{"id":"https://openalex.org/W19224715","doi":null,"title":"BDNF et stress oxydant : deux acteurs majeurs de la vuln\u00e9rabilit\u00e9 \u00e0 la d\u00e9pression","display_name":"BDNF et stress oxydant : deux acteurs majeurs de la vuln\u00e9rabilit\u00e9 \u00e0 la d\u00e9pression","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W19224715","mag":"19224715"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/892274","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/892274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/892274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051474885","display_name":"Elodie Bouvier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elodie Bouvier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051474885"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.19689999520778656,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9100000262260437},{"id":"https://openalex.org/keywords/vulnerability-to-depression","display_name":"depression vulnerability","score":0.9449999928474426},{"id":"https://openalex.org/keywords/social-defeat","display_name":"social defeat","score":0.6809999942779541},{"id":"https://openalex.org/keywords/chronic-mild-stress","display_name":"chronic mild stress","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hippocampal-atrophy","display_name":"hippocampal atrophy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nrf2-translocation","display_name":"Nrf2 nuclear translocation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sulfiredoxin","display_name":"sulfiredoxin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/peroxiredoxin-2","display_name":"peroxiredoxin 2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antidepressant-targets","display_name":"antidepressant targets","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5005934238433838},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4839525520801544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46571826934814453},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.376659631729126},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.20677107572555542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17313003540039062}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/892274","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/892274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:19224715","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2012PA066693","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/892274","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/892274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5591214785","display_name":null,"funder_award_id":"N01-NS-42362","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7008159582","https://openalex.org/W7148932945","https://openalex.org/W4392326048","https://openalex.org/W4404260285","https://openalex.org/W83840249","https://openalex.org/W615587170","https://openalex.org/W7010746584","https://openalex.org/W7001314102","https://openalex.org/W14838658","https://openalex.org/W3021678070"],"abstract_inverted_index":{"Un":[0],"stress":[1,38,65,231],"intense":[2],"peut":[3,27],"\u00eatre":[4],"\u00e0":[5,20,46,50,61,130,136,177,197,204,217,233,249],"l":[6,126,140,178,198,205,234,237],"origine":[7,206,235],"d":[8,34,42,207],"une":[9,35,43,137,208,244],"d\u00e9pression,":[10,132],"des":[11,14,21,30,48,71,84,116,192,247,253],"mois,":[12],"voire":[13],"ann\u00e9es":[15],"plus":[16,59],"tard,":[17,60],"en":[18,181],"r\u00e9ponse":[19],"\u00e9v\u00e8nements":[22],"de":[23,53,64,74,79,101,106,125,128,139,148,159,167,186,194,200,210,214,220,223,230,236,251,258],"vie":[24],"mineurs.":[25],"Il":[26],"ainsi":[28,203],"laisser":[29],"traces":[31],"r\u00e9siduelles,":[32],"responsables":[33],"sensibilisation":[36],"aux":[37],"ult\u00e9rieurs.":[39],"Au":[40],"terme":[41],"proc\u00e9dure":[44],"consistant":[45],"soumettre":[47],"rats":[49,107],"un":[51,57,77,94,228],"protocole":[52],"d\u00e9faite":[54],"sociale,":[55],"puis,":[56],"mois":[58],"trois":[62],"semaines":[63],"chroniques":[66],"l\u00e9gers":[67],"(SCL),":[68],"42":[69],"%":[70,86],"animaux,":[72],"qualifi\u00e9s":[73],"r\u00e9pondeurs,":[75],"pr\u00e9sentent":[76],"profil":[78],"type":[80],"d\u00e9pressif,":[81],"au":[82],"contraire":[83],"58":[85],"restants,":[87],"appel\u00e9s":[88],"non-r\u00e9pondeurs.":[89],"Le":[90,151],"BDNF":[91,195],"s\u00e9rique":[92],"repr\u00e9sente":[93],"marqueur":[95],"biologique":[96],"pertinent,":[97],"car":[98],"il":[99],"permet":[100],"distinguer":[102],"ces":[103],"deux":[104],"populations":[105],"avant":[108],"le":[109,113,119],"SCL,":[110],"alors":[111,227],"que":[112],"ph\u00e9notype":[114],"comportemental":[115],"animaux":[117],"est":[118,123,134,202],"m\u00eame.":[120],"Sa":[121],"diminution":[122,219],"caract\u00e9ristique":[124],"\u00e9tat":[127,199,229],"vuln\u00e9rabilit\u00e9":[129,201],"la":[131,144,154,165,173,183,187,211,218,221,224],"et":[133,256],"associ\u00e9e":[135,196],"atrophie":[138,238],"hippocampe":[141],"qui":[142,175],"constitue":[143],"trace":[145],"r\u00e9siduelle":[146],"responsable":[147],"cet":[149],"\u00e9tat.":[150],"BDNF,":[152],"contr\u00f4lant":[153],"translocation":[155,212],"nucl\u00e9aire":[156,213],"du":[157],"facteur":[158],"transcription":[160,166,222],"redox":[161,180],"sensible":[162],"Nrf2,":[163,215],"favorise":[164],"prot\u00e9ines":[168],"antioxydantes.":[169],"Parmi":[170],"elles,":[171],"figure":[172],"sulfir\u00e9doxine":[174],"participe":[176],"\u00e9quilibre":[179],"restaurant":[182],"forme":[184],"active":[185],"peroxir\u00e9doxine":[188],"2.":[189],"La":[190],"baisse":[191],"taux":[193],"r\u00e9duction":[209],"conduisant":[216],"sulfir\u00e9doxine,":[225],"entra\u00eenant":[226],"oxydatif":[232],"hippocampique.":[239],"Ces":[240],"r\u00e9sultats":[241],"laissent":[242],"envisager":[243],"identification":[245],"pr\u00e9coce":[246],"individus":[248],"risque":[250],"d\u00e9velopper":[252],"troubles":[254],"d\u00e9pressifs":[255],"ouvrent":[257],"nouvelles":[259],"perspectives":[260],"th\u00e9rapeutiques":[261]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
