{"id":"https://openalex.org/W1924256936","doi":"https://doi.org/10.1089/ten.tea.2015.0139","title":"Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts","display_name":"Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts","publication_year":2015,"publication_date":"2015-07-02","ids":{"openalex":"https://openalex.org/W1924256936","doi":"https://doi.org/10.1089/ten.tea.2015.0139","mag":"1924256936","pmid":"https://pubmed.ncbi.nlm.nih.gov/26135533","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4554934"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tea.2015.0139","doi":"https://doi.org/10.1089/ten.tea.2015.0139","is_oa":true,"landing_page_url":"https://doi.org/10.1089/ten.tea.2015.0139","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/ten.tea.2015.0139","source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.liebertpub.com/doi/pdf/10.1089/ten.tea.2015.0139","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112493785","display_name":"Christianne M. A. Reijnders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christianne M.A. Reijnders","raw_affiliation_strings":["Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113824306","display_name":"Amanda van Lier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Amanda van Lier","raw_affiliation_strings":["Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002922584","display_name":"Sanne Roffel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sanne Roffel","raw_affiliation_strings":["Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080934306","display_name":"Duco Kramer","orcid":"https://orcid.org/0000-0003-2091-8436","observed_orcids":["https://orcid.org/0000-0003-2091-8436"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Duco Kramer","raw_affiliation_strings":["Department of Dermatology, University Medical Centre Groningen, Groningen, The Netherlands","2 Department of Dermatology, University Medical Centre Groningen , Groningen, The Netherlands "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Medical Centre Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"2 Department of Dermatology, University Medical Centre Groningen , Groningen, The Netherlands ","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111739443","display_name":"Rik J. Scheper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rik J. Scheper","raw_affiliation_strings":["Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042019508","display_name":"Susan Gibbs","orcid":"https://orcid.org/0000-0002-3446-6138","observed_orcids":["https://orcid.org/0000-0002-3446-6138"]},"institutions":[{"id":"https://openalex.org/I2898155008","display_name":"Academic Center for Dentistry Amsterdam","ror":"https://ror.org/04x5wnb75","country_code":"NL","type":"education","lineage":["https://openalex.org/I2898155008"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Susan Gibbs","raw_affiliation_strings":["Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands","Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898155008","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042019508"],"corresponding_institution_ids":["https://openalex.org/I2898155008","https://openalex.org/I887064364","https://openalex.org/I911458345"],"apc_list":null,"apc_paid":null,"fwci":10.9218,"has_fulltext":true,"cited_by_count":149,"citation_normalized_percentile":{"value":0.98951619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"21","issue":"17-18","first_page":"2448","last_page":"2459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-skin-equivalents","display_name":"human skin equivalents","score":0.9539999961853027},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7540000081062317},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.9760000109672546},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cold-injury","display_name":"cold injury","score":0.9890000224113464},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.746999979019165},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.6990000009536743},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.8320000171661377},{"id":"https://openalex.org/keywords/epidermal-differentiation","display_name":"epidermal differentiation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/skin-on-a-chip","display_name":"skin-on-a-chip","score":0.75},{"id":"https://openalex.org/keywords/in-vitro-skin-model","display_name":"in vitro skin model","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C147075424","wikidata":"https://www.wikidata.org/wiki/Q1604780","display_name":"Hemidesmosome","level":3,"score":0.8432216644287109},{"id":"https://openalex.org/C2776391296","wikidata":"https://www.wikidata.org/wiki/Q7535389","display_name":"Skin equivalent","level":4,"score":0.7058497667312622},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.6494526863098145},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6421969532966614},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6286191940307617},{"id":"https://openalex.org/C3060791","wikidata":"https://www.wikidata.org/wiki/Q3216737","display_name":"Lamina