{"id":"https://openalex.org/W1925250493","doi":null,"title":"Thioredoxin Reductase as a Target Enzyme for Electrophilic Anticancer Drugs","display_name":"Thioredoxin Reductase as a Target Enzyme for Electrophilic Anticancer Drugs","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1925250493","mag":"1925250493"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26899798","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Thioredoxin_reductase_as_a_target_enzyme_for_electrophilic_anticancer_drugs/26899798","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/40771","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000987444","display_name":"Sofi E. Eriksson","orcid":"https://orcid.org/0000-0001-5214-9219","observed_orcids":["https://orcid.org/0000-0001-5214-9219"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sofi Eriksson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5214-9219","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000987444"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thioredoxin-reductase","display_name":"thioredoxin reductase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/txnrd1","display_name":"thioredoxin reductase 1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/selenocysteine","display_name":"selenocysteine","score":0.8230000138282776},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7179999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6380000114440918},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6629999876022339},{"id":"https://openalex.org/keywords/rita","display_name":"RITA","score":0.9779999852180481},{"id":"https://openalex.org/keywords/red-wine-polyphenols","display_name":"red wine polyphenols","score":0.8230000138282776},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.871999979019165},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.7509999871253967},{"id":"https://openalex.org/keywords/selenoproteins","display_name":"selenoproteins","score":0.6060000061988831},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.453000009059906},{"id":"https://openalex.org/keywords/menadione","display_name":"menadione","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2777737464","wikidata":"https://www.wikidata.org/wiki/Q2540636","display_name":"Thioredoxin reductase","level":4,"score":0.9131094217300415},{"id":"https://openalex.org/C2776841403","wikidata":"https://www.wikidata.org/wiki/Q2745644","display_name":"Selenoprotein","level":5,"score":0.8444105386734009},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.6578748226165771},{"id":"https://openalex.org/C4710235","wikidata":"https://www.wikidata.org/wiki/Q420089","display_name":"Ribonucleotide reductase","level":4,"score":0.620083212852478},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5887457132339478},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5703126192092896},{"id":"https://openalex.org/C2776087148","wikidata":"https://www.wikidata.org/wiki/Q408663","display_name":"Selenocysteine","level":4,"score":0.5415172576904297},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5044523477554321},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46991339325904846},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.45937666296958923},{"id":"https://openalex.org/C2776243873","wikidata":"https://www.wikidata.org/wiki/Q421230","display_name":"Auranofin","level":3,"score":0.4561424255371094},{"id":"https://openalex.org/C2777486698","wikidata":"https://www.wikidata.org/wiki/Q24782718","display_name":"Aldo-keto reductase","level":4,"score":0.4409513771533966},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4320603609085083},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.4041670560836792},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3879323899745941},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3654381036758423},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3344351053237915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2794903516769409},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.2727806270122528},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.259518027305603