{"id":"https://openalex.org/W1925157258","doi":"https://doi.org/10.1128/mcb.19.7.4643","title":"Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase","display_name":"Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W1925157258","doi":"https://doi.org/10.1128/mcb.19.7.4643","mag":"1925157258","pmid":"https://pubmed.ncbi.nlm.nih.gov/10373513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/84262"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.19.7.4643","doi":"https://doi.org/10.1128/mcb.19.7.4643","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.19.7.4643","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/84262","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxia Li","raw_affiliation_strings":["Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037641016","display_name":"Mairead Commane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mairead Commane","raw_affiliation_strings":["Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032068307","display_name":"Carmel Burns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmel Burns","raw_affiliation_strings":["Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063231200","display_name":"Kalpa K. Vithalani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalpa Vithalani","raw_affiliation_strings":["Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108483875","display_name":"Zhaodan Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zhaodan Cao","raw_affiliation_strings":["Tularik, Incorporated","#N#Tularik, Incorporated, South San Francisco, California 94080#N#2#N##N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tularik, Incorporated","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"#N#Tularik, Incorporated, South San Francisco, California 94080#N#2#N##N#","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080998429","display_name":"George Robert Stark","orcid":"https://orcid.org/0000-0002-8776-9597","observed_orcids":["https://orcid.org/0000-0002-8776-9597"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George R. Stark","raw_affiliation_strings":["Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"#N#Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,#N#1#N# and","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9049,"has_fulltext":false,"cited_by_count":222,"citation_normalized_percentile":{"value":0.9703528,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"7","first_page":"4643","last_page":"4652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7871000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7871000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-1-signaling","display_name":"IL-1 signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interleukin-1-receptor-associated-kinase","display_name":"IRAK","score":0.9259999990463257},{"id":"https://openalex.org/keywords/complementation-analysis","display_name":"complementation analysis","score":0.503000020980835},{"id":"https://openalex.org/keywords/recessive-mutations","display_name":"recessive mutations","score":0.7409999966621399},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/jun-kinase","display_name":"Jun kinase","score":0.796999990940094},{"id":"https://openalex.org/keywords/atp-binding-site-mutation","display_name":"ATP-binding site mutation","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.837896466255188},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.6764118075370789},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6726576685905457},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6491391062736511},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6055156588554382},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5570983290672302},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.5289400219917297},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48334142565727234},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4515754282474518},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4142664968967438},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3013903796672821},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2679394781589508},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18159180879592896},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053592","descriptor_name":"Interleukin-1 Receptor-Associated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.19.7.4643","doi":"https://doi.org/10.1128/mcb.19.7.4643","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.19.7.4643","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:84262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/84262","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:10373513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10373513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.3382","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.3382","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/19/7/4643.