{"id":"https://openalex.org/W1923739628","doi":"https://doi.org/10.1111/j.1460-9568.2012.08147.x","title":"GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABAB receptors in the rat globus pallidus","display_name":"GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABAB receptors in the rat globus pallidus","publication_year":2012,"publication_date":"2012-05-23","ids":{"openalex":"https://openalex.org/W1923739628","doi":"https://doi.org/10.1111/j.1460-9568.2012.08147.x","mag":"1923739628","pmid":"https://pubmed.ncbi.nlm.nih.gov/22616751"},"language":"en","primary_location":{"id":"doi:10.1111/j.1460-9568.2012.08147.x","doi":"https://doi.org/10.1111/j.1460-9568.2012.08147.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2012.08147.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3424346","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111774426","display_name":"Xiao\u2010Tao Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4392738091","display_name":"Emory National Primate Research Center","ror":"https://ror.org/038kr2d80","country_code":null,"type":"facility","lineage":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Tao Jin","raw_affiliation_strings":["Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005765817","display_name":"Jean\u2010Fran\u00e7ois Par\u00e9","orcid":"https://orcid.org/0000-0001-5621-9472","observed_orcids":["https://orcid.org/0000-0001-5621-9472"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4392738091","display_name":"Emory National Primate Research Center","ror":"https://ror.org/038kr2d80","country_code":null,"type":"facility","lineage":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean\u2010Francois Par\u00e9","raw_affiliation_strings":["Division of Neuroscience, Yerkes National Primate Research Center Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA","Division of Neuroscience, Yerkes National Primate Research Center \u2028Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Yerkes National Primate Research Center Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]},{"raw_affiliation_string":"Division of Neuroscience, Yerkes National Primate Research Center \u2028Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051289855","display_name":"Yoland Smith","orcid":"https://orcid.org/0000-0002-8700-878X","observed_orcids":["https://orcid.org/0000-0002-8700-878X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4392738091","display_name":"Emory National Primate Research Center","ror":"https://ror.org/038kr2d80","country_code":null,"type":"facility","lineage":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoland Smith","raw_affiliation_strings":["Division of Neuroscience, Yerkes National Primate Research Center Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA","Division of Neuroscience, Yerkes National Primate Research Center \u2028Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Yerkes National Primate Research Center Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]},{"raw_affiliation_string":"Division of Neuroscience, Yerkes National Primate Research Center \u2028Department of Neurology, UDALL Center of Excellence for Parkinson\u2019s Disease, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051289855"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":0.1199,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.4082942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"4","first_page":"2482","last_page":"2492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presynaptic-gabab-receptors","display_name":"presynaptic GABAB receptors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.9150000214576721},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"globus pallidus","score":0.972000002861023},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.6990000009536743},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-currents","display_name":"excitatory postsynaptic currents","score":0.7900000214576721},{"id":"https://openalex.org/keywords/miniature-excitatory-postsynaptic-currents","display_name":"miniature excitatory postsynaptic currents","score":0.8769999742507935},{"id":"https://openalex.org/keywords/paired-pulse-ratio","display_name":"paired-pulse ratio","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.8052470684051514},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7423930764198303},{"id":"https://openalex.org/C2779046065","wikidata":"https://www.wikidata.org/wiki/Q5512772","display_name":"GABA transporter","level":4,"score":0.7350584864616394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6499616503715515},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5661766529083252},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5526712536811829},{"id":"https://openalex.org/C2910581834","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Postsynaptic