{"id":"https://openalex.org/W1925242062","doi":"https://doi.org/10.4049/jimmunol.143.5.1453","title":"Resistance of cytolytic lymphocytes to perforin-mediated killing. Murine cytotoxic T lymphocytes and human natural killer cells do not contain functional soluble homologous restriction factor or other specific soluble protective factors.","display_name":"Resistance of cytolytic lymphocytes to perforin-mediated killing. Murine cytotoxic T lymphocytes and human natural killer cells do not contain functional soluble homologous restriction factor or other specific soluble protective factors.","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W1925242062","doi":"https://doi.org/10.4049/jimmunol.143.5.1453","mag":"1925242062","pmid":"https://pubmed.ncbi.nlm.nih.gov/2503557"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.143.5.1453","doi":"https://doi.org/10.4049/jimmunol.143.5.1453","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.143.5.1453","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Jiang","raw_affiliation_strings":["Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027668084","display_name":"Pedro Muanis Persechini","orcid":"https://orcid.org/0000-0002-3278-1951","observed_orcids":["https://orcid.org/0000-0002-3278-1951"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P M Persechini","raw_affiliation_strings":["Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031324690","display_name":"BICE PERUSSIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Perussia","raw_affiliation_strings":["Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","The Wistar Institute of Anatomy and Biology , Philadelphia, PA 19104","Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113669862","display_name":"J D Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D E Young","raw_affiliation_strings":["Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, The Rockefeller University , New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4998,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81991481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"143","issue":"5","first_page":"1453","last_page":"1460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8190000057220459},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":1.0},{"id":"https://openalex.org/keywords/cytolytic-granules","display_name":"cytolytic granules","score":0.6899999976158142},{"id":"https://openalex.org/keywords/large-granular-lymphocytes","display_name":"large granular lymphocytes","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cytolysin","display_name":"cytolysin","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.9379732608795166},{"id":"https://openalex.org/C80595800","wikidata":"https://www.wikidata.org/wiki/Q937863","display_name":"Cytolysin","level":4,"score":0.8640735149383545},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8129656910896301},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.7844259738922119},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.7360386848449707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6168871521949768},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.47848933935165405},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.45784705877304077},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3793575167655945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3439885973930359},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2672165632247925},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14826700091362},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010206","descriptor_name":"Papain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018957","descriptor_name":"CD59 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054353","descriptor_name":"Perforin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.143.5.1453","doi":"https://doi.org/10.4049/jimmunol.143.5.1453","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.143.5.1453","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:2503557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2503557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2551425573","display_name":"RECEPTORS FOR IMMUNOGLOBULIN G ON LEUKOCYTES","funder_award_id":"R01CA037155","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3193714930","display_name":null,"funder_award_id":"AI 24755","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4037081101","display_name":"MOLECULAR MECHANISMS OF LYMPHOCYTE MEDIATED KILLING","funder_award_id":"R01CA047307","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994288430","https://openalex.org/W2087590608","https://openalex.org/W2137930664","https://openalex.org/W2049956305","https://openalex.org/W2062052846","https://openalex.org/W7134312723","https://openalex.org/W2406311186","https://openalex.org/W1899031583","https://openalex.org/W2014663444","https://openalex.org/W2032360303"],"abstract_inverted_index":{"CTL":[0,105,167],"and":[1,27,53,106,137,168,185],"NK":[2,108,169],"cells":[3,18],"produce":[4],"a":[5,72,91,155,200],"cytolytic":[6],"pore-forming":[7],"protein":[8],"(perforin,":[9],"cytolysin)":[10],"localized":[11],"in":[12,68,97,161,210],"their":[13],"cytoplasmic":[14],"granules.":[15],"These":[16],"cytotoxic":[17,214],"are":[19],"resistant":[20],"to":[21,43,46,66,70,117,132,134,138,142,192],"killing":[22],"mediated":[23],"by":[24,28,122],"other":[25,207],"lymphocytes":[26,62,215],"purified":[29],"perforin.":[30],"A":[31,146],"membrane":[32],"factor,":[33],"known":[34],"as":[35],"homologous":[36],"restriction":[37],"factor":[38],"(HRF),":[39],"has":[40,182],"been":[41,64],"suggested":[42],"confer":[44],"protection":[45],"different":[47],"cell":[48,177],"types":[49],"against":[50,199,216],"both":[51],"C-":[52],"perforin-mediated":[54,217],"lysis.":[55,218],"The":[56],"granules":[57,99],"of":[58,103,213],"human":[59,107],"large":[60],"granular":[61],"have":[63],"reported":[65],"contain,":[67],"addition":[69],"perforin,":[71],"soluble":[73,92,203,208],"HRF":[74,93,118,205],"activity":[75,94,149],"that":[76,90,113,180,187],"can":[77],"be":[78,120],"eluted":[79,152],"from":[80,153,166,173],"anion-exchange":[81],"columns":[82],"at":[83,140],"115":[84],"mM":[85,144],"NaCl.":[86,145],"Here,":[87],"we":[88],"report":[89],"is":[95,189],"absent":[96],"the":[98,101,114,193],"or":[100,206],"cytosol":[102],"murine":[104],"cells.":[109],"Our":[110,196],"data":[111],"indicate":[112],"inhibition":[115],"attributed":[116],"could":[119],"explained":[121],"exogenous":[123],"EDTA":[124,129],"added":[125],"during":[126],"granule":[127,204],"fractionation.":[128],"was":[130,150,159],"shown":[131],"bind":[133],"Mono":[135],"Q":[136],"elute":[139],"90":[141],"120":[143],"second":[147],"perforin-inhibitory":[148],"also":[151,172],"such":[154],"column.":[156],"However,":[157],"it":[158,181,188],"present":[160],"preparations":[162],"obtained":[163],"not":[164],"only":[165],"cells,":[170],"but":[171],"some":[174],"perforin-susceptible":[175],"tumor":[176],"lines,":[178],"indicating":[179],"nonrestricted":[183],"distribution":[184],"suggesting":[186],"probably":[190],"irrelevant":[191],"perforin-protection":[194],"mechanism.":[195],"results":[197],"argue":[198],"role":[201],"for":[202],"factors":[209],"mediating":[211],"resistance":[212]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