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20437106490135193},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.17990270256996155},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.13583365082740784},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.13365280628204346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09737551212310791},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26899798","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Thioredoxin_reductase_as_a_target_enzyme_for_electrophilic_anticancer_drugs/26899798","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/40771","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40771","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1925250493","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/40771/Thesis_Sofi_Eriksson.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/40771","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40771","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":217,"referenced_works":["https://openalex.org/W2751652","https://openalex.org/W12424231","https://openalex.org/W148936752","https://openalex.org/W354932013","https://openalex.org/W574669807","https://openalex.org/W1208971950","https://openalex.org/W1493042866","https://openalex.org/W1504064499","https://openalex.org/W1504571050","https://openalex.org/W1511056828","https://openalex.org/W1513390880","https://openalex.org/W1551392207","https://openalex.org/W1581414347","https://openalex.org/W1583295309","https://openalex.org/W1595838029","https://openalex.org/W1650797637","https://openalex.org/W1787410800","https://openalex.org/W1809723326","https://openalex.org/W1834580303","https://openalex.org/W1917090889","https://openalex.org/W1964448478","https://openalex.org/W1964764834","https://openalex.org/W1965788245","https://openalex.org/W1965804065","https://openalex.org/W1966597938","https://openalex.org/W1968075505","https://openalex.org/W1969268163","https://openalex.org/W1973328612","https://openalex.org/W1977046275","https://openalex.org/W1979172728","https://openalex.org/W1980023909","https://openalex.org/W1980411311","https://openalex.org/W1981120411","https://openalex.org/W1981649873","https://openalex.org/W1984568177","https://openalex.org/W1984697058","https://openalex.org/W1985498546","https://openalex.org/W1986251916","https://openalex.org/W1986370482","https://openalex.org/W1986454658","https://openalex.org/W1987338970","https://openalex.org/W1989412579","https://openalex.org/W1990050039","https://openalex.org/W1991303607","https://openalex.org/W1991387227","https://openalex.org/W1991568967","https://openalex.org/W1992049458","https://openalex.org/W1992533564","https://openalex.org/W1992726314","https://openalex.org/W1994420474","https://openalex.org/W1994977897","https://openalex.org/W1995185113","https://openalex.org/W1995592237","https://openalex.org/W1995856733","https://openalex.org/W1997046377","https://openalex.org/W1998937133","https://openalex.org/W1999162622","https://openalex.org/W1999721954","https://openalex.org/W2001415595","https://openalex.org/W2002907671","https://openalex.org/W2003675056","https://openalex.org/W2003701831","https://openalex.org/W2008203769","https://openalex.org/W2008820074","https://openalex.org/W2009401998","https://openalex.org/W2010930508","https://openalex.org/W2013485244","https://openalex.org/W2013986083","https://openalex.org/W2014602110","https://openalex.org/W2015803999","https://openalex.org/W2015837249","https://openalex.org/W2016066167","https://openalex.org/W2016318035","https://openalex.org/W2017695252","https://openalex.org/W2018038176","https://openalex.org/W2018123263","https://openalex.org/W2020170893","https://openalex.org/W2020821477","https://openalex.org/W2020986313","https://openalex.org/W2021679868","https://openalex.org/W2022911774","https://openalex.org/W2023598024","https://openalex.org/W2023970655","https://openalex.org/W2023971274","https://openalex.org/W2027413271","https://openalex.org/W2027724252","https://openalex.org/W2028553570","https://openalex.org/W2028556682","https://openalex.org/W2028905776","https://openalex.org/W2028919538","https://openalex.org/W2029