{"id":"https://openalex.org/W1921739958","doi":"https://doi.org/10.1093/ajcn/71.5.1270s","title":"Role of cholesterol in embryonic development","display_name":"Role of cholesterol in embryonic development","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W1921739958","doi":"https://doi.org/10.1093/ajcn/71.5.1270s","mag":"1921739958","pmid":"https://pubmed.ncbi.nlm.nih.gov/10799401"},"language":"en","primary_location":{"id":"doi:10.1093/ajcn/71.5.1270s","doi":"https://doi.org/10.1093/ajcn/71.5.1270s","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ajcn/71.5.1270s","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0002916523071551/pdf","source":{"id":"https://openalex.org/S71285955","display_name":"American Journal of Clinical Nutrition","issn_l":"0002-9165","issn":["0002-9165","1938-3207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Clinical Nutrition","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0002916523071551/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108076862","display_name":"Charles Roux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charles Roux","raw_affiliation_strings":["Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale, CHU Saint-Antoine, Paris, France. chroux@ccr.jussieu.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale, CHU Saint-Antoine, Paris, France. chroux@ccr.jussieu.fr","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110118882","display_name":"Claude Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Wolf","raw_affiliation_strings":["From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105530428","display_name":"N Mulliez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicole Mulliez","raw_affiliation_strings":["From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080371707","display_name":"Wassila Gaoua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wassila Gaoua","raw_affiliation_strings":["From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001767521","display_name":"Val\u00e9rie Cormier\u2010Daire","orcid":"https://orcid.org/0000-0002-2839-9856","observed_orcids":["https://orcid.org/0000-0002-2839-9856"]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valerie Cormier","raw_affiliation_strings":["From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046129674","display_name":"Fran\u00e7oise Chevy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Chevy","raw_affiliation_strings":["Direction de la Recherche et des Etudes Doctorales (A 1533 ) and Centre d'Etude de Recherche et d'Information sur la Nutrition","From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Direction de la Recherche et des Etudes Doctorales (A 1533 ) and Centre d'Etude de Recherche et d'Information sur la Nutrition","institution_ids":[]},{"raw_affiliation_string":"From the Laboratoire d'Embryologie Pathologique Exp\u00e9rimentale , CHU Saint-Antoine , Paris ; the","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021816122","display_name":"Dani\u00e8le Citadelle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dani\u00e8le Citadelle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.0597,"has_fulltext":true,"cited_by_count":149,"citation_normalized_percentile":{"value":0.6424581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"71","issue":"5","first_page":"1270S","last_page":"1279S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.16349999606609344,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8119999766349792},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.9890000224113464},{"id":"https://openalex.org/keywords/smith-lemli-opitz-syndrome","display_name":"Smith-Lemli-Opitz syndrome","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dhcr7","display_name":"DHCR7","score":0.9020000100135803},{"id":"https://openalex.org/keywords/7-dehydrocholesterol","display_name":"7-dehydrocholesterol","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hypocholesterolemia","display_name":"hypocholesterolemia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/ay-9944","display_name":"AY-9944","score":0.9340000152587891},{"id":"https://openalex.org/keywords/triparanol","display_name":"triparanol","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.7820000052452087},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7369999885559082},{"id":"https://openalex.org/keywords/holoprosencephaly","display_name":"holoprosencephaly","score":0.9279999732971191},{"id":"https://openalex.org/keywords/limb-malformations","display_name":"limb malformations","score":0.7540000081062317},{"id":"https://openalex.org/keywords/46-xy-disorders-of-sex-development","display_name":"46,XY disorders of sex development","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cholesterol-synthesis-inhibitors","display_name":"cholesterol biosynthesis inhibitors","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2780716534","wikidata":"https://www.wikidata.org/wiki/Q998273","display_name":"Smith\u2013Lemli\u2013Opitz