{"id":"https://openalex.org/W1923798281","doi":"https://doi.org/10.1242/jeb.200.2.269","title":"Molecular Characteristics Of Mammalian And Insect Amino Acid Transporters: Implications For Amino Acid Homeostasis","display_name":"Molecular Characteristics Of Mammalian And Insect Amino Acid Transporters: Implications For Amino Acid Homeostasis","publication_year":1997,"publication_date":"1997-01-15","ids":{"openalex":"https://openalex.org/W1923798281","doi":"https://doi.org/10.1242/jeb.200.2.269","mag":"1923798281","pmid":"https://pubmed.ncbi.nlm.nih.gov/9050235"},"language":"en","primary_location":{"id":"doi:10.1242/jeb.200.2.269","doi":"https://doi.org/10.1242/jeb.200.2.269","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.200.2.269","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000037631","display_name":"Michela Castagna","orcid":"https://orcid.org/0000-0001-8144-9173","observed_orcids":["https://orcid.org/0000-0001-8144-9173"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michela Castagna","raw_affiliation_strings":["1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025147349","display_name":"Chairat Shayakul","orcid":"https://orcid.org/0000-0002-1729-7555","observed_orcids":["https://orcid.org/0000-0002-1729-7555"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chairat Shayakul","raw_affiliation_strings":["1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078857071","display_name":"Davide Trotti","orcid":"https://orcid.org/0000-0001-6338-6404","observed_orcids":["https://orcid.org/0000-0001-6338-6404"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Trotti","raw_affiliation_strings":["1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109264668","display_name":"Vellea Franca Sacchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Franca Sacchi","raw_affiliation_strings":["2 Istituto di Fisiologia Generale e Chimica Biologica, Facolta di Farmacia, Via Trentacoste 2, 20134 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Istituto di Fisiologia Generale e Chimica Biologica, Facolta di Farmacia, Via Trentacoste 2, 20134 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110865451","display_name":"William R. Harvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Harvey","raw_affiliation_strings":["Temple University 3 Department of Biology , , Philadelphia, PA 19122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University 3 Department of Biology , , Philadelphia, PA 19122, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7013,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.90053591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"200","issue":"2","first_page":"269","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ers","display_name":"ERS","score":0.9879999756813049},{"id":"https://openalex.org/keywords/amino-acid-homeostasis","display_name":"amino acid homeostasis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/system-b0","display_name":"system b0,+","score":0.9399999976158142},{"id":"https://openalex.org/keywords/eaac1","display_name":"EAAC1","score":0.902999997138977},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cystinuria","display_name":"cystinuria","score":0.722000002861023},{"id":"https://openalex.org/keywords/insect-midgut","display_name":"insect midgut","score":0.7490000128746033},{"id":"https://openalex.org/keywords/brush-border-membrane-vesicles","display_name":"brush border membrane vesicles","score":0.6930000185966492},{"id":"https://openalex.org/keywords/v-atpase","display_name":"V-ATPase","score":0.6809999942779541},{"id":"https://openalex.org/keywords/caterpillars","display_name":"caterpillars","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.8260278701782227},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.7609546780586243},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7245473861694336},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.7028992176055908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6631876826286316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6558433771133423},{"id":"https://openalex.org/C168785527","wikidata":"https://www.wikidata.org/wiki/Q1401099","display_name":"Solute carrier family","level":4,"score":0.4670492708683014},{"id":"https://openalex.org/C2781313199","wikidata":"https://www.wikidata.org/wiki/Q4746435","display_name":"Amino acid