{"id":"https://openalex.org/W1925191485","doi":"https://doi.org/10.4049/jimmunol.175.9.5637","title":"Cholera Toxin B-Subunit Prevents Activation and Proliferation of Human CD4+ T Cells by Activation of a Neutral Sphingomyelinase in Lipid Rafts","display_name":"Cholera Toxin B-Subunit Prevents Activation and Proliferation of Human CD4+ T Cells by Activation of a Neutral Sphingomyelinase in Lipid Rafts","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W1925191485","doi":"https://doi.org/10.4049/jimmunol.175.9.5637","mag":"1925191485","pmid":"https://pubmed.ncbi.nlm.nih.gov/16237053"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.175.9.5637","doi":"https://doi.org/10.4049/jimmunol.175.9.5637","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.9.5637","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/175/9/5637/1213238/5637.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/175/9/5637/1213238/5637.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003744102","display_name":"Alexandre K. Rouquette\u2010Jazdanian","orcid":"https://orcid.org/0000-0003-2646-0040","observed_orcids":["https://orcid.org/0000-0003-2646-0040"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre K Rouquette-Jazdanian","raw_affiliation_strings":["Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]},{"raw_affiliation_string":"*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072226202","display_name":"Arnaud Foussat","orcid":"https://orcid.org/0000-0002-8938-9993","observed_orcids":["https://orcid.org/0000-0002-8938-9993"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arnaud Foussat","raw_affiliation_strings":["Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]},{"raw_affiliation_string":"*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045375697","display_name":"Laurence Lamy","orcid":"https://orcid.org/0000-0002-6967-9969","observed_orcids":["https://orcid.org/0000-0002-6967-9969"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Lamy","raw_affiliation_strings":["Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]},{"raw_affiliation_string":"*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044009414","display_name":"Claudette Pelassy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claudette Pelassy","raw_affiliation_strings":["Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]},{"raw_affiliation_string":"*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082298580","display_name":"Patricia Lagadec","orcid":"https://orcid.org/0000-0002-5105-782X","observed_orcids":["https://orcid.org/0000-0002-5105-782X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patricia Lagadec","raw_affiliation_strings":["INSERM Unit 526, Activation des Cellules He\u0301matopoi\u0308e\u0301tiques, Physiologie de la Survie et de la Mort Cellulaires et Infections Virales, IFR 50 Ge\u0301ne\u0301tique et Signalisation Mole\u0301culaires, Faculte\u0301 de Me\u0301decine Pasteur , Nice Cedex 2 ,","\u2020 INSERM Unit 526, Activation des Cellules He\u0301matopoi\u0308e\u0301tiques, Physiologie de la Survie et de la Mort Cellulaires et Infections Virales, IFR 50 Ge\u0301ne\u0301tique et Signalisation Mole\u0301culaires, Faculte\u0301 de Me\u0301decine Pasteur, Nice Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 526, Activation des Cellules He\u0301matopoi\u0308e\u0301tiques, Physiologie de la Survie et de la Mort Cellulaires et Infections Virales, IFR 50 Ge\u0301ne\u0301tique et Signalisation Mole\u0301culaires, Faculte\u0301 de Me\u0301decine Pasteur , Nice Cedex 2 ,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"\u2020 INSERM Unit 526, Activation des Cellules He\u0301matopoi\u0308e\u0301tiques, Physiologie de la Survie et de la Mort Cellulaires et Infections Virales, IFR 50 Ge\u0301ne\u0301tique et Signalisation Mole\u0301culaires, Faculte\u0301 de Me\u0301decine Pasteur, Nice Cedex 2, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110105344","display_name":"Jean\u2010Philippe Breittmayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Breittmayer","raw_affiliation_strings":["Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]},{"raw_affiliation_string":"*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110164023","display_name":"Claude Aussel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Aussel","raw_affiliation_strings":["Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I , Nice Cedex 3 ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]},{"raw_affiliation_string":"*Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unit 576, IFR 50, Ho\u0302pital de l\u2019Archet I, Nice Cedex 3, France; and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.7227,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.62057015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"175","issue":"9","first_page":"5637","last_page":"5648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholera-toxin-b-subunit","display_name":"cholera toxin B subunit","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cd4-t-cell-activation","display_name":"CD4+ T cell activation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neutral-sphingomyelinase","display_name":"neutral sphingomyelinase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sphingomyelin-synthesis","display_name":"sphingomyelin synthesis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.699999988079071},{"id":"https://openalex.org/keywords/gm1-ganglioside","display_name":"GM1 ganglioside","score":0.9049999713897705},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.7360000014305115},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/phosphatidylcholine-biosynthesis","display_name":"phosphatidylcholine