{"id":"https://openalex.org/W1925258614","doi":null,"title":"Verapamil Hydrochloride Systems Design for Pulsincap Drug Delivery: Development and Evaluation Studies","display_name":"Verapamil Hydrochloride Systems Design for Pulsincap Drug Delivery: Development and Evaluation Studies","publication_year":2012,"publication_date":"2012-11-24","ids":{"openalex":"https://openalex.org/W1925258614","mag":"1925258614"},"language":"en","primary_location":{"id":"pmh:oai:jbpr.in:article/488","doi":null,"is_oa":true,"landing_page_url":"https://jbpr.in/index.php/jbpr/article/view/488","pdf_url":null,"source":{"id":"https://openalex.org/S2764427339","display_name":"Journal of Biomedical and Pharmaceutical Research","issn_l":"2279-0594","issn":["2279-0594","2589-8752"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361153829","host_organization_name":"CAB PUBLISHER","host_organization_lineage":["https://openalex.org/P4361153829"],"host_organization_lineage_names":["CAB PUBLISHER"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2589-8752","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jbpr.in/index.php/jbpr/article/view/488","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027279026","display_name":"P Muniswamy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Muniswamy","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur, Karnataka, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113692534","display_name":"Madanahalli R Jagannath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madanahalli R Jagannath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676322","display_name":"M.N. Hafsa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.N. Hafsa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009914975","display_name":"Shanta Kumar S.M","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanta Kumar S.M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039288776","display_name":"Putta Rajesh Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Putta Rajesh Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06956991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"03","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulsatile-drug-delivery","display_name":"pulsatile drug delivery","score":0.9229999780654907},{"id":"https://openalex.org/keywords/verapamil-hydrochloride","display_name":"verapamil hydrochloride","score":0.9020000100135803},{"id":"https://openalex.org/keywords/xanthan-gum","display_name":"xanthan gum","score":0.9629999995231628},{"id":"https://openalex.org/keywords/guar-gum","display_name":"guar gum","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.9100000262260437},{"id":"https://openalex.org/keywords/time-delay","display_name":"time delay","score":0.6890000104904175},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tablet-formulation-optimization","display_name":"tablet formulation optimization","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C2780100132","wikidata":"https://www.wikidata.org/wiki/Q410768","display_name":"Xanthan gum","level":3,"score":0.7672950029373169},{"id":"https://openalex.org/C2776725572","wikidata":"https://www.wikidata.org/wiki/Q422071","display_name":"Guar gum","level":2,"score":0.7302381992340088},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.6970555782318115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6325080394744873},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.6172751784324646},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.5584859848022461},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5375810265541077},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4995229244232178},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.48355361819267273},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.42759838700294495},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.425142765045166},{"id":"https://openalex.org/C88463166","wikidata":"https://www.wikidata.org/wiki/Q1543243","display_name":"Granulation","level":2,"score":0.42275270819664},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.23464566469192505},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2018040120601654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09636491537094116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09489452838897705},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07892373204231262},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.07876250147819519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jbpr.in:article/488","doi":null,"is_oa":true,"landing_page_url":"https://jbpr.in/index.php/jbpr/article/view/488","pdf_url":null,"source":{"id":"https://openalex.org/S2764427339","display_name":"Journal of Biomedical and Pharmaceutical