transporter","level":4,"score":0.4666925072669983},{"id":"https://openalex.org/C120405084","wikidata":"https://www.wikidata.org/wiki/Q285307","display_name":"Symporter","level":4,"score":0.45961329340934753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3928542137145996},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22712963819503784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17293396592140198},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.11848783493041992},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007313","descriptor_name":"Insecta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007313","descriptor_name":"Insecta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/jeb.200.2.269","doi":"https://doi.org/10.1242/jeb.200.2.269","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.200.2.269","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},{"id":"pmid:9050235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9050235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2969343864","display_name":null,"funder_award_id":"AI 30464","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8918286541","display_name":"MOLECULAR BIOLOGY OF BRUSH BORDER TRANSPORT PROTEINS","funder_award_id":"R01DK043171","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":204,"referenced_works":["https://openalex.org/W59367387","https://openalex.org/W91131327","https://openalex.org/W146261261","https://openalex.org/W181243240","https://openalex.org/W195923807","https://openalex.org/W221359381","https://openalex.org/W314960756","https://openalex.org/W1439525013","https://openalex.org/W1481077857","https://openalex.org/W1483242733","https://openalex.org/W1485152408","https://openalex.org/W1491108164","https://openalex.org/W1492432276","https://openalex.org/W1499693439","https://openalex.org/W1504256022","https://openalex.org/W1506990787","https://openalex.org/W1507082667","https://openalex.org/W1508427433","https://openalex.org/W1511763846","https://openalex.org/W1512148160","https://openalex.org/W1512720139","https://openalex.org/W1516995650","https://openalex.org/W1519991112","https://openalex.org/W1524627078","https://openalex.org/W1525006850","https://openalex.org/W1528724750","https://openalex.org/W1528744681","https://openalex.org/W1538758087","https://openalex.org/W1540979786","https://openalex.org/W1550534589","https://openalex.org/W1552195617","https://openalex.org/W1554256515","https://openalex.org/W1569463778","https://openalex.org/W1571311092","https://openalex.org/W1571640119","https://openalex.org/W1572652901","https://openalex.org/W1575097947","https://openalex.org/W1578249395","https://openalex.org/W1579793406","https://openalex.org/W1582359873","https://openalex.org/W1588789025","https://openalex.org/W1598691209","https://openalex.org/W1604834760","https://openalex.org/W1605408170","https://openalex.org/W1607148144","https://openalex.org/W1607476467","https://openalex.org/W1667106472","https://openalex.org/W1828734212","https://openalex.org/W1889155473","https://openalex.org/W1900227502","https://openalex.org/W1909791093","https://openalex.org/W1918683962","https://openalex.org/W1927131295","https://openalex.org/W1945689355","https://openalex.org/W1956322496","https://openalex.org/W1956844386","https://openalex.org/W1966967267","https://openalex.org/W1968537876","https://openalex.org/W1969339813","https://openalex.org/W1969387091","https://openalex.org/W1969400861","https://openalex.org/W1969535697","https://openalex.org/W1971095258","https://openalex.org/W1971871218","https://openalex.org/W1972685651","https://openalex.org/W1974027406","https://openalex.org/W1975715220","https://openalex.org/W1976129354","https://openalex.org/W1976754780","https://openalex.org/W1977638337","https://openalex.org/W1978756149","https://openalex.org/W1980253852","https://openalex.org/W1980263219","https://openalex.org/W1982557947","https://openalex.org/W1983034500","https://openalex.org/W1983197885","https://openalex.org/W1983783341","https://openalex.org/W1985205653","https://openalex.org/W1985911070","https://openalex.org/W1986125198","https://openalex.org/W1986451853","https://openalex.org/W1987307039","https://openalex.org/W1988754369","https://openalex.org/W1989875735","https://openalex.org/W1990892010","https://openalex.org/W1991442236","https://openalex.org/W1991701465","https://openalex.org/W1991866758","https://openalex.org/W1995309400","https://openalex.org/W1996096481","https://openalex.org/W1997634040","https://openalex.org/W1999613366","https://openalex.org/W2000434903","https://openalex.org/W2003266390","https://openalex.org/W2003410399","https://openalex.org/W2004234023","https://openalex.org/W2005725623","https://openalex.org/W2007938003","https://openalex.org/W2011174851","https://openalex.org/W2012344586","https://openalex.org/W2013736327","https://openalex.org/W2