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:84262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/84262","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5062867232","display_name":"Integrated EGFR function in cytokine-driven inflammation and cancer","funder_award_id":"P01CA062220","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W75708282","https://openalex.org/W107172435","https://openalex.org/W118616534","https://openalex.org/W135294775","https://openalex.org/W1483162601","https://openalex.org/W1489638598","https://openalex.org/W1492571211","https://openalex.org/W1513954632","https://openalex.org/W1515994079","https://openalex.org/W1571320850","https://openalex.org/W1601124709","https://openalex.org/W1914692347","https://openalex.org/W1963761369","https://openalex.org/W1965971815","https://openalex.org/W1969501356","https://openalex.org/W1969929211","https://openalex.org/W1969979508","https://openalex.org/W1972414794","https://openalex.org/W1976681032","https://openalex.org/W1979520552","https://openalex.org/W1979634801","https://openalex.org/W1980768491","https://openalex.org/W1982390204","https://openalex.org/W1983668987","https://openalex.org/W1985118687","https://openalex.org/W1986663284","https://openalex.org/W1987274954","https://openalex.org/W1989166339","https://openalex.org/W1989844987","https://openalex.org/W1995507251","https://openalex.org/W1997509253","https://openalex.org/W1998160288","https://openalex.org/W2001343165","https://openalex.org/W2004986546","https://openalex.org/W2005758394","https://openalex.org/W2005900169","https://openalex.org/W2006470470","https://openalex.org/W2017883909","https://openalex.org/W2025609599","https://openalex.org/W2029275361","https://openalex.org/W2032514624","https://openalex.org/W2040470926","https://openalex.org/W2041576624","https://openalex.org/W2050311264","https://openalex.org/W2051538397","https://openalex.org/W2053128835","https://openalex.org/W2056831005","https://openalex.org/W2064558057","https://openalex.org/W2064676254","https://openalex.org/W2065257477","https://openalex.org/W2067680656","https://openalex.org/W2070597700","https://openalex.org/W2071503299","https://openalex.org/W2077575210","https://openalex.org/W2078136106","https://openalex.org/W2086008721","https://openalex.org/W2087596041","https://openalex.org/W2089372467","https://openalex.org/W2089938437","https://openalex.org/W2091695331","https://openalex.org/W2095308206","https://openalex.org/W2097610774","https://openalex.org/W2103565638","https://openalex.org/W2122312331","https://openalex.org/W2123898551","https://openalex.org/W2136690547","https://openalex.org/W2142541950","https://openalex.org/W2147541997","https://openalex.org/W2149098147","https://openalex.org/W2151707666","https://openalex.org/W2151892297","https://openalex.org/W2154283357","https://openalex.org/W2157086104","https://openalex.org/W2159979956","https://openalex.org/W2161239928","https://openalex.org/W2167212079","https://openalex.org/W2167259834","https://openalex.org/W2314225431","https://openalex.org/W2331176038","https://openalex.org/W2336702489","https://openalex.org/W2399467729","https://openalex.org/W2728081960"],"related_works":["https://openalex.org/W1964985092","https://openalex.org/W1988217385","https://openalex.org/W2030618676","https://openalex.org/W1893931735","https://openalex.org/W2036475326","https://openalex.org/W2141150979","https://openalex.org/W2013205499","https://openalex.org/W121555879","https://openalex.org/W1977835740","https://openalex.org/W2034615108"],"abstract_inverted_index":{"Mutagenized":[0],"human":[1],"293":[2],"cells":[3,75],"containing":[4],"an":[5],"interleukin-1":[6],"(IL-1)-regulated":[7],"herpes":[8],"thymidine":[9],"kinase":[10,49,86,114,130,177],"gene,":[11],"selected":[12],"in":[13,42,54,61,73,89,98,118,150,169],"IL-1":[14,47,119,141],"and":[15,35,163],"gancyclovir,":[16],"have":[17],"yielded":[18],"many":[19],"independent":[20],"clones":[21,29],"that":[22,64,102,172],"are":[23,59,96],"unresponsive":[24],"to":[25,80],"IL-1.":[26,81],"The":[27],"four":[28],"analyzed":[30],"here":[31],"carry":[32],"recessive":[33],"mutations":[34],"represent":[36],"three":[37],"complementation":[38,43],"groups.":[39],"Mutant":[40],"A":[41],"group":[44],"I1":[45],"lacks":[46],"receptor-associated":[48],"(IRAK),":[50],"while":[51],"the":[52,55,110,113,148,151],"mutants":[53],"other":[56],"two":[57],"groups":[58],"defective":[60],"unknown":[62],"components":[63],"function":[65],"upstream":[66],"of":[67,70,112,116],"IRAK.":[68],"Expression":[69],"exogenous":[71],"IRAK":[72,103,117,155],"I1A":[74,91,134],"(I1A-IRAK)":[76],"restores":[77],"their":[78],"responsiveness":[79],"Neither":[82],"NFkappaB":[83],"nor":[84],"Jun":[85],"is":[87,104],"activated":[88],"IL-1-treated":[90],"cells,":[92,100,135],"but":[93],"these":[94],"responses":[95],"restored":[97],"I1A-IRAK":[99],"indicating":[101],"required":[105],"for":[106],"both.":[107],"To":[108],"address":[109],"role":[111,168],"activity":[115],"signaling,":[120],"its":[121,176],"ATP":[122],"binding":[123],"site":[124],"was":[125,137],"mutated":[126],"(K239A),":[127],"completely":[128],"abolishing":[129],"activity.":[131,178],"In":[132],"transfected":[133],"IRAK-K239A":[136],"still":[138,145],"phosphorylated":[139,158],"upon":[140],"stimulation":[142],"and,":[143],"surprisingly,":[144],"complemented":[146],"all":[147],"defects":[149],"mutant":[152],"cells.":[153],"Therefore,":[154],"must":[156,165],"be":[157],"by":[159],"a":[160,167],"different":[161],"kinase,":[162],"phospho-IRAK":[164],"play":[166],"IL-1-mediated":[170],"signaling":[171],"does":[173],"not":[174],"require":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