synthesis","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.9072320461273193},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.8908934593200684},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.8234325647354126},{"id":"https://openalex.org/C9132879","wikidata":"https://www.wikidata.org/wiki/Q17100313","display_name":"Raft","level":4,"score":0.7727991938591003},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.7717303037643433},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5999285578727722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.585513174533844},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5533843636512756},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.5385850667953491},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5306322574615479},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.44636037945747375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39844760298728943},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32651931047439575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2910619378089905},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.11801651120185852},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.08883371949195862},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005677","descriptor_name":"G(M1) Ganglioside","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005677","descriptor_name":"G(M1) Ganglioside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015759","descriptor_name":"Ionomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D051571","descriptor_name":"Protein Kinase C-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.175.9.5637","doi":"https://doi.org/10.4049/jimmunol.175.9.5637","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.9.5637","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/175/9/5637/1213238/5637.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16237053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16237053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.7934","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.7934","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jimmunol.org/content/175/9/5637.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.175.9.5637","doi":"https://doi.org/10.4049/jimmunol.175.9.5637","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.9.5637","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/175/9/5637/1213238/5637.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1925191485.pdf","grobid_xml":"https://content.openalex.org/works/W1925191485.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W10200443","https://openalex.org/W130980808","https://openalex.org/W1483800894","https://openalex.org/W1494122614","https://openalex.org/W1496196372","https://openalex.org/W1514632338","https://openalex.org/W1535494842","https://openalex.org/W1539477594","https://openalex.org/W1549255782","https://openalex.org/W1549346812","https://openalex.org/W1577004966","https://openalex.org/W1784927340","https://openalex.org/W1966641285","https://openalex.org/W1969095467","https://openalex.org/W1980334501","https://openalex.org/W1984905622","https://openalex.org/W1998166016","https://openalex.org/W1998249059","https://openalex.org/W2011303793","https://openalex.org/W2014154667","https://openalex.org/W2018140161","https://openalex.org/W2018622490","https://openalex.org/W2018747439","https://openalex.org/W2027999368","https://openalex.org/W2033933409","https://openalex.org/W2034252204","https://openalex.org/W2041576624","https://openalex.org/W2056178732","https://openalex.org/W2057072329","https://openalex.org/W2059510815","https://openalex.org/W2068504553","https://openalex.org/W2070005836","https://openalex.org/W2071046100","https://openalex.org/W2074860444","https://openalex.org/W2074867935","https://openalex.org/W2074885818","https://openalex.org/W2088826163","https://openalex.org/W2092187419","https://openalex.org/W2094032879","https://openalex.org/W2097703746","https://openalex.org/W2105019124","https://openalex.org/W2134423247","https://openalex.org/W2134812217","https://openalex.org/W2142465751","https://openalex.org/W2143447170","https://openalex.org/W2146429642","https://openalex.org/W2152311269","https://openalex.org/W2155265479","https://openalex.org/W2158485209","https://openalex.org/W2161428900","https://openalex.org/W2162181798","https://openalex.org/W2163045442","https://openalex.org/W2164981523","https://openalex.org/W2167598859","https://openalex.org/W2170378058"],"related_works":["https://openalex.org/W7096506492","https://openalex.org/W2073031404","https://openalex.org/W2035383673","https://openalex.org/W185519849","https://openalex.org/W1494655942","https://openalex.org/W1999034769","https://openalex.org/W1535494842","https://openalex.org/W2122715090","https://openalex.org/W2108599822","https://openalex.org/W7097151157"],"abstract_inverted_index":{"The":[0],"inhibition":[1,36],"of":[2,37,55,121],"human":[3],"CD4+":[4,38,134],"T":[5,39,135],"lymphocyte":[6],"activation":[7,131],"and":[8,49,67,97,129],"proliferation":[9],"by":[10],"cholera":[11],"toxin":[12],"B-subunit":[13],"(CTB)":[14],"is":[15],"a":[16,46,71,83],"well-established":[17],"phenomenon;":[18],"nevertheless,":[19],"the":[20,26,34,52,101],"exact":[21],"mechanism":[22],"remained":[23],"unclear.":[24],"In":[25],"present":[27],"study,":[28],"we":[29,106],"propose":[30],"an":[31],"explanation":[32],"for":[33],"rCTB-induced":[35,109],"lymphocytes.":[40],"rCTB":[41,58],"specifically":[42],"binds":[43],"to":[44,76,133],"GM1,":[45],"raft":[47,117],"marker,":[48],"strongly":[50],"modifies":[51],"lipid":[53,103],"composition":[54],"rafts.":[56,104],"First,":[57],"inhibits":[59],"sphingomyelin":[60],"synthesis;":[61,66],"second,":[62],"it":[63,69],"enhances":[64],"phosphatidylcholine":[65],"third,":[68],"activates":[70],"raft-resident":[72],"neutral":[73,77],"sphingomyelinase":[74,78],"resembling":[75],"type":[79],"1,":[80],"thus":[81],"generating":[82],"transient":[84],"ceramide":[85,110,123],"production.":[86],"We":[87],"demonstrated":[88],"that":[89,108],"these":[90],"ceramides":[91],"inhibit":[92],"protein":[93,125],"kinase":[94,126],"Calpha":[95,127],"phosphorylation":[96],"its":[98],"translocation":[99],"into":[100],"modified":[102],"Furthermore,":[105],"show":[107],"production":[111],"activate":[112],"NF-kappaB.":[113],"Combined":[114],"all":[115],"together:":[116],"modification":[118],"in":[119],"terms":[120],"lipids,":[122],"production,":[124],"inhibition,":[128],"NF-kappaB":[130],"lead":[132],"cell":[136],"inhibition.":[137]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