Current","level":4,"score":0.51738440990448},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5043751001358032},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4935826063156128},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4555531442165375},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.44704416394233704},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.4227685332298279},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3412752151489258},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25203317403793335},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.1969132423400879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18665459752082825},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11666038632392883},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.10981243848800659},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.04885503649711609}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000840","descriptor_name":"Anisoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000840","descriptor_name":"Anisoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000840","descriptor_name":"Anisoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000840","descriptor_name":"Anisoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005917","descriptor_name":"Globus Pallidus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005917","descriptor_name":"Globus Pallidus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005917","descriptor_name":"Globus Pallidus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005917","descriptor_name":"Globus Pallidus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009557","descriptor_name":"Nipecotic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009557","descriptor_name":"Nipecotic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009557","descriptor_name":"Nipecotic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009557","descriptor_name":"Nipecotic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010721","descriptor_name":"Phosphinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010721","descriptor_name":"Phosphinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010721","descriptor_name":"Phosphinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010721","descriptor_name":"Phosphinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058788","descriptor_name":"GABA-B Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058788","descriptor_name":"GABA-B Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058788","descriptor_name":"GABA-B Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058788","descriptor_name":"GABA-B Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058805","descriptor_name":"GABA Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058805","descriptor_name":"GABA Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058805","descriptor_name":"GABA Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058805","descriptor_name":"GABA Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1460-9568.2012.08147.x","doi":"https://doi.org/10.1111/j.1460-9568.2012.08147.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2012.08147.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:22616751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22616751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2720526","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3424346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3424346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3424346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3424346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3424346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G243208949","display_name":null,"funder_award_id":"RR-00 165","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2866559844","display_name":null,"funder_award_id":"R34 NS043293","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3286356257","display_name":null,"funder_award_id":"R01 NS 043293","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G351718288","display_name":null,"funder_award_id":"P51 RR000165","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4936443542","display_name":"GABAB Receptors and Parkinson's Disease","funder_award_id":"R01NS042937","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G574656479","display_name":null,"funder_award_id":"P50-NS071669","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7512266143","display_name":"Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy","funder_award_id":"5p50ns071669-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W67022927","https://openalex.org/W99477398","https://openalex.org/W276979954","https://openalex.org/W1510554078","https://openalex.org/W1516995431","https://openalex.org/W1517200518","https://openalex.org/W1526327880","https://openalex.org/W1558862799","https://openalex.org/W1597836184","https://openalex.org/W1844768017","https://openalex.org/W1877124937","https://openalex.org/W1971982338","https://openalex.org/W1974122096","https://openalex.org/W1975005653","https://openalex.org/W1978595303","https://openalex.org/W1990429945","https://openalex.org/W1991325525","https://openalex.org/W