densa","level":3,"score":0.6182000637054443},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6108221411705017},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.603122889995575},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5846702456474304},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.582593560218811},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.5822945833206177},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.5257502198219299},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5214720964431763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49869608879089355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49468299746513367},{"id":"https://openalex.org/C2779333224","wikidata":"https://www.wikidata.org/wiki/Q809756","display_name":"Basal lamina","level":3,"score":0.4501955509185791},{"id":"https://openalex.org/C25834368","wikidata":"https://www.wikidata.org/wiki/Q5262737","display_name":"Dermoepidermal junction","level":3,"score":0.4445993900299072},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4258617162704468},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41424083709716797},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.326722115278244},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3107742667198181},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30657267570495605},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.17741763591766357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1536858081817627},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14626851677894592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06599894165992737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D017768","descriptor_name":"Skin, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":14,"locations":[{"id":"doi:10.1089/ten.tea.2015.0139","doi":"https://doi.org/10.1089/ten.tea.2015.0139","is_oa":true,"landing_page_url":"https://doi.org/10.1089/ten.tea.2015.0139","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/ten.tea.2015.0139","source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4554934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4554934","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},{"id":"pmid:26135533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26135533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part A","raw_type":"Journal Article"},{"id":"pmh:oai:dare.uva.nl:openaire/bae9caa1-e46a-4fbe-a234-b2d34f5e6cc4","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/development-of-a-fullthickness-human-skin-equivalent-in-vitro-model-derived-from-tertimmortalized-keratinocytes-and-fibroblasts(bae9caa1-e46a-4fbe-a234-b2d34f5e6cc4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reijnders, C M A, van Lier, A, Roffel, S, Kramer, D, Scheper, R J & Gibbs, S 2015, 'Development of a full-thickness human skin equivalent in vitro model derived from TERT-immortalized keratinocytes and fibroblasts', Tissue Engineering. Part A, vol. 21, no. 17-18, pp. 2448-2459. https://doi.org/10.1089/ten.tea.2015.0139","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/bae9caa1-e46a-4fbe-a234-b2d34f5e6cc4","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/development-of-a-fullthickness-human-skin-equivalent-in-vitro-model-derived-from-tertimmortalized-keratinocytes-and-fibroblasts(bae9caa1-e46a-4fbe-a234-b2d34f5e6cc4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reijnders, C M A, van Lier, A, Roffel, S, Kramer, D, Scheper, R J & Gibbs, S 2015, 'Development of a full-thickness human skin equivalent in vitro model derived from TERT-immortalized keratinocytes and fibroblasts', Tissue Engineering. Part A, vol. 21, no. 17-18, pp. 2448-2459. https://doi.org/10.1089/ten.tea.2015.0139","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/01532d37-a8e6-4642-82c7-70e3a04f9849","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/01532d37-a8e6-4642-82c7-70e3a04f9849","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reijnders, C M A, van Lier, A, Roffel, S, Kramer, D, Scheper, R J & Gibbs, S 2015, 'Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts', Tissue Engineering Part A, vol. 21, no. 17-18, pp. 2448-2459. https://doi.org/10.1089/ten.tea.2015.0139","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.rug.nl:openaire/22689226-fb35-4958-b917-63fa7bae7edf","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/22689226-fb35-4958-b917-63fa7bae7edf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reijnders, C M A, van Lier, A, Roffel, S, Kramer, D, Scheper, R J & Gibbs, S 2015, 'Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts', Tissue Engineering. Part A, vol. 21, no. 17-18, pp. 