{"id":"https://openalex.org/W1925147002","doi":"https://doi.org/10.4049/jimmunol.149.6.1833","title":"Mechanism of peripheral T cell activation by coengagement of CD44 and CD2","display_name":"Mechanism of peripheral T cell activation by coengagement of CD44 and CD2","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W1925147002","doi":"https://doi.org/10.4049/jimmunol.149.6.1833","mag":"1925147002","pmid":"https://pubmed.ncbi.nlm.nih.gov/1381388"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.149.6.1833","doi":"https://doi.org/10.4049/jimmunol.149.6.1833","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.149.6.1833","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113502910","display_name":"Patricia J. Conrad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Conrad","raw_affiliation_strings":["Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091117200","display_name":"Barbara L. Rothman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B L Rothman","raw_affiliation_strings":["Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027889393","display_name":"Keith A. Kelley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K A Kelley","raw_affiliation_strings":["Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109717533","display_name":"M L Blue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Blue","raw_affiliation_strings":["Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Inflammation and Autoimmunity, Miles Research Center, West Haven, CT 06516","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.2057,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.78829567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"149","issue":"6","first_page":"1833","last_page":"1839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.05790000036358833,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd2","display_name":"CD2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.7680000066757202},{"id":"https://openalex.org/keywords/t-cell-adhesion","display_name":"T cell adhesion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lfa-3","display_name":"LFA-3","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cell-adhesion-receptors","display_name":"cell adhesion receptors","score":0.5400000214576721},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.766802191734314},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5593067407608032},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.48948442935943604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4094654321670532},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3470919728279114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33992475271224976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20113354921340942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18472009897232056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1191166341304779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1115511953830719},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0930120050907135},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016201","descriptor_name":"Receptors, Lymphocyte Homing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018801","descriptor_name":"CD2 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018968","descriptor_name":"CD58 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.149.6.1833","doi":"https://doi.org/10.4049/jimmunol.149.6.1833","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.149.6.1833","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1381388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1381388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2162535045","https://openalex.org/W1569428681","https://openalex.org/W2007408185","https://openalex.org/W2069881280","https://openalex.org/W1909484207","https://openalex.org/W1521068320","https://openalex.org/W1538799972","https://openalex.org/W1479909263","https://openalex.org/W2153932970","https://openalex.org/W2079654323"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,17,20,34,132,159,180,184,190,198,212,234],"CD44":[3,28,46,54,80,112,164,185,222],"antibodies":[4,133],"are":[5],"known":[6,178],"to":[7,124,139],"augment":[8],"peripheral":[9,35,51,153,213],"T":[10,36,52,93,104,119,141,154,160,214],"cell":[11,105,120,142,161],"proliferation":[12],"stimulated":[13],"with":[14,136],"suboptimal":[15],"concentrations":[16],"activating":[18],"pairs":[19],"CD2":[21,48,56,78,114,191],"mAb.":[22],"These":[23,218],"findings":[24],"have":[25,41],"implicated":[26],"the":[27,32,64,87,130,177,195,199,210],"adhesion":[29,95,150],"receptor":[30],"in":[31,59,66,89,103,118,187,209],"activation":[33,201,211],"cells":[37,155,215],"via":[38,216],"CD2.":[39,181,217,235],"We":[40],"investigated":[42],"early":[43],"events":[44,85,229],"after":[45,77,107,111],"and":[47,55,79,113,156],"coengagement":[49,57],"on":[50,173,227],"cells.":[53],"resulted":[58,186],"enhanced":[60],"[Ca2+]i":[61,67],"mobilization.":[62],"However,":[63,182],"increase":[65,102,117],"mobilization":[68],"did":[69],"not":[70,167],"occur":[71],"until":[72],"at":[73],"least":[74],"3":[75],"min":[76,110],"coengagement,":[81],"suggesting":[82],"that":[83,125,221],"other":[84,140],"precede":[86],"elevation":[88],"[Ca2+]i.":[90],"Using":[91],"a":[92,100,170],"cell/fibroblast":[94],"assay,":[96],"we":[97],"could":[98,205],"demonstrate":[99],"dramatic":[101],"adhesiveness":[106,121,162],"about":[108],"1":[109],"coengagement.":[115],"The":[116],"was":[122,146,166],"comparable":[123],"induced":[126],"by":[127,169,194,230],"PMA.":[128],"In":[129],"absence":[131],"or":[134],"treatment":[135],"mAb":[137],"directed":[138],"surface":[143],"Ag,":[144],"there":[145],"little":[147],"if":[148],"any":[149],"between":[151],"unstimulated":[152],"fibroblasts.":[157],"Enhancement":[158],"through":[163],"engagement":[165],"mediated":[168],"direct":[171],"effect":[172],"lymphocyte-function":[174],"associated":[175],"Ag-3,":[176],"ligand":[179],"cross-linking":[183],"epitopic":[188,232],"modulation":[189,233],"as":[192],"demonstrated":[193],"increased":[196],"expression":[197],"T11(3)":[200],"epitope.":[202],"Furthermore,":[203],"anti-CD44":[204],"substitute":[206],"for":[207],"anti-T11(2)":[208],"results":[219],"suggest":[220],"ligation":[223],"has":[224],"profound":[225],"effects":[226],"CD2-mediated":[228],"inducing":[231]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}