017460353","https://openalex.org/W2018048128","https://openalex.org/W2018149549","https://openalex.org/W2020854995","https://openalex.org/W2020972755","https://openalex.org/W2021864163","https://openalex.org/W2022200746","https://openalex.org/W2022628608","https://openalex.org/W2026127603","https://openalex.org/W2028206171","https://openalex.org/W2028604388","https://openalex.org/W2028714627","https://openalex.org/W2031338827","https://openalex.org/W2035115978","https://openalex.org/W2038049630","https://openalex.org/W2039988054","https://openalex.org/W2042503380","https://openalex.org/W2043049122","https://openalex.org/W2046507378","https://openalex.org/W2049429481","https://openalex.org/W2054683291","https://openalex.org/W2058107876","https://openalex.org/W2058382351","https://openalex.org/W2059381396","https://openalex.org/W2060137396","https://openalex.org/W2060296585","https://openalex.org/W2060355646","https://openalex.org/W2062095186","https://openalex.org/W2063201064","https://openalex.org/W2064831937","https://openalex.org/W2064974294","https://openalex.org/W2067320780","https://openalex.org/W2068132259","https://openalex.org/W2070065790","https://openalex.org/W2072620493","https://openalex.org/W2075010865","https://openalex.org/W2078310394","https://openalex.org/W2079507733","https://openalex.org/W2079812049","https://openalex.org/W2080669569","https://openalex.org/W2081143366","https://openalex.org/W2083674889","https://openalex.org/W2083729530","https://openalex.org/W2084995030","https://openalex.org/W2085222910","https://openalex.org/W2085367844","https://openalex.org/W2087339186","https://openalex.org/W2089201134","https://openalex.org/W2090752527","https://openalex.org/W2090796300","https://openalex.org/W2091910605","https://openalex.org/W2093012870","https://openalex.org/W2094673798","https://openalex.org/W2096557732","https://openalex.org/W2099202697","https://openalex.org/W2107658967","https://openalex.org/W2109740923","https://openalex.org/W2114824538","https://openalex.org/W2117295873","https://openalex.org/W2120195818","https://openalex.org/W2127112852","https://openalex.org/W2127361023","https://openalex.org/W2127905851","https://openalex.org/W2135152819","https://openalex.org/W2143515094","https://openalex.org/W2149979678","https://openalex.org/W2151211195","https://openalex.org/W2151440675","https://openalex.org/W2157853053","https://openalex.org/W2159021543","https://openalex.org/W2164056657","https://openalex.org/W2166786750","https://openalex.org/W2170676702","https://openalex.org/W2172003643","https://openalex.org/W2180360215","https://openalex.org/W2189292290","https://openalex.org/W2219978756","https://openalex.org/W2274063107","https://openalex.org/W2287024850","https://openalex.org/W2288378895","https://openalex.org/W2313326603","https://openalex.org/W2330970815","https://openalex.org/W2337465575","https://openalex.org/W2338977294","https://openalex.org/W2361551265","https://openalex.org/W2397666130","https://openalex.org/W2408221665","https://openalex.org/W2409998961","https://openalex.org/W2412924697","https://openalex.org/W2414384379","https://openalex.org/W2415687621","https://openalex.org/W2418407797","https://openalex.org/W2431479088","https://openalex.org/W2439980688","https://openalex.org/W2440011951","https://openalex.org/W2460875008","https://openalex.org/W2495387164","https://openalex.org/W3145894777","https://openalex.org/W4205775889","https://openalex.org/W4250756743","https://openalex.org/W4390903527","https://openalex.org/W6714547312","https://openalex.org/W6843544121"],"related_works":["https://openalex.org/W2145806440","https://openalex.org/W2001669389","https://openalex.org/W2535433409","https://openalex.org/W2333851958","https://openalex.org/W2151211195","https://openalex.org/W2174879004","https://openalex.org/W1982557947","https://openalex.org/W1994214667","https://openalex.org/W2303734540","https://openalex.org/W940303376"],"abstract_inverted_index":{"In":[0,228,263,309,404],"mammalian":[1,400],"cells,":[2],"the":[3,27,35,51,55,75,98,110,152,168,179,189,199,214,223,229,237,240,255,265,299,326,330,339,370,399,410,428,444,460,492],"uptake":[4,80,266,321,462],"of":[5,29,37,54,58,126,151,188,201,217,243,260,329,351,431,440,446,459,463,475,483],"amino":[6,102,158,219,261,304,319,347,371,394,415],"acids":[7],"is":[8,233,275,332,337,478],"mediated":[9],"by":[10,65,79,88,277,398],"specialized,":[11],"energy-dependent":[12,21],"and":[13,71,87,100,109,112,115,136,161,186,248,274,306,413,417,466,498],"passive":[14],"transporters":[15,22,40,44,77,95,155,173,221,477],"with":[16,67,206,286,302],"overlapping