{"id":"https://openalex.org/W1925357871","doi":"https://doi.org/10.1016/s0021-9258(18)43931-2","title":"Serotonin regulation of interleukin-1 messenger RNA in rat uterine smooth muscle cells. Relationship to the production of interstitial collagenase.","display_name":"Serotonin regulation of interleukin-1 messenger RNA in rat uterine smooth muscle cells. Relationship to the production of interstitial collagenase.","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W1925357871","doi":"https://doi.org/10.1016/s0021-9258(18)43931-2","mag":"1925357871","pmid":"https://pubmed.ncbi.nlm.nih.gov/7961954"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)43931-2","doi":"https://doi.org/10.1016/s0021-9258(18)43931-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)43931-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)43931-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108431433","display_name":"B D Wilcox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B D Wilcox","raw_affiliation_strings":["Albany Medic& College, 47 New Scotland Ave., Albany, NY 12268","From the Departments of medicine, IBiochemistw and Molecular Biology, and /Pharmacology and Toxicology, Albany Medical College, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany Medic& College, 47 New Scotland Ave., Albany, NY 12268","institution_ids":["https://openalex.org/I4405260259"]},{"raw_affiliation_string":"From the Departments of medicine, IBiochemistw and Molecular Biology, and /Pharmacology and Toxicology, Albany Medical College, Albany, New York 12208","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111507420","display_name":"Jo Ann Dumin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Dumin","raw_affiliation_strings":["Albany Medic& College, 47 New Scotland Ave., Albany, NY 12268","From the Departments of medicine, IBiochemistw and Molecular Biology, and /Pharmacology and Toxicology, Albany Medical College, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany Medic& College, 47 New Scotland Ave., Albany, NY 12268","institution_ids":["https://openalex.org/I4405260259"]},{"raw_affiliation_string":"From the Departments of medicine, IBiochemistw and Molecular Biology, and /Pharmacology and Toxicology, Albany Medical College, Albany, New York 12208","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011806639","display_name":"John J. Jeffrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J J Jeffrey","raw_affiliation_strings":["Albany Medic& College, 47 New Scotland Ave., Albany, NY 12268","From the Departments of medicine, IBiochemistw and Molecular Biology, and /Pharmacology and Toxicology, Albany Medical College, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany Medic& College, 47 New Scotland Ave., Albany, NY 12268","institution_ids":["https://openalex.org/I4405260259"]},{"raw_affiliation_string":"From the Departments of medicine, IBiochemistw and Molecular Biology, and /Pharmacology and Toxicology, Albany Medical College, Albany, New York 12208","institution_ids":["https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405260259"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.0289,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.74149879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"269","issue":"47","first_page":"29658","last_page":"29664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.7870000004768372},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.7110000252723694},{"id":"https://openalex.org/keywords/uterine-smooth-muscle-cells","display_name":"uterine smooth muscle cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/myometrium","display_name":"myometrium","score":0.9869999885559082},{"id":"https://openalex.org/keywords/5-ht2-receptor","display_name":"5-HT2 receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/autocrine-regulation","display_name":"autocrine regulation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.703000009059906},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bacterial-endotoxin","display_name":"bacterial endotoxin","score":0.890999972820282},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.8287954330444336},{"id":"https://openalex.org/C2776747403","wikidata":"https://www.wikidata.org/wiki/Q13033710","display_name":"Interstitial