1992945202","https://openalex.org/W1993861337","https://openalex.org/W1994376562","https://openalex.org/W2007110690","https://openalex.org/W2015677561","https://openalex.org/W2021194790","https://openalex.org/W2030108063","https://openalex.org/W2032733509","https://openalex.org/W2035447387","https://openalex.org/W2036067700","https://openalex.org/W2039633685","https://openalex.org/W2045678127","https://openalex.org/W2058011414","https://openalex.org/W2059058978","https://openalex.org/W2060588252","https://openalex.org/W2066694525","https://openalex.org/W2072462647","https://openalex.org/W2073417426","https://openalex.org/W2074402500","https://openalex.org/W2077225716","https://openalex.org/W2077648124","https://openalex.org/W2080760355","https://openalex.org/W2082436201","https://openalex.org/W2084765880","https://openalex.org/W2095951518","https://openalex.org/W2098220634","https://openalex.org/W2099666439","https://openalex.org/W2110469184","https://openalex.org/W2114135055","https://openalex.org/W2127725235","https://openalex.org/W2130791093","https://openalex.org/W2131784236","https://openalex.org/W2134348865","https://openalex.org/W2136569779","https://openalex.org/W2138008736","https://openalex.org/W2142619185","https://openalex.org/W2144869674","https://openalex.org/W2150009200","https://openalex.org/W2157230965","https://openalex.org/W2165731751","https://openalex.org/W2171601518","https://openalex.org/W2340859740","https://openalex.org/W2409547278","https://openalex.org/W2418731042"],"related_works":["https://openalex.org/W1818157351","https://openalex.org/W1996815194","https://openalex.org/W2085625619","https://openalex.org/W2080708567","https://openalex.org/W2748185513","https://openalex.org/W2947630452","https://openalex.org/W2168868151","https://openalex.org/W1977324759","https://openalex.org/W2025553361","https://openalex.org/W2063482618"],"abstract_inverted_index":{"The":[0,147,164],"intra-pallidal":[1],"application":[2,112,118],"of":[3,32,45,74,89,104,113,119,132,150,167,178,188,210],"\u03b3-aminobutyric":[4],"acid":[5,20,26],"(GABA)":[6],"transporter":[7,13,17,57],"subtype":[8,14],"1":[9],"(GAT-1)":[10],"or":[11,24,124,216],"GABA":[12,53,56,202,243],"3":[15],"(GAT-3)":[16],"blockers":[18],"[1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic":[19],"hydrochloride":[21],"(SKF":[22],"89976A)":[23],"1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic":[25],"(SNAP":[27],"5114)]":[28],"reduces":[29],"the":[30,43,66,72,87,102,110,130,172,176,186,208,234],"activity":[31,261],"pallidal":[33],"neurons":[34],"in":[35,49,86,95,185,228,241,265],"monkey.":[36],"This":[37],"effect":[38,137,149],"could":[39],"be":[40,263],"mediated":[41],"through":[42,207],"activation":[44,209],"presynaptic":[46,194,211,225],"GABA(B)":[47,106,161,212,226],"heteroreceptors":[48,213,227],"glutamatergic":[50,205,230],"terminals":[51],"by":[52,109,157,245,257],"spillover":[54],"following":[55,214],"(GAT)":[58],"blockade.":[59,218],"To":[60],"test":[61],"this":[62],"hypothesis,":[63],"we":[64],"applied":[65],"whole-cell":[67],"recording":[68],"technique":[69],"to":[70,233,239],"study":[71],"effects":[73],"SKF":[75,120],"89976A":[76,121],"and":[77,142],"SNAP":[78,125],"5114":[79,126],"on":[80,138,153],"evoked":[81],"excitatory":[82,180],"postsynaptic":[83,105,181],"currents":[84,182],"(eEPSCs)":[85],"presence":[88,187],"gabazine,":[90],"a":[91,135,160,193,254],"GABA(A)":[92],"receptor":[93,107,162],"antagonist,":[94],"rat":[96],"globus":[97,235],"pallidus":[98,236],"slice":[99],"preparations.":[100],"Under":[101],"condition":[103],"blockade":[108,152,252],"intra-cellular":[111],"N-(2,6-dimethylphenylcarbamoylmethyl)-triethylammonium":[114],"bromide":[115],"(OX314),":[116],"bath":[117],"(10":[122,127],"\u03bcM)":[123,128],"decreased":[129],"amplitude":[131],"eEPSCs,":[133],"without":[134],"significant":[136],"its":[139],"holding":[140],"current":[141],"whole":[143],"cell":[144],"input":[145],"resistance.":[146],"inhibitory":[148],"GAT":[151,190,246,251],"eEPSCs":[154,168],"was":[155,169,183],"blocked":[156],"(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic":[158],"acid,":[159],"antagonist.":[163],"paired-pulse":[165],"ratio":[166],"increased,":[170],"whereas":[171],"frequency,":[173],"but":[174],"not":[175],"amplitude,":[177],"miniature":[179],"reduced":[184,264],"either":[189],"blocker,":[191],"demonstrating":[192],"effect.":[195],"These":[196],"results":[197],"suggest":[198],"that":[199,224,250],"synaptically":[200],"released":[201],"can":[203],"inhibit":[204],"transmission":[206],"GAT-1":[215],"GAT-3":[217],"In":[219],"conclusion,":[220],"our":[221],"findings":[222],"demonstrate":[223],"putative":[229],"subthalamic":[231],"afferents":[232],"are":[237],"sensitive":[238],"increases":[240],"extracellular":[242],"induced":[244],"inactivation,":[247],"thereby":[248],"suggesting":[249],"represents":[253],"potential":[255],"mechanism":[256],"which":[258],"overactive":[259],"subthalamopallidal":[260],"may":[262],"parkinsonism.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}