347},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3308602273464203},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32405218482017517}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017500","descriptor_name":"Adenovirus E1A Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.18.11.6777","doi":"https://doi.org/10.1128/mcb.18.11.6777","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.18.11.6777","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:109261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/109261","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC109261/pdf/mb006777.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:174638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/109261","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:9774691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9774691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.509.7168","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.509.7168","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.imbb.forth.gr/people/spilianakis/pdf/14.MCB1998.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:109261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/109261","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC109261/pdf/mb006777.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1925763316.pdf","grobid_xml":"https://content.openalex.org/works/W1925763316.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1532498149","https://openalex.org/W1545666072","https://openalex.org/W1613167641","https://openalex.org/W1653126782","https://openalex.org/W1942735513","https://openalex.org/W1966063731","https://openalex.org/W1969043367","https://openalex.org/W1977964349","https://openalex.org/W1978800911","https://openalex.org/W1978943108","https://openalex.org/W1985063313","https://openalex.org/W1985130877","https://openalex.org/W1987485969","https://openalex.org/W1991185690","https://openalex.org/W1996202980","https://openalex.org/W1997228571","https://openalex.org/W2004988279","https://openalex.org/W2010605653","https://openalex.org/W2012872675","https://openalex.org/W2013279950","https://openalex.org/W2022713347","https://openalex.org/W2027874507","https://openalex.org/W2037841288","https://openalex.org/W2039463698","https://openalex.org/W2043789254","https://openalex.org/W2051147182","https://openalex.org/W2060320549","https://openalex.org/W2070338838","https://openalex.org/W2072457100","https://openalex.org/W2075496313","https://openalex.org/W2075891777","https://openalex.org/W2083080708","https://openalex.org/W2084480440","https://openalex.org/W2093184750","https://openalex.org/W2095217266","https://openalex.org/W2098677328","https://openalex.org/W2105191579","https://openalex.org/W2112093664","https://openalex.org/W2112260561","https://openalex.org/W2118556518","https://openalex.org/W2122506044","https://openalex.org/W2126568240","https://openalex.org/W2134461114","https://openalex.org/W2143241514","https://openalex.org/W2145012483","https://openalex.org/W2159566110","https://openalex.org/W2164212926"],"related_works":["https://openalex.org/W7096733096","https://openalex.org/W1853154894","https://openalex.org/W1985219178","https://openalex.org/W2039908573","https://openalex.org/W2116228493","https://openalex.org/W2725999024","https://openalex.org/W2043817901","https://openalex.org/W1557584283","https://openalex.org/W2072649015","https://openalex.org/W1824777900"],"abstract_inverted_index":{"The":[0],"class":[1,19,61,82,132],"II":[2,20,62,83,133],"transactivator":[3],"(CIITA)":[4],"is":[5],"a":[6,116],"key":[7],"regulatory":[8],"factor":[9],"that":[10,22,39,88],"controls":[11],"expression":[12,58,143],"of":[13,32,48,59,72,95,108,115],"the":[14,33,40,46,69,73,89,101,104,113,121,126],"major":[15],"histocompatibility":[16],"complex":[17],"(MHC)":[18],"genes":[21],"are":[23],"essential":[24],"components":[25],"for":[26,68,140],"antigen":[27],"presentation":[28],"and":[29,50,54,79,103,125,144],"thus":[30],"regulation":[31],"immune":[34],"response.":[35],"We":[36,86],"show":[37],"here":[38],"adenovirus":[41],"E1A":[42],"protein":[43,75],"interferes":[44],"with":[45,99],"action":[47],"CIITA":[49,96,124],"inhibits":[51],"both":[52,100,141],"B-cell-specific":[53],"gamma":[55],"interferon":[56],"(IFN-gamma)-induced":[57],"MHC":[60,81,131],"promoters.":[63],"Transfection":[64],"studies":[65],"provide":[66],"evidence":[67],"functional":[70],"role":[71],"CREB-binding":[74],"(CBP)":[76],"in":[77,130],"IFN-gamma":[78],"CIITA-mediated":[80],"promoter":[84],"activation.":[85],"demonstrate":[87],"N-terminally":[90],"located":[91],"transcription":[92],"activation":[93],"domain":[94],"physically":[97],"interacts":[98],"N-terminal":[102],"E1A-binding":[105],"(C/H3)":[106],"regions":[107],"CBP.":[109],"These":[110],"results":[111],"suggest":[112],"involvement":[114],"multisubunit":[117],"complex,":[118],"which":[119,136],"contains":[120],"gene-specific":[122],"coactivator":[123,128],"versatile":[127],"CBP,":[129],"gene":[134],"regulation,":[135],"may":[137],"be":[138],"responsible":[139],"high-level":[142],"modulation":[145],"by":[146],"different":[147],"signaling":[148],"pathways.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}