{"id":"https://openalex.org/W1925388323","doi":"https://doi.org/10.15252/embr.201540750","title":"miR\u20109\u20105p suppresses pro\u2010fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2","display_name":"miR\u20109\u20105p suppresses pro\u2010fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2","publication_year":2015,"publication_date":"2015-08-27","ids":{"openalex":"https://openalex.org/W1925388323","doi":"https://doi.org/10.15252/embr.201540750","mag":"1925388323","pmid":"https://pubmed.ncbi.nlm.nih.gov/26315535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4766462"},"language":"en","primary_location":{"id":"doi:10.15252/embr.201540750","doi":"https://doi.org/10.15252/embr.201540750","is_oa":false,"landing_page_url":"https://doi.org/10.15252/embr.201540750","pdf_url":null,"source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4766462/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059767046","display_name":"Marta Fierro\u2010Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Fierro\u2010Fern\u00e1ndez","raw_affiliation_strings":["Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064772186","display_name":"\u00d3scar Busnadiego","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00d3scar Busnadiego","raw_affiliation_strings":["Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000572178","display_name":"Pilar Sandoval","orcid":"https://orcid.org/0000-0002-5893-7037","observed_orcids":["https://orcid.org/0000-0002-5893-7037"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Sandoval","raw_affiliation_strings":["Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002353150","display_name":"Cristina Espinosa\u2010D\u00edez","orcid":"https://orcid.org/0000-0002-5868-3807","observed_orcids":["https://orcid.org/0000-0002-5868-3807"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Espinosa\u2010D\u00edez","raw_affiliation_strings":["Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087584872","display_name":"Eva Mar\u00eda Blanco","orcid":"https://orcid.org/0000-0001-5940-1827","observed_orcids":["https://orcid.org/0000-0001-5940-1827"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eva Blanco\u2010Ruiz","raw_affiliation_strings":["Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111874345","display_name":"Macarena Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Macarena Rodr\u00edguez","raw_affiliation_strings":["Department of Pathology, Hospital Universitario \"Ram\u00f3n y Cajal\", IRYCIS, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitario \"Ram\u00f3n y Cajal\", IRYCIS, Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043490939","display_name":"H\u00e9ctor Gerardo Pian","orcid":"https://orcid.org/0000-0002-7175-3988","observed_orcids":["https://orcid.org/0000-0002-7175-3988"]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"H\u00e9ctor Pian","raw_affiliation_strings":["Department of Pathology, Hospital Universitario \"Ram\u00f3n y Cajal\", IRYCIS, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitario \"Ram\u00f3n y Cajal\", IRYCIS, Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013846620","display_name":"Ricardo Ramos","orcid":"https://orcid.org/0000-0003-4893-2205","observed_orcids":["https://orcid.org/0000-0003-4893-2205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ricardo Ramos","raw_affiliation_strings":["Genomic Facility, Parque Cient\u00edfico de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Facility, Parque Cient\u00edfico de Madrid, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022441204","display_name":"Manuel L\u00f3pez\u2010Cabrera","orcid":"https://orcid.org/0000-0002-0976-9719","observed_orcids":["https://orcid.org/0000-0002-0976-9719"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel L\u00f3pez\u2010Cabrera","raw_affiliation_strings":["Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054147399","display_name":"Laura Garc\u00eda\u2010Bermejo","orcid":"https://orcid.org/0000-0002-8167-2276","observed_orcids":["https://orcid.org/0000-0002-8167-2276"]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Laura Garc\u00eda\u2010Bermejo","raw_affiliation_strings":["Department of Pathology, Hospital Universitario \"Ram\u00f3n y Cajal\", IRYCIS, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitario \"Ram\u00f3n y Cajal\", IRYCIS, Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082409536","display_name":"Santiago Lamas","orcid":"https://orcid.org/0000-0001-5166-4155","observed_orcids":["https://orcid.org/0000-0001-5166-4155"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Santiago Lamas","raw_affiliation_strings":["Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain slamas@cbm.csic.es","Department of Cell Biology and Immunology Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CBMSO) Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular \"Severo Ochoa\" (CBMSO), Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, Madrid, Spain slamas@cbm.csic.es","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]},{"raw_affiliation_string":"Department of Cell Biology and Immunology Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CBMSO) Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5082409536"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":6.209,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.97036185,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"10","first_page":"1358","last_page":"1377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-9-5p","display_name":"miR-9-5p","score":1.0},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/myofibroblast-transformation","display_name":"myofibroblast transformation","score":0.902999997138977},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7620000243186951},{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/extracellular-matrix-production","display_name":"extracellular