414958","https://openalex.org/W2030396459","https://openalex.org/W2030421521","https://openalex.org/W2031478032","https://openalex.org/W2032790033","https://openalex.org/W2034269086","https://openalex.org/W2035022316","https://openalex.org/W2035153027","https://openalex.org/W2037303548","https://openalex.org/W2038411014","https://openalex.org/W2039013494","https://openalex.org/W2040252306","https://openalex.org/W2040856926","https://openalex.org/W2042567737","https://openalex.org/W2043427695","https://openalex.org/W2043825211","https://openalex.org/W2045899523","https://openalex.org/W2047437538","https://openalex.org/W2047558133","https://openalex.org/W2049460161","https://openalex.org/W2050608555","https://openalex.org/W2052544801","https://openalex.org/W2053200644","https://openalex.org/W2053567988","https://openalex.org/W2054912533","https://openalex.org/W2058210960","https://openalex.org/W2058461613","https://openalex.org/W2059378857","https://openalex.org/W2061958603","https://openalex.org/W2062061471","https://openalex.org/W2062263217","https://openalex.org/W2063537749","https://openalex.org/W2065259435","https://openalex.org/W2066004242","https://openalex.org/W2066411725","https://openalex.org/W2067138633","https://openalex.org/W2067912293","https://openalex.org/W2068102085","https://openalex.org/W2069326406","https://openalex.org/W2071497993","https://openalex.org/W2073861666","https://openalex.org/W2074280810","https://openalex.org/W2076358165","https://openalex.org/W2076748372","https://openalex.org/W2077117930","https://openalex.org/W2077792640","https://openalex.org/W2078363421","https://openalex.org/W2079293913","https://openalex.org/W2079801324","https://openalex.org/W2079912175","https://openalex.org/W2080388275","https://openalex.org/W2081325732","https://openalex.org/W2081718595","https://openalex.org/W2082334667","https://openalex.org/W2082467091","https://openalex.org/W2083904981","https://openalex.org/W2084004698","https://openalex.org/W2084015464","https://openalex.org/W2085035611","https://openalex.org/W2086793077","https://openalex.org/W2088888368","https://openalex.org/W2089999198","https://openalex.org/W2093775600","https://openalex.org/W2095557093","https://openalex.org/W2095617847","https://openalex.org/W2096492418","https://openalex.org/W2098776116","https://openalex.org/W2099115268","https://openalex.org/W2099792161","https://openalex.org/W2099877688","https://openalex.org/W2099903047","https://openalex.org/W2100399003","https://openalex.org/W2100616791","https://openalex.org/W2101861123","https://openalex.org/W2102944887","https://openalex.org/W2103492103","https://openalex.org/W2103650142","https://openalex.org/W2103665725","https://openalex.org/W2104010513","https://openalex.org/W2104928760","https://openalex.org/W2113555591","https://openalex.org/W2113714326","https://openalex.org/W2115560639","https://openalex.org/W2115708356","https://openalex.org/W2117692326","https://openalex.org/W2119402894","https://openalex.org/W2121374374","https://openalex.org/W2124524961","https://openalex.org/W2126461779","https://openalex.org/W2127525676","https://openalex.org/W2127908806","https://openalex.org/W2128920732","https://openalex.org/W2128977212","https://openalex.org/W2129486363","https://openalex.org/W2132863919","https://openalex.org/W2136573391","https://openalex.org/W2139864041","https://openalex.org/W2142461351","https://openalex.org/W2144486308","https://openalex.org/W2145402376","https://openalex.org/W2146316921","https://openalex.org/W2146558971","https://openalex.org/W2149659371","https://openalex.org/W2149668250","https://openalex.org/W2150104999","https://openalex.org/W2154975058","https://openalex.org/W2158103448","https://openalex.org/W2158106682","https://openalex.org/W2161446823","https://openalex.org/W2162289848","https://openalex.org/W2163187840","https://openalex.org/W2164051171","https://openalex.org/W2165138445","https://openalex.org/W2168433858","https://openalex.org/W2168973737","https://openalex.org/W2171258641","https://openalex.org/W2172183886","https://openalex.org/W2178778111","https://openalex.org/W2181654645","https://openalex.org/W2204123985","https