{"id":"https://openalex.org/W1925459337","doi":"https://doi.org/10.1093/clinchem/47.9.1641","title":"Mitochondrial Gene Mutations in the tRNALeu(UUR) Region and Diabetes: Prevalence and Clinical Phenotypes in Japan","display_name":"Mitochondrial Gene Mutations in the tRNALeu(UUR) Region and Diabetes: Prevalence and Clinical Phenotypes in Japan","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W1925459337","doi":"https://doi.org/10.1093/clinchem/47.9.1641","mag":"1925459337","pmid":"https://pubmed.ncbi.nlm.nih.gov/11514398"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/47.9.1641","doi":"https://doi.org/10.1093/clinchem/47.9.1641","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/47.9.1641","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113767939","display_name":"Kumiko Ohkubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kumiko Ohkubo","raw_affiliation_strings":["Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030466458","display_name":"Akemi Yamano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akemi Yamano","raw_affiliation_strings":["The First Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mariko Nagashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Nagashima","raw_affiliation_strings":["Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036593923","display_name":"Yumiko Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Mori","raw_affiliation_strings":["Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054851148","display_name":"Keizo Anzai","orcid":"https://orcid.org/0000-0002-8208-5321","observed_orcids":["https://orcid.org/0000-0002-8208-5321"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keizo Anzai","raw_affiliation_strings":["Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083803430","display_name":"Yuko Akehi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Akehi","raw_affiliation_strings":["Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000862101","display_name":"Riku Nomiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Riku Nomiyama","raw_affiliation_strings":["The First Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085780525","display_name":"Takashi Asano","orcid":"https://orcid.org/0000-0002-5472-5723","observed_orcids":["https://orcid.org/0000-0002-5472-5723"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Asano","raw_affiliation_strings":["The First Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048770061","display_name":"Akinori Urae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115738","display_name":"SOUSEIKAI Global Clinical Research Center","ror":"https://ror.org/022bpxw56","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115738"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinori Urae","raw_affiliation_strings":["Kyushu Clinical Pharmacology Research Clinic, 2-13-16, Jigyo, Chuo-ku, Fukuoka, 810-0065, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu Clinical Pharmacology Research Clinic, 2-13-16, Jigyo, Chuo-ku, Fukuoka, 810-0065, Japan","institution_ids":["https://openalex.org/I4210115738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082073136","display_name":"Junko Ono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Ono","raw_affiliation_strings":["Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113767939"],"corresponding_institution_ids":["https://openalex.org/I31784960"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":0.577,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.58752793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"9","first_page":"1641","last_page":"1648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.8939999938011169},{"id":"https://openalex.org/keywords/a3243g-mutation","display_name":"A3243G mutation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.871999979019165},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.9829999804496765},{"id":"https://openalex.org/keywords/heteroplasmy","display_name":"heteroplasmy","score":0.925000011920929},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.746999979019165},{"id":"https://openalex.org/keywords/gad-antibodies","display_name":"glutamic acid decarboxylase antibodies","score":0.6520000100135803},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.972000002861023},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7319999933242798},{"id":"https://openalex.org/keywords/preclinical-diagnosis","display_name":"preclinical