collagenase","level":4,"score":0.5998560190200806},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5562140941619873},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5521352887153625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4995992183685303},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4962528347969055},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.492424339056015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4847521483898163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46146801114082336},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4472615420818329},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.438687264919281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.388965904712677},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.37536922097206116},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3291015028953552},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2826770842075348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1792060136795044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1751594841480255},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16677212715148926},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1434887945652008},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11543917655944824}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)43931-2","doi":"https://doi.org/10.1016/s0021-9258(18)43931-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)43931-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7961954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7961954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)43931-2","doi":"https://doi.org/10.1016/s0021-9258(18)43931-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)43931-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4196177074","display_name":null,"funder_award_id":"HD05291","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W161157908","https://openalex.org/W1532387473","https://openalex.org/W1551681863","https://openalex.org/W1564545106","https://openalex.org/W1568142005","https://openalex.org/W1900380445","https://openalex.org/W1973315321","https://openalex.org/W1993742161","https://openalex.org/W2012450323","https://openalex.org/W2016710605","https://openalex.org/W2027468709","https://openalex.org/W2033686530","https://openalex.org/W2034090792","https://openalex.org/W2044633715","https://openalex.org/W2054541934","https://openalex.org/W2056267520","https://openalex.org/W2068406471","https://openalex.org/W2071506127","https://openalex.org/W2075195713","https://openalex.org/W2076340864","https://openalex.org/W2082422505","https://openalex.org/W2094302710","https://openalex.org/W2109658199","https://openalex.org/W2114576105","https://openalex.org/W2144743138","https://openalex.org/W2155189322","https://openalex.org/W2341140535","https://openalex.org/W2400755806"],"related_works":["https://openalex.org/W2047893395","https://openalex.org/W1551681863","https://openalex.org/W2082422505","https://openalex.org/W2026994065","https://openalex.org/W2093769834","https://openalex.org/W2076340864","https://openalex.org/W1983696599","https://openalex.org/W2048659710","https://openalex.org/W1553067425","https://openalex.org/W2782784927"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"shown":[3],"that":[4,83,109,175,189],"the":[5,32,40,114,129,180],"production":[6,45,130,178,187,195],"of":[7,52,89,131],"interstitial":[8],"collagenase":[9,25,44,68,70,146,162,165,186],"by":[10,49,99,113,179],"rat":[11],"myometrial":[12,142,181],"smooth":[13],"muscle":[14],"cells":[15,21,120,143],"is":[16,84,111,183],"dependent":[17],"on":[18],"serotonin.":[19,90],"These":[20,172],"fail":[22,156],"to":[23,144,157],"produce":[24,31,145,164],"early":[26,41,147],"in":[27,94,122,140,148,192],"culture,":[28,123],"however,":[29],"and":[30,61,69,77,81,106,166,188],"enzyme":[33],"only":[34],"8-12":[35],"days":[36],"after":[37],"confluence.":[38],"During":[39],"quiescent":[42],"period,":[43],"can":[46],"be":[47],"induced":[48],"low":[50],"concentrations":[51],"bacterial":[53],"endotoxin.":[54],"Under":[55],"these":[56],"conditions,":[57],"interleukin":[58],"(IL)-1":[59],"alpha":[60,76],"IL-1":[62,75,78,95,124,135,153,159,167,177,190],"beta":[63,79],"mRNAs":[64,96,125,160,168],"increase":[65,126],"coincident":[66,127],"with":[67,102,128,152],"mRNA.":[71],"Serotonin":[72],"removal":[73],"decreases":[74],"mRNAs,":[80],"effect":[82],"rapidly":[85],"reversed":[86],"upon":[87],"readdition":[88],"Conversely,":[91],"serotonin-dependent":[92,176],"increases":[93],"are":[97],"blocked":[98],"progesterone.":[100],"Experiments":[101],"5-HT2":[103,115],"receptor":[104,116,154],"agonists":[105],"antagonists":[107],"indicate":[108,174],"induction":[110],"mediated":[112],"subtype.":[117],"In":[118],"serotonin-treated":[119],"late":[121],"collagenase.":[132],"Similarly,":[133],"exogenous":[134],"fully":[136],"substitutes":[137],"for":[138,185],"lipopolysaccharide":[139],"stimulating":[141],"culture.":[149],"Cells":[150],"treated":[151],"antagonist":[155,170],"make":[158],"or":[161],"but":[163],"following":[169],"removal.":[171],"results":[173],"cell":[182],"required":[184],"participates":[191],"its":[193],"own":[194],"via":[196],"an":[197],"autocrine":[198],"mechanism.":[199]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
