{"id":"https://openalex.org/W1924285665","doi":"https://doi.org/10.1242/jeb.203.1.29","title":"Cross-Linking and Electron Microscopy Studies of the Structure and Functioning of the Escherichia Coli ATP Synthase","display_name":"Cross-Linking and Electron Microscopy Studies of the Structure and Functioning of the Escherichia Coli ATP Synthase","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1924285665","doi":"https://doi.org/10.1242/jeb.203.1.29","mag":"1924285665","pmid":"https://pubmed.ncbi.nlm.nih.gov/10600670"},"language":"en","primary_location":{"id":"doi:10.1242/jeb.203.1.29","doi":"https://doi.org/10.1242/jeb.203.1.29","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.203.1.29","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111419743","display_name":"Roderick Capaldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roderick A. Capaldi","raw_affiliation_strings":["Institute of Molecular Biology, University of Oregon, Eugene, OR 97403-1229, USA. rcapaldi@oregon.uoregon.edu","Institute of Molecular Biology, University of Oregon Eugene OR 97403-1229 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, University of Oregon, Eugene, OR 97403-1229, USA. rcapaldi@oregon.uoregon.edu","institution_ids":["https://openalex.org/I181233156"]},{"raw_affiliation_string":"Institute of Molecular Biology, University of Oregon Eugene OR 97403-1229 USA","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080317638","display_name":"Birte Schulenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Birte Schulenberg","raw_affiliation_strings":["University of Oregon Institute of Molecular Biology , , Eugene, OR 97403-1229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oregon Institute of Molecular Biology , , Eugene, OR 97403-1229, USA","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020227077","display_name":"James M. Murray","orcid":"https://orcid.org/0000-0003-3706-4895","observed_orcids":["https://orcid.org/0000-0003-3706-4895"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Murray","raw_affiliation_strings":["University of Oregon Institute of Molecular Biology , , Eugene, OR 97403-1229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oregon Institute of Molecular Biology , , Eugene, OR 97403-1229, USA","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052566766","display_name":"Robert J. Aggeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Aggeler","raw_affiliation_strings":["University of Oregon Institute of Molecular Biology , , Eugene, OR 97403-1229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oregon Institute of Molecular Biology , , Eugene, OR 97403-1229, USA","institution_ids":["https://openalex.org/I181233156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181233156"],"apc_list":null,"apc_paid":null,"fwci":0.7279,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.58522727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"203","issue":"1","first_page":"29","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.8169999718666077},{"id":"https://openalex.org/keywords/electron-microscopy","display_name":"electron microscopy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.7910000085830688},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/proton-gradient","display_name":"proton gradient","score":0.718999981880188},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.675000011920929},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.8098344206809998},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.74931800365448},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.6695075035095215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3917972147464752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37140846252441406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35960856080055237},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3548619747161865},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34480810165405273},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3350624442100525},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22946929931640625},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.11385846138000488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0614224374294281}],"mesh":[{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/jeb.203.1.29","doi":"https://doi.org/10.1242/jeb.203.1.29","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.203.1.29","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},{"id":"pmid:10600670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10600670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental biology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jexbio:203/1/29","doi":null,"is_oa":false,"landing_page_url":"http://jeb.biologists.org/cgi/content/short/203/1/29","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4712836196","display_name":"STALK AND FO OF THE ATP SYNTHASE","funder_award_id":"R01HL058671","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G825929916","display_name":"STUDIES OF ATP SYNTHASE","funder_award_id":"R01HL024526","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1515981715","https://openalex.org/W1520835638","https://openalex.org/W1525965421","https://openalex.org/W1547200966","https://openalex.org/W1570668744","https://openalex.org/W1597027477","https://openalex.org/W1964044497","https://openalex.org/W1967213708","https://openalex.org/W1968512647","https://openalex.org/W1970666814","https://openalex.org/W1974430395","https://openalex.org/W1979111913","https://openalex.org/W1981862156","https://openalex.org/W1984161749","https://openalex.org/W1984706865","https://openalex.org/W1990485814","https://openalex.org/W1992502548","https://openalex.org/W1996931402","https://openalex.org/W1998189549","https://openalex.org/W2000809937","https://openalex.org/W2007580517","https://openalex.org/W2010071674","https://openalex.org/W2011568252","https://openalex.org/W2019396695","https://openalex.org/W2021864436","https://openalex.org/W2022910838","https://openalex.org/W2023307589","https://openalex.org/W2033099907","https://openalex.org/W2038555024","https://openalex.org/W2043162072","https://openalex.org/W2058415148","https://openalex.org/W2068634955","https://openalex.org/W2069771371","https://openalex.org/W2071950147","https://openalex.org/W2074033410","https://openalex.org/W2080779717","https://openalex.org/W2082629421","https://openalex.org/W2085148502","https://openalex.org/W2095492608","https://openalex.org/W2119710448","https://openalex.org/W2127545076","https://openalex.org/W2156154530","https://openalex.org/W2161308640","https://openalex.org/W2415908292"],"related_works":["https://openalex.org/W2218136270","https://openalex.org/W62360688","https://openalex.org/W3139645640","https://openalex.org/W2073950472","https://openalex.org/W7095736504","https://openalex.org/W2093118137","https://openalex.org/W2021864436","https://openalex.org/W1984706865","https://openalex.org/W5756713","https://openalex.org/W187871566"],"abstract_inverted_index":{"ATP":[0,9,22,80],"synthase,":[1,81],"also":[2],"called":[3],"F(1)F(o)-ATPase,":[4],"catalyzes":[5],"the":[6,36,68,74,79],"synthesis":[7],"of":[8,47,61,78],"during":[10],"oxidative":[11],"phosphorylation.":[12],"The":[13,59],"enzyme":[14,37],"is":[15,18],"reversible":[16],"and":[17,56,67,76],"able":[19],"to":[20,23,49],"use":[21],"drive":[24],"a":[25,45],"proton":[26],"gradient":[27],"for":[28],"transport":[29],"purposes.":[30],"Our":[31],"work":[32],"has":[33],"focused":[34],"on":[35],"from":[38],"Escherichia":[39],"coli":[40],"(ECF(1)F(o)).":[41],"We":[42],"have":[43],"used":[44],"combination":[46],"methods":[48],"study":[50],"this":[51],"enzyme,":[52],"including":[53],"electron":[54],"microscopy":[55],"chemical":[57],"cross-linking.":[58],"utility":[60],"these":[62],"two":[63],"approaches":[64],"in":[65],"particular,":[66],"important":[69],"insights":[70],"they":[71],"give":[72],"into":[73],"structure":[75],"mechanism":[77],"are":[82],"reviewed.":[83]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}