syndrome","level":5,"score":0.9082575440406799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6972945928573608},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6705905795097351},{"id":"https://openalex.org/C2778978578","wikidata":"https://www.wikidata.org/wiki/Q10295810","display_name":"Hypocholesterolemia","level":3,"score":0.6594516038894653},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5199488401412964},{"id":"https://openalex.org/C2781374659","wikidata":"https://www.wikidata.org/wiki/Q1459821","display_name":"Holoprosencephaly","level":4,"score":0.51729416847229},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.49533143639564514},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.4791916608810425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46057865023612976},{"id":"https://openalex.org/C2780022283","wikidata":"https://www.wikidata.org/wiki/Q3218465","display_name":"Lathosterol","level":5,"score":0.4132794141769409},{"id":"https://openalex.org/C104788683","wikidata":"https://www.wikidata.org/wiki/Q259292","display_name":"7-Dehydrocholesterol reductase","level":4,"score":0.36574268341064453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2786563038825989},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19010141491889954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15907546877861023},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.14755156636238098},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12611204385757446},{"id":"https://openalex.org/C2781471481","wikidata":"https://www.wikidata.org/wiki/Q2756479","display_name":"Campesterol","level":4,"score":0.11268845200538635},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.07290637493133545}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001371","descriptor_name":"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003684","descriptor_name":"Dehydrocholesterols","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014308","descriptor_name":"Triparanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D019082","descriptor_name":"Smith-Lemli-Opitz Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D019082","descriptor_name":"Smith-Lemli-Opitz Syndrome","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D019082","descriptor_name":"Smith-Lemli-Opitz Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajcn/71.5.1270s","doi":"https://doi.org/10.1093/ajcn/71.5.1270s","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ajcn/71.5.1270s","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0002916523071551/pdf","source":{"id":"https://openalex.org/S71285955","display_name":"American Journal of Clinical Nutrition","issn_l":"0002-9165","issn":["0002-9165","1938-3207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Clinical Nutrition","raw_type":"journal-article"},{"id":"pmid:10799401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10799401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of clinical nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/ajcn/71.5.1270s","doi":"https://doi.org/10.1093/ajcn/71.5.1270s","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ajcn/71.5.1270s","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0002916523071551/pdf","source":{"id":"https://openalex.org/S71285955","display_name":"American Journal of Clinical Nutrition","issn_l":"0002-9165","issn":["0002-9165","1938-3207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Clinical Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1921739958.pdf","grobid_xml":"https://content.openalex.org/works/W1921739958.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1488668665","https://openalex.org/W1511240493","https://openalex.org/W1859885259","https://openalex.org/W1903300978","https://openalex.org/W1964390696","https://openalex.org/W1966435498","https://openalex.org/W1969336236","https://openalex.org/W1970195398","https://openalex.org/W1976551834","https://openalex.org/W1988437387","https://openalex.org/W1992887441","https://openalex.org/W1994620081","https://openalex.org/W1995689947","https://openalex.org/W2002249795","https://openalex.org/W2006329459","https://openalex.org/W2023772381","https://openalex.org/W2025864519","https://openalex.org/W2026983637","https://openalex.org/W2038031724","https://openalex.org/W2050029166","https://openalex.org/W2059614045","https://openalex.org/W2067633454","https://openalex.org/W2084755905","https://openalex.org/W2094813413","https://openalex.org/W2096730084","https://openalex.org/W2100510117","https://openalex.org/W2102345821","https://openalex.org/W2112170664","https://openalex.org/W2120584900","https://openalex.org/W2141367941","https://openalex.org/W2156679744","https://openalex.org/W2168246831","https://openalex.org/W2188739220"],"related_works":["https://openalex.org/W2065490699","https://openalex.org/W2104214767","https://openalex.org/W2168246831","https://openalex.org/W2038031724","https://openalex.org/W2108798120","https://openalex.org/W2274378040","https://openalex.org/W1989008618","https://openalex.org/W1999999252","https://openalex.org/W2112383897","https://openalex.org/W2018127412"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}