2448-2459. https://doi.org/10.1089/ten.tea.2015.0139","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research.vu.nl:openaire/b90c12fe-60cd-46b1-80ad-0016c176ef1e","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/b90c12fe-60cd-46b1-80ad-0016c176ef1e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reijnders, C M A, van Lier, A, Roffel, S, Kramer, D, Scheper, R J & Gibbs, S 2015, 'Development of a full-thickness human skin equivalent in vitro model derived from TERT-immortalized keratinocytes and fibroblasts', Tissue Engineering. Part A, vol. 21, no. 17-18, pp. 2448-2459. https://doi.org/10.1089/ten.tea.2015.0139","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/2961761d-e664-41f1-ae16-ffa90ed73125","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/2961761d-e664-41f1-ae16-ffa90ed73125","pdf_url":"https://pure.amsterdamumc.nl/ws/files/176633619/Development-of-a-full-thickness-human-skin-equivalent-in-vitro-model-derived-from-tert-immortalized-keratinocytes-and-fi.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reijnders, C M A, van Lier, A, Roffel, S, Kramer, D, Scheper, R J & Gibbs, S 2015, 'Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts', Tissue Engineering Part A, vol. 21, no. 17-18, pp. 2448-2459. https://doi.org/10.1089/ten.tea.2015.0139","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/22689226-fb35-4958-b917-63fa7bae7edf","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/22689226-fb35-4958-b917-63fa7bae7edf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tissue Engineering. Part A, 21(17-18), 2448 - 2459. MARY ANN LIEBERT, INC","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/bae9caa1-e46a-4fbe-a234-b2d34f5e6cc4","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/development-of-a-fullthickness-human-skin-equivalent-in-vitro-model-derived-from-tertimmortalized-keratinocytes-and-fibroblasts(bae9caa1-e46a-4fbe-a234-b2d34f5e6cc4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tissue Engineering. Part A, 21(17-18), 2448 - 2459. Mary Ann Liebert Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/87453c66-ee4d-4c84-b27d-28a696f57041","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/87453c66-ee4d-4c84-b27d-28a696f57041","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tissue Engineering Part A, 21(17-18), 2448 - 2459","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/b90c12fe-60cd-46b1-80ad-0016c176ef1e","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/b90c12fe-60cd-46b1-80ad-0016c176ef1e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tissue Engineering. Part A, 21(17-18), 2448 - 2459. Mary Ann Liebert Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/01532d37-a8e6-4642-82c7-70e3a04f9849","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/01532d37-a8e6-4642-82c7-70e3a04f9849","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tissue Engineering Part A, 21(17-18), 2448 - 2459. Mary Ann Liebert Inc.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1089/ten.tea.2015.0139","doi":"https://doi.org/10.1089/ten.tea.2015.0139","is_oa":true,"landing_page_url":"https://doi.org/10.1089/ten.tea.2015.0139","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/ten.tea.2015.0139","source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1117131603","display_name":null,"funder_award_id":"91111.006","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G2879289663","display_name":null,"funder_award_id":"40-42600-98-010","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G8941364411","display_name":null,"funder_award_id":"91111","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321014","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1924256936.pdf","grobid_xml":"https://content.openalex.org/works/W1924256936.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W323657687","https://openalex.org/W1483869814","https://openalex.org/W1603490962","https://openalex.org/W1931315964","https://openalex.org/W1937213869","https://openalex.org/W1946081194","https://openalex.org/W1969833025","https://openalex.org/W1978749513","https://openalex.org/W1980199807","https://openalex.org/W1984172495","https://openalex.org/W1985426569","https://openalex.org/W1986281647","https://openalex.org/W1992104579","https://openalex.org/W1996923179","https://openalex.org/W1997327997","https://openalex.org/W1999319565","https://openalex.org/W2000288773","https://openalex.org/W2000971499","https://openalex.org/W2013174909","https://openalex.org/W2013334136","https://openalex.org/W2015188671","https://openalex.org/W2023626896","https://openalex.org/W2026233104","https://openalex.org/W2037370275","https://openalex.org/W2037436681","https://openalex.org/W2038549720","https://openalex.org/W2041460044","https://openalex.org/W2042207484","https://openalex.org/W2043060307","https://openalex.org/W2046947071","https://openalex.org/W2047199455","https://openalex.org/W2049915974","https://openalex.org/W2058522480","https://openalex.org/W2060119002