{"id":"https://openalex.org/W1924763554","doi":"https://doi.org/10.1111/j.1574-6968.2010.01905.x","title":"Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation","display_name":"Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation","publication_year":2010,"publication_date":"2010-01-20","ids":{"openalex":"https://openalex.org/W1924763554","doi":"https://doi.org/10.1111/j.1574-6968.2010.01905.x","mag":"1924763554","pmid":"https://pubmed.ncbi.nlm.nih.gov/20158521"},"language":"en","primary_location":{"id":"doi:10.1111/j.1574-6968.2010.01905.x","doi":"https://doi.org/10.1111/j.1574-6968.2010.01905.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1574-6968.2010.01905.x","pdf_url":null,"source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071199868","display_name":"Padmanabhan Srinivasan","orcid":"https://orcid.org/0000-0003-2067-7273","observed_orcids":["https://orcid.org/0000-0003-2067-7273"]},"institutions":[{"id":"https://openalex.org/I13268429","display_name":"Madurai Kamaraj University","ror":"https://ror.org/04c8e9019","country_code":"IN","type":"education","lineage":["https://openalex.org/I13268429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Padmanabhan Srinivasan","raw_affiliation_strings":["Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India","institution_ids":["https://openalex.org/I13268429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077244545","display_name":"Sankara Naynar Palani","orcid":"https://orcid.org/0000-0003-1933-9146","observed_orcids":["https://orcid.org/0000-0003-1933-9146"]},"institutions":[{"id":"https://openalex.org/I13268429","display_name":"Madurai Kamaraj University","ror":"https://ror.org/04c8e9019","country_code":"IN","type":"education","lineage":["https://openalex.org/I13268429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sankara Naynar Palani","raw_affiliation_strings":["Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India","institution_ids":["https://openalex.org/I13268429"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007676823","display_name":"Ranjan Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13268429","display_name":"Madurai Kamaraj University","ror":"https://ror.org/04c8e9019","country_code":"IN","type":"education","lineage":["https://openalex.org/I13268429"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ranjan Prasad","raw_affiliation_strings":["Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India","institution_ids":["https://openalex.org/I13268429"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007676823"],"corresponding_institution_ids":["https://openalex.org/I13268429"],"apc_list":{"value":2500,"currency":"GBP","value_usd":3297},"apc_paid":null,"fwci":1.5532,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79513086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"305","issue":"1","first_page":"18","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/streptomyces-peucetius","display_name":"Streptomyces peucetius","score":0.996999979019165},{"id":"https://openalex.org/keywords/drra","display_name":"DrrA","score":0.734000027179718},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8009999990463257},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.8209999799728394},{"id":"https://openalex.org/keywords/self-resistance","display_name":"self-resistance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/feedback-regulation","display_name":"feedback regulation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/polyketide-synthase","display_name":"polyketide synthase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antibiotic-biosynthesis","display_name":"antibiotic biosynthesis","score":0.7379999756813049},{"id":"https://openalex.org/keywords/knockout-mutants","display_name":"knockout mutants","score":0.5569999814033508},{"id":"https://openalex.org/keywords/intracellular-drug-concentration","display_name":"intracellular drug concentration","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.9361191391944885},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8730013370513916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6487776041030884},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6260862350463867},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.6085531711578369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5071902275085449},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.43532639741897583},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.35930269956588745},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34809309244155884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29210638999938965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21226376295089722},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1574-6968.2010.01905.x","doi":"https://doi.org/10.1111/j.1574-6968.2010.01905.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1574-6968.2010.01905.x","pdf_url":null,"source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},{"id":"pmid:20158521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20158521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS microbiology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W592483937","https://openalex.org/W1530407945","https://openalex.org/W1683563157","https://openalex.org/W1827848435","https://openalex.org/W1865359541","https://openalex.org/W1963354155","https://openalex.org/W1970697372","https://openalex.org/W1972301225","https://openalex.org/W1975990801","https://openalex.org/W1979412000","https://openalex.org/W1988206065","https://openalex.org/W1989376656","https://openalex.org/W1991785762","https://openalex.org/W1995995599","https://openalex.org/W2005235948","https://openalex.org/W2033750752","https://openalex.org/W2060375450","https://openalex.org/W2095384347","https://openalex.org/W2108153887","https://openalex.org/W2109064205","https://openalex.org/W2109689865","https://openalex.org/W2128862717","https://openalex.org/W2140460750","https://openalex.org/W2142357370","https://openalex.org/W2146496903","https://openalex.org/W2248274612","https://openalex.org/W2479672359","https://openalex.org/W6631716119"],"related_works":["https://openalex.org/W4403235395","https://openalex.org/W1839599695","https://openalex.org/W2038021649","https://openalex.org/W2016001910","https://openalex.org/W1996467013","https://openalex.org/W2038569576","https://openalex.org/W2737312947","https://openalex.org/W1989376656","https://openalex.org/W804473774","https://openalex.org/W1683563157"],"abstract_inverted_index":{"Streptomyces":[0],"peucetius":[1],"self-resistance":[2,49],"genes":[3,134],"drrA":[4,39],"and":[5,21,40,50,124,136],"drrB":[6,41],"encode":[7],"membrane-associated":[8],"proteins":[9],"that":[10,80],"function":[11],"like":[12],"an":[13],"ABC":[14],"transporter":[15],"for":[16,45],"the":[17,30,33,38,70,75,81,89,98,110,117,120,130,144],"efflux":[18,86],"of":[19,29,83,92,109,119,132],"daunorubicin":[20,146],"to":[22,59,100],"maintain":[23],"a":[24,84,113],"constant":[25],"subinhibitory":[26],"physiological":[27],"concentration":[28,91,147],"drug":[31,47,65,103],"within":[32],"cell.":[34],"In":[35],"this":[36],"study,":[37],"operons":[42],"were":[43],"disrupted":[44],"investigating":[46],"production,":[48],"regulation.":[51],"The":[52],"drrA-drrB":[53],"null":[54,71],"mutant":[55,72,111],"was":[56,67,138],"highly":[57],"sensitive":[58],"daunorubicin.":[60],"A":[61],"10-fold":[62],"decrease":[63],"in":[64,69,116],"production":[66],"observed":[68],"compared":[73],"with":[74],"wild-type":[76],"strain.":[77],"We":[78],"propose":[79],"absence":[82],"drug-specific":[85],"pump":[87],"increases":[88],"intracellular":[90,145],"daunorubicin,":[93],"which":[94],"is":[95,148],"sensed":[96],"by":[97],"organism":[99],"turn":[101],"down":[102],"production.":[104],"Quantitative":[105],"real-time":[106],"PCR":[107],"analysis":[108],"showed":[112],"drastic":[114],"reduction":[115],"expression":[118,131],"key":[121],"regulator":[122],"dnrI":[123],"polyketide":[125],"synthase":[126],"gene":[127],"dpsA.":[128],"However,":[129],"regulatory":[133],"dnrO":[135],"dnrN":[137],"increased.":[139],"Feedback":[140],"regulation":[141],"based":[142],"on":[143],"discussed.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}