://openalex.org/W2269435967","https://openalex.org/W2270207284","https://openalex.org/W2415763315","https://openalex.org/W2415835525","https://openalex.org/W2416282704","https://openalex.org/W3118977482","https://openalex.org/W4245684785"],"related_works":["https://openalex.org/W2520236130","https://openalex.org/W1772790083","https://openalex.org/W2803786383","https://openalex.org/W3196211867","https://openalex.org/W2750563004","https://openalex.org/W4242206009","https://openalex.org/W2066520651","https://openalex.org/W2082334667","https://openalex.org/W1782197118","https://openalex.org/W1991303607"],"abstract_inverted_index":{"Induced":[0],"production":[1],"of":[2,11,28,35,51,131,156,164,211,235,324,331,388,439,505,513,529,558,565,639,683,710],"reactive":[3],"oxygen":[4],"species":[5,363],"(ROS)":[6],"is":[7,30,122,137,144,347,391,491],"a":[8,123,167,195,220,227,261,336,370,456,643,680],"common":[9],"attribute":[10],"most":[12],"cancer":[13,18,254,457],"cells.":[14,375],"One":[15],"strategy":[16],"for":[17,77,118,171,178,445,645],"cells":[19,282,296],"to":[20,31,105,160,198,242,248,252,312,368,561],"maneuver":[21],"the":[22,33,43,54,129,162,183,267,290,305,332,342,374,386,394,436,503,562,708],"increased":[23,274,421],"and":[24,38,53,71,94,101,125,143,174,205,237,247,272,278,355,360,400,428,477,480,507,595,602,635,705],"potentially":[25],"toxic":[26,251],"levels":[27,293,479,528],"ROS":[29],"induce":[32,199],"expression":[34,416],"cellular":[36],"antioxidants":[37],"redox":[39],"regulators,":[40],"such":[41,352],"as":[42,115,166,353,642],"thioredoxin":[44,56,530,596],"(Trx)":[45],"system.":[46],"The":[47,134,154],"Trx":[48,52,314],"system":[49],"consists":[50],"NADPH-dependent":[55],"reductase":[57,74,531,597,700],"(TrxR":[58],"protein/Txnrd1":[59],"gene).":[60],"TrxR":[61,121,245,268,307,395,403,415,482],"reduces":[62,66],"Trx,":[63],"which":[64,472],"subsequently":[65],"disulfides":[67],"in":[68,108,128,226,260,294,318,373,380,397,405,417,431,673,703],"various":[69,253],"proteins":[70],"supplies":[72],"ribonucleotide":[73],"with":[75,182,341,349,409,420],"electrons":[76],"DNA":[78,671],"synthesis.":[79],"Mammalian":[80],"TrxRs":[81],"have":[82,103,364,498],"wide":[83],"substrate":[84],"specificity,":[85],"also":[86,240,462],"reducing":[87],"other":[88],"targets":[89,117],"than":[90,444],"Trx.":[91],"Cytosolic":[92],"Trx1":[93],"TrxR1":[95,165,258,280,359,490,559],"are":[96,112],"induced":[97,219,469],"upon":[98],"oxidative":[99],"stress":[100],"both":[102,398],"proven":[104],"be":[106,249],"overexpressed":[107],"many":[109],"tumors.":[110],"They":[111],"therefore":[113],"proposed":[114],"potential":[116,168],"anticancer":[119,172,186,493],"therapy.":[120],"selenoprotein":[124],"contains":[126],"selenium":[127],"form":[130],"selenocysteine":[132],"(Sec).":[133],"Sec":[135],"residue":[136],"mostly":[138],"de-protonated":[139],"at":[140],"physiological":[141],"pH":[142],"highly":[145,250],"nucleophilic,":[146],"thus":[147,447],"being":[148],"easily":[149],"targeted":[150],"by":[151,203,270,393,567,713],"electrophilic":[152],"drugs.":[153],"aim":[155],"this":[157,486],"thesis":[158,191,487],"was":[159,239,310,407,441,461,473],"address":[161],"role":[163,372],"drug":[169,187,494],"target":[170,495],"therapy":[173],"evaluate":[175],"its":[176,508],"importance":[177,638],"side":[179,350,510],"effects":[180,351,599],"associated":[181,348,408,509],"widely":[184],"used":[185],"cisplatin":[188],"(cDDP).":[189],"This":[190],"reports":[192],"that":[193,217,304,321,385,435,464,489,496],"RITA,":[194],"compound":[196],"shown":[197,241,367,463],"p53":[200,207,228],"dependent":[201,229,474],"cell-death":[202],"interacting":[204],"restoring":[206],"activity,":[208],"caused":[209,273,481],"inhibition":[210,557],"TrxR1.":[212],"Cell":[213,569,605],"culture":[214],"experiments":[215,317],"showed":[216,320,434],"RITA":[218],"130":[221],"kDa":[222],"covalently":[223],"linked":[224],"TrxR1-dimer,":[225],"fashion.":[230],"Furthermore,":[231],"red":[232],"wine,":[233],"rich":[234],"polyphenols":[236],"flavonoids,":[238],"efficiently":[243],"inhibit":[244],"activity":[246,269,308,404],"cell":[255,264,301,458,470,593],"lines.":