diagnosis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/japan","display_name":"Japan","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C181561989","wikidata":"https://www.wikidata.org/wiki/Q2581905","display_name":"Heteroplasmy","level":4,"score":0.9027183651924133},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7545958161354065},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6143266558647156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5306417346000671},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5167552828788757},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4744221568107605},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.46634548902511597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45779189467430115},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4127238690853119},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40902990102767944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3340319097042084}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012356","descriptor_name":"RNA, Transfer, Leu","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/clinchem/47.9.1641","doi":"https://doi.org/10.1093/clinchem/47.9.1641","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/47.9.1641","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:11514398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11514398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.512.3194","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.512.3194","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.clinchem.org/content/47/9/1641.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1497179990","https://openalex.org/W1978555203","https://openalex.org/W1980305657","https://openalex.org/W1980681204","https://openalex.org/W1988276497","https://openalex.org/W2004399834","https://openalex.org/W2004688378","https://openalex.org/W2006413668","https://openalex.org/W2008629489","https://openalex.org/W2010859350","https://openalex.org/W2016254652","https://openalex.org/W2019530794","https://openalex.org/W2032118993","https://openalex.org/W2037204981","https://openalex.org/W2038545492","https://openalex.org/W2043531162","https://openalex.org/W2056174109","https://openalex.org/W2062226417","https://openalex.org/W2069661122","https://openalex.org/W2070342136","https://openalex.org/W2091456721","https://openalex.org/W2094388145","https://openalex.org/W2105909048","https://openalex.org/W2112328520","https://openalex.org/W2113999599","https://openalex.org/W2124207622","https://openalex.org/W2131783890","https://openalex.org/W2132726974","https://openalex.org/W2134293572","https://openalex.org/W2136029366","https://openalex.org/W2139369899","https://openalex.org/W2145242451","https://openalex.org/W2159650080","https://openalex.org/W2338125871","https://openalex.org/W4300487321"],"related_works":["https://openalex.org/W3150958943","https://openalex.org/W2004627285","https://openalex.org/W2094268940","https://openalex.org/W165099299","https://openalex.org/W2390204736","https://openalex.org/W2066979699","https://openalex.org/W2100685977","https://openalex.org/W2093877771","https://openalex.org/W2058212390","https://openalex.org/W2348672784"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mitochondrial":[1],"gene":[2,87,196],"mutations":[3,24,83,197],"play":[4],"a":[5,140,149,156,173],"role":[6],"in":[7,25,28,84,98,126,176,216],"the":[8,16,19,29,82,85,108,113,131,206,212],"development":[9],"of":[10,18,34,43,110,117,152,194,201,205,214,231],"diabetes":[11,47,202],"mellitus.":[12],"We":[13,65],"have":[14],"assessed":[15],"frequency":[17],"A3243G":[20,74,94],"and":[21,27,61,75,101,112,122,154,180,203,229],"other":[22],"mitochondrial":[23,86,195],"Japan":[26],"relationship":[30,104],"to":[31,80,159],"clinical":[32,136,142],"features":[33],"diabetes.":[35,118],"METHODS:":[36],"DNA":[37],"was":[38,96,105],"obtained":[39],"from":[40],"peripheral":[41],"leukocytes":[42],"240":[44],"patients":[45,145],"with":[46,50,54,58,146,163,170,218],"mellitus":[48],"(39":[49],"type":[51,55],"1;":[52],"188":[53],"2;":[56],"13":[57],"gestational":[59],"diabetes)":[60],"125":[62],"control":[63],"subjects.":[64],"used":[66],"PCR-restriction":[67],"fragment":[68],"length":[69],"polymorphism":[70,78],"analysis":[71,79],"(ApaI)":[72],"for":[73,226],"PCR-single-strand":[76],"conformation":[77],"determine":[81],"including":[88],"nucleotide":[89],"position":[90],"3243.":[91],"RESULTS:":[92],"The":[93,144,192],"mutation":[95,133],"found":[97],"seven":[99],"patients,":[100],"an":[102,160],"inverse":[103],"observed":[106],"between":[107],"degree":[109,213],"heteroplasmy":[111,215],"age":[114,207],"at":[115,208],"onset":[116,151,209],"A3156G,":[119],"G3357A,":[120],"C3375A,":[121],"T3394C":[123,171],"were":[124],"detected":[125],"addition.":[127],"Those":[128,169],"who":[129],"shared":[130],"same":[132],"showed":[134,155,172],"similar":[135],"characteristics,":[137],"thus":[138],"representing":[139],"putative":[141],"subtype.":[143],"A3156G":[147],"had":[148],"sudden":[150],"hyperglycemia":[153,181],"rapid":[157],"progression":[158],"insulin-dependent":[161],"state":[162],"positive":[164],"anti-glutamic":[165],"acid":[166],"decarboxylase":[167],"antibody.":[168],"mild":[174],"defect":[175],"glucose-stimulated":[177],"insulin":[178],"secretion,":[179],"appeared":[182],"after":[183],"adding":[184],"such":[185],"factors":[186],"as":[187],"aging":[188],"or":[189],"obesity.":[190],"CONCLUSIONS:":[191],"identification":[193,230],"allows":[198],"preclinical":[199],"diagnosis":[200],"prediction":[204],"by":[210],"evaluating":[211],"cases":[217],"A3243G.":[219],"Mutation":[220],"detection":[221],"may":[222],"also":[223],"be":[224],"important":[225],"patient":[227],"management":[228],"affected":[232],"family":[233],"members.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