Research","issn_l":"2279-0594","issn":["2279-0594","2589-8752"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361153829","host_organization_name":"CAB PUBLISHER","host_organization_lineage":["https://openalex.org/P4361153829"],"host_organization_lineage_names":["CAB PUBLISHER"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2589-8752","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1925258614","doi":null,"is_oa":true,"landing_page_url":"http://jbpr.in/index.php/jbpr/article/view/488","pdf_url":null,"source":{"id":"https://openalex.org/S2764427339","display_name":"Journal of Biomedical and Pharmaceutical Research","issn_l":"2279-0594","issn":["2279-0594","2589-8752"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361153829","host_organization_name":"CAB PUBLISHER","host_organization_lineage":["https://openalex.org/P4361153829"],"host_organization_lineage_names":["CAB PUBLISHER"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biomedical and Pharmaceutical Research","raw_type":null}],"best_oa_location":{"id":"pmh:oai:jbpr.in:article/488","doi":null,"is_oa":true,"landing_page_url":"https://jbpr.in/index.php/jbpr/article/view/488","pdf_url":null,"source":{"id":"https://openalex.org/S2764427339","display_name":"Journal of Biomedical and Pharmaceutical Research","issn_l":"2279-0594","issn":["2279-0594","2589-8752"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361153829","host_organization_name":"CAB PUBLISHER","host_organization_lineage":["https://openalex.org/P4361153829"],"host_organization_lineage_names":["CAB PUBLISHER"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2589-8752","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7216981744","https://openalex.org/W2963520211","https://openalex.org/W2363550362","https://openalex.org/W4360619156","https://openalex.org/W2899735788","https://openalex.org/W1911105504","https://openalex.org/W2150130350","https://openalex.org/W7219391712","https://openalex.org/W7219193086","https://openalex.org/W6949216877"],"abstract_inverted_index":{"Aim":[0],"of":[1,18,28,50,74,85,174,185,202,219,268],"the":[2,26,128,200,217,223,266],"present":[3],"work":[4],"was":[5,149,239],"to":[6,14,62,122,153,197,204,212,214],"formulate":[7],"and":[8,54,90,97,103,125,136,146,206],"evaluate":[9],"pulsatile":[10,247,251],"drug":[11,52,64,121,133,230,270,275],"delivery":[12,46],"system":[13,47],"achieve":[15],"time":[16,39,238],"release":[17,63,139,162,191,231,252],"Verapamil":[19,86,108,277],"HCl,":[20],"based":[21],"on":[22],"pulsincap":[23],"approach":[24],"for":[25,127,171,182,192,207,245],"treatment":[27],"anti":[29],"hypertensive":[30],"drug.":[31],"As":[32],"fat":[33],"production":[34],"takes":[35],"place":[36],"in":[37,137,160,199],"night":[38],"is":[40,48],"more":[41],"than":[42],"day":[43],"time.":[44,69],"Pulsatile":[45,274],"capable":[49],"delivering":[51],"when":[53],"where":[55],"it":[56],"required":[57],"most.":[58],"Time-delayed":[59],"tablets,":[60],"designed":[61],"after":[65],"a":[66,100,155,172,183,260],"predictable":[67],"lag":[68,157,237],"The":[70,107,159,188,249],"basic":[71],"design":[72],"consists":[73],"an":[75,242],"insoluble":[76],"hard":[77],"gelatin":[78],"capsule":[79],"body":[80],"filled":[81],"with":[82,88,99,117,235,265],"physical":[83,114],"mixture":[84,115],"HCl":[87,109],"HPMC":[89,193],"Guar":[91,208,281],"gum,":[92],"lactose":[93,118],"as":[94,151,241],"channeling":[95],"agent":[96],"sealed":[98],"Sodium":[101,144],"alginate":[102,145],"xanthan":[104],"gum":[105,148,209],"plug.":[106],"pulsincaps":[110],"were":[111,164,195,210],"prepared":[112,257],"by":[113,119],"method":[116],"varying":[120],"polymer":[123,143],"ratio":[124],"evaluated":[126],"micromeretic":[129],"property,":[130],"percentage":[131],"yield,":[132],"content,":[134],"IR":[135],"vitro":[138,161,284],"study.":[140,285],"A":[141],"hydrogel":[142],"Xanthan":[147,279],"used":[150],"plugs":[152],"maintain":[154],"suitable":[156],"period.":[158],"study":[163],"carried":[165],"out":[166],"using":[167],"pH":[168,179],"1.2":[169],"buffer":[170,181],"period":[173,184],"2":[175],"h":[176,234,262],"then":[177],"7.4":[178],"phosphate":[180],"10":[186],"h.":[187,221],"cumulative":[189],"%":[190],"formulations":[194],"found":[196,211],"be":[198],"range":[201],"82.87%":[203],"90.28%":[205],"be75.28":[213],"98.08%":[215],"at":[216,232],"end":[218],"12":[220,233,261],"From":[222],"obtained":[224],"result":[225],"formulation":[226,244,258],"GS3":[227],"showing":[228],"94.5%":[229],"3h":[236],"selected":[240],"optimized":[243],"designing":[246],"device.":[248],"programmable":[250],"has":[253],"been":[254],"achieved":[255],"from":[256],"over":[259],"period,":[263],"consistent":[264],"demands":[267],"Pulsincap":[269],"delivery.":[271],"KEY":[272],"WORDS:":[273],"delivery;":[276],"HCl;":[278],"gum;":[280,282],"In":[283]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}