[256],"Transient":[257],"knockdown":[259,281,295],"lung":[262],"carcinoma":[263],"line":[265,459],"lowered":[266],"90%":[271],"sensitivity":[275],"towards":[276,287],"menadione":[277],"1-chloro-2,4-dinitrobenzene.":[279],"were,":[283],"however,":[284],"more":[285,410],"resistant":[286],"cDDP.":[288],"Depleting":[289],"glutathione":[291,678],"(GSH)":[292],"had":[297],"no":[298],"effect":[299],"on":[300,377,426,475,502],"growth,":[302],"suggesting":[303],"remaining":[306],"still":[309],"enough":[311],"sustain":[313],"function.":[315],"Recent":[316],"mice":[319,381],"normal":[322],"replication":[323,672],"hepatocytes":[325],"required":[326],"either":[327,677],"one":[328],"functional":[329,337],"copy":[330],"Txnrd1":[333],"gene":[334],"or":[335,679],"GSH":[338],"system,":[339],"agreeing":[340],"previous":[343],"interpretation.":[344],"cDDP":[345,357,427,440],"treatment":[346],"ototoxicity":[354],"nephrotoxicity.":[356],"inhibits":[358],"cDDP-derivatized":[361],"enzyme":[362],"previously":[365],"been":[366],"gain":[369],"pro-oxidant":[371],"Data":[376],"cDDP-triggered":[378],"nephrotoxicity":[379,711],"presented":[382],"herein":[383],"suggest":[384],"degree":[387],"kidney":[389,418,422,706],"damage":[390],"influenced":[392],"status":[396,702],"liver":[399,406,675,704],"kidney.":[401],"Decreased":[402],"renal":[411],"damage,":[412],"while":[413],"high":[414],"correlated":[419],"toxicity.":[423],"Pharmacokinetic":[424],"studies":[425],"oxaliplatin":[429,636],"(Oxa)":[430],"guinea":[432],"pig,":[433],"cochlear":[437,640],"uptake":[438],"significantly":[442],"higher":[443],"Oxa,":[446,468],"explaining":[448],"why":[449],"Oxa":[450],"only":[451],"rarely":[452],"causes":[453],"ototoxicity.":[454,646],"Using":[455],"it":[460],"cDDP,":[465],"but":[466],"not":[467],"death":[471,594],"calcium":[476],"superoxide":[478],"inhibition.":[483],"In":[484],"summary,":[485],"shows":[488],"an":[492,499],"can":[497],"important":[500],"impact":[501],"outcome":[504],"chemotherapy":[506],"effects.":[511],"List":[512],"scientific":[514],"papers":[515],"I.":[516],"Eriksson":[517,548,580,616,658,687],"SE,":[518],"Prast-Nielsen":[519],"S,":[520,549,581,617,625,659,688],"Flaberg":[521],"E,":[522,547,619,621],"Szekely":[523],"L,":[524,583],"Arn\u00e9r":[525,552,584,626,666,695],"ES.":[526],"High":[527],"1":[532,701],"modulate":[533],"drug-specific":[534],"cytotoxic":[535],"efficacy.":[536],"Free":[537],"Radic":[538],"Biol":[539],"Med.":[540],"2009":[541,571,607,651],"Dec":[542],"1;47(11):1661-71.":[543],"https://doi.org/10.1016/j.freeradbiomed.2009.09.016":[544],"II.":[545],"Hedstr\u00f6m":[546],"Zawacka-Pankau":[550],"J,":[551],"ES,":[553,585,627,667,696],"Selivanova":[554],"G.":[555,633],"p53-dependent":[556],"contributes":[560],"tumor-specific":[563],"induction":[564],"apoptosis":[566],"RITA.":[568],"Cycle.":[570],"Nov":[572],"1;8(21):3576-83.":[573],"https://doi.org/10.4161/cc.8.21.9977":[574],"III.":[575],"Wallenborg":[576],"K,":[577],"Vlachos":[578],"P,":[579],"Huijbregts":[582],"Joseph":[586],"B,":[587],"Hermanson":[588],"O.":[589],"Red":[590],"wine":[591],"triggers":[592],"inhibition:":[598],"beyond":[600],"resveratrol":[601],"SIRT1.":[603],"Exp":[604],"Res.":[606],"May":[608],"1;315(8):1360-71.":[609],"https://doi.org/10.1016/j.yexcr.2009.02.022":[610],"IV.":[611],"Hellberg":[612],"V,":[613],"Wallin":[614],"I,":[615],"Hernlund":[618],"Jerremalm":[620],"Berndtsson":[622],"M,":[623,629],"Eksborg":[624],"Shoshan":[628],"Ehrsson":[630],"H,":[631],"Laurell":[632],"Cisplatin":[634],"toxicity:":[637],"kinetics":[641],"determinant":[644],"J":[647],"Natl":[648],"Cancer":[649],"Inst.":[650],"Jan":[652],"7;101(1):37-47.":[653],"https://doi.org/10.1093/jnci/djn418":[654],"V.":[655],"Prigge":[656,691],"JR,":[657,692],"Iverson":[660,689],"SV,":[661,690],"Meade":[662],"TA,":[663],"Capecchi":[664,693],"MR,":[665,694],"Schmidt":[668,697],"EE.":[669,698],"Hepatocyte":[670],"growing":[674],"requires":[676],"single":[681],"allele":[682],"txnrd1.":[684],"[Submitted]":[685],"VI.":[686],"Thioredoxin":[699],"influences":[707],"extent":[709],"triggered":[712],"cisplatin.":[714],"[Manuscript]":[715]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
