{"id":"https://openalex.org/W1925706468","doi":"https://doi.org/10.1007/s10620-015-3917-0","title":"Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series","display_name":"Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series","publication_year":2015,"publication_date":"2015-10-15","ids":{"openalex":"https://openalex.org/W1925706468","doi":"https://doi.org/10.1007/s10620-015-3917-0","mag":"1925706468","pmid":"https://pubmed.ncbi.nlm.nih.gov/26470867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4761007"},"language":"en","primary_location":{"id":"doi:10.1007/s10620-015-3917-0","doi":"https://doi.org/10.1007/s10620-015-3917-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10620-015-3917-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10620-015-3917-0.pdf","source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10620-015-3917-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009025762","display_name":"Shinya Ashizuka","orcid":"https://orcid.org/0000-0003-2530-760X","observed_orcids":["https://orcid.org/0000-0003-2530-760X"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinya Ashizuka","raw_affiliation_strings":["Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. shinya_ashizuka@med.miyazaki-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. shinya_ashizuka@med.miyazaki-u.ac.jp","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112903847","display_name":"Haruhiko Inatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruhiko Inatsu","raw_affiliation_strings":["Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. inacchi@med.miyazaki-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. inacchi@med.miyazaki-u.ac.jp","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018910712","display_name":"Toshihiro Kita","orcid":"https://orcid.org/0000-0003-1903-9012","observed_orcids":["https://orcid.org/0000-0003-1903-9012"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Kita","raw_affiliation_strings":["Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. toshihiro_kita@med.miyazaki-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. toshihiro_kita@med.miyazaki-u.ac.jp","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101726602","display_name":"Kazuo Kitamura","orcid":"https://orcid.org/0000-0002-5124-9549","observed_orcids":["https://orcid.org/0000-0002-5124-9549"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Kitamura","raw_affiliation_strings":["Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. kazuokit@med.miyazaki-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. kazuokit@med.miyazaki-u.ac.jp","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009025762"],"corresponding_institution_ids":["https://openalex.org/I118574687"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":3.4307,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.9143094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"61","issue":"3","first_page":"872","last_page":"880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenomedullin","display_name":"adrenomedullin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/refractory-ulcerative-colitis","display_name":"refractory ulcerative colitis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/intravenous-infusion","display_name":"intravenous infusion","score":0.777999997138977},{"id":"https://openalex.org/keywords/mucosal-healing","display_name":"mucosal healing","score":0.8799999952316284},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.9850000143051147},{"id":"https://openalex.org/keywords/disease-activity-index","display_name":"disease activity index","score":0.8579999804496765},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9401912689208984},{"id":"https://openalex.org/C2777152744","wikidata":"https://www.wikidata.org/wiki/Q366935","display_name":"Adrenomedullin","level":3,"score":0.8128277063369751},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7730547785758972},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7254042029380798},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.6600440144538879},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6148631572723389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6005629301071167},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5737446546554565},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.47820258140563965},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3795275092124939},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20031225681304932},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08367124199867249},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053607","descriptor_name":"Adrenomedullin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10620-015-3917-0","doi":"https://doi.org/10.1007/s10620-015-3917-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10620-015-3917-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10620-015-3917-0.pdf","source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},{"id":"pmid:26470867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26470867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive