{"id":"https://openalex.org/W192228547","doi":null,"title":"Impact of diabetes on induction of the mitochondrial permeability transition.","display_name":"Impact of diabetes on induction of the mitochondrial permeability transition.","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W192228547","mag":"192228547","pmid":"https://pubmed.ncbi.nlm.nih.gov/12194377"},"language":"en","primary_location":{"id":"pmid:12194377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12194377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100747732","display_name":"Paulo Jorge Oliveira","orcid":"https://orcid.org/0000-0002-5201-9948","observed_orcids":["https://orcid.org/0000-0002-5201-9948"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paulo J Oliveira","raw_affiliation_strings":["Centro de Neuroci\u00eancias de Coimbra, Unidade de Investiga\u00e7\u00e3o B\u00e1sica em Cardiologia, Universidade de Coimbra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Neuroci\u00eancias de Coimbra, Unidade de Investiga\u00e7\u00e3o B\u00e1sica em Cardiologia, Universidade de Coimbra","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024381508","display_name":"Anabela Pinto Rolo","orcid":"https://orcid.org/0000-0003-3535-9630","observed_orcids":["https://orcid.org/0000-0003-3535-9630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anabela P Rolo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088899608","display_name":"Raquel Maria Fino Sei\u00e7a","orcid":"https://orcid.org/0000-0002-8378-0895","observed_orcids":["https://orcid.org/0000-0002-8378-0895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raquel Sei\u00e7a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020520139","display_name":"Vilma A. Sard\u00e3o","orcid":"https://orcid.org/0000-0001-7014-4614","observed_orcids":["https://orcid.org/0000-0001-7014-4614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vilma Sard\u00e3o","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031874851","display_name":"Pedro F. Monteiro","orcid":"https://orcid.org/0000-0002-6631-207X","observed_orcids":["https://orcid.org/0000-0002-6631-207X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Monteiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038080240","display_name":"Lino Manuel Martins Gon\u00e7alves","orcid":"https://orcid.org/0000-0001-9255-3064","observed_orcids":["https://orcid.org/0000-0001-9255-3064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lino Gon\u00e7alves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108492720","display_name":"Lu\u00eds Provid\u00eancia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu\u00eds Provid\u00eancia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082432780","display_name":"Carlos M. Palmeira","orcid":"https://orcid.org/0000-0002-2639-7697","observed_orcids":["https://orcid.org/0000-0002-2639-7697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos M Palmeira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026086117","display_name":"Maria S. Santos","orcid":"https://orcid.org/0000-0002-6881-9392","observed_orcids":["https://orcid.org/0000-0002-6881-9392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria S Santos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041425326","display_name":"Ant\u00f3nio J. Moreno","orcid":"https://orcid.org/0000-0003-3575-7604","observed_orcids":["https://orcid.org/0000-0003-3575-7604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio J M Moreno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1912,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.41358494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"6","first_page":"759","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.15049999952316284,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-mitochondria","display_name":"heart mitochondria","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mitochondrial-calcium-accumulation","display_name":"mitochondrial calcium accumulation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8650000095367432},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mitochondrial-swelling","display_name":"mitochondrial swelling","score":0.7039999961853027},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.7369999885559082},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.7831407785415649},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7707598209381104},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.694778561592102},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.632800817489624},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6264404654502869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5446961522102356},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.5015180110931396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4945063292980194},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4905835688114166},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47595831751823425},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33533766865730286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2971838414669037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2576196789741516},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.23068475723266602},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20834088325500488},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15290063619613647},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.12353134155273438},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0887124240398407}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008933","descriptor_name":"Mitochondrial Swelling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12194377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12194377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},{"id":"mag:192228547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12194377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095063209","https://openalex.org/W2216286835","https://openalex.org/W1980091076","https://openalex.org/W2049311910","https://openalex.org/W2352319070","https://openalex.org/W2328987043","https://openalex.org/W1541318946","https://openalex.org/W2728511390","https://openalex.org/W2075957528","https://openalex.org/W2891582801"],"abstract_inverted_index":{"Diabetes":[0],"is":[1,77],"one":[2],"of":[3,9,21,36,53,65,99,107,122,140,147,161,168],"the":[4,19,28,31,37,50,54,63,66,71,105,114,123,129,138,141,169,208],"most":[5],"common":[6],"metabolic":[7],"diseases":[8],"our":[10],"times.":[11],"Specific":[12],"cardiovascular":[13],"alterations":[14],"are":[15],"often":[16],"associated":[17,88,152],"with":[18,89,143,153,166],"progression":[20],"this":[22,100],"disease.":[23],"Considerable":[24],"controversy":[25],"exists":[26],"in":[27,116,199,207],"literature":[29],"concerning":[30],"greater":[32,155],"or":[33],"lesser":[34],"susceptibility":[35,52,106],"diabetic":[38,111,130,183,201],"heart":[39],"to":[40,49,56,62,103,113,118,157,190],"ischemia":[41,94,194],"and":[42,95,173,195],"reperfusion.":[43,96],"Cardiac":[44,126],"mitochondria":[45,108,127],"may":[46,185],"be":[47,187],"fundamental":[48],"differential":[51],"cardiomyocyte":[55],"pathologic":[57],"phenomena,":[58],"particularly":[59],"those":[60],"due":[61],"induction":[64],"degenerative":[67],"process":[68],"known":[69],"as":[70],"mitochondrial":[72,81],"permeability":[73],"transition":[74],"(MPT),":[75],"which":[76],"triggered":[78],"by":[79],"excessive":[80],"calcium":[82,134],"accumulation.":[83],"The":[84,97],"MPT":[85],"has":[86],"been":[87],"cellular":[90],"dysfunction":[91],"resulting":[92,192],"from":[93,110,128,182,193],"objective":[98],"work":[101],"was":[102,151],"examine":[104],"isolated":[109],"rats":[112,121,131],"MPT,":[115,142],"comparison":[117],"healthy":[119],"control":[120],"same":[124],"age.":[125],"had":[132],"higher":[133],"loading":[135],"capacity":[136,156],"before":[137],"development":[139],"a":[144,154],"decreased":[145],"incidence":[146],"MPTP-associated":[148],"features.":[149],"This":[150,177],"sustain":[158],"multiple":[159],"pulses":[160],"externally":[162],"added":[163],"calcium,":[164],"simultaneously":[165],"maintenance":[167],"transmembrane":[170],"electrical":[171],"potential":[172],"reduced":[174],"swelling":[175],"amplitude.":[176],"could":[178],"mean":[179],"that":[180],"cardiomyocytes":[181],"hearts":[184],"indeed":[186],"less":[188],"prone":[189],"dysfunctions":[191],"reperfusion,":[196],"at":[197],"least":[198],"milder":[200],"conditions,":[202],"thus":[203],"explaining":[204],"many":[205],"reports":[206],"literature.":[209]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