","https://openalex.org/W2061353993","https://openalex.org/W2063844758","https://openalex.org/W2066577674","https://openalex.org/W2068036342","https://openalex.org/W2070051436","https://openalex.org/W2071290289","https://openalex.org/W2077430978","https://openalex.org/W2079214615","https://openalex.org/W2079897764","https://openalex.org/W2085875208","https://openalex.org/W2090396823","https://openalex.org/W2092342210","https://openalex.org/W2092896554","https://openalex.org/W2097088367","https://openalex.org/W2097156023","https://openalex.org/W2101602122","https://openalex.org/W2104702791","https://openalex.org/W2108482850","https://openalex.org/W2110265874","https://openalex.org/W2110705467","https://openalex.org/W2111344666","https://openalex.org/W2116774388","https://openalex.org/W2124041753","https://openalex.org/W2125169413","https://openalex.org/W2125268957","https://openalex.org/W2131363312","https://openalex.org/W2132707515","https://openalex.org/W2142550173","https://openalex.org/W2145040122","https://openalex.org/W2149000137","https://openalex.org/W2149974098","https://openalex.org/W2156213262","https://openalex.org/W2161316598","https://openalex.org/W4237884298"],"related_works":["https://openalex.org/W2572962022","https://openalex.org/W2755555321","https://openalex.org/W3132940684","https://openalex.org/W1605309104","https://openalex.org/W1971415872","https://openalex.org/W6904690445","https://openalex.org/W6959287375","https://openalex.org/W2131363312","https://openalex.org/W2064761422","https://openalex.org/W1526642354"],"abstract_inverted_index":{"Currently,":[0],"human":[1,18,58,76,274],"skin":[2,19,31,59,86,162,233,285],"equivalents":[3,72],"(HSEs)":[4],"used":[5,291],"for":[6,11,66,100,292,301],"in":[7,67,246,250,283,306],"vitro":[8,68,284],"assays":[9],"(e.g.,":[10],"wound":[12],"healing)":[13],"make":[14],"use":[15,36],"of":[16,22,29,37,124,138,142,150,169,211,225],"primary":[17,23,88,164,236,251],"cells.":[20],"Limitations":[21],"keratinocytes":[24,78,171],"and":[25,32,79,82,87,95,103,109,128,140,155,163,184,197,215,248,261,287,295,299],"fibroblasts":[26,80],"include":[27],"availability":[28],"donor":[30,33],"variation.":[34],"The":[35,46,146,166,222],"physiologically":[38],"relevant":[39],"cell":[40,60,275],"lines":[41],"could":[42,63],"solve":[43],"these":[44],"limitations.":[45],"aim":[47],"was":[48,115,148,228,244,257],"to":[49,160,219,231,259,281],"develop":[50],"a":[51,151,156,181,212],"fully":[52,152],"differentiated":[53,153],"HSE":[54],"constructed":[55,74,271],"entirely":[56,272],"from":[57,75,273],"lines,":[61,276],"which":[62],"be":[64,290],"applied":[65],"wound-healing":[69,144,264],"assays.":[70],"Skin":[71],"were":[73,91,131,199],"TERT-immortalized":[77],"(TERT-HSE)":[81],"compared":[83],"with":[84,98,117],"native":[85,161,220,232],"HSEs.":[89,252],"HSEs":[90],"characterized":[92],"by":[93,134,177,204],"hematoxylin-eosin":[94],"immunohistochemical":[96,135],"stainings":[97],"markers":[99],"epidermal":[101],"proliferation":[102],"differentiation,":[104],"basement":[105],"membrane":[106,191],"(BM),":[107],"fibroblasts,":[108],"the":[110,122,125,173,188,190,208,226,235,255,268,307],"extracellular":[111],"matrix":[112,224],"(ECM).":[113],"Ultrastructure":[114],"determined":[116],"electron":[118],"microscopy.":[119],"To":[120],"test":[121],"functionality":[123],"TERT-HSE,":[126,189,270],"burn":[127],"cold":[129],"injuries":[130],"applied,":[132],"followed":[133,176],"stainings,":[136],"measurement":[137],"reepithelialization,":[139],"determination":[141],"secreted":[143],"mediators.":[145,265],"TERT-HSE":[147,227,256],"composed":[149],"epidermis":[154,167],"fibroblast-populated":[157],"dermis":[158],"comparable":[159,218],"HSE.":[165],"consisted":[168,210],"proliferating":[170],"within":[172],"basal":[174],"layer,":[175,183],"multiple":[178],"spinous":[179],"layers,":[180],"granular":[182],"cornified":[185],"layers.":[186],"Within":[187],"junctions":[192],"such":[193],"as":[194,202],"corneosomes,":[195],"desmosomes,":[196],"hemidesmosomes":[198],"well":[200],"developed":[201],"shown":[203],"ultrastructure":[205],"pictures.":[206],"Furthermore,":[207],"BM":[209],"lamina":[213,216],"lucida":[214],"densa":[217],"skin.":[221],"dermal":[223],"more":[229],"similar":[230],"than":[234],"construct,":[237],"since":[238],"collagen":[239],"III,":[240],"an":[241,278],"ECM":[242],"marker,":[243],"present":[245],"TERT-HSEs":[247],"absent":[249],"After":[253],"wounding,":[254],"able":[258],"reepithelialize":[260],"secrete":[262],"inflammatory":[263],"In":[266],"conclusion,":[267],"novel":[269],"provides":[277],"excellent":[279],"opportunity":[280],"study":[282],"biology":[286],"can":[288],"also":[289],"drug":[293],"targeting":[294],"testing":[296],"new":[297],"therapeutics,":[298],"ultimately,":[300],"incorporating":[302],"into":[303],"skin-on-a":[304],"chip":[305],"future.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}