diseases and sciences","raw_type":"Clinical Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:4761007","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4761007/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dig Dis Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10620-015-3917-0","doi":"https://doi.org/10.1007/s10620-015-3917-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10620-015-3917-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10620-015-3917-0.pdf","source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310723","display_name":"Japan Foundation for Applied Enzymology","ror":"https://ror.org/0293d8d10"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1925706468.pdf","grobid_xml":"https://content.openalex.org/works/W1925706468.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1963532021","https://openalex.org/W1969830999","https://openalex.org/W1971910159","https://openalex.org/W1978593886","https://openalex.org/W1991982882","https://openalex.org/W2013580888","https://openalex.org/W2013688429","https://openalex.org/W2015231010","https://openalex.org/W2022307818","https://openalex.org/W2025680563","https://openalex.org/W2056214437","https://openalex.org/W2062686511","https://openalex.org/W2080231911","https://openalex.org/W2082439167","https://openalex.org/W2092419989","https://openalex.org/W2104539207","https://openalex.org/W2114033715","https://openalex.org/W2119951548","https://openalex.org/W2120338084","https://openalex.org/W2128698379","https://openalex.org/W2141414993","https://openalex.org/W2149013679","https://openalex.org/W2169988437","https://openalex.org/W2321205867","https://openalex.org/W3093244026"],"related_works":["https://openalex.org/W3096178006","https://openalex.org/W2013688429","https://openalex.org/W2291042598","https://openalex.org/W2141414993","https://openalex.org/W2897684929","https://openalex.org/W2913800933","https://openalex.org/W3194702648","https://openalex.org/W2767304149","https://openalex.org/W4285591122","https://openalex.org/W2013580888"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Adrenomedullin":[3],"(AM)":[4],"is":[5,234],"a":[6,145,217,235,242],"multifunctional":[7],"biologically":[8],"active":[9,78],"peptide":[10],"that":[11,215,239],"has":[12],"an":[13],"ameliorative":[14],"effect":[15,219],"against":[16],"inflammatory":[17],"bowel":[18],"disease":[19],"in":[20,38,69,119,130,140,151,196,209,253],"several":[21],"experimental":[22],"models.":[23],"We":[24],"reported":[25],"the":[26,47,50,61],"first":[27],"case":[28],"where":[29],"AM":[30,55,68,87,113,123,202,204,211,233],"infusion":[31,85],"dramatically":[32],"improved":[33,118,158],"symptoms":[34],"and":[35,52,82,97,106,108,135,172,191,223,250],"colonoscopy":[36],"findings":[37],"patients":[39,70,76,121,142,194,254],"with":[40,71,77,188,227,255],"refractory":[41,72,79,256],"ulcerative":[42],"colitis":[43],"(UC).":[44],"To":[45],"confirm":[46],"reproducibility":[48],"of":[49,54,64,67,86,186],"efficacy":[51],"safety":[53],"infusion,":[56],"this":[57],"pilot":[58],"study":[59],"evaluated":[60,104],"clinical":[62,197,251],"feasibility":[63],"intravenous":[65,84],"administration":[66,205],"UC.":[73,257],"METHODS:":[74],"Seven":[75],"UC":[80],"participated":[81],"received":[83],"(1.5":[88],"pmol/kg/min)":[89],"for":[90,94],"8":[91],"h":[92],"daily":[93],"14":[95],"days,":[96],"their":[98],"Disease":[99],"Activity":[100],"Index":[101],"(DAI)":[102],"were":[103,117,138],"before":[105],"2":[107,126,170],"12":[109,179,199],"weeks":[110],"after":[111,122,201],"beginning":[112],"administration.":[114,124],"RESULTS:":[115],"DAI":[116,131,157],"all":[120],"Within":[125],"weeks,":[127,171],"marked":[128],"declines":[129],"(\u2265":[132],"3":[133],"points":[134],"\u2265":[136],"30%)":[137],"observed":[139,150],"six":[141],"(85.7%),":[143],"while":[144],"more":[146],"modest":[147],"decline":[148],"was":[149],"one":[152],"patient":[153],"(14.3%).":[154],"Overall":[155],"mean":[156],"from":[159],"9.3":[160],"\u00b1":[161,167,176],"0.6":[162],"at":[163,169,178],"baseline":[164],"to":[165,174,245],"4.6":[166],"0.8":[168],"then":[173],"1.2":[175],"0.5":[177],"weeks.":[180],"Endoscopic":[181],"examination":[182],"revealed":[183],"substantial":[184],"amelioration":[185],"ulcers,":[187],"mucosal":[189,248],"healing":[190,249],"scarring.":[192],"Four":[193],"remained":[195],"remission":[198,252],"months":[200],"treatment.":[203],"produced":[206],"significant":[207],"increases":[208],"plasma":[210],"concentrations":[212],"(approximately":[213],"2.5-fold)":[214],"had":[216],"mild":[218],"on":[220],"blood":[221],"pressure":[222],"heart":[224],"rate,":[225],"but":[226],"no":[228],"serious":[229],"adverse":[230],"effects.":[231],"CONCLUSION:":[232],"potentially":[236],"useful":[237],"agent":[238],"acts":[240],"via":[241],"novel":[243],"mechanism":[244],"safely":[246],"induce":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