matrix synthesis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mesothelial-cells","display_name":"mesothelial cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/peritoneal-dialysis","display_name":"peritoneal dialysis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/bleomycin-induced-fibrosis","display_name":"bleomycin-induced fibrosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3891567587852478},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.3738325238227844},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.24440491199493408}],"mesh":[{"descriptor_ui":"D000074663","descriptor_name":"NADPH Oxidase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058628","descriptor_name":"Myofibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.15252/embr.201540750","doi":"https://doi.org/10.15252/embr.201540750","is_oa":false,"landing_page_url":"https://doi.org/10.15252/embr.201540750","pdf_url":null,"source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},{"id":"pmid:26315535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26315535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4766462","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4766462/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Rep","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.907.9699","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.907.9699","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://embor.embopress.org/content/embor/early/2015/08/26/embr.201540750.full.pdf","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/139938","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/139938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:dnet:ricscm______::3982968080b84ac40ca950192c62818e","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12530/43926","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4766462","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4766462/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Rep","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1350937022","display_name":null,"funder_award_id":"SAF 2012\u201031338","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G4991338292","display_name":null,"funder_award_id":"SAF 2013\u201047611","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G797043228","display_name":null,"funder_award_id":"CSD-2007-00020","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320310214","display_name":"Fundaci\u00f3n Ram\u00f3n Areces","ror":"https://ror.org/04ra91131"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W101515753","https://openalex.org/W144423133","https://openalex.org/W151728954","https://openalex.org/W201653061","https://openalex.org/W1577577364","https://openalex.org/W1588127651","https://openalex.org/W1958284284","https://openalex.org/W1966672647","https://openalex.org/W1972484042","https://openalex.org/W1975304818","https://openalex.org/W1977919177","https://openalex.org/W1980130854","https://openalex.org/W1980295849","https://openalex.org/W1980325398","https://openalex.org/W1985098845","https://openalex.org/W1986164061","https://openalex.org/W1986267718","https://openalex.org/W1994836525","https://openalex.org/W1996757076","https://openalex.org/W2005791384","https://openalex.org/W2006432922","https://openalex.org/W2007701028","https://openalex.org/W2009001235","https://openalex.org/W2014187911","https://openalex.org/W2014946489","https://openalex.org/W2027875827","https://openalex.org/W2031780066","https://openalex.org/W2041588050","https://openalex.org/W2041967307","https://openalex.org/W2045142779","https://openalex.org/W2047362768","https://openalex.org/W2054236285","https://openalex.org/W2055043387","https://openalex.org/W2056269088","https://openalex.org/W2061558045","https://openalex.org/W2062200817","https://openalex.org/W2066298061","https://openalex.org/W2068961255","https://openalex.org/W2075539598","https://openalex.org/W2081098333","https://openalex.org/W2087467372","https://openalex.org/W2087757614","https://openalex.org/W2088876544","https://openalex.org/W2090463334","https://openalex.org/W2090897026","https://openalex.org/W2093478617","https://openalex.org/W2094077020","https://openalex.org/W2095605427","https://openalex.org/W2097603228","https://openalex.org/W2098637032","https://openalex.org/W2105231460","https://openalex.org/W2105423509","https://openalex.org/W2105621799","https://openalex.org/W2107277218","https://openalex.org/W2110065044","https://openalex.org/W2112618205","https://openalex.org/W2115469285","https://openalex.org/W2116163278","https://openalex.org/W2116871724","https://openalex.org/W2117324021","https://openalex.org/W2120055234","https://openalex.org/W2122683221","https://openalex.org/W2122808924","https://openalex.org/W2124283853","https://openalex.org/W2132300840","https://openalex.org/W2134294936","https://openalex.org/W2143924572","https://openalex.org/W2143992450","https://openalex.org/W2145190346","https://openalex.org/W2154568166","https://openalex.org/W2157101382","https://openalex.org/W2157977329","https://openalex.org/W2159267519","https://openalex.org/W2159864284","https://openalex.org/W2162514162","https://openalex.org/W2164615751","https://openalex.org/W2167557255","https://openalex.org/W2170449834","https://openalex.org/W2339783540","https://openalex.org/W2406979537","https://openalex.org/W4211067148","https://openalex.org/W4251765607"],"related_works":["https://openalex.org/W2414932780","https://openalex.org/W3175601239","https://openalex.org/W2028008068","https://openalex.org/W2139985808","https://openalex.org/W3084815368","https://openalex.org/W1985362243","https://openalex.org/W2037572861","https://openalex.org/W3165254074","https://openalex.org/W2754640436","https://openalex.org/W2087467372"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