":[17],"substrate":[18,387],"specificities.":[19,308],"Most":[20],"are":[23,41,174,212,294,424],"coupled":[24,317],"either":[25,42],"to":[26,34,50,90,140,196,311,318,366,369,406,426,456,494],"cotransport":[28],"Na+":[30,313],"or":[31,33,45],"Cl-":[32],"countertransport":[36],"K+.":[38],"Passive":[39],"facilitated":[43],"channels.":[46],"As":[47],"a":[48,278,385,454],"prelude":[49],"molecular":[52,215,429,473,486],"characterization":[53,125],"different":[56,141],"classes":[57],"transporters,":[59],"we":[60,72,211],"have":[61,73,193,290,384],"isolated":[62],"transporter":[63,119],"cDNAs":[64],"expression-cloning":[66],"Xenopus":[68,450],"laevis":[69,451],"oocytes":[70,83,452],"characterized":[74,377],"cloned":[76],"functionally":[78],"studies":[81,423],"into":[82,236,409,414,449],"using":[84],"radiolabelled":[85],"substrates":[86],"electrophysiology":[89],"determine":[91],"substrate-evoked":[92],"currents.":[93],"Mammalian":[94],"investigated":[96],"include":[97],"dibasic":[99],"neutral":[101,346],"acid":[103,159,220,305,320,348,372,395,416],"transport":[104,134,296,349,373],"protein":[105],"D2/NBAT":[106],"(system":[107,121],"b0+)":[108],"Na(+)-":[111],"K(+)-dependent":[113],"neuronal":[114],"epithelial":[116,380],"high-affinity":[117],"glutamate":[118,172,181],"EAAC1":[120],"XAG-).":[122],"A":[123],"detailed":[124],"these":[127,154,432,476],"proteins":[128],"has":[129,146,354],"provided":[130],"new":[131],"information":[132],"on":[133],"characteristics":[135,216,430],"mechanisms":[137],"for":[138,198,258],"coupling":[139,341],"inorganic":[142],"ions.":[143],"This":[144],"work":[145],"furthermore":[147],"advanced":[148],"our":[149],"understanding":[150],"roles":[153],"play":[156],"in":[157,162,167,177,204,222,298,343,378,420,480,491],"homeostasis":[160,419],"various":[163],"pathologies.":[164],"For":[165],"example,":[166],"central":[169],"nervous":[170],"system,":[171],"critically":[175],"important":[176],"maintaining":[178],"extracellular":[180],"concentration":[182],"below":[183],"neurotoxic":[184],"levels,":[185],"defects":[187],"human":[190],"D2":[191],"gene":[192],"been":[194,355],"shown":[195,291],"account":[197],"formation":[200],"kidney":[202],"stones":[203],"patients":[205],"cystinuria.":[207],"Using":[208],"similar":[209],"approaches,":[210],"investigating":[213],"K(+)-coupled":[218],"larval":[224,230,300,352],"lepidopteran":[225],"insect":[226,433,499],"midgut.":[227],"midgut,":[231],"K+":[232,336,418],"actively":[234],"secreted":[235],"lumen":[238],"through":[239],"concerted":[241],"action":[242],"an":[244,249,393],"apical":[245,250],"H+":[246],"V-ATPase":[247],"K+/2H+":[251],"antiporter,":[252],"thereby":[253],"providing":[254],"driving":[256],"force":[257],"absorption":[259],"acids.":[262],"vivo,":[264],"occurs":[267],"at":[268,322],"extremely":[269],"high":[270],"pH":[271,470],"(pH":[272],"10)":[273],"driven":[276],"large":[279],"potential":[280],"difference":[281],"(approximately":[282],"-200":[283],"mV).":[284],"Studies":[285],"brush-border":[287],"membrane":[288],"vesicles":[289],"that":[292,335,438],"there":[293],"several":[295],"systems":[297,383],"intestine":[301],"distinct":[303],"cation":[307,362],"addition":[310],"K+,":[312],"can":[314],"also":[315],"be":[316,367,489],"lower":[323],"pH,":[324],"but":[325],"Na+/K+":[327],"ratio":[328],"hemolymph":[331],"so":[333],"low":[334],"probably":[338],"major":[340],"ion":[342],"vivo.":[344],"The":[345,472],"system":[350,374,402],"midgut":[353,445],"studied":[356],"most":[357],"extensively.":[358],"Apart":[359],"from":[360,443],"its":[361],"selectivity,":[363],"it":[364],"appears":[365],"related":[368],"B":[375],"previously":[376],"vertebrate":[379],"cells.":[381],"Both":[382],"broad":[386],"range":[388],"which":[389],"excludes":[390],"2-(methylamino)-isobutyric":[391],"acid,":[392],"analog":[396],"accepted":[397],"Na(+)-coupled":[401],"A.":[403],"order":[405],"gain":[407],"insights":[408],"K(+)-coupling":[411],"mechanism":[412],"insects,":[421],"current":[422],"designed":[425],"delineate":[427],"transporters.":[434],"Recent":[435],"data":[436],"showed":[437],"injection":[439],"mRNA":[441],"prepared":[442],"Manduca":[447],"sexta":[448],"induced":[453],"1.5-":[455],"2.5-fold":[457],"stimulation":[458],"Na(+)-dependent":[461],"both":[464],"leucine":[465],"phenylalanine":[467],"(0.2":[468],"mmoll-1,":[469],"8).":[471],"cloning":[474],"now":[479],"progress.":[481],"Knowledge":[482],"their":[484],"unique":[485],"properties":[487],"could":[488],"exploited":[490],"future":[493],"control":[495],"disease":[496],"vectors":[497],"pests.":[500]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
